Association Between DNA and RNA Oxidative Damage and Mortality of Patients with Traumatic Brain Injury View Full Text


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Article Info

DATE

2019-08-05

AUTHORS

Leonardo Lorente, María M. Martín, Agustín F. González-Rivero, Antonia Pérez-Cejas, Pedro Abreu-González, Luis Ramos, Mónica Argueso, Juan J. Cáceres, Jordi Solé-Violán, Andrea Alvarez-Castillo, Alejandro Jiménez, Victor García-Marín

ABSTRACT

BackgroundThe hyperoxidative state in traumatic brain injury (TBI) could produce oxidative damage on the ribonucleic acid (RNA) and deoxyribonucleic acid (DNA). Oxidative damage to nucleic acids in TBI patients has been studied, and higher concentrations of 8-OHdG were found in postmortem brain samples of subjects who died following TBI than in subjects who died from sudden cardiac death. Thus, the objective of this study was to determine whether there is an association between serum DNA and RNA oxidative damage and mortality in TBI patients.MethodsWe included patients with severe isolated TBI defined as a lower score than 9 points in the Glasgow Coma Scale (GCS) and lower than 9 points in non-cranial aspects in the Injury Severity Score. We determined serum concentrations of the three oxidized guanine species (OGS) (8-OHdG from DNA, 8-hydroxyguanosine from RNA, and 8-hydroxyguanine from DNA or RNA) and malondialdehyde (to estimate lipid peroxidation) on the day of TBI. Mortality at 30 days was the end-point study. ResultsWe found higher serum concentrations of OGS (p < 0.001) and malondialdehyde (p < 0.001) in non-surviving (n = 34) than in surviving patients (n = 90), an association between serum OGS levels and 30-day mortality after control for CGS, age, and computed tomography findings (OR = 1.397; 95% CI = 1.137–1.716; p = 0.001), and a positive correlation between serum levels of OGS and malondialdehyde (rho = 0.24; p = 0.01). ConclusionsTo our knowledge, our study is the largest series reporting data on DNA oxidative damage in TBI patients and is the first reporting DNA and RNA oxidative damage in TBI patients associating lipid peroxidation and mortality. More... »

PAGES

790-795

Journal

TITLE

Neurocritical Care

ISSUE

3

VOLUME

32

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12028-019-00800-w

DOI

http://dx.doi.org/10.1007/s12028-019-00800-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1120134976

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31385181


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29 schema:description BackgroundThe hyperoxidative state in traumatic brain injury (TBI) could produce oxidative damage on the ribonucleic acid (RNA) and deoxyribonucleic acid (DNA). Oxidative damage to nucleic acids in TBI patients has been studied, and higher concentrations of 8-OHdG were found in postmortem brain samples of subjects who died following TBI than in subjects who died from sudden cardiac death. Thus, the objective of this study was to determine whether there is an association between serum DNA and RNA oxidative damage and mortality in TBI patients.MethodsWe included patients with severe isolated TBI defined as a lower score than 9 points in the Glasgow Coma Scale (GCS) and lower than 9 points in non-cranial aspects in the Injury Severity Score. We determined serum concentrations of the three oxidized guanine species (OGS) (8-OHdG from DNA, 8-hydroxyguanosine from RNA, and 8-hydroxyguanine from DNA or RNA) and malondialdehyde (to estimate lipid peroxidation) on the day of TBI. Mortality at 30 days was the end-point study. ResultsWe found higher serum concentrations of OGS (p < 0.001) and malondialdehyde (p < 0.001) in non-surviving (n = 34) than in surviving patients (n = 90), an association between serum OGS levels and 30-day mortality after control for CGS, age, and computed tomography findings (OR = 1.397; 95% CI = 1.137–1.716; p = 0.001), and a positive correlation between serum levels of OGS and malondialdehyde (rho = 0.24; p = 0.01). ConclusionsTo our knowledge, our study is the largest series reporting data on DNA oxidative damage in TBI patients and is the first reporting DNA and RNA oxidative damage in TBI patients associating lipid peroxidation and mortality.
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36 Coma Scale
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38 DNA oxidative damage
39 Glasgow Coma Scale
40 Injury Severity Score
41 MethodsWe
42 OGS
43 RNA oxidative damage
44 ResultsWe
45 TBI patients
46 acid
47 age
48 aspects
49 association
50 brain injury
51 brain samples
52 cardiac death
53 concentration
54 control
55 correlation
56 damage
57 data
58 days
59 days of TBI
60 death
61 deoxyribonucleic acid
62 end-point study
63 findings
64 guanine species
65 high concentrations
66 higher serum concentrations
67 hyperoxidative state
68 injury
69 knowledge
70 large series
71 levels
72 lipid peroxidation
73 lower scores
74 malondialdehyde
75 mortality
76 mortality of patients
77 non-cranial aspects
78 nucleic acids
79 objective
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81 patients
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85 postmortem brain samples
86 ribonucleic acid
87 samples
88 scale
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94 species
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