Regional Differences in Cerebral Glucose Metabolism After Cardiac Arrest and Resuscitation in Rats Using [18F]FDG Positron Emission Tomography and Autoradiography View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-09-05

AUTHORS

Alessandro Putzu, Silvia Valtorta, Giuseppe Di Grigoli, Matthias Haenggi, Sara Belloli, Antonio Malgaroli, Marco Gemma, Giovanni Landoni, Luigi Beretta, Rosa Maria Moresco

ABSTRACT

BackgroundCardiac arrest is an important cause of morbidity and mortality. Brain injury severity and prognosis of cardiac arrest patients are related to the cerebral areas affected. To this aim, we evaluated the variability and the distribution of brain glucose metabolism after cardiac arrest and resuscitation in an adult rat model.MethodsTen rats underwent 8-min cardiac arrest, induced with a mixture of potassium and esmolol, and resuscitation, performed with chest compressions and epinephrine. Eight sham animals received anesthesia and experimental procedures identical to the ischemic group except cardiac arrest induction. Brain metabolism was assessed using [18F]FDG autoradiography and small animal-dedicated positron emission tomography.ResultsThe absolute glucose metabolism measured with [18F]FDG autoradiography 2 h after cardiac arrest and resuscitation was lower in the frontal, parietal, occipital, and temporal cortices of cardiac arrest animals, showing, respectively, a 36% (p = 0.006), 32% (p = 0.016), 36% (p = 0.009), and 32% (p = 0.013) decrease compared to sham group. Striatum, hippocampus, thalamus, brainstem, and cerebellum showed no significant changes. Relative regional metabolism indicated a redistribution of metabolism from cortical area to brainstem and cerebellum.ConclusionsOur data suggest that cerebral regions have different susceptibility to moderate global ischemia in terms of glucose metabolism. The neocortex showed a higher sensibility to hypoxia–ischemia than other regions. Other subcortical regions, in particular brainstem and cerebellum, showed no significant change compared to non-ischemic rats. More... »

PAGES

370-378

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12028-017-0445-0

DOI

http://dx.doi.org/10.1007/s12028-017-0445-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091493535

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28875429


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