Intraventricular Tissue Plasminogen Activator in Subarachnoid Hemorrhage Patients: A Prospective, Randomized, Placebo-Controlled Pilot Trial View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-10

AUTHORS

Andreas H. Kramer, Derek J. Roberts, Jessalyn Holodinsky, Stephanie Todd, Michael D. Hill, David A. Zygun, Peter Faris, John H. Wong

ABSTRACT

BACKGROUND: The quantity of subarachnoid (SAH) and intraventricular hemorrhage (IVH) occurring in the setting of a ruptured cerebral aneurysm is strongly associated with subsequent complications and poor outcomes. METHODS: We randomly allocated aneurysmal SAH patients with a modified Fisher score of 4, who had been treated with endovascular coil embolization and ventricular drainage, to receive either 2 mg intraventricular tissue plasminogen activator (TPA) every 12 h (maximum 10 mg) or placebo. Computed tomography scans were performed 12, 48, and 72 h after administration. Primary outcomes included feasibility (enrollment and consent rates), safety (assessed by prospectively screening for complications), and rate of intracranial blood clearance (measured using sequential IVH, modified Graeb, and SAH sum scores). Secondary outcomes included angiographic vasospasm, delayed cerebral ischemia, need for ventriculoperitoneal shunting, and 6-month neurological outcomes. RESULTS: Seventy-seven patients were screened, 17 were eligible, and 12 were randomized. The consent rate was 87 %. There were no cases of new intracranial hemorrhage complicating use of TPA. Models fit using generalized estimating equations demonstrated more rapid reduction in IVH volume (p = 0.009), modified Graeb score (p < 0.001), and SAH sum score (p < 0.001) among patients treated with TPA. SAH clearance at 48 h was enhanced by earlier drug administration (p = 0.02). There were no differences in secondary outcomes. CONCLUSIONS: Intraventricular TPA accelerates clearance of SAH and IVH, especially when administered early. A larger-scale clinical trial of intraventricular TPA is feasible, will need to be conducted at multiple centers, and is required to determine whether this practice reduces complications and improves outcomes. More... »

PAGES

275-284

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12028-014-9965-z

DOI

http://dx.doi.org/10.1007/s12028-014-9965-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044879786

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24627207


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibrinolytic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Injections, Intraventricular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pilot Projects", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Placebos", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Subarachnoid Hemorrhage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Plasminogen Activator", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Calgary", 
          "id": "https://www.grid.ac/institutes/grid.22072.35", 
          "name": [
            "Department of Critical Care Medicine, Foothills Medical Center, University of Calgary, McCaig Tower, 3134 Hospital Drive N.W., T2N 2T9, Calgary, AB, Canada", 
            "Department of Clinical Neuroscience, University of Calgary, Calgary, AB, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kramer", 
        "givenName": "Andreas H.", 
        "id": "sg:person.01333576411.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333576411.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Calgary", 
          "id": "https://www.grid.ac/institutes/grid.22072.35", 
          "name": [
            "Department of Critical Care Medicine, Foothills Medical Center, University of Calgary, McCaig Tower, 3134 Hospital Drive N.W., T2N 2T9, Calgary, AB, Canada", 
            "Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roberts", 
        "givenName": "Derek J.", 
        "id": "sg:person.01256723101.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256723101.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Calgary", 
          "id": "https://www.grid.ac/institutes/grid.22072.35", 
          "name": [
            "Department of Critical Care Medicine, Foothills Medical Center, University of Calgary, McCaig Tower, 3134 Hospital Drive N.W., T2N 2T9, Calgary, AB, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Holodinsky", 
        "givenName": "Jessalyn", 
        "id": "sg:person.01022376000.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022376000.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Calgary", 
          "id": "https://www.grid.ac/institutes/grid.22072.35", 
          "name": [
            "Department of Critical Care Medicine, Foothills Medical Center, University of Calgary, McCaig Tower, 3134 Hospital Drive N.W., T2N 2T9, Calgary, AB, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Todd", 
        "givenName": "Stephanie", 
        "id": "sg:person.01072757261.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072757261.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Calgary", 
          "id": "https://www.grid.ac/institutes/grid.22072.35", 
          "name": [
            "Department of Clinical Neuroscience, University of Calgary, Calgary, AB, Canada", 
            "Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hill", 
        "givenName": "Michael D.", 
        "id": "sg:person.0733164361.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733164361.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Alberta", 
          "id": "https://www.grid.ac/institutes/grid.17089.37", 
          "name": [
            "Department of Critical Care Medicine, Foothills Medical Center, University of Calgary, McCaig Tower, 3134 Hospital Drive N.W., T2N 2T9, Calgary, AB, Canada", 
            "Department of Clinical Neuroscience, University of Calgary, Calgary, AB, Canada", 
            "Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada", 
            "Department of Medicine (4), University of Alberta, Edmonton, AB, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zygun", 
        "givenName": "David A.", 
        "id": "sg:person.01106532316.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106532316.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Calgary", 
          "id": "https://www.grid.ac/institutes/grid.22072.35", 
          "name": [
            "Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Faris", 
        "givenName": "Peter", 
        "id": "sg:person.01170455666.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170455666.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Calgary", 
          "id": "https://www.grid.ac/institutes/grid.22072.35", 
          "name": [
            "Department of Clinical Neuroscience, University of Calgary, Calgary, AB, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wong", 
        "givenName": "John H.", 
        "id": "sg:person.01073637307.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073637307.38"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.idc.2011.09.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001138851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.110.610949", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001349132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.110.610949", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001349132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.113.001790", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004614031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.113.001790", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004614031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e318198683a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005295125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0b013e318198683a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005295125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/emj.20.5.453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006441485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.107.484360", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007863746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.107.484360", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007863746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006123-200207000-00024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009777364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.110.600775", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010742319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.110.600775", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010742319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.110.600775", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010742319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1227/01.neu.0000370920.44359.91", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012319591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(09)70025-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015488699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.110.589275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016908314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.110.589275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016908314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.110.589275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016908314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.21.8.1156", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019229317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1227/01.neu.0000147973.83688.d8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020466925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1227/01.neu.0000108422.10842.60", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025016779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1227/01.neu.0000108422.10842.60", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025016779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1745-6215-11-32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029353690", 
          "https://doi.org/10.1186/1745-6215-11-32"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jocn.2011.09.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034089093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4757-3462-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034876164", 
          "https://doi.org/10.1007/978-1-4757-3462-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4757-3462-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034876164", 
          "https://doi.org/10.1007/978-1-4757-3462-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1227/neu.0b013e3181ed1379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035810678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12028-010-9429-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037585153", 
          "https://doi.org/10.1007/s12028-010-9429-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10143-013-0469-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039337606", 
          "https://doi.org/10.1007/s10143-013-0469-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000094731.63690.ff", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042609121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000094731.63690.ff", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042609121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.112.670653", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042663018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.112.670653", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042663018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1227/01.neu.0000134473.98192.b1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043061974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.108.519942", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044045596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.108.519942", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044045596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nec.2009.10.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044326061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.111.627448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053317384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.111.627448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053317384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0028-1087214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057106939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000035748.91128.c2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064344774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000035748.91128.c2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064344774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000035748.91128.c2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064344774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000035748.91128.c2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064344774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.39.11.1514", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064368184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1227/00006123-199306000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064432560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1227/00006123-199507000-00041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064433600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns/2008/109/8/0199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns/2008/109/8/0199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns/2008/109/8/0199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2004.101.2.0255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071101232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2004.101.2.0255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071101232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2004.101.2.0255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071101232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2004.101.2.0255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071101232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2006.104.1.101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071101823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2006.104.1.101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071101823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2006.104.1.101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071101823"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-10", 
    "datePublishedReg": "2014-10-01", 
    "description": "BACKGROUND: The quantity of subarachnoid (SAH) and intraventricular hemorrhage (IVH) occurring in the setting of a ruptured cerebral aneurysm is strongly associated with subsequent complications and poor outcomes.\nMETHODS: We randomly allocated aneurysmal SAH patients with a modified Fisher score of 4, who had been treated with endovascular coil embolization and ventricular drainage, to receive either 2 mg intraventricular tissue plasminogen activator (TPA) every 12 h (maximum 10 mg) or placebo. Computed tomography scans were performed 12, 48, and 72 h after administration. Primary outcomes included feasibility (enrollment and consent rates), safety (assessed by prospectively screening for complications), and rate of intracranial blood clearance (measured using sequential IVH, modified Graeb, and SAH sum scores). Secondary outcomes included angiographic vasospasm, delayed cerebral ischemia, need for ventriculoperitoneal shunting, and 6-month neurological outcomes.\nRESULTS: Seventy-seven patients were screened, 17 were eligible, and 12 were randomized. The consent rate was 87 %. There were no cases of new intracranial hemorrhage complicating use of TPA. Models fit using generalized estimating equations demonstrated more rapid reduction in IVH volume (p = 0.009), modified Graeb score (p < 0.001), and SAH sum score (p < 0.001) among patients treated with TPA. SAH clearance at 48 h was enhanced by earlier drug administration (p = 0.02). There were no differences in secondary outcomes.\nCONCLUSIONS: Intraventricular TPA accelerates clearance of SAH and IVH, especially when administered early. A larger-scale clinical trial of intraventricular TPA is feasible, will need to be conducted at multiple centers, and is required to determine whether this practice reduces complications and improves outcomes.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12028-014-9965-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1031461", 
        "issn": [
          "1541-6933", 
          "1556-0961"
        ], 
        "name": "Neurocritical Care", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "name": "Intraventricular Tissue Plasminogen Activator in Subarachnoid Hemorrhage Patients: A Prospective, Randomized, Placebo-Controlled Pilot Trial", 
    "pagination": "275-284", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d5c676585eb87d03fa1d8e8818b62f01e00d0f36854f23808a3986ad1eb8c747"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24627207"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101156086"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12028-014-9965-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1044879786"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12028-014-9965-z", 
      "https://app.dimensions.ai/details/publication/pub.1044879786"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:35", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000524.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs12028-014-9965-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12028-014-9965-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12028-014-9965-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12028-014-9965-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12028-014-9965-z'


 

This table displays all metadata directly associated to this object as RDF triples.

292 TRIPLES      21 PREDICATES      78 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12028-014-9965-z schema:about N31cfff1111134914a791a1b9ddd30b2f
2 N4b031407b7da4eab8d0fff33994d6eca
3 N52ae834637474c47bc6437260d23a187
4 N5b88b8a539ca4c0f8b1c7f1630111062
5 N67ca5a6854d4418fb9acfaae485ae2a7
6 N725f58d2bfe14354a48816dc991c5982
7 N74c67a10da5341349ac30d9b47eedeff
8 N871cc677015a41a08a0959271e0b3c8b
9 N8fd4158cd6624d97998375363427561b
10 N9c0c6b0b5fc34035bb29ec0158d8de2a
11 Na5f9286256e34072a314b9dfd4598111
12 Naa9bcaefbbe54fb8a14a5df452b31938
13 Nd24dda6400324880bf4e5a6cf64ff99c
14 Nd97c0eb093384d8b82d89fc93ba74290
15 Nf6119544e165433a8bc76de4cfb62208
16 anzsrc-for:11
17 anzsrc-for:1103
18 schema:author N5cd4645e24ad4bdb95e2ce882cb08649
19 schema:citation sg:pub.10.1007/978-1-4757-3462-1
20 sg:pub.10.1007/s10143-013-0469-7
21 sg:pub.10.1007/s12028-010-9429-z
22 sg:pub.10.1186/1745-6215-11-32
23 https://doi.org/10.1016/j.idc.2011.09.006
24 https://doi.org/10.1016/j.jocn.2011.09.030
25 https://doi.org/10.1016/j.nec.2009.10.013
26 https://doi.org/10.1016/s1474-4422(09)70025-0
27 https://doi.org/10.1055/s-0028-1087214
28 https://doi.org/10.1097/00006123-200207000-00024
29 https://doi.org/10.1097/ccm.0b013e318198683a
30 https://doi.org/10.1136/emj.20.5.453
31 https://doi.org/10.1161/01.str.0000094731.63690.ff
32 https://doi.org/10.1161/01.str.21.8.1156
33 https://doi.org/10.1161/strokeaha.107.484360
34 https://doi.org/10.1161/strokeaha.108.519942
35 https://doi.org/10.1161/strokeaha.110.589275
36 https://doi.org/10.1161/strokeaha.110.600775
37 https://doi.org/10.1161/strokeaha.110.610949
38 https://doi.org/10.1161/strokeaha.111.627448
39 https://doi.org/10.1161/strokeaha.112.670653
40 https://doi.org/10.1161/strokeaha.113.001790
41 https://doi.org/10.1212/01.wnl.0000035748.91128.c2
42 https://doi.org/10.1212/wnl.39.11.1514
43 https://doi.org/10.1227/00006123-199306000-00010
44 https://doi.org/10.1227/00006123-199507000-00041
45 https://doi.org/10.1227/01.neu.0000108422.10842.60
46 https://doi.org/10.1227/01.neu.0000134473.98192.b1
47 https://doi.org/10.1227/01.neu.0000147973.83688.d8
48 https://doi.org/10.1227/01.neu.0000370920.44359.91
49 https://doi.org/10.1227/neu.0b013e3181ed1379
50 https://doi.org/10.3171/jns.2004.101.2.0255
51 https://doi.org/10.3171/jns.2006.104.1.101
52 https://doi.org/10.3171/jns/2008/109/8/0199
53 schema:datePublished 2014-10
54 schema:datePublishedReg 2014-10-01
55 schema:description BACKGROUND: The quantity of subarachnoid (SAH) and intraventricular hemorrhage (IVH) occurring in the setting of a ruptured cerebral aneurysm is strongly associated with subsequent complications and poor outcomes. METHODS: We randomly allocated aneurysmal SAH patients with a modified Fisher score of 4, who had been treated with endovascular coil embolization and ventricular drainage, to receive either 2 mg intraventricular tissue plasminogen activator (TPA) every 12 h (maximum 10 mg) or placebo. Computed tomography scans were performed 12, 48, and 72 h after administration. Primary outcomes included feasibility (enrollment and consent rates), safety (assessed by prospectively screening for complications), and rate of intracranial blood clearance (measured using sequential IVH, modified Graeb, and SAH sum scores). Secondary outcomes included angiographic vasospasm, delayed cerebral ischemia, need for ventriculoperitoneal shunting, and 6-month neurological outcomes. RESULTS: Seventy-seven patients were screened, 17 were eligible, and 12 were randomized. The consent rate was 87 %. There were no cases of new intracranial hemorrhage complicating use of TPA. Models fit using generalized estimating equations demonstrated more rapid reduction in IVH volume (p = 0.009), modified Graeb score (p < 0.001), and SAH sum score (p < 0.001) among patients treated with TPA. SAH clearance at 48 h was enhanced by earlier drug administration (p = 0.02). There were no differences in secondary outcomes. CONCLUSIONS: Intraventricular TPA accelerates clearance of SAH and IVH, especially when administered early. A larger-scale clinical trial of intraventricular TPA is feasible, will need to be conducted at multiple centers, and is required to determine whether this practice reduces complications and improves outcomes.
56 schema:genre research_article
57 schema:inLanguage en
58 schema:isAccessibleForFree false
59 schema:isPartOf N1700ba227e2444678d38e6e22cd0e046
60 N7c0cee4d2d4c489c80bad838e4b2662b
61 sg:journal.1031461
62 schema:name Intraventricular Tissue Plasminogen Activator in Subarachnoid Hemorrhage Patients: A Prospective, Randomized, Placebo-Controlled Pilot Trial
63 schema:pagination 275-284
64 schema:productId N03ba4a2c27934f1bbba4d17110c33b21
65 N0436dbf7445f4b828bc5e6cfea478a95
66 N77becc8fde25420289db90d67d98efe7
67 N8fbfe2904bfe4f5cbe21ec46ddc58abc
68 N9fede4ec8d1c47c1a07a5357c9fdb753
69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044879786
70 https://doi.org/10.1007/s12028-014-9965-z
71 schema:sdDatePublished 2019-04-10T22:35
72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
73 schema:sdPublisher Nba52c850ae3e4e2aab4ba020c82137dd
74 schema:url http://link.springer.com/10.1007%2Fs12028-014-9965-z
75 sgo:license sg:explorer/license/
76 sgo:sdDataset articles
77 rdf:type schema:ScholarlyArticle
78 N03ba4a2c27934f1bbba4d17110c33b21 schema:name dimensions_id
79 schema:value pub.1044879786
80 rdf:type schema:PropertyValue
81 N0436dbf7445f4b828bc5e6cfea478a95 schema:name doi
82 schema:value 10.1007/s12028-014-9965-z
83 rdf:type schema:PropertyValue
84 N102c1ee034094f4d8f9e6550831ce668 rdf:first sg:person.01073637307.38
85 rdf:rest rdf:nil
86 N15be9da8c4c449cca84dbccedc0e19a2 rdf:first sg:person.01022376000.70
87 rdf:rest N3eb0af778fa743789ec903efeaa743ca
88 N1700ba227e2444678d38e6e22cd0e046 schema:volumeNumber 21
89 rdf:type schema:PublicationVolume
90 N31cfff1111134914a791a1b9ddd30b2f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Injections, Intraventricular
92 rdf:type schema:DefinedTerm
93 N3eb0af778fa743789ec903efeaa743ca rdf:first sg:person.01072757261.59
94 rdf:rest N848a466c3b754fdca5dc761f4e889f50
95 N4b031407b7da4eab8d0fff33994d6eca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Pilot Projects
97 rdf:type schema:DefinedTerm
98 N4b88ff778740474a8e5ce2d71ab3d517 rdf:first sg:person.01170455666.29
99 rdf:rest N102c1ee034094f4d8f9e6550831ce668
100 N52ae834637474c47bc6437260d23a187 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Male
102 rdf:type schema:DefinedTerm
103 N5b88b8a539ca4c0f8b1c7f1630111062 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Radiography
105 rdf:type schema:DefinedTerm
106 N5cd4645e24ad4bdb95e2ce882cb08649 rdf:first sg:person.01333576411.15
107 rdf:rest N8d06023eeb74472ea624dc7d28cd32e2
108 N67ca5a6854d4418fb9acfaae485ae2a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Subarachnoid Hemorrhage
110 rdf:type schema:DefinedTerm
111 N725f58d2bfe14354a48816dc991c5982 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Treatment Outcome
113 rdf:type schema:DefinedTerm
114 N74c67a10da5341349ac30d9b47eedeff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Aged
116 rdf:type schema:DefinedTerm
117 N77becc8fde25420289db90d67d98efe7 schema:name readcube_id
118 schema:value d5c676585eb87d03fa1d8e8818b62f01e00d0f36854f23808a3986ad1eb8c747
119 rdf:type schema:PropertyValue
120 N7c0cee4d2d4c489c80bad838e4b2662b schema:issueNumber 2
121 rdf:type schema:PublicationIssue
122 N848a466c3b754fdca5dc761f4e889f50 rdf:first sg:person.0733164361.51
123 rdf:rest Nf4a26a2568c04cb289f34c8cc8600478
124 N871cc677015a41a08a0959271e0b3c8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Placebos
126 rdf:type schema:DefinedTerm
127 N8d06023eeb74472ea624dc7d28cd32e2 rdf:first sg:person.01256723101.52
128 rdf:rest N15be9da8c4c449cca84dbccedc0e19a2
129 N8fbfe2904bfe4f5cbe21ec46ddc58abc schema:name pubmed_id
130 schema:value 24627207
131 rdf:type schema:PropertyValue
132 N8fd4158cd6624d97998375363427561b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Aged, 80 and over
134 rdf:type schema:DefinedTerm
135 N9c0c6b0b5fc34035bb29ec0158d8de2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Middle Aged
137 rdf:type schema:DefinedTerm
138 N9fede4ec8d1c47c1a07a5357c9fdb753 schema:name nlm_unique_id
139 schema:value 101156086
140 rdf:type schema:PropertyValue
141 Na5f9286256e34072a314b9dfd4598111 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Prospective Studies
143 rdf:type schema:DefinedTerm
144 Naa9bcaefbbe54fb8a14a5df452b31938 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Tissue Plasminogen Activator
146 rdf:type schema:DefinedTerm
147 Nba52c850ae3e4e2aab4ba020c82137dd schema:name Springer Nature - SN SciGraph project
148 rdf:type schema:Organization
149 Nd24dda6400324880bf4e5a6cf64ff99c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Humans
151 rdf:type schema:DefinedTerm
152 Nd97c0eb093384d8b82d89fc93ba74290 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Fibrinolytic Agents
154 rdf:type schema:DefinedTerm
155 Nf4a26a2568c04cb289f34c8cc8600478 rdf:first sg:person.01106532316.03
156 rdf:rest N4b88ff778740474a8e5ce2d71ab3d517
157 Nf6119544e165433a8bc76de4cfb62208 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Female
159 rdf:type schema:DefinedTerm
160 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
161 schema:name Medical and Health Sciences
162 rdf:type schema:DefinedTerm
163 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
164 schema:name Clinical Sciences
165 rdf:type schema:DefinedTerm
166 sg:journal.1031461 schema:issn 1541-6933
167 1556-0961
168 schema:name Neurocritical Care
169 rdf:type schema:Periodical
170 sg:person.01022376000.70 schema:affiliation https://www.grid.ac/institutes/grid.22072.35
171 schema:familyName Holodinsky
172 schema:givenName Jessalyn
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022376000.70
174 rdf:type schema:Person
175 sg:person.01072757261.59 schema:affiliation https://www.grid.ac/institutes/grid.22072.35
176 schema:familyName Todd
177 schema:givenName Stephanie
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072757261.59
179 rdf:type schema:Person
180 sg:person.01073637307.38 schema:affiliation https://www.grid.ac/institutes/grid.22072.35
181 schema:familyName Wong
182 schema:givenName John H.
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073637307.38
184 rdf:type schema:Person
185 sg:person.01106532316.03 schema:affiliation https://www.grid.ac/institutes/grid.17089.37
186 schema:familyName Zygun
187 schema:givenName David A.
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106532316.03
189 rdf:type schema:Person
190 sg:person.01170455666.29 schema:affiliation https://www.grid.ac/institutes/grid.22072.35
191 schema:familyName Faris
192 schema:givenName Peter
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170455666.29
194 rdf:type schema:Person
195 sg:person.01256723101.52 schema:affiliation https://www.grid.ac/institutes/grid.22072.35
196 schema:familyName Roberts
197 schema:givenName Derek J.
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256723101.52
199 rdf:type schema:Person
200 sg:person.01333576411.15 schema:affiliation https://www.grid.ac/institutes/grid.22072.35
201 schema:familyName Kramer
202 schema:givenName Andreas H.
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333576411.15
204 rdf:type schema:Person
205 sg:person.0733164361.51 schema:affiliation https://www.grid.ac/institutes/grid.22072.35
206 schema:familyName Hill
207 schema:givenName Michael D.
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733164361.51
209 rdf:type schema:Person
210 sg:pub.10.1007/978-1-4757-3462-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034876164
211 https://doi.org/10.1007/978-1-4757-3462-1
212 rdf:type schema:CreativeWork
213 sg:pub.10.1007/s10143-013-0469-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039337606
214 https://doi.org/10.1007/s10143-013-0469-7
215 rdf:type schema:CreativeWork
216 sg:pub.10.1007/s12028-010-9429-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1037585153
217 https://doi.org/10.1007/s12028-010-9429-z
218 rdf:type schema:CreativeWork
219 sg:pub.10.1186/1745-6215-11-32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029353690
220 https://doi.org/10.1186/1745-6215-11-32
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/j.idc.2011.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001138851
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.jocn.2011.09.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034089093
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.nec.2009.10.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044326061
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/s1474-4422(09)70025-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015488699
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1055/s-0028-1087214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057106939
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1097/00006123-200207000-00024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009777364
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1097/ccm.0b013e318198683a schema:sameAs https://app.dimensions.ai/details/publication/pub.1005295125
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1136/emj.20.5.453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006441485
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1161/01.str.0000094731.63690.ff schema:sameAs https://app.dimensions.ai/details/publication/pub.1042609121
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1161/01.str.21.8.1156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019229317
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1161/strokeaha.107.484360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007863746
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1161/strokeaha.108.519942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044045596
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1161/strokeaha.110.589275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016908314
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1161/strokeaha.110.600775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010742319
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1161/strokeaha.110.610949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001349132
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1161/strokeaha.111.627448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053317384
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1161/strokeaha.112.670653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042663018
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1161/strokeaha.113.001790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004614031
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1212/01.wnl.0000035748.91128.c2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064344774
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1212/wnl.39.11.1514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064368184
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1227/00006123-199306000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064432560
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1227/00006123-199507000-00041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064433600
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1227/01.neu.0000108422.10842.60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025016779
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1227/01.neu.0000134473.98192.b1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043061974
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1227/01.neu.0000147973.83688.d8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020466925
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1227/01.neu.0000370920.44359.91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012319591
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1227/neu.0b013e3181ed1379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035810678
275 rdf:type schema:CreativeWork
276 https://doi.org/10.3171/jns.2004.101.2.0255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071101232
277 rdf:type schema:CreativeWork
278 https://doi.org/10.3171/jns.2006.104.1.101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071101823
279 rdf:type schema:CreativeWork
280 https://doi.org/10.3171/jns/2008/109/8/0199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071083798
281 rdf:type schema:CreativeWork
282 https://www.grid.ac/institutes/grid.17089.37 schema:alternateName University of Alberta
283 schema:name Department of Clinical Neuroscience, University of Calgary, Calgary, AB, Canada
284 Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada
285 Department of Critical Care Medicine, Foothills Medical Center, University of Calgary, McCaig Tower, 3134 Hospital Drive N.W., T2N 2T9, Calgary, AB, Canada
286 Department of Medicine (4), University of Alberta, Edmonton, AB, Canada
287 rdf:type schema:Organization
288 https://www.grid.ac/institutes/grid.22072.35 schema:alternateName University of Calgary
289 schema:name Department of Clinical Neuroscience, University of Calgary, Calgary, AB, Canada
290 Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada
291 Department of Critical Care Medicine, Foothills Medical Center, University of Calgary, McCaig Tower, 3134 Hospital Drive N.W., T2N 2T9, Calgary, AB, Canada
292 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...