A Systematic Review of the Burden of Pancreatic Cancer in Europe: Real-World Impact on Survival, Quality of Life and Costs View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-09

AUTHORS

A. Carrato, A. Falcone, M. Ducreux, J. W. Valle, A. Parnaby, K. Djazouli, K. Alnwick-Allu, A. Hutchings, C. Palaska, I. Parthenaki

ABSTRACT

PURPOSE: The purpose of this study was to assess the overall burden of pancreatic cancer in Europe, with a focus on survival time in a real-world setting, and the overall healthy life lost to the disease. METHODS: Real-world data were retrieved from peer-reviewed, observational studies identified by an electronic search. We performed two de novo analyses: a proportional shortfall analysis to quantify the proportion of healthy life lost to pancreatic cancer and an estimation of the aggregate life-years lost annually in Europe. RESULTS: Ninety-one studies were included. The median, age-standardised incidence of pancreatic cancer per 100,000 was 7.6 in men and 4.9 in women. Overall median survival from diagnosis was 4.6 months; median survival was 2.8-5.7 months in patients with metastatic disease. The proportional shortfall analysis showed that pancreatic cancer results in a 98 % loss of healthy life, with a life expectancy at diagnosis of 4.6 months compared to 15.1 years for an age-matched healthy population. Annually, 610,000-915,000 quality-adjusted life-years (QALYs) are lost to pancreatic cancer in Europe. Patients had significantly lower scores on validated health-related quality of life instruments versus population norms. CONCLUSIONS: To the best of our knowledge, this is the first study to systematically review real-world overall survival and patient outcomes of pancreatic cancer patients in Europe outside the context of clinical trials. Our findings confirm the poor prognosis and short survival reported by national studies. Pancreatic cancer is a substantial burden in Europe, with nearly a million aggregate life-years lost annually and almost complete loss of healthy life in affected individuals. More... »

PAGES

201-211

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12029-015-9724-1

DOI

http://dx.doi.org/10.1007/s12029-015-9724-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012283784

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25972062


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Europe", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quality of Life", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Ram\u00f3n y Cajal", 
          "id": "https://www.grid.ac/institutes/grid.411347.4", 
          "name": [
            "Medical Oncology Department, Ramon y Cajal University Hospital, Ctra. Colmenar Viejo Km. 9,100, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carrato", 
        "givenName": "A.", 
        "id": "sg:person.0602425043.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602425043.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
          "id": "https://www.grid.ac/institutes/grid.144189.1", 
          "name": [
            "Unit of Medical Oncology, Pisa University Hospital, Via Roma 67, 56126, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Falcone", 
        "givenName": "A.", 
        "id": "sg:person.01006230145.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006230145.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Gustave Roussy", 
          "id": "https://www.grid.ac/institutes/grid.14925.3b", 
          "name": [
            "Gastrointestinal Unit, Gustave Roussy Institute, 114 Rue Edouard-Vaillant, 94805, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ducreux", 
        "givenName": "M.", 
        "id": "sg:person.014017005377.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014017005377.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Medical Oncology, University of Manchester and Christie NHS Foundation Trust, Wilmslow Rd, M20 4BX, Manchester, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Valle", 
        "givenName": "J. W.", 
        "id": "sg:person.01316070764.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316070764.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Celgene Corporation, Route de Perreux 1, 2017, Boudry, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Parnaby", 
        "givenName": "A.", 
        "id": "sg:person.0721535265.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721535265.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Celgene Corporation, Route de Perreux 1, 2017, Boudry, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Djazouli", 
        "givenName": "K.", 
        "id": "sg:person.01243533754.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243533754.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Dolon Ltd, 175-185 Grays Inn Road, WC1X 8UE, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alnwick-Allu", 
        "givenName": "K.", 
        "id": "sg:person.01035763665.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035763665.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Dolon Ltd, 175-185 Grays Inn Road, WC1X 8UE, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hutchings", 
        "givenName": "A.", 
        "id": "sg:person.01254140274.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254140274.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Dolon Ltd, 175-185 Grays Inn Road, WC1X 8UE, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Palaska", 
        "givenName": "C.", 
        "id": "sg:person.01152212265.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152212265.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Dolon Ltd, 175-185 Grays Inn Road, WC1X 8UE, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Parthenaki", 
        "givenName": "I.", 
        "id": "sg:person.01220325465.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220325465.75"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00268-011-1208-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000276253", 
          "https://doi.org/10.1007/s00268-011-1208-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00365528509088885", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000278252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910570605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000599548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00520-012-1514-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000705769", 
          "https://doi.org/10.1007/s00520-012-1514-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00520-012-1514-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000705769", 
          "https://doi.org/10.1007/s00520-012-1514-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00520-012-1505-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000763630", 
          "https://doi.org/10.1007/s00520-012-1505-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1590-8658(02)80024-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001396223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpa.0b013e31824c3dbf", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003056576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpa.0b013e31824c3dbf", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003056576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01717461", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003246021", 
          "https://doi.org/10.1007/bf01717461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01717461", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003246021", 
          "https://doi.org/10.1007/bf01717461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0215(20000701)87:1<122::aid-ijc18>3.0.co;2-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003541448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000098177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003578162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.27490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004769020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00520-006-0067-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005086205", 
          "https://doi.org/10.1007/s00520-006-0067-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00520-006-0067-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005086205", 
          "https://doi.org/10.1007/s00520-006-0067-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cej.0b013e328345f99e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006891824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cej.0b013e328345f99e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006891824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cej.0b013e328345f99e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006891824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/02841860310000386", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007126982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdh346", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008177073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2008.11.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008410465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1040-8428(00)00075-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011610042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mds024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012331439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6604576", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013082684", 
          "https://doi.org/10.1038/sj.bjc.6604576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cej.0b013e3283465426", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013865660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cej.0b013e3283465426", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013865660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cej.0b013e3283465426", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013865660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdg754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014018113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.26315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014668147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cej.0b013e32809b4cba", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015430510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cej.0b013e32809b4cba", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015430510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clon.2008.02.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015894394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canep.2012.03.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018163788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00104-012-2455-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018295362", 
          "https://doi.org/10.1007/s00104-012-2455-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00365529108998591", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019204219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/clep.s20611", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021144887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.21166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021817259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2008.06.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024344783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2012.07.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025555654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2007.12.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025907215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10552-007-9073-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026068375", 
          "https://doi.org/10.1007/s10552-007-9073-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10552-007-9073-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026068375", 
          "https://doi.org/10.1007/s10552-007-9073-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.2009-0333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026728018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpa.0b013e31819b71ae", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027252952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpa.0b013e31819b71ae", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027252952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpa.0b013e31819b71ae", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027252952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2005.03.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028488991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2005.03.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028488991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpa.0b013e318216f693", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028531544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpa.0b013e318216f693", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028531544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2036.2006.02860.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028725281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2036.2006.02860.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028725281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2036.2005.02570.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029089810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2036.2005.02570.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029089810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jso.2930230302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029196840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1258/135581903321466030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030770362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1258/135581903321466030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030770362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/096914139400100111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031217211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/096914139400100111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031217211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-14-0155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031427202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdq774", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031669635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejso.2006.12.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033045047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10198-011-0346-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034208726", 
          "https://doi.org/10.1007/s10198-011-0346-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(98)00330-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036592635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00365520903358899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040034015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/0284186x.2011.599338", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040742887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01299577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042717206", 
          "https://doi.org/10.1007/bf01299577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2168.1998.00920.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043583238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/0284186x.2014.953257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043621764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdr131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043708925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mc.20785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043956291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006676-200308000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045606316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006676-200308000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045606316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2010.01.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046541219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2004.047191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047741076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/canjclin.55.2.74", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048020321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1013764220293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048154796", 
          "https://doi.org/10.1023/a:1013764220293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa032295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048680038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.cej.0000136719.42948.5a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048826725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.cej.0000136719.42948.5a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048826725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-5-82", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050971854", 
          "https://doi.org/10.1186/1471-2407-5-82"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/ceor.s66309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052795307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdg110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053276922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpa.0b013e318291fbc5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053544991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpa.0b013e318291fbc5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053544991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1991.136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053735235", 
          "https://doi.org/10.1038/bjc.1991.136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1991.136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053735235", 
          "https://doi.org/10.1038/bjc.1991.136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1756283x13478680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064076494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1756283x13478680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064076494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1758834014564775", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064077361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1758834014564775", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064077361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3325/cmj.2008.49.792", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071145488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3402/ijch.v67i5.18359", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071273712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077629990", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078050323", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1700/1190.13195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078660555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079920688", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/030089161209800504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100898947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/030089161209800504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100898947"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-09", 
    "datePublishedReg": "2015-09-01", 
    "description": "PURPOSE: The purpose of this study was to assess the overall burden of pancreatic cancer in Europe, with a focus on survival time in a real-world setting, and the overall healthy life lost to the disease.\nMETHODS: Real-world data were retrieved from peer-reviewed, observational studies identified by an electronic search. We performed two de novo analyses: a proportional shortfall analysis to quantify the proportion of healthy life lost to pancreatic cancer and an estimation of the aggregate life-years lost annually in Europe.\nRESULTS: Ninety-one studies were included. The median, age-standardised incidence of pancreatic cancer per 100,000 was 7.6 in men and 4.9 in women. Overall median survival from diagnosis was 4.6 months; median survival was 2.8-5.7 months in patients with metastatic disease. The proportional shortfall analysis showed that pancreatic cancer results in a 98 % loss of healthy life, with a life expectancy at diagnosis of 4.6 months compared to 15.1 years for an age-matched healthy population. Annually, 610,000-915,000 quality-adjusted life-years (QALYs) are lost to pancreatic cancer in Europe. Patients had significantly lower scores on validated health-related quality of life instruments versus population norms.\nCONCLUSIONS: To the best of our knowledge, this is the first study to systematically review real-world overall survival and patient outcomes of pancreatic cancer patients in Europe outside the context of clinical trials. Our findings confirm the poor prognosis and short survival reported by national studies. Pancreatic cancer is a substantial burden in Europe, with nearly a million aggregate life-years lost annually and almost complete loss of healthy life in affected individuals.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12029-015-9724-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1297362", 
        "issn": [
          "1941-6628", 
          "1941-6636"
        ], 
        "name": "Journal of Gastrointestinal Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "46"
      }
    ], 
    "name": "A Systematic Review of the Burden of Pancreatic Cancer in Europe: Real-World Impact on Survival, Quality of Life and Costs", 
    "pagination": "201-211", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3a862af4b6fd5d0a31685163053d9ffd7bb67e859abfdfdfe3adb4d28a62abd1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25972062"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101479627"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12029-015-9724-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1012283784"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12029-015-9724-1", 
      "https://app.dimensions.ai/details/publication/pub.1012283784"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:09", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88236_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs12029-015-9724-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12029-015-9724-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12029-015-9724-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12029-015-9724-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12029-015-9724-1'


 

This table displays all metadata directly associated to this object as RDF triples.

419 TRIPLES      21 PREDICATES      112 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12029-015-9724-1 schema:about N0938269901c44958b274472aaf86c43b
2 N402a63d358c04d60ac43d4fb38178be1
3 N403a851dd77e418fb81bf2e17b68a716
4 N4cfb2a13d9b446f1838a24b3345c9edf
5 N5092975aa10c4f9ab9997828c6fdd108
6 N56c02c66de9d48ebb6248e813c6fedcf
7 Ndaeba1c60ca74bf1862a2c1366c873a2
8 Nf1346665702c4664b58c6f8e23bc8154
9 anzsrc-for:11
10 anzsrc-for:1112
11 schema:author N560b229de73e4c2cb82f2e3cd4e90fd5
12 schema:citation sg:pub.10.1007/bf01299577
13 sg:pub.10.1007/bf01717461
14 sg:pub.10.1007/s00104-012-2455-y
15 sg:pub.10.1007/s00268-011-1208-2
16 sg:pub.10.1007/s00520-006-0067-0
17 sg:pub.10.1007/s00520-012-1505-9
18 sg:pub.10.1007/s00520-012-1514-8
19 sg:pub.10.1007/s10198-011-0346-7
20 sg:pub.10.1007/s10552-007-9073-x
21 sg:pub.10.1023/a:1013764220293
22 sg:pub.10.1038/bjc.1991.136
23 sg:pub.10.1038/sj.bjc.6604576
24 sg:pub.10.1186/1471-2407-5-82
25 https://app.dimensions.ai/details/publication/pub.1077629990
26 https://app.dimensions.ai/details/publication/pub.1078050323
27 https://app.dimensions.ai/details/publication/pub.1079920688
28 https://doi.org/10.1002/1097-0215(20000701)87:1<122::aid-ijc18>3.0.co;2-w
29 https://doi.org/10.1002/cncr.27490
30 https://doi.org/10.1002/ijc.26315
31 https://doi.org/10.1002/ijc.2910570605
32 https://doi.org/10.1002/jso.2930230302
33 https://doi.org/10.1002/mc.20785
34 https://doi.org/10.1016/j.canep.2012.03.010
35 https://doi.org/10.1016/j.clon.2008.02.003
36 https://doi.org/10.1016/j.ejca.2005.03.037
37 https://doi.org/10.1016/j.ejca.2007.12.015
38 https://doi.org/10.1016/j.ejca.2008.06.013
39 https://doi.org/10.1016/j.ejca.2008.11.008
40 https://doi.org/10.1016/j.ejca.2010.01.029
41 https://doi.org/10.1016/j.ejca.2012.07.017
42 https://doi.org/10.1016/j.ejso.2006.12.022
43 https://doi.org/10.1016/s0959-8049(98)00330-x
44 https://doi.org/10.1016/s1040-8428(00)00075-5
45 https://doi.org/10.1016/s1590-8658(02)80024-x
46 https://doi.org/10.1046/j.1365-2168.1998.00920.x
47 https://doi.org/10.1056/nejmoa032295
48 https://doi.org/10.1080/02841860310000386
49 https://doi.org/10.1093/annonc/mdg110
50 https://doi.org/10.1093/annonc/mdg754
51 https://doi.org/10.1093/annonc/mdh346
52 https://doi.org/10.1093/annonc/mdq774
53 https://doi.org/10.1093/annonc/mdr131
54 https://doi.org/10.1093/annonc/mds024
55 https://doi.org/10.1097/00006676-200308000-00006
56 https://doi.org/10.1097/01.cej.0000136719.42948.5a
57 https://doi.org/10.1097/cej.0b013e32809b4cba
58 https://doi.org/10.1097/cej.0b013e328345f99e
59 https://doi.org/10.1097/cej.0b013e3283465426
60 https://doi.org/10.1097/mpa.0b013e31819b71ae
61 https://doi.org/10.1097/mpa.0b013e318216f693
62 https://doi.org/10.1097/mpa.0b013e31824c3dbf
63 https://doi.org/10.1097/mpa.0b013e318291fbc5
64 https://doi.org/10.1111/j.1365-2036.2005.02570.x
65 https://doi.org/10.1111/j.1365-2036.2006.02860.x
66 https://doi.org/10.1136/gut.2004.047191
67 https://doi.org/10.1158/0008-5472.can-14-0155
68 https://doi.org/10.1159/000098177
69 https://doi.org/10.1177/030089161209800504
70 https://doi.org/10.1177/096914139400100111
71 https://doi.org/10.1177/1756283x13478680
72 https://doi.org/10.1177/1758834014564775
73 https://doi.org/10.1258/135581903321466030
74 https://doi.org/10.1634/theoncologist.2009-0333
75 https://doi.org/10.1700/1190.13195
76 https://doi.org/10.2147/ceor.s66309
77 https://doi.org/10.2147/clep.s20611
78 https://doi.org/10.3109/00365520903358899
79 https://doi.org/10.3109/00365528509088885
80 https://doi.org/10.3109/00365529108998591
81 https://doi.org/10.3109/0284186x.2011.599338
82 https://doi.org/10.3109/0284186x.2014.953257
83 https://doi.org/10.3322/caac.21166
84 https://doi.org/10.3322/canjclin.55.2.74
85 https://doi.org/10.3325/cmj.2008.49.792
86 https://doi.org/10.3402/ijch.v67i5.18359
87 schema:datePublished 2015-09
88 schema:datePublishedReg 2015-09-01
89 schema:description PURPOSE: The purpose of this study was to assess the overall burden of pancreatic cancer in Europe, with a focus on survival time in a real-world setting, and the overall healthy life lost to the disease. METHODS: Real-world data were retrieved from peer-reviewed, observational studies identified by an electronic search. We performed two de novo analyses: a proportional shortfall analysis to quantify the proportion of healthy life lost to pancreatic cancer and an estimation of the aggregate life-years lost annually in Europe. RESULTS: Ninety-one studies were included. The median, age-standardised incidence of pancreatic cancer per 100,000 was 7.6 in men and 4.9 in women. Overall median survival from diagnosis was 4.6 months; median survival was 2.8-5.7 months in patients with metastatic disease. The proportional shortfall analysis showed that pancreatic cancer results in a 98 % loss of healthy life, with a life expectancy at diagnosis of 4.6 months compared to 15.1 years for an age-matched healthy population. Annually, 610,000-915,000 quality-adjusted life-years (QALYs) are lost to pancreatic cancer in Europe. Patients had significantly lower scores on validated health-related quality of life instruments versus population norms. CONCLUSIONS: To the best of our knowledge, this is the first study to systematically review real-world overall survival and patient outcomes of pancreatic cancer patients in Europe outside the context of clinical trials. Our findings confirm the poor prognosis and short survival reported by national studies. Pancreatic cancer is a substantial burden in Europe, with nearly a million aggregate life-years lost annually and almost complete loss of healthy life in affected individuals.
90 schema:genre research_article
91 schema:inLanguage en
92 schema:isAccessibleForFree true
93 schema:isPartOf N236c61a238f646b9aa55b383ce090627
94 Nf542eeaf32dd415d8714806010137142
95 sg:journal.1297362
96 schema:name A Systematic Review of the Burden of Pancreatic Cancer in Europe: Real-World Impact on Survival, Quality of Life and Costs
97 schema:pagination 201-211
98 schema:productId N81ed3b063bed405d8356d9020b7c6bd3
99 Nbe31d6dca4fe43169ead74035a7e5e5b
100 Nd6137fe61ec3426d95fc2c7aedb079f1
101 Ne716557aa5fc4984b9f980b43fcbd950
102 Ned6d4527a3b545c9a43c2762b8de8c0a
103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012283784
104 https://doi.org/10.1007/s12029-015-9724-1
105 schema:sdDatePublished 2019-04-11T13:09
106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
107 schema:sdPublisher N8c68ac385d124dff998acc57bac82c6f
108 schema:url https://link.springer.com/10.1007%2Fs12029-015-9724-1
109 sgo:license sg:explorer/license/
110 sgo:sdDataset articles
111 rdf:type schema:ScholarlyArticle
112 N0938269901c44958b274472aaf86c43b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Pancreatic Neoplasms
114 rdf:type schema:DefinedTerm
115 N0a6b08c4f32645a992c8826bae3c88f0 rdf:first sg:person.01316070764.15
116 rdf:rest N378a708e563d44fdb397b36a8cf8fdc4
117 N14133004d9584ebe9e66b7c97783bcbd rdf:first sg:person.01243533754.07
118 rdf:rest Nc48feee1621b41caafc68632aea61f4b
119 N236c61a238f646b9aa55b383ce090627 schema:volumeNumber 46
120 rdf:type schema:PublicationVolume
121 N28bccb75fbb4491d94b03214aedfcee7 schema:name Dolon Ltd, 175-185 Grays Inn Road, WC1X 8UE, London, UK
122 rdf:type schema:Organization
123 N3162d8c0a2c643d4b0b4f909fb6c5528 rdf:first sg:person.01254140274.89
124 rdf:rest Neb14436979d04586ad5df16b9ac32f7d
125 N378a708e563d44fdb397b36a8cf8fdc4 rdf:first sg:person.0721535265.19
126 rdf:rest N14133004d9584ebe9e66b7c97783bcbd
127 N402a63d358c04d60ac43d4fb38178be1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Europe
129 rdf:type schema:DefinedTerm
130 N403a851dd77e418fb81bf2e17b68a716 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Humans
132 rdf:type schema:DefinedTerm
133 N44476f0f6dcc400da659913104989a5d schema:name Dolon Ltd, 175-185 Grays Inn Road, WC1X 8UE, London, UK
134 rdf:type schema:Organization
135 N4cfb2a13d9b446f1838a24b3345c9edf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Survival Analysis
137 rdf:type schema:DefinedTerm
138 N5092975aa10c4f9ab9997828c6fdd108 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Male
140 rdf:type schema:DefinedTerm
141 N560b229de73e4c2cb82f2e3cd4e90fd5 rdf:first sg:person.0602425043.70
142 rdf:rest N94f60f9068d94a05a2e7f950e9a7c0ae
143 N56c02c66de9d48ebb6248e813c6fedcf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Female
145 rdf:type schema:DefinedTerm
146 N66e65801057c4fb1963e3f4e4a5ade55 rdf:first sg:person.014017005377.47
147 rdf:rest N0a6b08c4f32645a992c8826bae3c88f0
148 N81ed3b063bed405d8356d9020b7c6bd3 schema:name dimensions_id
149 schema:value pub.1012283784
150 rdf:type schema:PropertyValue
151 N85293f53aff040888449e60f966bd78a schema:name Celgene Corporation, Route de Perreux 1, 2017, Boudry, Switzerland
152 rdf:type schema:Organization
153 N8c68ac385d124dff998acc57bac82c6f schema:name Springer Nature - SN SciGraph project
154 rdf:type schema:Organization
155 N94f60f9068d94a05a2e7f950e9a7c0ae rdf:first sg:person.01006230145.44
156 rdf:rest N66e65801057c4fb1963e3f4e4a5ade55
157 N9554b2fb6f6d4ee2930014aa2386bd8c schema:name Celgene Corporation, Route de Perreux 1, 2017, Boudry, Switzerland
158 rdf:type schema:Organization
159 N9e3629e79ea24c11b27fda04fa289369 rdf:first sg:person.01220325465.75
160 rdf:rest rdf:nil
161 Nbe31d6dca4fe43169ead74035a7e5e5b schema:name doi
162 schema:value 10.1007/s12029-015-9724-1
163 rdf:type schema:PropertyValue
164 Nc48feee1621b41caafc68632aea61f4b rdf:first sg:person.01035763665.47
165 rdf:rest N3162d8c0a2c643d4b0b4f909fb6c5528
166 Nd180672db8654a298f888cac3d42e221 schema:name Department of Medical Oncology, University of Manchester and Christie NHS Foundation Trust, Wilmslow Rd, M20 4BX, Manchester, UK
167 rdf:type schema:Organization
168 Nd6137fe61ec3426d95fc2c7aedb079f1 schema:name nlm_unique_id
169 schema:value 101479627
170 rdf:type schema:PropertyValue
171 Ndaeba1c60ca74bf1862a2c1366c873a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Aged
173 rdf:type schema:DefinedTerm
174 Ne716557aa5fc4984b9f980b43fcbd950 schema:name readcube_id
175 schema:value 3a862af4b6fd5d0a31685163053d9ffd7bb67e859abfdfdfe3adb4d28a62abd1
176 rdf:type schema:PropertyValue
177 Ne8befbe7c5304dc8a9bba45c0a08427a schema:name Dolon Ltd, 175-185 Grays Inn Road, WC1X 8UE, London, UK
178 rdf:type schema:Organization
179 Neb14436979d04586ad5df16b9ac32f7d rdf:first sg:person.01152212265.94
180 rdf:rest N9e3629e79ea24c11b27fda04fa289369
181 Ned6d4527a3b545c9a43c2762b8de8c0a schema:name pubmed_id
182 schema:value 25972062
183 rdf:type schema:PropertyValue
184 Nf1346665702c4664b58c6f8e23bc8154 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Quality of Life
186 rdf:type schema:DefinedTerm
187 Nf542eeaf32dd415d8714806010137142 schema:issueNumber 3
188 rdf:type schema:PublicationIssue
189 Nfdeab356da8b44f1b126376a48138959 schema:name Dolon Ltd, 175-185 Grays Inn Road, WC1X 8UE, London, UK
190 rdf:type schema:Organization
191 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
192 schema:name Medical and Health Sciences
193 rdf:type schema:DefinedTerm
194 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
195 schema:name Oncology and Carcinogenesis
196 rdf:type schema:DefinedTerm
197 sg:journal.1297362 schema:issn 1941-6628
198 1941-6636
199 schema:name Journal of Gastrointestinal Cancer
200 rdf:type schema:Periodical
201 sg:person.01006230145.44 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
202 schema:familyName Falcone
203 schema:givenName A.
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006230145.44
205 rdf:type schema:Person
206 sg:person.01035763665.47 schema:affiliation N28bccb75fbb4491d94b03214aedfcee7
207 schema:familyName Alnwick-Allu
208 schema:givenName K.
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035763665.47
210 rdf:type schema:Person
211 sg:person.01152212265.94 schema:affiliation N44476f0f6dcc400da659913104989a5d
212 schema:familyName Palaska
213 schema:givenName C.
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152212265.94
215 rdf:type schema:Person
216 sg:person.01220325465.75 schema:affiliation Nfdeab356da8b44f1b126376a48138959
217 schema:familyName Parthenaki
218 schema:givenName I.
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220325465.75
220 rdf:type schema:Person
221 sg:person.01243533754.07 schema:affiliation N85293f53aff040888449e60f966bd78a
222 schema:familyName Djazouli
223 schema:givenName K.
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243533754.07
225 rdf:type schema:Person
226 sg:person.01254140274.89 schema:affiliation Ne8befbe7c5304dc8a9bba45c0a08427a
227 schema:familyName Hutchings
228 schema:givenName A.
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254140274.89
230 rdf:type schema:Person
231 sg:person.01316070764.15 schema:affiliation Nd180672db8654a298f888cac3d42e221
232 schema:familyName Valle
233 schema:givenName J. W.
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316070764.15
235 rdf:type schema:Person
236 sg:person.014017005377.47 schema:affiliation https://www.grid.ac/institutes/grid.14925.3b
237 schema:familyName Ducreux
238 schema:givenName M.
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014017005377.47
240 rdf:type schema:Person
241 sg:person.0602425043.70 schema:affiliation https://www.grid.ac/institutes/grid.411347.4
242 schema:familyName Carrato
243 schema:givenName A.
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602425043.70
245 rdf:type schema:Person
246 sg:person.0721535265.19 schema:affiliation N9554b2fb6f6d4ee2930014aa2386bd8c
247 schema:familyName Parnaby
248 schema:givenName A.
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721535265.19
250 rdf:type schema:Person
251 sg:pub.10.1007/bf01299577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042717206
252 https://doi.org/10.1007/bf01299577
253 rdf:type schema:CreativeWork
254 sg:pub.10.1007/bf01717461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003246021
255 https://doi.org/10.1007/bf01717461
256 rdf:type schema:CreativeWork
257 sg:pub.10.1007/s00104-012-2455-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1018295362
258 https://doi.org/10.1007/s00104-012-2455-y
259 rdf:type schema:CreativeWork
260 sg:pub.10.1007/s00268-011-1208-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000276253
261 https://doi.org/10.1007/s00268-011-1208-2
262 rdf:type schema:CreativeWork
263 sg:pub.10.1007/s00520-006-0067-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005086205
264 https://doi.org/10.1007/s00520-006-0067-0
265 rdf:type schema:CreativeWork
266 sg:pub.10.1007/s00520-012-1505-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000763630
267 https://doi.org/10.1007/s00520-012-1505-9
268 rdf:type schema:CreativeWork
269 sg:pub.10.1007/s00520-012-1514-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000705769
270 https://doi.org/10.1007/s00520-012-1514-8
271 rdf:type schema:CreativeWork
272 sg:pub.10.1007/s10198-011-0346-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034208726
273 https://doi.org/10.1007/s10198-011-0346-7
274 rdf:type schema:CreativeWork
275 sg:pub.10.1007/s10552-007-9073-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026068375
276 https://doi.org/10.1007/s10552-007-9073-x
277 rdf:type schema:CreativeWork
278 sg:pub.10.1023/a:1013764220293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048154796
279 https://doi.org/10.1023/a:1013764220293
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/bjc.1991.136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053735235
282 https://doi.org/10.1038/bjc.1991.136
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/sj.bjc.6604576 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013082684
285 https://doi.org/10.1038/sj.bjc.6604576
286 rdf:type schema:CreativeWork
287 sg:pub.10.1186/1471-2407-5-82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050971854
288 https://doi.org/10.1186/1471-2407-5-82
289 rdf:type schema:CreativeWork
290 https://app.dimensions.ai/details/publication/pub.1077629990 schema:CreativeWork
291 https://app.dimensions.ai/details/publication/pub.1078050323 schema:CreativeWork
292 https://app.dimensions.ai/details/publication/pub.1079920688 schema:CreativeWork
293 https://doi.org/10.1002/1097-0215(20000701)87:1<122::aid-ijc18>3.0.co;2-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1003541448
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1002/cncr.27490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004769020
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1002/ijc.26315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014668147
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1002/ijc.2910570605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000599548
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1002/jso.2930230302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029196840
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1002/mc.20785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043956291
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/j.canep.2012.03.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018163788
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/j.clon.2008.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015894394
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/j.ejca.2005.03.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028488991
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.ejca.2007.12.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025907215
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/j.ejca.2008.06.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024344783
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.ejca.2008.11.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008410465
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/j.ejca.2010.01.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046541219
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/j.ejca.2012.07.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025555654
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/j.ejso.2006.12.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033045047
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/s0959-8049(98)00330-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036592635
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/s1040-8428(00)00075-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011610042
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/s1590-8658(02)80024-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001396223
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1046/j.1365-2168.1998.00920.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043583238
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1056/nejmoa032295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048680038
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1080/02841860310000386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007126982
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1093/annonc/mdg110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053276922
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1093/annonc/mdg754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014018113
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1093/annonc/mdh346 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008177073
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1093/annonc/mdq774 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031669635
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1093/annonc/mdr131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043708925
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1093/annonc/mds024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012331439
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1097/00006676-200308000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045606316
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1097/01.cej.0000136719.42948.5a schema:sameAs https://app.dimensions.ai/details/publication/pub.1048826725
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1097/cej.0b013e32809b4cba schema:sameAs https://app.dimensions.ai/details/publication/pub.1015430510
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1097/cej.0b013e328345f99e schema:sameAs https://app.dimensions.ai/details/publication/pub.1006891824
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1097/cej.0b013e3283465426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013865660
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1097/mpa.0b013e31819b71ae schema:sameAs https://app.dimensions.ai/details/publication/pub.1027252952
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1097/mpa.0b013e318216f693 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028531544
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1097/mpa.0b013e31824c3dbf schema:sameAs https://app.dimensions.ai/details/publication/pub.1003056576
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1097/mpa.0b013e318291fbc5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053544991
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1111/j.1365-2036.2005.02570.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029089810
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1111/j.1365-2036.2006.02860.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028725281
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1136/gut.2004.047191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047741076
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1158/0008-5472.can-14-0155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031427202
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1159/000098177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003578162
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1177/030089161209800504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100898947
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1177/096914139400100111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031217211
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1177/1756283x13478680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064076494
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1177/1758834014564775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064077361
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1258/135581903321466030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030770362
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1634/theoncologist.2009-0333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026728018
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1700/1190.13195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078660555
388 rdf:type schema:CreativeWork
389 https://doi.org/10.2147/ceor.s66309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052795307
390 rdf:type schema:CreativeWork
391 https://doi.org/10.2147/clep.s20611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021144887
392 rdf:type schema:CreativeWork
393 https://doi.org/10.3109/00365520903358899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040034015
394 rdf:type schema:CreativeWork
395 https://doi.org/10.3109/00365528509088885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000278252
396 rdf:type schema:CreativeWork
397 https://doi.org/10.3109/00365529108998591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019204219
398 rdf:type schema:CreativeWork
399 https://doi.org/10.3109/0284186x.2011.599338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040742887
400 rdf:type schema:CreativeWork
401 https://doi.org/10.3109/0284186x.2014.953257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043621764
402 rdf:type schema:CreativeWork
403 https://doi.org/10.3322/caac.21166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021817259
404 rdf:type schema:CreativeWork
405 https://doi.org/10.3322/canjclin.55.2.74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048020321
406 rdf:type schema:CreativeWork
407 https://doi.org/10.3325/cmj.2008.49.792 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071145488
408 rdf:type schema:CreativeWork
409 https://doi.org/10.3402/ijch.v67i5.18359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071273712
410 rdf:type schema:CreativeWork
411 https://www.grid.ac/institutes/grid.144189.1 schema:alternateName Azienda Ospedaliera Universitaria Pisana
412 schema:name Unit of Medical Oncology, Pisa University Hospital, Via Roma 67, 56126, Pisa, Italy
413 rdf:type schema:Organization
414 https://www.grid.ac/institutes/grid.14925.3b schema:alternateName Institut Gustave Roussy
415 schema:name Gastrointestinal Unit, Gustave Roussy Institute, 114 Rue Edouard-Vaillant, 94805, Villejuif, France
416 rdf:type schema:Organization
417 https://www.grid.ac/institutes/grid.411347.4 schema:alternateName Hospital Universitario Ramón y Cajal
418 schema:name Medical Oncology Department, Ramon y Cajal University Hospital, Ctra. Colmenar Viejo Km. 9,100, Madrid, Spain
419 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...