Golimumab and malignancies: true or false association? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-06

AUTHORS

Ines Zidi, Aicha Bouaziz, Wissem Mnif, Aghleb Bartegi, Nidhal Ben Amor

ABSTRACT

Malignancy is one of the comorbidities linked to golimumab, a biological TNF-α blocker. In this systematic review and meta-analysis, we searched different databases and analyzed original publications to elucidate the remaining open question about the real association of malignancies with golimumab therapy. The most frequent cancer in patients treated with golimumab, in association or not with methotrexate, is the lung adenocarcinoma. However, lymphoma is not very commonly represented in these patients. We show that there is no major and evident risk of malignancies associated with golimumab in current scientific literature. An increased risk of malignancies may be associated with golimumab, but this warrants further clinical confirmation. Also, this risk mentioned in different studies must be taken with caution because of number of limits and biases. More... »

PAGES

641-648

References to SciGraph publications

  • 2009-04. Golimumab in BIODRUGS
  • 2010-06. TNF-α and its inhibitors in cancer in MEDICAL ONCOLOGY
  • 2009-09. Golimumab in NATURE REVIEWS DRUG DISCOVERY
  • 2009-08. Update on the treatment of peripheral arthritis in psoriatic arthritis in CURRENT RHEUMATOLOGY REPORTS
  • 2009-06. TNF-blocker triple approval in NATURE BIOTECHNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12032-010-9490-7

    DOI

    http://dx.doi.org/10.1007/s12032-010-9490-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1046859888

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20373059


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    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12032-010-9490-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12032-010-9490-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12032-010-9490-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12032-010-9490-7'


     

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