Development of chimeric candidate vaccine against HPV18: a proof of concept View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-06

AUTHORS

Mohammed Wahiduzzaman, Chandresh Sharma, Bindu Dey, Neerja Bhatla, Neeta Singh

ABSTRACT

Human papillomaviruses (HPVs) are prerequisite for the development of cervical cancer, with HPV16 and HPV18 being the most prevalent. Despite the fact that two prophylactic vaccines against HPVs are in the market, wide-scale application of the vaccine in developing countries is a major problem as far as cost of the vaccine and lack of therapeutic efficacy are concerned. Hence, the aim of our study was to develop HPV18 L1E7 chimeric virus-like particles (CVLPs) vaccine candidate possessing both, prophylactic and therapeutic potential against HPV18-associated cervical cancer. In this study, we have developed a potential candidate vaccine against HPV18 involving HPV18 L1E7 CVLPs, which was expressed in E. coli and assembled in vitro. These CVLPs were able to induce a neutralizing antibody response as well as a cell-mediated immune response in mice. More... »

PAGES

189-197

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12026-015-8650-4

DOI

http://dx.doi.org/10.1007/s12026-015-8650-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039635009

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25929429


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N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12026-015-8650-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12026-015-8650-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12026-015-8650-4'


 

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