Impact of age and co-morbidities in patients with newly diagnosed glioblastoma: a pooled data analysis of three prospective mono-institutional phase ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-12

AUTHORS

Mario Balducci, Alba Fiorentino, Pasquale De Bonis, Silvia Chiesa, Stefania Manfrida, Giuseppe Roberto D’Agostino, Giovanna Mantini, Vincenzo Frascino, Gian Carlo Mattiucci, Berardino De Bari, Annunziato Mangiola, Francesco Miccichè, Maria Antonietta Gambacorta, Gabriella Colicchio, Alessio Giuseppe Morganti, Carmelo Anile, Vincenzo Valentini

ABSTRACT

To analyse the impact of age and co-morbidities on compliance and outcomes in GBM patients enrolled in three prospective phase II trials. GBM patients (≥ 18 years) were treated with radiotherapy (60 Gy) or enrolled in a Fractionated Stereotactic Conformal-Radiotherapy Phase II trial (69.4 Gy). Concomitant and adjuvant chemotherapy with Temozolomide (TMZ) was administered. Charlson Index Co-morbidity (CCI) was used to assess co-morbidity. Toxicity was evaluated according to RTOG score. Survival analysis was performed by the Kaplan-Maier. Influence of age and co-morbidity was evaluated using log-rank test. From 2001 to 2008, 146 patients were enrolled: 56 (38.4 %) aged over 65 and 90 under 65. CCI ≥ 1 was observed in 41 % of elderly and 22 % of young group. Patients' compliance was 97.9 % for radio-chemotherapy. Acute toxicity was mild with no difference between the groups. Global median progression-free survival (PFS) and overall survival (OS) were 12 and 18 months, respectively. Age, surgery and radiation dose correlated with survival (p = 0.01, p = 0.04 and p = 0.03). CCI ≤ 2 did not show any influence on OS. Our data show that elderly with a good performance status and few co-morbidity may be treated as younger patients; moreover, age confirms a negative impact on survival while CCI ≤ 2 did not correlated with OS. More... »

PAGES

3478-3483

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12032-012-0263-3

DOI

http://dx.doi.org/10.1007/s12032-012-0263-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013371484

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22674154


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