NLRP1 and NTN1, Deregulated Blood Differentially Methylated Regions in Mild Cognitive Impairment Patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-11-05

AUTHORS

Min-Koo Park, Ji-Won Lee, Jeong-Chan Lee, Sung-Joo Hwang, Hyun Woong Roh, Chang Hyung Hong, Sang Joon Son

ABSTRACT

Epigenetic dysregulation has been known to be involved in neurodegenerative diseases, including amnestic mild cognitive impairment (MCI). The aim of this study was to investigate the genome-wide DNA methylation analysis, in order to identify epigenetic dysregulation in blood from patients with MCI. Here, we investigated whether epigenetic dysregulation in MCI and whether such an aberration could be detected in blood circulation. Genome-wide bisulfite sequencing targeted 84 million bases covering 3.7 million CpG sites was comparatively analyzed in MCI and control groups. And correlation between DNA methylation and transcriptomic changes was sought. Significant differentially methylated regions (DMRs) distinguishing the MCI and control groups were identified and functionally annotated. Most DMRs specific to MCI were enriched between – 2 kb and + 2 kb of the CpG island start sites located within or near gene promoters. Representative hypo- and hypermethylated DMRs in MCI were confirmed to be correlated to mRNA expression changes with the comparative delta Ct method. DNA methylation aberrations involving metal ion homeostasis, axon growth, inflammasome, and others in this study may be less-invasive, easily measurable blood biomarker candidates for MCI. More... »

PAGES

561-571

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12031-018-1180-5

DOI

http://dx.doi.org/10.1007/s12031-018-1180-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1108040132

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30397880


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