A Case of Explosive Progression of Hepatocellular Carcinoma in a Patient with Common Variable Immunodeficiency (CVID) View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-12

AUTHORS

Kaushang Gandhi, Purvi Parikh, Wilbert S. Aronow, Harit Desai, Harshad Amin, Mala Sharma, Arye Rubinstein

ABSTRACT

OBJECTIVE: While it is well known that patients with common variable immunodeficiency (CVID) are predisposed to various malignancies, primarily non-Hodgkin's lymphoma and gastric carcinomas, to our knowledge no cases of hepatocellular carcinoma have been reported in the absence of preexisting liver disease. METHOD AND RESULTS: We report a 50-year-old male patient with CVID with a B- and T-cell deficiency. The patient was on prophylactic intravenous gammaglobulin and had received several years earlier a course of rituximab for an autoimmune disorder. He had no history of hepatitis. The patient developed a rapidly progressing hepatocellular carcinoma within 3 to 4 weeks. CONCLUSIONS: Although patients with CVID are predisposed to malignancies such as lymphoma and adenocarcinoma of the stomach, rapidly progressive hepatocellular carcinoma in the absence of any preexisting liver disease has not been described. More... »

PAGES

281-284

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12029-010-9158-8

DOI

http://dx.doi.org/10.1007/s12029-010-9158-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029757413

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20473587


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