α-Synuclein Transgenic Mice Reveal Compensatory Increases in Parkinson's Disease-Associated Proteins DJ-1 and Parkin and Have Enhanced α-Synuclein and PINK1 Levels ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-05-13

AUTHORS

Sonia George, Su San Mok, Milawaty Nurjono, Scott Ayton, David I. Finkelstein, Colin L. Masters, Qiao-Xin Li, Janetta G. Culvenor

ABSTRACT

Parkinson's disease (PD) is a severe neurodegenerative disorder characterised by loss of dopaminergic neurons of the substantia nigra. The pathological hallmarks are cytoplasmic inclusions termed Lewy bodies consisting primarily of aggregated α-synuclein (αSN). Different lines of transgenic mice have been developed to model PD but have failed to recapitulate the hallmarks of this disease. Since treatment of rodents with the pesticide rotenone can reproduce nigrostriatal cell loss and other features of PD, we aimed to test chronic oral administration of rotenone to transgenic mice over-expressing human αSN with the A53T mutation. Initial assessment of this transgenic line for compensatory molecular changes indicated decreased brain β-synuclein expression and significantly increased levels of the PD-associated oxidative stress response protein, DJ-1, and the E3 ubiquitin ligase enzyme, Parkin. Rotenone treatment of 30 mg/kg for 25 doses over a 35-day period was tolerated in the transgenic mice and resulted in decreased spontaneous locomotor movement and increased cytoplasmic αSN expression. The mitochondrial Parkinson's-associated PTEN-induced kinase 1 protein levels were also increased in transgenic mouse brain after rotenone treatment; there was no change in brain dopamine levels or nigrostriatal cell loss. These hA53T αSN transgenic mice provide a useful model for presymptomatic Parkinson's features and are valuable for study of associated compensatory changes in early Parkinson's disease stages. More... »

PAGES

243-254

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12031-010-9378-1

DOI

http://dx.doi.org/10.1007/s12031-010-9378-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049271041

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20464527


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C3H", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Parkinsonian Disorders", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peroxiredoxins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Deglycase DJ-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rotenone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ubiquitin-Protein Ligases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Uncoupling Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Up-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "alpha-Synuclein", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The Mental Health Research Institute of Victoria, Parkville, 3052, Melbourne, Victoria, Australia", 
          "id": "http://www.grid.ac/institutes/grid.415325.4", 
          "name": [
            "Department of Pathology, The University of Melbourne, Parkville, 3010, Melbourne, Victoria, Australia", 
            "The Centre for Neuroscience, The University of Melbourne, Parkville, 3010, Melbourne, Victoria, Australia", 
            "The Mental Health Research Institute of Victoria, Parkville, 3052, Melbourne, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "George", 
        "givenName": "Sonia", 
        "id": "sg:person.0757413201.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757413201.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Mental Health Research Institute of Victoria, Parkville, 3052, Melbourne, Victoria, Australia", 
          "id": "http://www.grid.ac/institutes/grid.415325.4", 
          "name": [
            "Department of Pathology, The University of Melbourne, Parkville, 3010, Melbourne, Victoria, Australia", 
            "The Centre for Neuroscience, The University of Melbourne, Parkville, 3010, Melbourne, Victoria, Australia", 
            "The Mental Health Research Institute of Victoria, Parkville, 3052, Melbourne, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mok", 
        "givenName": "Su San", 
        "id": "sg:person.0606134552.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606134552.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Mental Health Research Institute of Victoria, Parkville, 3052, Melbourne, Victoria, Australia", 
          "id": "http://www.grid.ac/institutes/grid.415325.4", 
          "name": [
            "The Mental Health Research Institute of Victoria, Parkville, 3052, Melbourne, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nurjono", 
        "givenName": "Milawaty", 
        "id": "sg:person.0611354561.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611354561.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Mental Health Research Institute of Victoria, Parkville, 3052, Melbourne, Victoria, Australia", 
          "id": "http://www.grid.ac/institutes/grid.415325.4", 
          "name": [
            "The Mental Health Research Institute of Victoria, Parkville, 3052, Melbourne, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ayton", 
        "givenName": "Scott", 
        "id": "sg:person.01303422641.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303422641.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Mental Health Research Institute of Victoria, Parkville, 3052, Melbourne, Victoria, Australia", 
          "id": "http://www.grid.ac/institutes/grid.415325.4", 
          "name": [
            "The Centre for Neuroscience, The University of Melbourne, Parkville, 3010, Melbourne, Victoria, Australia", 
            "The Mental Health Research Institute of Victoria, Parkville, 3052, Melbourne, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Finkelstein", 
        "givenName": "David I.", 
        "id": "sg:person.01065042101.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065042101.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Mental Health Research Institute of Victoria, Parkville, 3052, Melbourne, Victoria, Australia", 
          "id": "http://www.grid.ac/institutes/grid.415325.4", 
          "name": [
            "Department of Pathology, The University of Melbourne, Parkville, 3010, Melbourne, Victoria, Australia", 
            "The Mental Health Research Institute of Victoria, Parkville, 3052, Melbourne, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Masters", 
        "givenName": "Colin L.", 
        "id": "sg:person.0643473627.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643473627.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Mental Health Research Institute of Victoria, Parkville, 3052, Melbourne, Victoria, Australia", 
          "id": "http://www.grid.ac/institutes/grid.415325.4", 
          "name": [
            "Department of Pathology, The University of Melbourne, Parkville, 3010, Melbourne, Victoria, Australia", 
            "The Centre for Neuroscience, The University of Melbourne, Parkville, 3010, Melbourne, Victoria, Australia", 
            "The Mental Health Research Institute of Victoria, Parkville, 3052, Melbourne, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Qiao-Xin", 
        "id": "sg:person.01022570001.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022570001.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Mental Health Research Institute of Victoria, Parkville, 3052, Melbourne, Victoria, Australia", 
          "id": "http://www.grid.ac/institutes/grid.415325.4", 
          "name": [
            "Department of Pathology, The University of Melbourne, Parkville, 3010, Melbourne, Victoria, Australia", 
            "The Centre for Neuroscience, The University of Melbourne, Parkville, 3010, Melbourne, Victoria, Australia", 
            "The Mental Health Research Institute of Victoria, Parkville, 3052, Melbourne, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Culvenor", 
        "givenName": "Janetta G.", 
        "id": "sg:person.0745211154.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745211154.54"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/81834", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006666875", 
          "https://doi.org/10.1038/81834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03033569", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049098675", 
          "https://doi.org/10.1007/bf03033569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04779", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033391441", 
          "https://doi.org/10.1038/nature04779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1001958023096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048287697", 
          "https://doi.org/10.1023/a:1001958023096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11064-007-9533-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052493281", 
          "https://doi.org/10.1007/s11064-007-9533-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00441-004-0937-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008288617", 
          "https://doi.org/10.1007/s00441-004-0937-z"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-05-13", 
    "datePublishedReg": "2010-05-13", 
    "description": "Parkinson's disease (PD) is a severe neurodegenerative disorder characterised by loss of dopaminergic neurons of the substantia nigra. The pathological hallmarks are cytoplasmic inclusions termed Lewy bodies consisting primarily of aggregated \u03b1-synuclein (\u03b1SN). Different lines of transgenic mice have been developed to model PD but have failed to recapitulate the hallmarks of this disease. Since treatment of rodents with the pesticide rotenone can reproduce nigrostriatal cell loss and other features of PD, we aimed to test chronic oral administration of rotenone to transgenic mice over-expressing human \u03b1SN with the A53T mutation. Initial assessment of this transgenic line for compensatory molecular changes indicated decreased brain \u03b2-synuclein expression and significantly increased levels of the PD-associated oxidative stress response protein, DJ-1, and the E3 ubiquitin ligase enzyme, Parkin. Rotenone treatment of 30\u00a0mg/kg for 25 doses over a 35-day period was tolerated in the transgenic mice and resulted in decreased spontaneous locomotor movement and increased cytoplasmic \u03b1SN expression. The mitochondrial Parkinson's-associated PTEN-induced kinase 1 protein levels were also increased in transgenic mouse brain after rotenone treatment; there was no change in brain dopamine levels or nigrostriatal cell loss. These hA53T \u03b1SN transgenic mice provide a useful model for presymptomatic Parkinson's features and are valuable for study of associated compensatory changes in early Parkinson's disease stages.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s12031-010-9378-1", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1094289", 
        "issn": [
          "0895-8696", 
          "2168-8729"
        ], 
        "name": "Journal of Molecular Neuroscience", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "42"
      }
    ], 
    "keywords": [
      "nigrostriatal cell loss", 
      "Parkinson's disease", 
      "transgenic mice", 
      "disease stage", 
      "rotenone treatment", 
      "cell loss", 
      "early Parkinson's disease stages", 
      "features of PD", 
      "spontaneous locomotor movements", 
      "chronic oral administration", 
      "DJ-1", 
      "brain dopamine levels", 
      "Parkinson's disease stages", 
      "transgenic mouse brain", 
      "treatment of rodents", 
      "A53T mutation", 
      "Parkinson's features", 
      "severe neurodegenerative disorder", 
      "dopaminergic neurons", 
      "Lewy bodies", 
      "brain \u03b2", 
      "substantia nigra", 
      "oral administration", 
      "synuclein expression", 
      "dopamine levels", 
      "pathological hallmark", 
      "compensatory increase", 
      "mouse brain", 
      "pesticide rotenone", 
      "neurodegenerative disorders", 
      "cytoplasmic inclusions", 
      "mice", 
      "compensatory changes", 
      "locomotor movements", 
      "disease", 
      "initial assessment", 
      "protein levels", 
      "T mutation", 
      "molecular changes", 
      "treatment", 
      "protein DJ-1", 
      "PINK1 levels", 
      "synuclein", 
      "useful model", 
      "stress response proteins", 
      "hallmark", 
      "oxidative stress response proteins", 
      "response proteins", 
      "Parkin", 
      "levels", 
      "expression", 
      "ubiquitin ligase enzyme", 
      "neurons", 
      "administration", 
      "doses", 
      "nigra", 
      "brain", 
      "E3 ubiquitin ligase enzyme", 
      "disorders", 
      "Parkinson's", 
      "loss", 
      "rodents", 
      "changes", 
      "rotenone", 
      "mutations", 
      "assessment", 
      "period", 
      "lines", 
      "protein", 
      "study", 
      "features", 
      "\u03b1SN", 
      "increase", 
      "ligase enzyme", 
      "enzyme", 
      "body", 
      "stage", 
      "different lines", 
      "inclusion", 
      "transgenic lines", 
      "movement", 
      "model", 
      "human \u03b1SN", 
      "compensatory molecular changes", 
      "cytoplasmic \u03b1SN expression", 
      "\u03b1SN expression", 
      "mitochondrial Parkinson's", 
      "PTEN-induced kinase 1 protein levels", 
      "kinase 1 protein levels", 
      "hA53T \u03b1SN transgenic mice", 
      "T \u03b1SN transgenic mice", 
      "\u03b1SN transgenic mice", 
      "presymptomatic Parkinson's features", 
      "Synuclein Transgenic Mice Reveal Compensatory Increases", 
      "Transgenic Mice Reveal Compensatory Increases", 
      "Mice Reveal Compensatory Increases", 
      "Reveal Compensatory Increases", 
      "Parkinson's Disease-Associated Proteins DJ-1", 
      "'s Disease-Associated Proteins DJ-1"
    ], 
    "name": "\u03b1-Synuclein Transgenic Mice Reveal Compensatory Increases in Parkinson's Disease-Associated Proteins DJ-1 and Parkin and Have Enhanced \u03b1-Synuclein and PINK1 Levels After Rotenone Treatment", 
    "pagination": "243-254", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1049271041"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12031-010-9378-1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20464527"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12031-010-9378-1", 
      "https://app.dimensions.ai/details/publication/pub.1049271041"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_517.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s12031-010-9378-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12031-010-9378-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12031-010-9378-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12031-010-9378-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12031-010-9378-1'


 

This table displays all metadata directly associated to this object as RDF triples.

304 TRIPLES      22 PREDICATES      148 URIs      134 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12031-010-9378-1 schema:about N0d1779ebb48748009caf5eb453c89843
2 N1c37f46402ba48ff9dbe7d320c98f002
3 N1dd4c10d34ef411e88a0b736aa252bfc
4 N2dbd9637b9d94c05a6734c8cde547974
5 N37abae0830af4d1a85ecff947aba25d3
6 N5040f6f736344811bfa83318d1159865
7 N5785274766bc46c4a71f4edb08c5ca1f
8 N60c276788c8b465e9fc33772a566ced2
9 N6e301f06c7da4798b4e4d84ca2928bd4
10 N74f9d78605d3425cb111cf5761abbac9
11 N7e3fb4e2c2754556a62508a089562adc
12 Nbf6c92153f914666a4ac05e1541a2c93
13 Nc9f436daba28440cbb4385c80666d154
14 Ncfc5e46f219c4f7d9389ca5c5905e7fe
15 Ne6bf1f570f4b42348a72e50d2702e0c7
16 Ne81547ff331641f7ad65a0fab1ce7773
17 Nf3434e19d7b24675a5f7e59034188dbf
18 anzsrc-for:11
19 anzsrc-for:1109
20 schema:author N871cf0ecbf5841819c373afd556d5bf4
21 schema:citation sg:pub.10.1007/bf03033569
22 sg:pub.10.1007/s00441-004-0937-z
23 sg:pub.10.1007/s11064-007-9533-4
24 sg:pub.10.1023/a:1001958023096
25 sg:pub.10.1038/81834
26 sg:pub.10.1038/nature04779
27 schema:datePublished 2010-05-13
28 schema:datePublishedReg 2010-05-13
29 schema:description Parkinson's disease (PD) is a severe neurodegenerative disorder characterised by loss of dopaminergic neurons of the substantia nigra. The pathological hallmarks are cytoplasmic inclusions termed Lewy bodies consisting primarily of aggregated α-synuclein (αSN). Different lines of transgenic mice have been developed to model PD but have failed to recapitulate the hallmarks of this disease. Since treatment of rodents with the pesticide rotenone can reproduce nigrostriatal cell loss and other features of PD, we aimed to test chronic oral administration of rotenone to transgenic mice over-expressing human αSN with the A53T mutation. Initial assessment of this transgenic line for compensatory molecular changes indicated decreased brain β-synuclein expression and significantly increased levels of the PD-associated oxidative stress response protein, DJ-1, and the E3 ubiquitin ligase enzyme, Parkin. Rotenone treatment of 30 mg/kg for 25 doses over a 35-day period was tolerated in the transgenic mice and resulted in decreased spontaneous locomotor movement and increased cytoplasmic αSN expression. The mitochondrial Parkinson's-associated PTEN-induced kinase 1 protein levels were also increased in transgenic mouse brain after rotenone treatment; there was no change in brain dopamine levels or nigrostriatal cell loss. These hA53T αSN transgenic mice provide a useful model for presymptomatic Parkinson's features and are valuable for study of associated compensatory changes in early Parkinson's disease stages.
30 schema:genre article
31 schema:inLanguage en
32 schema:isAccessibleForFree false
33 schema:isPartOf N479668ab7e8445639ee4001750072c8a
34 Nabcb684ba8ac4f319626e751a28f085a
35 sg:journal.1094289
36 schema:keywords 's Disease-Associated Proteins DJ-1
37 A53T mutation
38 DJ-1
39 E3 ubiquitin ligase enzyme
40 Lewy bodies
41 Mice Reveal Compensatory Increases
42 PINK1 levels
43 PTEN-induced kinase 1 protein levels
44 Parkin
45 Parkinson's
46 Parkinson's Disease-Associated Proteins DJ-1
47 Parkinson's disease
48 Parkinson's disease stages
49 Parkinson's features
50 Reveal Compensatory Increases
51 Synuclein Transgenic Mice Reveal Compensatory Increases
52 T mutation
53 T αSN transgenic mice
54 Transgenic Mice Reveal Compensatory Increases
55 administration
56 assessment
57 body
58 brain
59 brain dopamine levels
60 brain β
61 cell loss
62 changes
63 chronic oral administration
64 compensatory changes
65 compensatory increase
66 compensatory molecular changes
67 cytoplasmic inclusions
68 cytoplasmic αSN expression
69 different lines
70 disease
71 disease stage
72 disorders
73 dopamine levels
74 dopaminergic neurons
75 doses
76 early Parkinson's disease stages
77 enzyme
78 expression
79 features
80 features of PD
81 hA53T αSN transgenic mice
82 hallmark
83 human αSN
84 inclusion
85 increase
86 initial assessment
87 kinase 1 protein levels
88 levels
89 ligase enzyme
90 lines
91 locomotor movements
92 loss
93 mice
94 mitochondrial Parkinson's
95 model
96 molecular changes
97 mouse brain
98 movement
99 mutations
100 neurodegenerative disorders
101 neurons
102 nigra
103 nigrostriatal cell loss
104 oral administration
105 oxidative stress response proteins
106 pathological hallmark
107 period
108 pesticide rotenone
109 presymptomatic Parkinson's features
110 protein
111 protein DJ-1
112 protein levels
113 response proteins
114 rodents
115 rotenone
116 rotenone treatment
117 severe neurodegenerative disorder
118 spontaneous locomotor movements
119 stage
120 stress response proteins
121 study
122 substantia nigra
123 synuclein
124 synuclein expression
125 transgenic lines
126 transgenic mice
127 transgenic mouse brain
128 treatment
129 treatment of rodents
130 ubiquitin ligase enzyme
131 useful model
132 αSN
133 αSN expression
134 αSN transgenic mice
135 schema:name α-Synuclein Transgenic Mice Reveal Compensatory Increases in Parkinson's Disease-Associated Proteins DJ-1 and Parkin and Have Enhanced α-Synuclein and PINK1 Levels After Rotenone Treatment
136 schema:pagination 243-254
137 schema:productId N69ab2207d37e4699a4df8939eeba17e5
138 Na585802c675f471d95792984fff82f59
139 Nfbde2527846146d9986c67afc6dd65aa
140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049271041
141 https://doi.org/10.1007/s12031-010-9378-1
142 schema:sdDatePublished 2021-12-01T19:23
143 schema:sdLicense https://scigraph.springernature.com/explorer/license/
144 schema:sdPublisher Na5bddff47b1e4cd9b39665bd3f874934
145 schema:url https://doi.org/10.1007/s12031-010-9378-1
146 sgo:license sg:explorer/license/
147 sgo:sdDataset articles
148 rdf:type schema:ScholarlyArticle
149 N0d1779ebb48748009caf5eb453c89843 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Up-Regulation
151 rdf:type schema:DefinedTerm
152 N1c37f46402ba48ff9dbe7d320c98f002 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Parkinsonian Disorders
154 rdf:type schema:DefinedTerm
155 N1dd4c10d34ef411e88a0b736aa252bfc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Mice
157 rdf:type schema:DefinedTerm
158 N2dbd9637b9d94c05a6734c8cde547974 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Animals
160 rdf:type schema:DefinedTerm
161 N37abae0830af4d1a85ecff947aba25d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Oncogene Proteins
163 rdf:type schema:DefinedTerm
164 N44012574fc2b4133bf8e0139afc7fbe7 rdf:first sg:person.0745211154.54
165 rdf:rest rdf:nil
166 N479668ab7e8445639ee4001750072c8a schema:volumeNumber 42
167 rdf:type schema:PublicationVolume
168 N5040f6f736344811bfa83318d1159865 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Ubiquitin-Protein Ligases
170 rdf:type schema:DefinedTerm
171 N5785274766bc46c4a71f4edb08c5ca1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name alpha-Synuclein
173 rdf:type schema:DefinedTerm
174 N60c276788c8b465e9fc33772a566ced2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Mice, Inbred C57BL
176 rdf:type schema:DefinedTerm
177 N69ab2207d37e4699a4df8939eeba17e5 schema:name dimensions_id
178 schema:value pub.1049271041
179 rdf:type schema:PropertyValue
180 N6e301f06c7da4798b4e4d84ca2928bd4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Protein Deglycase DJ-1
182 rdf:type schema:DefinedTerm
183 N74f9d78605d3425cb111cf5761abbac9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Humans
185 rdf:type schema:DefinedTerm
186 N762e237db09248b6ba2fd95997cb8896 rdf:first sg:person.01022570001.68
187 rdf:rest N44012574fc2b4133bf8e0139afc7fbe7
188 N7b04bb56794244ea8f31f4869fdfc9a6 rdf:first sg:person.0643473627.24
189 rdf:rest N762e237db09248b6ba2fd95997cb8896
190 N7e3fb4e2c2754556a62508a089562adc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Protein Kinases
192 rdf:type schema:DefinedTerm
193 N871cf0ecbf5841819c373afd556d5bf4 rdf:first sg:person.0757413201.28
194 rdf:rest N940fc5fe965549f8b6fdb67259e4a862
195 N940fc5fe965549f8b6fdb67259e4a862 rdf:first sg:person.0606134552.10
196 rdf:rest Ne2fd40801da14307a6427aff5a5c05c1
197 N9490b82c61da44329d58e826b711e1f5 rdf:first sg:person.01065042101.38
198 rdf:rest N7b04bb56794244ea8f31f4869fdfc9a6
199 N9a55f2f5011d481ebc3587e96ec99b15 rdf:first sg:person.01303422641.56
200 rdf:rest N9490b82c61da44329d58e826b711e1f5
201 Na585802c675f471d95792984fff82f59 schema:name pubmed_id
202 schema:value 20464527
203 rdf:type schema:PropertyValue
204 Na5bddff47b1e4cd9b39665bd3f874934 schema:name Springer Nature - SN SciGraph project
205 rdf:type schema:Organization
206 Nabcb684ba8ac4f319626e751a28f085a schema:issueNumber 2
207 rdf:type schema:PublicationIssue
208 Nbf6c92153f914666a4ac05e1541a2c93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Peroxiredoxins
210 rdf:type schema:DefinedTerm
211 Nc9f436daba28440cbb4385c80666d154 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Rotenone
213 rdf:type schema:DefinedTerm
214 Ncfc5e46f219c4f7d9389ca5c5905e7fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Uncoupling Agents
216 rdf:type schema:DefinedTerm
217 Ne2fd40801da14307a6427aff5a5c05c1 rdf:first sg:person.0611354561.87
218 rdf:rest N9a55f2f5011d481ebc3587e96ec99b15
219 Ne6bf1f570f4b42348a72e50d2702e0c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
220 schema:name Mice, Inbred C3H
221 rdf:type schema:DefinedTerm
222 Ne81547ff331641f7ad65a0fab1ce7773 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
223 schema:name Mice, Transgenic
224 rdf:type schema:DefinedTerm
225 Nf3434e19d7b24675a5f7e59034188dbf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
226 schema:name Disease Models, Animal
227 rdf:type schema:DefinedTerm
228 Nfbde2527846146d9986c67afc6dd65aa schema:name doi
229 schema:value 10.1007/s12031-010-9378-1
230 rdf:type schema:PropertyValue
231 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
232 schema:name Medical and Health Sciences
233 rdf:type schema:DefinedTerm
234 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
235 schema:name Neurosciences
236 rdf:type schema:DefinedTerm
237 sg:journal.1094289 schema:issn 0895-8696
238 2168-8729
239 schema:name Journal of Molecular Neuroscience
240 schema:publisher Springer Nature
241 rdf:type schema:Periodical
242 sg:person.01022570001.68 schema:affiliation grid-institutes:grid.415325.4
243 schema:familyName Li
244 schema:givenName Qiao-Xin
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022570001.68
246 rdf:type schema:Person
247 sg:person.01065042101.38 schema:affiliation grid-institutes:grid.415325.4
248 schema:familyName Finkelstein
249 schema:givenName David I.
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065042101.38
251 rdf:type schema:Person
252 sg:person.01303422641.56 schema:affiliation grid-institutes:grid.415325.4
253 schema:familyName Ayton
254 schema:givenName Scott
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303422641.56
256 rdf:type schema:Person
257 sg:person.0606134552.10 schema:affiliation grid-institutes:grid.415325.4
258 schema:familyName Mok
259 schema:givenName Su San
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606134552.10
261 rdf:type schema:Person
262 sg:person.0611354561.87 schema:affiliation grid-institutes:grid.415325.4
263 schema:familyName Nurjono
264 schema:givenName Milawaty
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611354561.87
266 rdf:type schema:Person
267 sg:person.0643473627.24 schema:affiliation grid-institutes:grid.415325.4
268 schema:familyName Masters
269 schema:givenName Colin L.
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643473627.24
271 rdf:type schema:Person
272 sg:person.0745211154.54 schema:affiliation grid-institutes:grid.415325.4
273 schema:familyName Culvenor
274 schema:givenName Janetta G.
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745211154.54
276 rdf:type schema:Person
277 sg:person.0757413201.28 schema:affiliation grid-institutes:grid.415325.4
278 schema:familyName George
279 schema:givenName Sonia
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757413201.28
281 rdf:type schema:Person
282 sg:pub.10.1007/bf03033569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049098675
283 https://doi.org/10.1007/bf03033569
284 rdf:type schema:CreativeWork
285 sg:pub.10.1007/s00441-004-0937-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1008288617
286 https://doi.org/10.1007/s00441-004-0937-z
287 rdf:type schema:CreativeWork
288 sg:pub.10.1007/s11064-007-9533-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052493281
289 https://doi.org/10.1007/s11064-007-9533-4
290 rdf:type schema:CreativeWork
291 sg:pub.10.1023/a:1001958023096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048287697
292 https://doi.org/10.1023/a:1001958023096
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/81834 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006666875
295 https://doi.org/10.1038/81834
296 rdf:type schema:CreativeWork
297 sg:pub.10.1038/nature04779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033391441
298 https://doi.org/10.1038/nature04779
299 rdf:type schema:CreativeWork
300 grid-institutes:grid.415325.4 schema:alternateName The Mental Health Research Institute of Victoria, Parkville, 3052, Melbourne, Victoria, Australia
301 schema:name Department of Pathology, The University of Melbourne, Parkville, 3010, Melbourne, Victoria, Australia
302 The Centre for Neuroscience, The University of Melbourne, Parkville, 3010, Melbourne, Victoria, Australia
303 The Mental Health Research Institute of Victoria, Parkville, 3052, Melbourne, Victoria, Australia
304 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...