Statins in the Management of Patients with Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-analysis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-04

AUTHORS

Andreas H. Kramer, Jeffrey J. Fletcher

ABSTRACT

BACKGROUND: Delayed ischemic neurological deficits (DINDs) contribute to morbidity and mortality following aneurysmal subarachnoid hemorrhage (SAH). Based on promising preliminary reports, some clinicians routinely administer statins to prevent DINDs. METHODS: Without language restriction, we searched MEDLINE, EMBASE, the Cochrane Central Register, references of review articles, proceedings of the International Stroke Conference, and gray literature sources. Studies were selected if they compared outcomes between statin-treated and untreated patients during the 2 weeks following SAH. Data were extracted and appraised independently and in duplicate, using standardized forms. Fixed or random effects models, as appropriate based on the degree of study heterogeneity, were applied to calculate summary measures. RESULTS: Four RCTs, two "pseudo" RCTs, five cohort studies, and one case-control study met eligibility criteria. In the RCTs, which enrolled a total of 309 patients, statins were found to significantly reduce the occurrence of DINDs [OR 0.38 (0.23-0.65); P < 0.001], but not mortality [OR 0.51 (0.25-1.02); P = 0.06] or poor neurological recovery [OR 0.81 (0.49-1.32); P = 0.39]. Observational studies assessed 1,542 patients, of whom 385 received statins. Statin-use was not associated with any reduction in DINDs [OR 0.96 (0.71-1.31); P = 0.80], mortality [OR 1.16 (0.78-1.73); P = 0.47] or poor neurological recovery [OR 1.20 (0.84-1.72); P = 0.31]. When the results of all studies were combined, statins had no statistically significant effect. CONCLUSIONS: Existing RCTs suggest that statins reduce DINDs, with a possible trend toward lower mortality. These findings are not supported by observational research. Although not assessed in all studies, current data do not indicate that statins improve neurological outcomes. More... »

PAGES

285-296

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12028-009-9306-9

DOI

http://dx.doi.org/10.1007/s12028-009-9306-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034372717

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19921470


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anticholesteremic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydroxymethylglutaryl-CoA Reductase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Subarachnoid Hemorrhage", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Calgary", 
          "id": "https://www.grid.ac/institutes/grid.22072.35", 
          "name": [
            "Departments of Critical Care Medicine and Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Foothills Medical Center, Room EG23J, 1403 29th St. N.W., T2N 2T9, Calgary, AB, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kramer", 
        "givenName": "Andreas H.", 
        "id": "sg:person.01333576411.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333576411.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fletcher", 
        "givenName": "Jeffrey J.", 
        "id": "sg:person.0700303512.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700303512.85"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1001/jama.1995.03520290060030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000662780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-211-75718-5_59", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002514138", 
          "https://doi.org/10.1007/978-3-211-75718-5_59"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1227/01.neu.0000249031.26372.13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004540740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0197-2456(95)00134-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004602843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.107.484360", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007863746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.107.484360", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007863746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.108.191395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012638758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.108.191395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012638758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd000277.pub3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013236033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.107.508341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015150537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.107.508341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015150537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.19.10.1250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017251071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc6333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017393309", 
          "https://doi.org/10.1186/cc6333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc6333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017393309", 
          "https://doi.org/10.1186/cc6333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.surneu.2007.12.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019796907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12028-008-9147-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020888121", 
          "https://doi.org/10.1007/s12028-008-9147-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.283.15.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023723086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc7267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027490569", 
          "https://doi.org/10.1186/cc7267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc7267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027490569", 
          "https://doi.org/10.1186/cc7267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jocn.2008.08.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033609015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.107.505875", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036020465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.107.505875", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036020465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(07)61602-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036200026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1227/01.neu.0000316009.19012.e3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039469892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1179/174313208x338034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040073671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.2009.59", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041275076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.2009.59", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041275076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000177879.11607.10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043501626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000177879.11607.10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043501626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.108.519942", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044045596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.108.519942", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044045596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/sim.1186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047418980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000176743.67564.5d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047970922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000176743.67564.5d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047970922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.273.5.408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054158551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.315.7121.1533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062781520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.315.7121.1533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062781520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000154523.21633.0e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000154523.21633.0e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000154523.21633.0e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2008.10.jns08901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071073707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2008.10.jns08901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071073707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2008.10.jns08901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071073707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/foc.2006.21.3.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071086025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/foc.2006.21.3.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071086025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/foc.2006.21.3.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071086025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/foc.2006.21.3.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071086025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/foc.2006.21.3.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071086025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1990.73.1.0018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071095786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1990.73.1.0018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071095786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1990.73.1.0018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071095786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1993.78.4.0548", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071096814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1993.78.4.0548", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071096814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1993.78.4.0548", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071096814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3310/hta7160", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071139732"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3310/hta7270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071139743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-151-4-200908180-00136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073710983"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-04", 
    "datePublishedReg": "2010-04-01", 
    "description": "BACKGROUND: Delayed ischemic neurological deficits (DINDs) contribute to morbidity and mortality following aneurysmal subarachnoid hemorrhage (SAH). Based on promising preliminary reports, some clinicians routinely administer statins to prevent DINDs.\nMETHODS: Without language restriction, we searched MEDLINE, EMBASE, the Cochrane Central Register, references of review articles, proceedings of the International Stroke Conference, and gray literature sources. Studies were selected if they compared outcomes between statin-treated and untreated patients during the 2 weeks following SAH. Data were extracted and appraised independently and in duplicate, using standardized forms. Fixed or random effects models, as appropriate based on the degree of study heterogeneity, were applied to calculate summary measures.\nRESULTS: Four RCTs, two \"pseudo\" RCTs, five cohort studies, and one case-control study met eligibility criteria. In the RCTs, which enrolled a total of 309 patients, statins were found to significantly reduce the occurrence of DINDs [OR 0.38 (0.23-0.65); P < 0.001], but not mortality [OR 0.51 (0.25-1.02); P = 0.06] or poor neurological recovery [OR 0.81 (0.49-1.32); P = 0.39]. Observational studies assessed 1,542 patients, of whom 385 received statins. Statin-use was not associated with any reduction in DINDs [OR 0.96 (0.71-1.31); P = 0.80], mortality [OR 1.16 (0.78-1.73); P = 0.47] or poor neurological recovery [OR 1.20 (0.84-1.72); P = 0.31]. When the results of all studies were combined, statins had no statistically significant effect.\nCONCLUSIONS: Existing RCTs suggest that statins reduce DINDs, with a possible trend toward lower mortality. These findings are not supported by observational research. Although not assessed in all studies, current data do not indicate that statins improve neurological outcomes.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12028-009-9306-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1031461", 
        "issn": [
          "1541-6933", 
          "1556-0961"
        ], 
        "name": "Neurocritical Care", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "Statins in the Management of Patients with Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-analysis", 
    "pagination": "285-296", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a3bcd6de9ca2d5a85825b62c434003cf80933a5afd8c34565e61969ed9864c42"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19921470"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101156086"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12028-009-9306-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1034372717"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12028-009-9306-9", 
      "https://app.dimensions.ai/details/publication/pub.1034372717"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:35", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000346_0000000346/records_99818_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs12028-009-9306-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12028-009-9306-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12028-009-9306-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12028-009-9306-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12028-009-9306-9'


 

This table displays all metadata directly associated to this object as RDF triples.

201 TRIPLES      21 PREDICATES      67 URIs      25 LITERALS      13 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12028-009-9306-9 schema:about N14a7e3ef3e204bc59c4372ff755744d7
2 N4d78a908e8654b958d193648ce51b1d5
3 N6db8149cab1847dca867e4e99e3cb6b9
4 Nef5030104429460bab04f79a42132ccb
5 anzsrc-for:11
6 anzsrc-for:1117
7 schema:author N3468312d35924322b98da01f7347c279
8 schema:citation sg:pub.10.1007/978-3-211-75718-5_59
9 sg:pub.10.1007/s12028-008-9147-y
10 sg:pub.10.1186/cc6333
11 sg:pub.10.1186/cc7267
12 https://doi.org/10.1001/jama.1995.03520290060030
13 https://doi.org/10.1001/jama.273.5.408
14 https://doi.org/10.1001/jama.283.15.2008
15 https://doi.org/10.1002/14651858.cd000277.pub3
16 https://doi.org/10.1002/sim.1186
17 https://doi.org/10.1016/0197-2456(95)00134-4
18 https://doi.org/10.1016/j.jocn.2008.08.001
19 https://doi.org/10.1016/j.surneu.2007.12.027
20 https://doi.org/10.1016/s0140-6736(07)61602-x
21 https://doi.org/10.1038/jcbfm.2009.59
22 https://doi.org/10.1136/bmj.315.7121.1533
23 https://doi.org/10.1161/01.str.0000176743.67564.5d
24 https://doi.org/10.1161/01.str.0000177879.11607.10
25 https://doi.org/10.1161/01.str.19.10.1250
26 https://doi.org/10.1161/strokeaha.107.484360
27 https://doi.org/10.1161/strokeaha.107.505875
28 https://doi.org/10.1161/strokeaha.107.508341
29 https://doi.org/10.1161/strokeaha.108.191395
30 https://doi.org/10.1161/strokeaha.108.519942
31 https://doi.org/10.1179/174313208x338034
32 https://doi.org/10.1212/01.wnl.0000154523.21633.0e
33 https://doi.org/10.1227/01.neu.0000249031.26372.13
34 https://doi.org/10.1227/01.neu.0000316009.19012.e3
35 https://doi.org/10.3171/2008.10.jns08901
36 https://doi.org/10.3171/foc.2006.21.3.1
37 https://doi.org/10.3171/jns.1990.73.1.0018
38 https://doi.org/10.3171/jns.1993.78.4.0548
39 https://doi.org/10.3310/hta7160
40 https://doi.org/10.3310/hta7270
41 https://doi.org/10.7326/0003-4819-151-4-200908180-00136
42 schema:datePublished 2010-04
43 schema:datePublishedReg 2010-04-01
44 schema:description BACKGROUND: Delayed ischemic neurological deficits (DINDs) contribute to morbidity and mortality following aneurysmal subarachnoid hemorrhage (SAH). Based on promising preliminary reports, some clinicians routinely administer statins to prevent DINDs. METHODS: Without language restriction, we searched MEDLINE, EMBASE, the Cochrane Central Register, references of review articles, proceedings of the International Stroke Conference, and gray literature sources. Studies were selected if they compared outcomes between statin-treated and untreated patients during the 2 weeks following SAH. Data were extracted and appraised independently and in duplicate, using standardized forms. Fixed or random effects models, as appropriate based on the degree of study heterogeneity, were applied to calculate summary measures. RESULTS: Four RCTs, two "pseudo" RCTs, five cohort studies, and one case-control study met eligibility criteria. In the RCTs, which enrolled a total of 309 patients, statins were found to significantly reduce the occurrence of DINDs [OR 0.38 (0.23-0.65); P < 0.001], but not mortality [OR 0.51 (0.25-1.02); P = 0.06] or poor neurological recovery [OR 0.81 (0.49-1.32); P = 0.39]. Observational studies assessed 1,542 patients, of whom 385 received statins. Statin-use was not associated with any reduction in DINDs [OR 0.96 (0.71-1.31); P = 0.80], mortality [OR 1.16 (0.78-1.73); P = 0.47] or poor neurological recovery [OR 1.20 (0.84-1.72); P = 0.31]. When the results of all studies were combined, statins had no statistically significant effect. CONCLUSIONS: Existing RCTs suggest that statins reduce DINDs, with a possible trend toward lower mortality. These findings are not supported by observational research. Although not assessed in all studies, current data do not indicate that statins improve neurological outcomes.
45 schema:genre research_article
46 schema:inLanguage en
47 schema:isAccessibleForFree false
48 schema:isPartOf N28adae4f90dd4e5ba429f69347e7cb5e
49 Nd9da0428482e468882e065096f4af1c6
50 sg:journal.1031461
51 schema:name Statins in the Management of Patients with Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-analysis
52 schema:pagination 285-296
53 schema:productId N6517dc04544a45989300fa16652d5545
54 N87763583d507427788b0c13c9f5ac214
55 N9499344f19584863a3bb68def58648c2
56 Nef5ec596f9334f3a82356ec1846a5128
57 Nfa404f38f00e4fee961de1c96cb80797
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034372717
59 https://doi.org/10.1007/s12028-009-9306-9
60 schema:sdDatePublished 2019-04-11T09:35
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher N7026cb5b88ca4560a39e3b3542fb8bd8
63 schema:url http://link.springer.com/10.1007%2Fs12028-009-9306-9
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N14a7e3ef3e204bc59c4372ff755744d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Hydroxymethylglutaryl-CoA Reductase Inhibitors
69 rdf:type schema:DefinedTerm
70 N28adae4f90dd4e5ba429f69347e7cb5e schema:volumeNumber 12
71 rdf:type schema:PublicationVolume
72 N3468312d35924322b98da01f7347c279 rdf:first sg:person.01333576411.15
73 rdf:rest N956cb5dfe0784cf5b54c7b6ce8c18338
74 N4d78a908e8654b958d193648ce51b1d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Anticholesteremic Agents
76 rdf:type schema:DefinedTerm
77 N6517dc04544a45989300fa16652d5545 schema:name dimensions_id
78 schema:value pub.1034372717
79 rdf:type schema:PropertyValue
80 N6db8149cab1847dca867e4e99e3cb6b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Humans
82 rdf:type schema:DefinedTerm
83 N7026cb5b88ca4560a39e3b3542fb8bd8 schema:name Springer Nature - SN SciGraph project
84 rdf:type schema:Organization
85 N87763583d507427788b0c13c9f5ac214 schema:name doi
86 schema:value 10.1007/s12028-009-9306-9
87 rdf:type schema:PropertyValue
88 N9499344f19584863a3bb68def58648c2 schema:name nlm_unique_id
89 schema:value 101156086
90 rdf:type schema:PropertyValue
91 N956cb5dfe0784cf5b54c7b6ce8c18338 rdf:first sg:person.0700303512.85
92 rdf:rest rdf:nil
93 Nd9da0428482e468882e065096f4af1c6 schema:issueNumber 2
94 rdf:type schema:PublicationIssue
95 Nef5030104429460bab04f79a42132ccb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Subarachnoid Hemorrhage
97 rdf:type schema:DefinedTerm
98 Nef5ec596f9334f3a82356ec1846a5128 schema:name pubmed_id
99 schema:value 19921470
100 rdf:type schema:PropertyValue
101 Nfa404f38f00e4fee961de1c96cb80797 schema:name readcube_id
102 schema:value a3bcd6de9ca2d5a85825b62c434003cf80933a5afd8c34565e61969ed9864c42
103 rdf:type schema:PropertyValue
104 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
105 schema:name Medical and Health Sciences
106 rdf:type schema:DefinedTerm
107 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
108 schema:name Public Health and Health Services
109 rdf:type schema:DefinedTerm
110 sg:journal.1031461 schema:issn 1541-6933
111 1556-0961
112 schema:name Neurocritical Care
113 rdf:type schema:Periodical
114 sg:person.01333576411.15 schema:affiliation https://www.grid.ac/institutes/grid.22072.35
115 schema:familyName Kramer
116 schema:givenName Andreas H.
117 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333576411.15
118 rdf:type schema:Person
119 sg:person.0700303512.85 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
120 schema:familyName Fletcher
121 schema:givenName Jeffrey J.
122 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700303512.85
123 rdf:type schema:Person
124 sg:pub.10.1007/978-3-211-75718-5_59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002514138
125 https://doi.org/10.1007/978-3-211-75718-5_59
126 rdf:type schema:CreativeWork
127 sg:pub.10.1007/s12028-008-9147-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1020888121
128 https://doi.org/10.1007/s12028-008-9147-y
129 rdf:type schema:CreativeWork
130 sg:pub.10.1186/cc6333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017393309
131 https://doi.org/10.1186/cc6333
132 rdf:type schema:CreativeWork
133 sg:pub.10.1186/cc7267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027490569
134 https://doi.org/10.1186/cc7267
135 rdf:type schema:CreativeWork
136 https://doi.org/10.1001/jama.1995.03520290060030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000662780
137 rdf:type schema:CreativeWork
138 https://doi.org/10.1001/jama.273.5.408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054158551
139 rdf:type schema:CreativeWork
140 https://doi.org/10.1001/jama.283.15.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023723086
141 rdf:type schema:CreativeWork
142 https://doi.org/10.1002/14651858.cd000277.pub3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013236033
143 rdf:type schema:CreativeWork
144 https://doi.org/10.1002/sim.1186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047418980
145 rdf:type schema:CreativeWork
146 https://doi.org/10.1016/0197-2456(95)00134-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004602843
147 rdf:type schema:CreativeWork
148 https://doi.org/10.1016/j.jocn.2008.08.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033609015
149 rdf:type schema:CreativeWork
150 https://doi.org/10.1016/j.surneu.2007.12.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019796907
151 rdf:type schema:CreativeWork
152 https://doi.org/10.1016/s0140-6736(07)61602-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036200026
153 rdf:type schema:CreativeWork
154 https://doi.org/10.1038/jcbfm.2009.59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041275076
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1136/bmj.315.7121.1533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062781520
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1161/01.str.0000176743.67564.5d schema:sameAs https://app.dimensions.ai/details/publication/pub.1047970922
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1161/01.str.0000177879.11607.10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043501626
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1161/01.str.19.10.1250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017251071
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1161/strokeaha.107.484360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007863746
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1161/strokeaha.107.505875 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036020465
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1161/strokeaha.107.508341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015150537
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1161/strokeaha.108.191395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012638758
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1161/strokeaha.108.519942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044045596
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1179/174313208x338034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040073671
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1212/01.wnl.0000154523.21633.0e schema:sameAs https://app.dimensions.ai/details/publication/pub.1064346903
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1227/01.neu.0000249031.26372.13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004540740
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1227/01.neu.0000316009.19012.e3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039469892
181 rdf:type schema:CreativeWork
182 https://doi.org/10.3171/2008.10.jns08901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071073707
183 rdf:type schema:CreativeWork
184 https://doi.org/10.3171/foc.2006.21.3.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071086025
185 rdf:type schema:CreativeWork
186 https://doi.org/10.3171/jns.1990.73.1.0018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071095786
187 rdf:type schema:CreativeWork
188 https://doi.org/10.3171/jns.1993.78.4.0548 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071096814
189 rdf:type schema:CreativeWork
190 https://doi.org/10.3310/hta7160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071139732
191 rdf:type schema:CreativeWork
192 https://doi.org/10.3310/hta7270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071139743
193 rdf:type schema:CreativeWork
194 https://doi.org/10.7326/0003-4819-151-4-200908180-00136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073710983
195 rdf:type schema:CreativeWork
196 https://www.grid.ac/institutes/grid.214458.e schema:alternateName University of Michigan–Ann Arbor
197 schema:name Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA
198 rdf:type schema:Organization
199 https://www.grid.ac/institutes/grid.22072.35 schema:alternateName University of Calgary
200 schema:name Departments of Critical Care Medicine and Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Foothills Medical Center, Room EG23J, 1403 29th St. N.W., T2N 2T9, Calgary, AB, Canada
201 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...