High Serum DNA and RNA Oxidative Damage in Non-surviving Patients with Spontaneous Intracerebral Hemorrhage View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-10-09

AUTHORS

Leonardo Lorente, María M. Martín, Agustín F. González-Rivero, Antonia Pérez-Cejas, Pedro Abreu-González, Rafael Sabatel, Luis Ramos, Mónica Argueso, Juan J. Cáceres, Jordi Solé-Violán, Alejandro Jiménez, Victor García-Marín

ABSTRACT

PurposeOne study found higher leukocytes 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels in patients with spontaneous intracerebral hemorrhage (ICH) than in healthy subjects due to the oxidation of guanosine from deoxyribonucleic acid (DNA). The objective of this study was to determine whether there is an association between oxidative damage of serum DNA and ribonucleic acid (RNA) and mortality in patients with ICH.MethodsIn this observational and prospective study, patients with severe supratentorial ICH (defined as Glasgow Coma Scale < 9) were included from six Intensive Care Units of Spanish hospitals. At the time of severe ICH diagnosis, concentrations in serum of malondialdehyde (as lipid peroxidation biomarker) and of the three oxidized guanine species (OGS) (8-hydroxyguanosine from RNA, 8-hydroxyguanine from DNA or RNA, and 8-OHdG from DNA) were determined. Thirty-day mortality was considered the end-point study.ResultsSerum levels of OGS (p < 0.001) and malondialdehyde (p = 0.002) were higher in non-surviving (n = 46) than in surviving patients (n = 54). There was an association of serum OGS levels with serum malondialdehyde levels (rho = 0.36; p = 0.001) and 30-day mortality (OR = 1.568; 95% CI 1.183–2.078; p = 0.002).ConclusionsThe novel and most important finding of our study was that serum OGS levels in ICH patients are associated with mortality. More... »

PAGES

90-96

Journal

TITLE

Neurocritical Care

ISSUE

1

VOLUME

33

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12028-019-00864-8

DOI

http://dx.doi.org/10.1007/s12028-019-00864-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1121623600

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31598840


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36 RNA oxidative damage
37 ResultsSerum levels
38 Spanish hospitals
39 Thirty-day mortality
40 acid
41 association
42 care unit
43 concentration
44 damage
45 deoxyribonucleic acid
46 diagnosis
47 end-point study
48 findings
49 guanine species
50 guanosine
51 healthy subjects
52 hemorrhage
53 higher leukocyte
54 hospital
55 important finding
56 intensive care unit
57 intracerebral hemorrhage
58 leukocytes
59 levels
60 malondialdehyde
61 malondialdehyde levels
62 mortality
63 non-surviving patients
64 novel
65 objective
66 oxidation
67 oxidation of guanosine
68 oxidative damage
69 patients
70 prospective study
71 ribonucleic acid
72 serum
73 serum malondialdehyde levels
74 species
75 spontaneous intracerebral hemorrhage
76 study
77 subjects
78 supratentorial intracerebral hemorrhage
79 time
80 units
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