Chemotherapy in clear cell sarcoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-09

AUTHORS

Robin L. Jones, Anastasia Constantinidou, Khin Thway, Sue Ashley, Michelle Scurr, Omar Al-Muderis, Cyril Fisher, Cristina R. Antonescu, David R. D’Adamo, Mary Louise Keohan, Robert G. Maki, Ian R. Judson

ABSTRACT

Clear cell sarcoma is a rare translocation-related sarcoma. There have been few studies documenting the response rate and progression-free survival in clear cell sarcoma patients treated with palliative chemotherapy. The prospectively maintained databases of two referral centres were searched to identify clear cell sarcoma patients treated with chemotherapy. Twenty-four patients were treated with palliative first-line chemotherapy with a median age of 30 years at diagnosis. There were 18 men and 6 women. One (4%) achieved a partial response and 9 (38%) had stable disease. Fourteen patients (58%) progressed on therapy. The median progression-free survival was 11 weeks (95% CI, 3–20 weeks). The median overall survival from commencing first-line chemotherapy was 39 weeks (95% CI, 34–45 weeks). Second-line chemotherapy was administered to 12 patients, 11 (92%) of these progressed and one (8%) had stable disease. Of the 5 patients treated with third-line chemotherapy, 4 (80%) progressed and one (20%) had stable disease. One patient received fourth-line chemotherapy and maintained stable disease for 4 months. Conventional chemotherapy has minimal activity in clear cell sarcoma as documented by the response rate of 4% and median progression-free survival of 11 weeks in this retrospective series. These data provide a reference for response and outcome in the assessment of novel agents in this histological subtype. More... »

PAGES

859-863

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12032-010-9502-7

DOI

http://dx.doi.org/10.1007/s12032-010-9502-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017685817

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20390470


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kaplan-Meier Estimate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sarcoma, Clear Cell", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Royal Marsden Hospital", 
          "id": "https://www.grid.ac/institutes/grid.424926.f", 
          "name": [
            "Royal Marsden Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jones", 
        "givenName": "Robin L.", 
        "id": "sg:person.01110361365.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110361365.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Marsden Hospital", 
          "id": "https://www.grid.ac/institutes/grid.424926.f", 
          "name": [
            "Royal Marsden Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Constantinidou", 
        "givenName": "Anastasia", 
        "id": "sg:person.01042246165.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042246165.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Marsden Hospital", 
          "id": "https://www.grid.ac/institutes/grid.424926.f", 
          "name": [
            "Royal Marsden Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thway", 
        "givenName": "Khin", 
        "id": "sg:person.01023745035.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023745035.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Marsden Hospital", 
          "id": "https://www.grid.ac/institutes/grid.424926.f", 
          "name": [
            "Royal Marsden Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ashley", 
        "givenName": "Sue", 
        "id": "sg:person.016055156132.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016055156132.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Marsden Hospital", 
          "id": "https://www.grid.ac/institutes/grid.424926.f", 
          "name": [
            "Royal Marsden Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scurr", 
        "givenName": "Michelle", 
        "id": "sg:person.01347746727.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347746727.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Marsden Hospital", 
          "id": "https://www.grid.ac/institutes/grid.424926.f", 
          "name": [
            "Royal Marsden Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Al-Muderis", 
        "givenName": "Omar", 
        "id": "sg:person.01331740103.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331740103.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Marsden Hospital", 
          "id": "https://www.grid.ac/institutes/grid.424926.f", 
          "name": [
            "Royal Marsden Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fisher", 
        "givenName": "Cyril", 
        "id": "sg:person.0650371415.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650371415.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Marsden Hospital", 
          "id": "https://www.grid.ac/institutes/grid.424926.f", 
          "name": [
            "Royal Marsden Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Antonescu", 
        "givenName": "Cristina R.", 
        "id": "sg:person.012544437337.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012544437337.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Marsden Hospital", 
          "id": "https://www.grid.ac/institutes/grid.424926.f", 
          "name": [
            "Royal Marsden Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "D\u2019Adamo", 
        "givenName": "David R.", 
        "id": "sg:person.01242231064.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242231064.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Marsden Hospital", 
          "id": "https://www.grid.ac/institutes/grid.424926.f", 
          "name": [
            "Royal Marsden Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Keohan", 
        "givenName": "Mary Louise", 
        "id": "sg:person.015640524407.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015640524407.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Marsden Hospital", 
          "id": "https://www.grid.ac/institutes/grid.424926.f", 
          "name": [
            "Royal Marsden Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maki", 
        "givenName": "Robert G.", 
        "id": "sg:person.0700603603.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700603603.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Marsden Hospital", 
          "id": "https://www.grid.ac/institutes/grid.424926.f", 
          "name": [
            "Royal Marsden Hospital, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Judson", 
        "givenName": "Ian R.", 
        "id": "sg:person.01132707630.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132707630.61"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/1097-0142(19841001)54:7<1412::aid-cncr2820540730>3.0.co;2-a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006686938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-198307000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006902424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-198307000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006902424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-198307000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006902424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0893-341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007021541", 
          "https://doi.org/10.1038/ng0893-341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19900115)65:2<367::aid-cncr2820650232>3.0.co;2-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008812721"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.2870040204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012008188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19831015)52:8<1482::aid-cncr2820520825>3.0.co;2-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017763547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.22380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024052341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejso.2007.10.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025338398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(196509)18:9<1163::aid-cncr2820180916>3.0.co;2-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031858124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1755-148x.2008.00480.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032273871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/106689699300100201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032435426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/106689699300100201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032435426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0277-5379(91)90509-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035241128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.10597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042797815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199212000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043977166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199212000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043977166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e31814b18fb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044542289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e31814b18fb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044542289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-07-0560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046328698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jso.1057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050385744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19990915)86:6<969::aid-cncr11>3.0.co;2-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052551252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.10.108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1259/0007-1285-52-615-238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064552454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/030089169908500617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074626594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/030089169908500617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074626594"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-09", 
    "datePublishedReg": "2011-09-01", 
    "description": "Clear cell sarcoma is a rare translocation-related sarcoma. There have been few studies documenting the response rate and progression-free survival in clear cell sarcoma patients treated with palliative chemotherapy. The prospectively maintained databases of two referral centres were searched to identify clear cell sarcoma patients treated with chemotherapy. Twenty-four patients were treated with palliative first-line chemotherapy with a median age of 30 years at diagnosis. There were 18 men and 6 women. One (4%) achieved a partial response and 9 (38%) had stable disease. Fourteen patients (58%) progressed on therapy. The median progression-free survival was 11 weeks (95% CI, 3\u201320 weeks). The median overall survival from commencing first-line chemotherapy was 39 weeks (95% CI, 34\u201345 weeks). Second-line chemotherapy was administered to 12 patients, 11 (92%) of these progressed and one (8%) had stable disease. Of the 5 patients treated with third-line chemotherapy, 4 (80%) progressed and one (20%) had stable disease. One patient received fourth-line chemotherapy and maintained stable disease for 4 months. Conventional chemotherapy has minimal activity in clear cell sarcoma as documented by the response rate of 4% and median progression-free survival of 11 weeks in this retrospective series. These data provide a reference for response and outcome in the assessment of novel agents in this histological subtype.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12032-010-9502-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1094524", 
        "issn": [
          "1357-0560", 
          "1559-131X"
        ], 
        "name": "Medical Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "28"
      }
    ], 
    "name": "Chemotherapy in clear cell sarcoma", 
    "pagination": "859-863", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "54442b39771e057e73164f6be34a9f206938f5be569824c6740af1639fbf32d9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20390470"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9435512"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12032-010-9502-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1017685817"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12032-010-9502-7", 
      "https://app.dimensions.ai/details/publication/pub.1017685817"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000521.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs12032-010-9502-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12032-010-9502-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12032-010-9502-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12032-010-9502-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12032-010-9502-7'


 

This table displays all metadata directly associated to this object as RDF triples.

242 TRIPLES      21 PREDICATES      58 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12032-010-9502-7 schema:about N04c630b02de349948e41408ae5322bb9
2 N0aafcfd1007448b3910df5990b48125e
3 N1788c7be4b4546f8ba52808aa78b9007
4 N3454b476dc5f4e4ea4d20ba963d29a48
5 N5233040416f5498e89a460d6da7d0de3
6 N6fd2739374af4608b0606a955e459e34
7 N84a6eb4e8bff4c3cb53dab087cf0745b
8 Ne60079508398496280f8993e77ec95c4
9 anzsrc-for:11
10 anzsrc-for:1112
11 schema:author N1741d4bb465c45908ab63a6fe47ff9c3
12 schema:citation sg:pub.10.1038/ng0893-341
13 https://doi.org/10.1002/(sici)1097-0142(19990915)86:6<969::aid-cncr11>3.0.co;2-z
14 https://doi.org/10.1002/1097-0142(196509)18:9<1163::aid-cncr2820180916>3.0.co;2-0
15 https://doi.org/10.1002/1097-0142(19831015)52:8<1482::aid-cncr2820520825>3.0.co;2-k
16 https://doi.org/10.1002/1097-0142(19841001)54:7<1412::aid-cncr2820540730>3.0.co;2-a
17 https://doi.org/10.1002/1097-0142(19900115)65:2<367::aid-cncr2820650232>3.0.co;2-x
18 https://doi.org/10.1002/cncr.10597
19 https://doi.org/10.1002/cncr.22380
20 https://doi.org/10.1002/gcc.2870040204
21 https://doi.org/10.1002/jso.1057
22 https://doi.org/10.1016/0277-5379(91)90509-c
23 https://doi.org/10.1016/j.ejso.2007.10.006
24 https://doi.org/10.1097/00000478-198307000-00003
25 https://doi.org/10.1097/00000478-199212000-00006
26 https://doi.org/10.1097/pas.0b013e31814b18fb
27 https://doi.org/10.1111/j.1755-148x.2008.00480.x
28 https://doi.org/10.1158/1535-7163.mct-07-0560
29 https://doi.org/10.1177/030089169908500617
30 https://doi.org/10.1177/106689699300100201
31 https://doi.org/10.1200/jco.2003.10.108
32 https://doi.org/10.1259/0007-1285-52-615-238
33 schema:datePublished 2011-09
34 schema:datePublishedReg 2011-09-01
35 schema:description Clear cell sarcoma is a rare translocation-related sarcoma. There have been few studies documenting the response rate and progression-free survival in clear cell sarcoma patients treated with palliative chemotherapy. The prospectively maintained databases of two referral centres were searched to identify clear cell sarcoma patients treated with chemotherapy. Twenty-four patients were treated with palliative first-line chemotherapy with a median age of 30 years at diagnosis. There were 18 men and 6 women. One (4%) achieved a partial response and 9 (38%) had stable disease. Fourteen patients (58%) progressed on therapy. The median progression-free survival was 11 weeks (95% CI, 3–20 weeks). The median overall survival from commencing first-line chemotherapy was 39 weeks (95% CI, 34–45 weeks). Second-line chemotherapy was administered to 12 patients, 11 (92%) of these progressed and one (8%) had stable disease. Of the 5 patients treated with third-line chemotherapy, 4 (80%) progressed and one (20%) had stable disease. One patient received fourth-line chemotherapy and maintained stable disease for 4 months. Conventional chemotherapy has minimal activity in clear cell sarcoma as documented by the response rate of 4% and median progression-free survival of 11 weeks in this retrospective series. These data provide a reference for response and outcome in the assessment of novel agents in this histological subtype.
36 schema:genre research_article
37 schema:inLanguage en
38 schema:isAccessibleForFree false
39 schema:isPartOf N275eedcd7239425bbeac9efab07f8526
40 N60efad9bc5724d4494314e1d10be841f
41 sg:journal.1094524
42 schema:name Chemotherapy in clear cell sarcoma
43 schema:pagination 859-863
44 schema:productId N08f9fcf68b284d2fb98744bb0fc41812
45 N0904cf9602ec4fa2b4d71e8695cc0d7a
46 N2fb33ba0a39d402187283354eb03d7d9
47 N44d14a35b98841fa90a8ddd4ca069954
48 Nf7ba35a282114572a2a7fe553c2b9522
49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017685817
50 https://doi.org/10.1007/s12032-010-9502-7
51 schema:sdDatePublished 2019-04-10T19:11
52 schema:sdLicense https://scigraph.springernature.com/explorer/license/
53 schema:sdPublisher Nd23ae5c5b1df404097a67136d26ff2ec
54 schema:url http://link.springer.com/10.1007%2Fs12032-010-9502-7
55 sgo:license sg:explorer/license/
56 sgo:sdDataset articles
57 rdf:type schema:ScholarlyArticle
58 N028004a43a92475a88fb08ccee5bbb01 rdf:first sg:person.0700603603.09
59 rdf:rest N559ec4372382434193723f1e1e34e780
60 N04c630b02de349948e41408ae5322bb9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
61 schema:name Antineoplastic Combined Chemotherapy Protocols
62 rdf:type schema:DefinedTerm
63 N08f9fcf68b284d2fb98744bb0fc41812 schema:name dimensions_id
64 schema:value pub.1017685817
65 rdf:type schema:PropertyValue
66 N0904cf9602ec4fa2b4d71e8695cc0d7a schema:name nlm_unique_id
67 schema:value 9435512
68 rdf:type schema:PropertyValue
69 N0aafcfd1007448b3910df5990b48125e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Sarcoma, Clear Cell
71 rdf:type schema:DefinedTerm
72 N1741d4bb465c45908ab63a6fe47ff9c3 rdf:first sg:person.01110361365.31
73 rdf:rest N9648b9b766e6409e8017b01e59b9b1b9
74 N1788c7be4b4546f8ba52808aa78b9007 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Kaplan-Meier Estimate
76 rdf:type schema:DefinedTerm
77 N20b86b3570c34cc7998c555c267a4986 rdf:first sg:person.01331740103.42
78 rdf:rest N547d06e708ad4b77b5cb43d3b8499893
79 N275eedcd7239425bbeac9efab07f8526 schema:volumeNumber 28
80 rdf:type schema:PublicationVolume
81 N2fb33ba0a39d402187283354eb03d7d9 schema:name pubmed_id
82 schema:value 20390470
83 rdf:type schema:PropertyValue
84 N3454b476dc5f4e4ea4d20ba963d29a48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Disease-Free Survival
86 rdf:type schema:DefinedTerm
87 N38b94b89373846ea8cf2c8acf832e2ac rdf:first sg:person.01347746727.92
88 rdf:rest N20b86b3570c34cc7998c555c267a4986
89 N3bb6f2ea94cc4e589a1bab224432ce21 rdf:first sg:person.016055156132.72
90 rdf:rest N38b94b89373846ea8cf2c8acf832e2ac
91 N436e4040196544e6bf8a8da991d6c356 rdf:first sg:person.01242231064.08
92 rdf:rest N7acdceb3449941fd94ce46b227a246ae
93 N44d14a35b98841fa90a8ddd4ca069954 schema:name doi
94 schema:value 10.1007/s12032-010-9502-7
95 rdf:type schema:PropertyValue
96 N5233040416f5498e89a460d6da7d0de3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Retrospective Studies
98 rdf:type schema:DefinedTerm
99 N547d06e708ad4b77b5cb43d3b8499893 rdf:first sg:person.0650371415.92
100 rdf:rest Nef363b517239440fa4cc0baac88e3cae
101 N559ec4372382434193723f1e1e34e780 rdf:first sg:person.01132707630.61
102 rdf:rest rdf:nil
103 N60efad9bc5724d4494314e1d10be841f schema:issueNumber 3
104 rdf:type schema:PublicationIssue
105 N6fd2739374af4608b0606a955e459e34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Female
107 rdf:type schema:DefinedTerm
108 N7acdceb3449941fd94ce46b227a246ae rdf:first sg:person.015640524407.07
109 rdf:rest N028004a43a92475a88fb08ccee5bbb01
110 N84a6eb4e8bff4c3cb53dab087cf0745b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Male
112 rdf:type schema:DefinedTerm
113 N947ec8b3f83b4c33904d6ddf1a1657ca rdf:first sg:person.01023745035.11
114 rdf:rest N3bb6f2ea94cc4e589a1bab224432ce21
115 N9648b9b766e6409e8017b01e59b9b1b9 rdf:first sg:person.01042246165.66
116 rdf:rest N947ec8b3f83b4c33904d6ddf1a1657ca
117 Nd23ae5c5b1df404097a67136d26ff2ec schema:name Springer Nature - SN SciGraph project
118 rdf:type schema:Organization
119 Ne60079508398496280f8993e77ec95c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Humans
121 rdf:type schema:DefinedTerm
122 Nef363b517239440fa4cc0baac88e3cae rdf:first sg:person.012544437337.82
123 rdf:rest N436e4040196544e6bf8a8da991d6c356
124 Nf7ba35a282114572a2a7fe553c2b9522 schema:name readcube_id
125 schema:value 54442b39771e057e73164f6be34a9f206938f5be569824c6740af1639fbf32d9
126 rdf:type schema:PropertyValue
127 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
128 schema:name Medical and Health Sciences
129 rdf:type schema:DefinedTerm
130 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
131 schema:name Oncology and Carcinogenesis
132 rdf:type schema:DefinedTerm
133 sg:journal.1094524 schema:issn 1357-0560
134 1559-131X
135 schema:name Medical Oncology
136 rdf:type schema:Periodical
137 sg:person.01023745035.11 schema:affiliation https://www.grid.ac/institutes/grid.424926.f
138 schema:familyName Thway
139 schema:givenName Khin
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023745035.11
141 rdf:type schema:Person
142 sg:person.01042246165.66 schema:affiliation https://www.grid.ac/institutes/grid.424926.f
143 schema:familyName Constantinidou
144 schema:givenName Anastasia
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042246165.66
146 rdf:type schema:Person
147 sg:person.01110361365.31 schema:affiliation https://www.grid.ac/institutes/grid.424926.f
148 schema:familyName Jones
149 schema:givenName Robin L.
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110361365.31
151 rdf:type schema:Person
152 sg:person.01132707630.61 schema:affiliation https://www.grid.ac/institutes/grid.424926.f
153 schema:familyName Judson
154 schema:givenName Ian R.
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132707630.61
156 rdf:type schema:Person
157 sg:person.01242231064.08 schema:affiliation https://www.grid.ac/institutes/grid.424926.f
158 schema:familyName D’Adamo
159 schema:givenName David R.
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242231064.08
161 rdf:type schema:Person
162 sg:person.012544437337.82 schema:affiliation https://www.grid.ac/institutes/grid.424926.f
163 schema:familyName Antonescu
164 schema:givenName Cristina R.
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012544437337.82
166 rdf:type schema:Person
167 sg:person.01331740103.42 schema:affiliation https://www.grid.ac/institutes/grid.424926.f
168 schema:familyName Al-Muderis
169 schema:givenName Omar
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331740103.42
171 rdf:type schema:Person
172 sg:person.01347746727.92 schema:affiliation https://www.grid.ac/institutes/grid.424926.f
173 schema:familyName Scurr
174 schema:givenName Michelle
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347746727.92
176 rdf:type schema:Person
177 sg:person.015640524407.07 schema:affiliation https://www.grid.ac/institutes/grid.424926.f
178 schema:familyName Keohan
179 schema:givenName Mary Louise
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015640524407.07
181 rdf:type schema:Person
182 sg:person.016055156132.72 schema:affiliation https://www.grid.ac/institutes/grid.424926.f
183 schema:familyName Ashley
184 schema:givenName Sue
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016055156132.72
186 rdf:type schema:Person
187 sg:person.0650371415.92 schema:affiliation https://www.grid.ac/institutes/grid.424926.f
188 schema:familyName Fisher
189 schema:givenName Cyril
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650371415.92
191 rdf:type schema:Person
192 sg:person.0700603603.09 schema:affiliation https://www.grid.ac/institutes/grid.424926.f
193 schema:familyName Maki
194 schema:givenName Robert G.
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700603603.09
196 rdf:type schema:Person
197 sg:pub.10.1038/ng0893-341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007021541
198 https://doi.org/10.1038/ng0893-341
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1002/(sici)1097-0142(19990915)86:6<969::aid-cncr11>3.0.co;2-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1052551252
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1002/1097-0142(196509)18:9<1163::aid-cncr2820180916>3.0.co;2-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031858124
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1002/1097-0142(19831015)52:8<1482::aid-cncr2820520825>3.0.co;2-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1017763547
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1002/1097-0142(19841001)54:7<1412::aid-cncr2820540730>3.0.co;2-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1006686938
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1002/1097-0142(19900115)65:2<367::aid-cncr2820650232>3.0.co;2-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008812721
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1002/cncr.10597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042797815
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1002/cncr.22380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024052341
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1002/gcc.2870040204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012008188
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1002/jso.1057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050385744
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/0277-5379(91)90509-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1035241128
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/j.ejso.2007.10.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025338398
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1097/00000478-198307000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006902424
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1097/00000478-199212000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043977166
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1097/pas.0b013e31814b18fb schema:sameAs https://app.dimensions.ai/details/publication/pub.1044542289
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1111/j.1755-148x.2008.00480.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032273871
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1158/1535-7163.mct-07-0560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046328698
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1177/030089169908500617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074626594
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1177/106689699300100201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032435426
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1200/jco.2003.10.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203916
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1259/0007-1285-52-615-238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064552454
239 rdf:type schema:CreativeWork
240 https://www.grid.ac/institutes/grid.424926.f schema:alternateName Royal Marsden Hospital
241 schema:name Royal Marsden Hospital, London, UK
242 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...