Differentiation syndrome in non-M3 acute myeloid leukemia treated with the retinoid X receptor agonist bexarotene View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-09

AUTHORS

Courtney D. DiNardo, Bonnie Ky, Dan T. Vogl, Paul Forfia, Alison Loren, Selina Luger, Anthony Mato, Donald E. Tsai

ABSTRACT

Differentiation Syndrome, also known as all-trans retinoic acid (ATRA) syndrome, is a well-described clinical phenomenon occurring in patients with the M3 subtype of acute myeloid leukemia receiving ATRA chemotherapy. Bexarotene is a novel synthetic compound that selectively binds and activates retinoic X receptors, a subclass of retinoid receptors not targeted by ATRA. We report a patient with refractory non-M3 acute promyelocytic leukemia (AML) who developed differentiation syndrome during bexarotene monotherapy. This case emphasizes the importance of monitoring for differentiation syndrome among patients receiving retinoid therapies and demonstrates the ability of bexarotene to stimulate differentiation of leukemic blasts. More... »

PAGES

299-302

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12032-007-9035-x

DOI

http://dx.doi.org/10.1007/s12032-007-9035-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042505449

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18181037


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