Utilization of recombinant activated factor VII for intracranial hematoma evacuation in coagulopathic nonhemophilic neurosurgical patients with normal international normalized ratios View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-10

AUTHORS

Shearwood McClelland, Eun Kyung Won, Cornelius H. Lam

ABSTRACT

BACKGROUND: Recombinant activated Factor VII (rFVIIa) has recently gained popularity for rapid reversal of coagulopathy during operative neurosurgery. Patients undergoing chronic subdural hematoma (CSDH) or epidural hematoma (EDH) evacuation often have their coagulation status judged by preoperative international normalized ratio (INR). We present our experience in two patients with significant clinical coagulopathy who were successfully reversed with rFVIIa in the setting of normal INR. METHODS: Patient one was a 79-year-old man with history of prostate cancer and three previous operative left CSDH evacuations, each complicated by coagulopathic bleeding, who presented with new-onset left EDH. Patient two was a 27-year-old woman with relapsed acute myelogenous leukemia with bilateral CSDH and mass effect on MRI. Neither patient had hemophilia, and preoperative INR was 1.2 in each case. Both patients underwent evacuation in the operating room, preceded by rFVIIa administration. RESULTS: Patient one underwent removal of his previous craniotomy flap followed by EDH evacuation. In patient two, coagulopathic bleeding upon surgical approach necessitated an additional dose of rFVIIa. Burrhole evacuation was well-tolerated with visible brain re-expansion following irrigation. Each case occurred with minimal blood loss and relatively easy hemostasis, with postoperative CT and clinical course revealing adequate evacuation. Neither patient experienced thromboembolic complications or required re-operation. CONCLUSION: These two patients are the first to be examined for the use of rFVIIa for reversal of clinical coagulopathy in the setting of normal INR. Our experience suggests that normal INR should not be a deterrent for patients to receive rFVIIa in the setting of strong neurosurgical suspicion for underlying clinical coagulopathy. More... »

PAGES

136-139

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12028-007-0040-x

DOI

http://dx.doi.org/10.1007/s12028-007-0040-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011134600

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17846720


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Coagulation Disorders", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Craniotomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Factor VIIa", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematoma, Epidural, Cranial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematoma, Subdural, Chronic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "International Normalized Ratio", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia, Myeloid, Acute", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tomography, X-Ray Computed", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Minnesota", 
          "id": "https://www.grid.ac/institutes/grid.17635.36", 
          "name": [
            "Department of Neurosurgery, University of Minnesota, Mayo Mail Code 96, 420 Delaware Street SE, 55455, Minneapolis, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McClelland", 
        "givenName": "Shearwood", 
        "id": "sg:person.01027446663.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027446663.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Minnesota", 
          "id": "https://www.grid.ac/institutes/grid.17635.36", 
          "name": [
            "Department of Neurosurgery, University of Minnesota, Mayo Mail Code 96, 420 Delaware Street SE, 55455, Minneapolis, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Won", 
        "givenName": "Eun Kyung", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Minnesota", 
          "id": "https://www.grid.ac/institutes/grid.17635.36", 
          "name": [
            "Department of Neurosurgery, University of Minnesota, Mayo Mail Code 96, 420 Delaware Street SE, 55455, Minneapolis, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lam", 
        "givenName": "Cornelius H.", 
        "id": "sg:person.0761123540.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761123540.00"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00404-002-0409-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002059767", 
          "https://doi.org/10.1007/s00404-002-0409-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pcc.0000123546.78900.67", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007024128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pcc.0000123546.78900.67", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007024128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pcc.0000123546.78900.67", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007024128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1537-2995.2004.04080.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013164864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008506-200310000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019703885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008506-200310000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019703885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.295.3.293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021647702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccc.2005.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022163299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccc.2005.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022163299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa042991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023365362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1227/01.neu.0000068830.54968.a8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024477820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ta.0000239261.48022.f1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025752652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ta.0000239261.48022.f1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025752652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1385/ncc:1:1:19", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026145110", 
          "https://doi.org/10.1385/ncc:1:1:19"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000149628.80251.b8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031891740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000149628.80251.b8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031891740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2516.2005.01098.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032507240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2516.2005.01098.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032507240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1385/ncc:2:3:263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037217726", 
          "https://doi.org/10.1385/ncc:2:3:263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1227/01.neu.0000180816.80626.c2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046699951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1227/01.neu.0000179915.74429.b2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046814995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10245330310001594252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058357850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2310/6670.2006.00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070716155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2310/6670.2006.00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070716155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2003.98.4.0737", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071100716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2003.98.4.0737", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071100716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2003.98.4.0737", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071100716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/ped.2006.104.1.55", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071102703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075348507", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0310057x0303100418", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075348507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0310057x0303100418", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075348507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076585064", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-10", 
    "datePublishedReg": "2007-10-01", 
    "description": "BACKGROUND: Recombinant activated Factor VII (rFVIIa) has recently gained popularity for rapid reversal of coagulopathy during operative neurosurgery. Patients undergoing chronic subdural hematoma (CSDH) or epidural hematoma (EDH) evacuation often have their coagulation status judged by preoperative international normalized ratio (INR). We present our experience in two patients with significant clinical coagulopathy who were successfully reversed with rFVIIa in the setting of normal INR.\nMETHODS: Patient one was a 79-year-old man with history of prostate cancer and three previous operative left CSDH evacuations, each complicated by coagulopathic bleeding, who presented with new-onset left EDH. Patient two was a 27-year-old woman with relapsed acute myelogenous leukemia with bilateral CSDH and mass effect on MRI. Neither patient had hemophilia, and preoperative INR was 1.2 in each case. Both patients underwent evacuation in the operating room, preceded by rFVIIa administration.\nRESULTS: Patient one underwent removal of his previous craniotomy flap followed by EDH evacuation. In patient two, coagulopathic bleeding upon surgical approach necessitated an additional dose of rFVIIa. Burrhole evacuation was well-tolerated with visible brain re-expansion following irrigation. Each case occurred with minimal blood loss and relatively easy hemostasis, with postoperative CT and clinical course revealing adequate evacuation. Neither patient experienced thromboembolic complications or required re-operation.\nCONCLUSION: These two patients are the first to be examined for the use of rFVIIa for reversal of clinical coagulopathy in the setting of normal INR. Our experience suggests that normal INR should not be a deterrent for patients to receive rFVIIa in the setting of strong neurosurgical suspicion for underlying clinical coagulopathy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12028-007-0040-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1031461", 
        "issn": [
          "1541-6933", 
          "1556-0961"
        ], 
        "name": "Neurocritical Care", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "Utilization of recombinant activated factor VII for intracranial hematoma evacuation in coagulopathic nonhemophilic neurosurgical patients with normal international normalized ratios", 
    "pagination": "136-139", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "350cc9fcc40919c2d9fce923e4d6c7183aaa017e3e63c6caf512a082f5144aa3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17846720"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101156086"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12028-007-0040-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1011134600"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12028-007-0040-x", 
      "https://app.dimensions.ai/details/publication/pub.1011134600"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:26", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000520.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs12028-007-0040-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12028-007-0040-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12028-007-0040-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12028-007-0040-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12028-007-0040-x'


 

This table displays all metadata directly associated to this object as RDF triples.

205 TRIPLES      21 PREDICATES      65 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12028-007-0040-x schema:about N05342c739edb4d1ebf83056f3ba74395
2 N265f739b3b914b4bb438d71a6df48c71
3 N297ac47a827047f3b5893884dddd36ca
4 N46ee63b5e2024886bba3361ef7f06b56
5 N550ee0b7154e4015950da0a8a5288d11
6 N5598619de8df42ef943b88871b4c1113
7 N5d41e27219354c838a4a53f5201022b0
8 N66d538800411462a90b7b633ba3bf2c1
9 N74bb6683a1ea4a1dbc0adaaaba4b88ae
10 Nc8f5c9cd63de4170bb32bf6da0bcfd81
11 Nd4ede1b0127c48fe88bcdec2a58c4028
12 Ne6cc186649fa43d7bc80b2ba40d4966f
13 Nf00e826771d04869bf1d0dd918202b94
14 Nff64db1f55c34aacb3c5046c2630aedc
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author N972d3db8160349a7ad1efb912254cb65
18 schema:citation sg:pub.10.1007/s00404-002-0409-1
19 sg:pub.10.1385/ncc:1:1:19
20 sg:pub.10.1385/ncc:2:3:263
21 https://app.dimensions.ai/details/publication/pub.1075348507
22 https://app.dimensions.ai/details/publication/pub.1076585064
23 https://doi.org/10.1001/jama.295.3.293
24 https://doi.org/10.1016/j.ccc.2005.04.001
25 https://doi.org/10.1056/nejmoa042991
26 https://doi.org/10.1080/10245330310001594252
27 https://doi.org/10.1097/00008506-200310000-00008
28 https://doi.org/10.1097/01.pcc.0000123546.78900.67
29 https://doi.org/10.1097/01.ta.0000239261.48022.f1
30 https://doi.org/10.1111/j.1365-2516.2005.01098.x
31 https://doi.org/10.1111/j.1537-2995.2004.04080.x
32 https://doi.org/10.1161/01.str.0000149628.80251.b8
33 https://doi.org/10.1177/0310057x0303100418
34 https://doi.org/10.1227/01.neu.0000068830.54968.a8
35 https://doi.org/10.1227/01.neu.0000179915.74429.b2
36 https://doi.org/10.1227/01.neu.0000180816.80626.c2
37 https://doi.org/10.2310/6670.2006.00004
38 https://doi.org/10.3171/jns.2003.98.4.0737
39 https://doi.org/10.3171/ped.2006.104.1.55
40 schema:datePublished 2007-10
41 schema:datePublishedReg 2007-10-01
42 schema:description BACKGROUND: Recombinant activated Factor VII (rFVIIa) has recently gained popularity for rapid reversal of coagulopathy during operative neurosurgery. Patients undergoing chronic subdural hematoma (CSDH) or epidural hematoma (EDH) evacuation often have their coagulation status judged by preoperative international normalized ratio (INR). We present our experience in two patients with significant clinical coagulopathy who were successfully reversed with rFVIIa in the setting of normal INR. METHODS: Patient one was a 79-year-old man with history of prostate cancer and three previous operative left CSDH evacuations, each complicated by coagulopathic bleeding, who presented with new-onset left EDH. Patient two was a 27-year-old woman with relapsed acute myelogenous leukemia with bilateral CSDH and mass effect on MRI. Neither patient had hemophilia, and preoperative INR was 1.2 in each case. Both patients underwent evacuation in the operating room, preceded by rFVIIa administration. RESULTS: Patient one underwent removal of his previous craniotomy flap followed by EDH evacuation. In patient two, coagulopathic bleeding upon surgical approach necessitated an additional dose of rFVIIa. Burrhole evacuation was well-tolerated with visible brain re-expansion following irrigation. Each case occurred with minimal blood loss and relatively easy hemostasis, with postoperative CT and clinical course revealing adequate evacuation. Neither patient experienced thromboembolic complications or required re-operation. CONCLUSION: These two patients are the first to be examined for the use of rFVIIa for reversal of clinical coagulopathy in the setting of normal INR. Our experience suggests that normal INR should not be a deterrent for patients to receive rFVIIa in the setting of strong neurosurgical suspicion for underlying clinical coagulopathy.
43 schema:genre research_article
44 schema:inLanguage en
45 schema:isAccessibleForFree false
46 schema:isPartOf N5fafbcf4a7554f2ab5b90f6e958b006e
47 N7c0d43e7431749fea32b8f1d7f2872d9
48 sg:journal.1031461
49 schema:name Utilization of recombinant activated factor VII for intracranial hematoma evacuation in coagulopathic nonhemophilic neurosurgical patients with normal international normalized ratios
50 schema:pagination 136-139
51 schema:productId N22b73e56d3dc4e5cbff7b8fc8b24e20e
52 N4c589c2ccf7a450f843144f0d9c4de1f
53 N728aed3c85b4403dac2428874166b88e
54 Nb43f4deee9f347fc8cf832679059fdca
55 Nf7ae4cb0d01a42e9a463b0c884a66dbf
56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011134600
57 https://doi.org/10.1007/s12028-007-0040-x
58 schema:sdDatePublished 2019-04-10T23:26
59 schema:sdLicense https://scigraph.springernature.com/explorer/license/
60 schema:sdPublisher N8c79c17f80ea44abbfb27546a1c6aae8
61 schema:url http://link.springer.com/10.1007%2Fs12028-007-0040-x
62 sgo:license sg:explorer/license/
63 sgo:sdDataset articles
64 rdf:type schema:ScholarlyArticle
65 N05342c739edb4d1ebf83056f3ba74395 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Blood Coagulation Disorders
67 rdf:type schema:DefinedTerm
68 N16b7b45ceba6440e8d015ee8c586a791 rdf:first sg:person.0761123540.00
69 rdf:rest rdf:nil
70 N22b73e56d3dc4e5cbff7b8fc8b24e20e schema:name doi
71 schema:value 10.1007/s12028-007-0040-x
72 rdf:type schema:PropertyValue
73 N265f739b3b914b4bb438d71a6df48c71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Tomography, X-Ray Computed
75 rdf:type schema:DefinedTerm
76 N297ac47a827047f3b5893884dddd36ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Adult
78 rdf:type schema:DefinedTerm
79 N456ce0aa4d844bb1bc747d2ba65bfba6 schema:affiliation https://www.grid.ac/institutes/grid.17635.36
80 schema:familyName Won
81 schema:givenName Eun Kyung
82 rdf:type schema:Person
83 N46ee63b5e2024886bba3361ef7f06b56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Aged
85 rdf:type schema:DefinedTerm
86 N4c589c2ccf7a450f843144f0d9c4de1f schema:name dimensions_id
87 schema:value pub.1011134600
88 rdf:type schema:PropertyValue
89 N550ee0b7154e4015950da0a8a5288d11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Leukemia, Myeloid, Acute
91 rdf:type schema:DefinedTerm
92 N5598619de8df42ef943b88871b4c1113 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Recombinant Proteins
94 rdf:type schema:DefinedTerm
95 N5d41e27219354c838a4a53f5201022b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Factor VIIa
97 rdf:type schema:DefinedTerm
98 N5fafbcf4a7554f2ab5b90f6e958b006e schema:volumeNumber 7
99 rdf:type schema:PublicationVolume
100 N66d538800411462a90b7b633ba3bf2c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Hematoma, Epidural, Cranial
102 rdf:type schema:DefinedTerm
103 N728aed3c85b4403dac2428874166b88e schema:name pubmed_id
104 schema:value 17846720
105 rdf:type schema:PropertyValue
106 N74bb6683a1ea4a1dbc0adaaaba4b88ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Craniotomy
108 rdf:type schema:DefinedTerm
109 N7c0d43e7431749fea32b8f1d7f2872d9 schema:issueNumber 2
110 rdf:type schema:PublicationIssue
111 N8c79c17f80ea44abbfb27546a1c6aae8 schema:name Springer Nature - SN SciGraph project
112 rdf:type schema:Organization
113 N972d3db8160349a7ad1efb912254cb65 rdf:first sg:person.01027446663.21
114 rdf:rest Nebbba66dc86546d9af5d3183556c680b
115 Nb43f4deee9f347fc8cf832679059fdca schema:name nlm_unique_id
116 schema:value 101156086
117 rdf:type schema:PropertyValue
118 Nc8f5c9cd63de4170bb32bf6da0bcfd81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Hematoma, Subdural, Chronic
120 rdf:type schema:DefinedTerm
121 Nd4ede1b0127c48fe88bcdec2a58c4028 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Humans
123 rdf:type schema:DefinedTerm
124 Ne6cc186649fa43d7bc80b2ba40d4966f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name International Normalized Ratio
126 rdf:type schema:DefinedTerm
127 Nebbba66dc86546d9af5d3183556c680b rdf:first N456ce0aa4d844bb1bc747d2ba65bfba6
128 rdf:rest N16b7b45ceba6440e8d015ee8c586a791
129 Nf00e826771d04869bf1d0dd918202b94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Male
131 rdf:type schema:DefinedTerm
132 Nf7ae4cb0d01a42e9a463b0c884a66dbf schema:name readcube_id
133 schema:value 350cc9fcc40919c2d9fce923e4d6c7183aaa017e3e63c6caf512a082f5144aa3
134 rdf:type schema:PropertyValue
135 Nff64db1f55c34aacb3c5046c2630aedc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Female
137 rdf:type schema:DefinedTerm
138 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
139 schema:name Medical and Health Sciences
140 rdf:type schema:DefinedTerm
141 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
142 schema:name Clinical Sciences
143 rdf:type schema:DefinedTerm
144 sg:journal.1031461 schema:issn 1541-6933
145 1556-0961
146 schema:name Neurocritical Care
147 rdf:type schema:Periodical
148 sg:person.01027446663.21 schema:affiliation https://www.grid.ac/institutes/grid.17635.36
149 schema:familyName McClelland
150 schema:givenName Shearwood
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027446663.21
152 rdf:type schema:Person
153 sg:person.0761123540.00 schema:affiliation https://www.grid.ac/institutes/grid.17635.36
154 schema:familyName Lam
155 schema:givenName Cornelius H.
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761123540.00
157 rdf:type schema:Person
158 sg:pub.10.1007/s00404-002-0409-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002059767
159 https://doi.org/10.1007/s00404-002-0409-1
160 rdf:type schema:CreativeWork
161 sg:pub.10.1385/ncc:1:1:19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026145110
162 https://doi.org/10.1385/ncc:1:1:19
163 rdf:type schema:CreativeWork
164 sg:pub.10.1385/ncc:2:3:263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037217726
165 https://doi.org/10.1385/ncc:2:3:263
166 rdf:type schema:CreativeWork
167 https://app.dimensions.ai/details/publication/pub.1075348507 schema:CreativeWork
168 https://app.dimensions.ai/details/publication/pub.1076585064 schema:CreativeWork
169 https://doi.org/10.1001/jama.295.3.293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021647702
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1016/j.ccc.2005.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022163299
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1056/nejmoa042991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023365362
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1080/10245330310001594252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058357850
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1097/00008506-200310000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019703885
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1097/01.pcc.0000123546.78900.67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007024128
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1097/01.ta.0000239261.48022.f1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025752652
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1111/j.1365-2516.2005.01098.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032507240
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1111/j.1537-2995.2004.04080.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013164864
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1161/01.str.0000149628.80251.b8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031891740
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1177/0310057x0303100418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075348507
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1227/01.neu.0000068830.54968.a8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024477820
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1227/01.neu.0000179915.74429.b2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046814995
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1227/01.neu.0000180816.80626.c2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046699951
196 rdf:type schema:CreativeWork
197 https://doi.org/10.2310/6670.2006.00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070716155
198 rdf:type schema:CreativeWork
199 https://doi.org/10.3171/jns.2003.98.4.0737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071100716
200 rdf:type schema:CreativeWork
201 https://doi.org/10.3171/ped.2006.104.1.55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071102703
202 rdf:type schema:CreativeWork
203 https://www.grid.ac/institutes/grid.17635.36 schema:alternateName University of Minnesota
204 schema:name Department of Neurosurgery, University of Minnesota, Mayo Mail Code 96, 420 Delaware Street SE, 55455, Minneapolis, MN, USA
205 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...