Severe toxicity of capecitabine following uncomplicated treatment with 5-fluorouracil/leucovorin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-12

AUTHORS

Famke L. Schneiders, H. Pieter van den Berg, Godefridus J. Peters, Henk M. W. Verheul, Hans J. van der Vliet

ABSTRACT

Colorectal carcinomas are among the most common tumor types and are generally treated with palliative chemotherapy in case of metastatic disease. Here, we describe the case of a 58 year old woman with metastatic rectal carcinoma who developed severe gastrointestinal toxicity when the thus far well-tolerated intravenous 5-fluorouracil (5-FU)/leucovorin containing chemotherapeutic regimen was replaced by the same chemotherapeutic regimen in combination with the oral 5-FU prodrug capecitabine. This increased toxicity is probably due to the intracellular retention of polyglutamated folates induced by prior leucovorin therapy which, upon subsequent administration of capecitabine, will result in an enhanced and prolonged inhibition of the, for DNA synthesis important, enzyme thymidylate synthase, essentially creating a situation equivalent to overdosing. More... »

PAGES

1136-1139

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12032-010-9598-9

DOI

http://dx.doi.org/10.1007/s12032-010-9598-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032138284

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20567941


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antimetabolites, Antineoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Atorvastatin Calcium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bisoprolol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Capecitabine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Deoxycytidine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorouracil", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heptanoic Acids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypercholesterolemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ileus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leucovorin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphatic Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nausea", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pyrroles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ventricular Premature Complexes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vomiting", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "VU University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "Department of Medical Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schneiders", 
        "givenName": "Famke L.", 
        "id": "sg:person.01012334447.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012334447.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VU University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "Department of Medical Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van den Berg", 
        "givenName": "H. Pieter", 
        "id": "sg:person.01207713557.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207713557.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VU University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "Department of Medical Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peters", 
        "givenName": "Godefridus J.", 
        "id": "sg:person.01255301342.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255301342.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VU University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "Department of Medical Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Verheul", 
        "givenName": "Henk M. W.", 
        "id": "sg:person.011543041217.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011543041217.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VU University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "Department of Medical Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van der Vliet", 
        "givenName": "Hans J.", 
        "id": "sg:person.0773345524.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773345524.33"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.clinthera.2005.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004705751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012947440", 
          "https://doi.org/10.1038/nrc1074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012947440", 
          "https://doi.org/10.1038/nrc1074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa032691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014051315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-001-0408-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023246735", 
          "https://doi.org/10.1007/s00280-001-0408-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.14.9898", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027137405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.15.9426", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039289012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2001.19.8.2282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074800018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2001.19.21.4097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074948894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075945718", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077079020", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083352537", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-12", 
    "datePublishedReg": "2011-12-01", 
    "description": "Colorectal carcinomas are among the most common tumor types and are generally treated with palliative chemotherapy in case of metastatic disease. Here, we describe the case of a 58 year old woman with metastatic rectal carcinoma who developed severe gastrointestinal toxicity when the thus far well-tolerated intravenous 5-fluorouracil (5-FU)/leucovorin containing chemotherapeutic regimen was replaced by the same chemotherapeutic regimen in combination with the oral 5-FU prodrug capecitabine. This increased toxicity is probably due to the intracellular retention of polyglutamated folates induced by prior leucovorin therapy which, upon subsequent administration of capecitabine, will result in an enhanced and prolonged inhibition of the, for DNA synthesis important, enzyme thymidylate synthase, essentially creating a situation equivalent to overdosing.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12032-010-9598-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1094524", 
        "issn": [
          "1357-0560", 
          "1559-131X"
        ], 
        "name": "Medical Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "28"
      }
    ], 
    "name": "Severe toxicity of capecitabine following uncomplicated treatment with 5-fluorouracil/leucovorin", 
    "pagination": "1136-1139", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9919cdf3113cb698a983937da19eb9a66420b52a84f43197faa90b72cef0b112"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20567941"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9435512"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12032-010-9598-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032138284"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12032-010-9598-9", 
      "https://app.dimensions.ai/details/publication/pub.1032138284"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000522.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs12032-010-9598-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12032-010-9598-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12032-010-9598-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12032-010-9598-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12032-010-9598-9'


 

This table displays all metadata directly associated to this object as RDF triples.

221 TRIPLES      21 PREDICATES      63 URIs      44 LITERALS      32 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12032-010-9598-9 schema:about N0032e9b2ca43454d82b729ef14dfa843
2 N05a23e6a5beb405081de1408511b31d2
3 N0e126a62e74046e5b967ba90c3d42f4a
4 N1f73995179da4a25ac850935ea8e9e0f
5 N37a1e6e6a6664dcbb8a270ff7e1a3dc4
6 N3a1e8558f61d4def81896e4f63ae38c6
7 N3db9a0eab02b4aa8842e9eafb6523a3c
8 N627459da250b47e1a8e48a5617ca7ef6
9 N672f75ef47924d8d85756355924ed71b
10 N6e0c110fe879419b8624df7a817dddfd
11 N75f7f7aa032648cca65b9cc23132a0b0
12 N7790403f22aa464db60b3a9b0449992c
13 N92fe1aba7e7247268da13ebe699c1f14
14 Naada0bb15acc46ef8af0cd87f5da2ead
15 Nac5cbcc9f35b485b8dcfdeb9e9809183
16 Nc7455eb09c6144c8b7982a428b94ecdf
17 Ncbc28e4331ec44479ec814fd5f37cbc9
18 Ncd2abb2034224ca58ae650d8d57a3a5c
19 Nd27e736c8b074575a4565245ff30890d
20 Nd27ffb8235c6428eba85fbe8106d8aac
21 Nf1edb1b6d75a43959a9e49e7dbf44759
22 Nf314ffc40afe4ed59737be973734bcac
23 Nfe7f53858b7b4b51bb842836a3a507ea
24 anzsrc-for:11
25 anzsrc-for:1112
26 schema:author Nbca69c41ff984f92a03a871608b97ce0
27 schema:citation sg:pub.10.1007/s00280-001-0408-0
28 sg:pub.10.1038/nrc1074
29 https://app.dimensions.ai/details/publication/pub.1075945718
30 https://app.dimensions.ai/details/publication/pub.1077079020
31 https://app.dimensions.ai/details/publication/pub.1083352537
32 https://doi.org/10.1016/j.clinthera.2005.01.005
33 https://doi.org/10.1056/nejmoa032691
34 https://doi.org/10.1200/jco.2001.19.21.4097
35 https://doi.org/10.1200/jco.2001.19.8.2282
36 https://doi.org/10.1200/jco.2007.14.9898
37 https://doi.org/10.1200/jco.2007.15.9426
38 schema:datePublished 2011-12
39 schema:datePublishedReg 2011-12-01
40 schema:description Colorectal carcinomas are among the most common tumor types and are generally treated with palliative chemotherapy in case of metastatic disease. Here, we describe the case of a 58 year old woman with metastatic rectal carcinoma who developed severe gastrointestinal toxicity when the thus far well-tolerated intravenous 5-fluorouracil (5-FU)/leucovorin containing chemotherapeutic regimen was replaced by the same chemotherapeutic regimen in combination with the oral 5-FU prodrug capecitabine. This increased toxicity is probably due to the intracellular retention of polyglutamated folates induced by prior leucovorin therapy which, upon subsequent administration of capecitabine, will result in an enhanced and prolonged inhibition of the, for DNA synthesis important, enzyme thymidylate synthase, essentially creating a situation equivalent to overdosing.
41 schema:genre research_article
42 schema:inLanguage en
43 schema:isAccessibleForFree false
44 schema:isPartOf N3060712bb6444097aa8340806db0c09b
45 N9c52e26228ac4192931518f492032aaf
46 sg:journal.1094524
47 schema:name Severe toxicity of capecitabine following uncomplicated treatment with 5-fluorouracil/leucovorin
48 schema:pagination 1136-1139
49 schema:productId N21bed0534fa245e1bf0c836f617639f9
50 N4b2fe073d57947038f632609f926a1ee
51 N4ed90a9b9c6c4cae866f04cdf535d2e2
52 Nef9d12d5d6f34bf7bc8d3378d3cf30b9
53 Nfd1f7d901acf491cb2349638e82ce1e4
54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032138284
55 https://doi.org/10.1007/s12032-010-9598-9
56 schema:sdDatePublished 2019-04-10T15:03
57 schema:sdLicense https://scigraph.springernature.com/explorer/license/
58 schema:sdPublisher N3584f92262854e5785873f6401dc944e
59 schema:url http://link.springer.com/10.1007%2Fs12032-010-9598-9
60 sgo:license sg:explorer/license/
61 sgo:sdDataset articles
62 rdf:type schema:ScholarlyArticle
63 N0032e9b2ca43454d82b729ef14dfa843 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
64 schema:name Ileus
65 rdf:type schema:DefinedTerm
66 N05a23e6a5beb405081de1408511b31d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Pyrroles
68 rdf:type schema:DefinedTerm
69 N0d54b60341944c299e2b321985cb4d0f rdf:first sg:person.01207713557.55
70 rdf:rest Ndf06f8a672e546b9943786bdf2ba2e95
71 N0e126a62e74046e5b967ba90c3d42f4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Nausea
73 rdf:type schema:DefinedTerm
74 N1f73995179da4a25ac850935ea8e9e0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Capecitabine
76 rdf:type schema:DefinedTerm
77 N21bed0534fa245e1bf0c836f617639f9 schema:name nlm_unique_id
78 schema:value 9435512
79 rdf:type schema:PropertyValue
80 N2277122de0e741d88c4dd1b230b8f1ee rdf:first sg:person.0773345524.33
81 rdf:rest rdf:nil
82 N3060712bb6444097aa8340806db0c09b schema:volumeNumber 28
83 rdf:type schema:PublicationVolume
84 N3584f92262854e5785873f6401dc944e schema:name Springer Nature - SN SciGraph project
85 rdf:type schema:Organization
86 N37a1e6e6a6664dcbb8a270ff7e1a3dc4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Lymphatic Metastasis
88 rdf:type schema:DefinedTerm
89 N3a1e8558f61d4def81896e4f63ae38c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Leucovorin
91 rdf:type schema:DefinedTerm
92 N3db9a0eab02b4aa8842e9eafb6523a3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Vomiting
94 rdf:type schema:DefinedTerm
95 N4b2fe073d57947038f632609f926a1ee schema:name readcube_id
96 schema:value 9919cdf3113cb698a983937da19eb9a66420b52a84f43197faa90b72cef0b112
97 rdf:type schema:PropertyValue
98 N4ed90a9b9c6c4cae866f04cdf535d2e2 schema:name pubmed_id
99 schema:value 20567941
100 rdf:type schema:PropertyValue
101 N627459da250b47e1a8e48a5617ca7ef6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Female
103 rdf:type schema:DefinedTerm
104 N672f75ef47924d8d85756355924ed71b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Bisoprolol
106 rdf:type schema:DefinedTerm
107 N6e0c110fe879419b8624df7a817dddfd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Colic
109 rdf:type schema:DefinedTerm
110 N7498136c19d044cca5b1ab798d271f96 rdf:first sg:person.011543041217.55
111 rdf:rest N2277122de0e741d88c4dd1b230b8f1ee
112 N75f7f7aa032648cca65b9cc23132a0b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Ventricular Premature Complexes
114 rdf:type schema:DefinedTerm
115 N7790403f22aa464db60b3a9b0449992c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Hypercholesterolemia
117 rdf:type schema:DefinedTerm
118 N92fe1aba7e7247268da13ebe699c1f14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Antimetabolites, Antineoplastic
120 rdf:type schema:DefinedTerm
121 N9c52e26228ac4192931518f492032aaf schema:issueNumber 4
122 rdf:type schema:PublicationIssue
123 Naada0bb15acc46ef8af0cd87f5da2ead schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Bone Neoplasms
125 rdf:type schema:DefinedTerm
126 Nac5cbcc9f35b485b8dcfdeb9e9809183 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Middle Aged
128 rdf:type schema:DefinedTerm
129 Nbca69c41ff984f92a03a871608b97ce0 rdf:first sg:person.01012334447.12
130 rdf:rest N0d54b60341944c299e2b321985cb4d0f
131 Nc7455eb09c6144c8b7982a428b94ecdf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Heptanoic Acids
133 rdf:type schema:DefinedTerm
134 Ncbc28e4331ec44479ec814fd5f37cbc9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Antineoplastic Combined Chemotherapy Protocols
136 rdf:type schema:DefinedTerm
137 Ncd2abb2034224ca58ae650d8d57a3a5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Colorectal Neoplasms
139 rdf:type schema:DefinedTerm
140 Nd27e736c8b074575a4565245ff30890d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Fluorouracil
142 rdf:type schema:DefinedTerm
143 Nd27ffb8235c6428eba85fbe8106d8aac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Deoxycytidine
145 rdf:type schema:DefinedTerm
146 Ndf06f8a672e546b9943786bdf2ba2e95 rdf:first sg:person.01255301342.17
147 rdf:rest N7498136c19d044cca5b1ab798d271f96
148 Nef9d12d5d6f34bf7bc8d3378d3cf30b9 schema:name dimensions_id
149 schema:value pub.1032138284
150 rdf:type schema:PropertyValue
151 Nf1edb1b6d75a43959a9e49e7dbf44759 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Atorvastatin Calcium
153 rdf:type schema:DefinedTerm
154 Nf314ffc40afe4ed59737be973734bcac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Humans
156 rdf:type schema:DefinedTerm
157 Nfd1f7d901acf491cb2349638e82ce1e4 schema:name doi
158 schema:value 10.1007/s12032-010-9598-9
159 rdf:type schema:PropertyValue
160 Nfe7f53858b7b4b51bb842836a3a507ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Adenocarcinoma
162 rdf:type schema:DefinedTerm
163 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
164 schema:name Medical and Health Sciences
165 rdf:type schema:DefinedTerm
166 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
167 schema:name Oncology and Carcinogenesis
168 rdf:type schema:DefinedTerm
169 sg:journal.1094524 schema:issn 1357-0560
170 1559-131X
171 schema:name Medical Oncology
172 rdf:type schema:Periodical
173 sg:person.01012334447.12 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
174 schema:familyName Schneiders
175 schema:givenName Famke L.
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012334447.12
177 rdf:type schema:Person
178 sg:person.011543041217.55 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
179 schema:familyName Verheul
180 schema:givenName Henk M. W.
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011543041217.55
182 rdf:type schema:Person
183 sg:person.01207713557.55 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
184 schema:familyName van den Berg
185 schema:givenName H. Pieter
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207713557.55
187 rdf:type schema:Person
188 sg:person.01255301342.17 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
189 schema:familyName Peters
190 schema:givenName Godefridus J.
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255301342.17
192 rdf:type schema:Person
193 sg:person.0773345524.33 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
194 schema:familyName van der Vliet
195 schema:givenName Hans J.
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773345524.33
197 rdf:type schema:Person
198 sg:pub.10.1007/s00280-001-0408-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023246735
199 https://doi.org/10.1007/s00280-001-0408-0
200 rdf:type schema:CreativeWork
201 sg:pub.10.1038/nrc1074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012947440
202 https://doi.org/10.1038/nrc1074
203 rdf:type schema:CreativeWork
204 https://app.dimensions.ai/details/publication/pub.1075945718 schema:CreativeWork
205 https://app.dimensions.ai/details/publication/pub.1077079020 schema:CreativeWork
206 https://app.dimensions.ai/details/publication/pub.1083352537 schema:CreativeWork
207 https://doi.org/10.1016/j.clinthera.2005.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004705751
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1056/nejmoa032691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014051315
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1200/jco.2001.19.21.4097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074948894
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1200/jco.2001.19.8.2282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074800018
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1200/jco.2007.14.9898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027137405
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1200/jco.2007.15.9426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039289012
218 rdf:type schema:CreativeWork
219 https://www.grid.ac/institutes/grid.16872.3a schema:alternateName VU University Medical Center
220 schema:name Department of Medical Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
221 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...