Ultrasensitive nucleic acid biosensors for early cancer diagnostics View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-09

AUTHORS

Zhiqiang Gao, Hong Xie, Yuan Hong Yu, Natalia C. Tansil

ABSTRACT

We have developed ultrasensitive nucleic acid detection systems involving an amplification step where the analytical signal correlates directly to the amount of nucleic acid in the solution So far, we have performed nucleic acid quantification on several breast cancer susceptibility genes and were able to detect nucleic acid amounts that ranged from 0.1–1.0 fg of nucleic acid, which is at least 1000 times more sensitive than conventional fluorescent detection methods. The biosensors are so sensitive that they can be used for direct detection of breast cancer susceptibility genes in mRNA without involving a PCR step. More... »

PAGES

283-285

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12030-005-0042-8

DOI

http://dx.doi.org/10.1007/s12030-005-0042-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052938557


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