New treatments for inflammatory rheumatic disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-12

AUTHORS

Carlo Selmi, Elena Generali, Marco Massarotti, Gerolamo Bianchi, Carlo A. Sciré

ABSTRACT

As our understanding of the pathogenesis of autoimmune diseases is growing, new therapies are being developed to target disease-specific pathways. Since the introduction of etanercept in 1998, several biotechnological agents have been developed, most of them indicated in the treatment of rheumatoid arthritis, but also psoriatic arthritis. Most currently available molecules target TNF-alfa with different strategies (i.e., etanercept, infliximab, adalimumab, golimumab, and certolizumab pegol), IL-6 (tocilizumab), CTLA-4 (abatacept), and B cells (rituximab, belimumab) as they are key mediators in the cascade of inflammation. Further, small molecules have been recently developed to target intracellular signaling, such as Janus Kinases for tofacitinib, the first FDA-approved small molecule for rheumatoid arthritis. Most novel treatments are being developed for arthritis with specific differences between rheumatoid and psoriatic arthritis, as well as for systemic lupus erythematosus, following the approval of belimumab. Finally, biologic therapies are effective also in gout, mainly targeting interleukin-1 to block the inflammasome. This review article describes the new and upcoming treatment options for rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, and gout to dissect what we should be aware of when discussing these new and promising molecules. More... »

PAGES

277-288

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12026-014-8565-5

DOI

http://dx.doi.org/10.1007/s12026-014-8565-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021458050

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25381481


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rheumatic Diseases", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Milan", 
          "id": "https://www.grid.ac/institutes/grid.4708.b", 
          "name": [
            "Division of Rheumatology and Clinical Immunology, Humanitas Clinical and Research Center, Humanitas Research Hospital, Via A. Manzoni 56, 20089, Rozzano, Milan, Italy", 
            "BIOMETRA Department, University of Milan, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Selmi", 
        "givenName": "Carlo", 
        "id": "sg:person.014502337657.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014502337657.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Milan", 
          "id": "https://www.grid.ac/institutes/grid.4708.b", 
          "name": [
            "Division of Rheumatology and Clinical Immunology, Humanitas Clinical and Research Center, Humanitas Research Hospital, Via A. Manzoni 56, 20089, Rozzano, Milan, Italy", 
            "BIOMETRA Department, University of Milan, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Generali", 
        "givenName": "Elena", 
        "id": "sg:person.01304066345.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304066345.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Humanitas Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417728.f", 
          "name": [
            "Division of Rheumatology and Clinical Immunology, Humanitas Clinical and Research Center, Humanitas Research Hospital, Via A. Manzoni 56, 20089, Rozzano, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Massarotti", 
        "givenName": "Marco", 
        "id": "sg:person.0612675344.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612675344.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Rheumatology, ASL3 Genovese, Genoa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bianchi", 
        "givenName": "Gerolamo", 
        "id": "sg:person.0607571556.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607571556.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Societ\u00e0 Italiana di Reumatologia", 
          "id": "https://www.grid.ac/institutes/grid.489604.7", 
          "name": [
            "Epidemiology Unit, Italian Society for Rheumatology, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scir\u00e9", 
        "givenName": "Carlo A.", 
        "id": "sg:person.0612525772.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612525772.39"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1161/circulationaha.107.731877", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000088584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/acr.21641", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001200429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.21249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001248249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.21249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001248249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/annrheumdis-2012-202715", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002409751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2474-12-153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002541037", 
          "https://doi.org/10.1186/1471-2474-12-153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03325637", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003094585", 
          "https://doi.org/10.1007/bf03325637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.24602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003703848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.24602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003703848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/annrheumdis-2013-205056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004467907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0961203309102803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005355144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0961203309102803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005355144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0961203309102803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005355144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(13)60594-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006274708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.30373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006324367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar3297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007446558", 
          "https://doi.org/10.1186/ar3297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/annrheumdis-2012-202864", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007626613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/annrheumdis-2011-200908", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007670405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.27524", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007881364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.27524", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007881364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/annrheumdis-2013-204741", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008184536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/rheumatology/keh201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008608898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar4347", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009110569", 
          "https://doi.org/10.1186/ar4347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13555-013-0023-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009419551", 
          "https://doi.org/10.1007/s13555-013-0023-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/annrheumdis-2011-200350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009950017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.2011.151522", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010107337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar3910", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010146141", 
          "https://doi.org/10.1186/ar3910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2014/321359", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010710419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.berh.2012.01.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011165085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40259-013-0025-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012014989", 
          "https://doi.org/10.1007/s40259-013-0025-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.2008.095257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013114571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/qjmed/hcu033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013233662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2567.2008.02878.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014498878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3899/jrheum.121118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015662864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.34339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016255127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.38286", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017603686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.semarthrit.2014.04.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017623800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaut.2014.06.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017682911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11926-004-0042-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018054484", 
          "https://doi.org/10.1007/s11926-004-0042-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00296-009-1041-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018077574", 
          "https://doi.org/10.1007/s00296-009-1041-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00296-009-1041-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018077574", 
          "https://doi.org/10.1007/s00296-009-1041-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00296-009-1041-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018077574", 
          "https://doi.org/10.1007/s00296-009-1041-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.27584", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018685765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.27584", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018685765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/rheumatology/kep252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019190040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/rheumatology/kep252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019190040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/annrheumdis-2012-202371", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019282348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.34627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019360116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/annrheumdis-2011-200706", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019506353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd005121.pub3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020198505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/14656566.2013.810208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020564739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.23178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020926947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1759720x10381431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021551490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1759720x10381431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021551490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.27395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021971478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3899/jrheum.130677", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022572521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11926-012-0257-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022778995", 
          "https://doi.org/10.1007/s11926-012-0257-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2014/419029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023211102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/11599820-000000000-00000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023379629", 
          "https://doi.org/10.2165/11599820-000000000-00000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar2669", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023780814", 
          "https://doi.org/10.1186/ar2669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.33317", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024179068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clim.2013.04.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024674395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcph.354", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025089780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.30176", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025115121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.2009.119404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025154014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar3179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025194873", 
          "https://doi.org/10.1186/ar3179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/annrheumdis-2012-201601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025272245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00296-012-2501-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025324488", 
          "https://doi.org/10.1007/s00296-012-2501-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0961203312469453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026448097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0961203312469453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026448097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0961203312469453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026448097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(14)60128-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026894700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2014/681678", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027218208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1529-8019.2011.01405.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027661685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/acr.21690", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029685370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1315231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030324726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10067-013-2294-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030580318", 
          "https://doi.org/10.1007/s10067-013-2294-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/annrheumdis-2013-205067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031309883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar3909", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032518030", 
          "https://doi.org/10.1186/ar3909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-med-080911-105830", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032814612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar4312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033190074", 
          "https://doi.org/10.1186/ar4312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.2010.144063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033607308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00296-012-2637-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033661451", 
          "https://doi.org/10.1007/s00296-012-2637-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00296-012-2637-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033661451", 
          "https://doi.org/10.1007/s00296-012-2637-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/annrheumdis-2013-205137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034222911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.24453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034333568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.24453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034333568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/annrheumdis-2012-202576", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035095468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.23732", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035463599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.27600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035604441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.27600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035604441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/odi.12153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035698082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.f5648", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036380848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/cei.12190", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036685112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra1004965", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038098608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/annrheumdis-2012-201897", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038575742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/annrheumdis-2013-204405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039047837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.27601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039312588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.27601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039312588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/annrheumdis-2012-202646", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039572764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/bor.0b013e3283373fa0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040116769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/bor.0b013e3283373fa0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040116769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/bor.0b013e3283373fa0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040116769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.autrev.2011.04.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040614443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coph.2013.02.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040900742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coph.2013.02.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040900742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.37820", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041061625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/annrheumdis-2013-204655", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041188784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.27334", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041364825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.27334", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041364825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.30372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041888251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11926-013-0368-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042415430", 
          "https://doi.org/10.1007/s11926-013-0368-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/imm.12142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043104979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.autrev.2012.10.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043650643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar2143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043880305", 
          "https://doi.org/10.1186/ar2143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.27221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045050471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.27221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045050471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10067-013-2329-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045868420", 
          "https://doi.org/10.1007/s10067-013-2329-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10067-013-2329-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045868420", 
          "https://doi.org/10.1007/s10067-013-2329-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1529-8019.2008.01215.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046210335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.33353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046530845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.autrev.2014.01.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046682257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.38617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047213793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2125.2011.03964.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047540604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/0976-500x.120943", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047581316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/0976-500x.120943", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047581316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/annrheumdis-2012-202775", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047808006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/bor.0b013e32835190ef", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047996206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/bor.0b013e32835190ef", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047996206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar2080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048147870", 
          "https://doi.org/10.1186/ar2080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/acr.21791", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048793863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1590/s0482-50042010000300014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049423492", 
          "https://doi.org/10.1590/s0482-50042010000300014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0087379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049471757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1314258", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049860938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/dddt.s32713", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049900245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/annrheumdis-2012-201940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050069306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40259-013-0031-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051315979", 
          "https://doi.org/10.1007/s40259-013-0031-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrrheum.2013.8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051368002", 
          "https://doi.org/10.1038/nrrheum.2013.8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3899/jrheum.110994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053388469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.59.9.688", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062764305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.59.9.688", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062764305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1759720x10381432", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064077456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1759720x10381432", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064077456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.12968/hmed.2012.73.1.12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064812086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3899/jrheum.120231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071542888"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3899/jrheum.120234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071542891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3899/jrheum.120886", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071543042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3899/jrheum.121110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071543084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3899/jrheum.130637", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071543264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3899/jrheum.131226", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071543365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/mabs.28614", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072305767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.170.2.838", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075214792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077489350", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078167659", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078664733", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-12", 
    "datePublishedReg": "2014-12-01", 
    "description": "As our understanding of the pathogenesis of autoimmune diseases is growing, new therapies are being developed to target disease-specific pathways. Since the introduction of etanercept in 1998, several biotechnological agents have been developed, most of them indicated in the treatment of rheumatoid arthritis, but also psoriatic arthritis. Most currently available molecules target TNF-alfa with different strategies (i.e., etanercept, infliximab, adalimumab, golimumab, and certolizumab pegol), IL-6 (tocilizumab), CTLA-4 (abatacept), and B cells (rituximab, belimumab) as they are key mediators in the cascade of inflammation. Further, small molecules have been recently developed to target intracellular signaling, such as Janus Kinases for tofacitinib, the first FDA-approved small molecule for rheumatoid arthritis. Most novel treatments are being developed for arthritis with specific differences between rheumatoid and psoriatic arthritis, as well as for systemic lupus erythematosus, following the approval of belimumab. Finally, biologic therapies are effective also in gout, mainly targeting interleukin-1 to block the inflammasome. This review article describes the new and upcoming treatment options for rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, and gout to dissect what we should be aware of when discussing these new and promising molecules.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12026-014-8565-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096613", 
        "issn": [
          "0257-277X", 
          "1559-0755"
        ], 
        "name": "Immunologic Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2-3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "60"
      }
    ], 
    "name": "New treatments for inflammatory rheumatic disease", 
    "pagination": "277-288", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "663c99e761948a68c016eb9a0d510416c7f227080e6409b57c1a058ffe42ed9f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25381481"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8611087"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12026-014-8565-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021458050"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12026-014-8565-5", 
      "https://app.dimensions.ai/details/publication/pub.1021458050"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000521.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs12026-014-8565-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12026-014-8565-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12026-014-8565-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12026-014-8565-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12026-014-8565-5'


 

This table displays all metadata directly associated to this object as RDF triples.

523 TRIPLES      21 PREDICATES      160 URIs      23 LITERALS      11 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12026-014-8565-5 schema:about N7573bc27e5b84cdeaf884884783b7f33
2 Nf58945ab60d3406cb63076f22b0450ad
3 anzsrc-for:11
4 anzsrc-for:1107
5 schema:author Na9f71b9b38f74ab6a52e2cf2bc4ed29b
6 schema:citation sg:pub.10.1007/bf03325637
7 sg:pub.10.1007/s00296-009-1041-1
8 sg:pub.10.1007/s00296-012-2501-6
9 sg:pub.10.1007/s00296-012-2637-4
10 sg:pub.10.1007/s10067-013-2294-3
11 sg:pub.10.1007/s10067-013-2329-9
12 sg:pub.10.1007/s11926-004-0042-z
13 sg:pub.10.1007/s11926-012-0257-3
14 sg:pub.10.1007/s11926-013-0368-5
15 sg:pub.10.1007/s13555-013-0023-0
16 sg:pub.10.1007/s40259-013-0025-6
17 sg:pub.10.1007/s40259-013-0031-8
18 sg:pub.10.1038/nrrheum.2013.8
19 sg:pub.10.1186/1471-2474-12-153
20 sg:pub.10.1186/ar2080
21 sg:pub.10.1186/ar2143
22 sg:pub.10.1186/ar2669
23 sg:pub.10.1186/ar3179
24 sg:pub.10.1186/ar3297
25 sg:pub.10.1186/ar3909
26 sg:pub.10.1186/ar3910
27 sg:pub.10.1186/ar4312
28 sg:pub.10.1186/ar4347
29 sg:pub.10.1590/s0482-50042010000300014
30 sg:pub.10.2165/11599820-000000000-00000
31 https://app.dimensions.ai/details/publication/pub.1077489350
32 https://app.dimensions.ai/details/publication/pub.1078167659
33 https://app.dimensions.ai/details/publication/pub.1078664733
34 https://doi.org/10.1002/14651858.cd005121.pub3
35 https://doi.org/10.1002/acr.21641
36 https://doi.org/10.1002/acr.21690
37 https://doi.org/10.1002/acr.21791
38 https://doi.org/10.1002/art.21249
39 https://doi.org/10.1002/art.23178
40 https://doi.org/10.1002/art.23732
41 https://doi.org/10.1002/art.24453
42 https://doi.org/10.1002/art.24602
43 https://doi.org/10.1002/art.27221
44 https://doi.org/10.1002/art.27334
45 https://doi.org/10.1002/art.27395
46 https://doi.org/10.1002/art.27524
47 https://doi.org/10.1002/art.27584
48 https://doi.org/10.1002/art.27600
49 https://doi.org/10.1002/art.27601
50 https://doi.org/10.1002/art.30176
51 https://doi.org/10.1002/art.30372
52 https://doi.org/10.1002/art.30373
53 https://doi.org/10.1002/art.33317
54 https://doi.org/10.1002/art.33353
55 https://doi.org/10.1002/art.34339
56 https://doi.org/10.1002/art.34627
57 https://doi.org/10.1002/art.37820
58 https://doi.org/10.1002/art.38286
59 https://doi.org/10.1002/art.38617
60 https://doi.org/10.1002/jcph.354
61 https://doi.org/10.1016/j.autrev.2011.04.017
62 https://doi.org/10.1016/j.autrev.2012.10.002
63 https://doi.org/10.1016/j.autrev.2014.01.050
64 https://doi.org/10.1016/j.berh.2012.01.003
65 https://doi.org/10.1016/j.clim.2013.04.012
66 https://doi.org/10.1016/j.coph.2013.02.006
67 https://doi.org/10.1016/j.jaut.2014.06.002
68 https://doi.org/10.1016/j.semarthrit.2014.04.002
69 https://doi.org/10.1016/s0140-6736(13)60594-2
70 https://doi.org/10.1016/s0140-6736(14)60128-8
71 https://doi.org/10.1056/nejmoa1314258
72 https://doi.org/10.1056/nejmoa1315231
73 https://doi.org/10.1056/nejmra1004965
74 https://doi.org/10.1093/qjmed/hcu033
75 https://doi.org/10.1093/rheumatology/keh201
76 https://doi.org/10.1093/rheumatology/kep252
77 https://doi.org/10.1097/bor.0b013e3283373fa0
78 https://doi.org/10.1097/bor.0b013e32835190ef
79 https://doi.org/10.1111/cei.12190
80 https://doi.org/10.1111/imm.12142
81 https://doi.org/10.1111/j.1365-2125.2011.03964.x
82 https://doi.org/10.1111/j.1365-2567.2008.02878.x
83 https://doi.org/10.1111/j.1529-8019.2008.01215.x
84 https://doi.org/10.1111/j.1529-8019.2011.01405.x
85 https://doi.org/10.1111/odi.12153
86 https://doi.org/10.1136/annrheumdis-2011-200350
87 https://doi.org/10.1136/annrheumdis-2011-200706
88 https://doi.org/10.1136/annrheumdis-2011-200908
89 https://doi.org/10.1136/annrheumdis-2012-201601
90 https://doi.org/10.1136/annrheumdis-2012-201897
91 https://doi.org/10.1136/annrheumdis-2012-201940
92 https://doi.org/10.1136/annrheumdis-2012-202371
93 https://doi.org/10.1136/annrheumdis-2012-202576
94 https://doi.org/10.1136/annrheumdis-2012-202646
95 https://doi.org/10.1136/annrheumdis-2012-202715
96 https://doi.org/10.1136/annrheumdis-2012-202775
97 https://doi.org/10.1136/annrheumdis-2012-202864
98 https://doi.org/10.1136/annrheumdis-2013-204405
99 https://doi.org/10.1136/annrheumdis-2013-204655
100 https://doi.org/10.1136/annrheumdis-2013-204741
101 https://doi.org/10.1136/annrheumdis-2013-205056
102 https://doi.org/10.1136/annrheumdis-2013-205067
103 https://doi.org/10.1136/annrheumdis-2013-205137
104 https://doi.org/10.1136/ard.2008.095257
105 https://doi.org/10.1136/ard.2009.119404
106 https://doi.org/10.1136/ard.2010.144063
107 https://doi.org/10.1136/ard.2011.151522
108 https://doi.org/10.1136/ard.59.9.688
109 https://doi.org/10.1136/bmj.f5648
110 https://doi.org/10.1146/annurev-med-080911-105830
111 https://doi.org/10.1155/2014/321359
112 https://doi.org/10.1155/2014/419029
113 https://doi.org/10.1155/2014/681678
114 https://doi.org/10.1161/circulationaha.107.731877
115 https://doi.org/10.1177/0961203309102803
116 https://doi.org/10.1177/0961203312469453
117 https://doi.org/10.1177/1759720x10381431
118 https://doi.org/10.1177/1759720x10381432
119 https://doi.org/10.12968/hmed.2012.73.1.12
120 https://doi.org/10.1371/journal.pone.0087379
121 https://doi.org/10.1517/14656566.2013.810208
122 https://doi.org/10.2147/dddt.s32713
123 https://doi.org/10.3899/jrheum.110994
124 https://doi.org/10.3899/jrheum.120231
125 https://doi.org/10.3899/jrheum.120234
126 https://doi.org/10.3899/jrheum.120886
127 https://doi.org/10.3899/jrheum.121110
128 https://doi.org/10.3899/jrheum.121118
129 https://doi.org/10.3899/jrheum.130637
130 https://doi.org/10.3899/jrheum.130677
131 https://doi.org/10.3899/jrheum.131226
132 https://doi.org/10.4049/jimmunol.170.2.838
133 https://doi.org/10.4103/0976-500x.120943
134 https://doi.org/10.4161/mabs.28614
135 schema:datePublished 2014-12
136 schema:datePublishedReg 2014-12-01
137 schema:description As our understanding of the pathogenesis of autoimmune diseases is growing, new therapies are being developed to target disease-specific pathways. Since the introduction of etanercept in 1998, several biotechnological agents have been developed, most of them indicated in the treatment of rheumatoid arthritis, but also psoriatic arthritis. Most currently available molecules target TNF-alfa with different strategies (i.e., etanercept, infliximab, adalimumab, golimumab, and certolizumab pegol), IL-6 (tocilizumab), CTLA-4 (abatacept), and B cells (rituximab, belimumab) as they are key mediators in the cascade of inflammation. Further, small molecules have been recently developed to target intracellular signaling, such as Janus Kinases for tofacitinib, the first FDA-approved small molecule for rheumatoid arthritis. Most novel treatments are being developed for arthritis with specific differences between rheumatoid and psoriatic arthritis, as well as for systemic lupus erythematosus, following the approval of belimumab. Finally, biologic therapies are effective also in gout, mainly targeting interleukin-1 to block the inflammasome. This review article describes the new and upcoming treatment options for rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, and gout to dissect what we should be aware of when discussing these new and promising molecules.
138 schema:genre research_article
139 schema:inLanguage en
140 schema:isAccessibleForFree false
141 schema:isPartOf N162464d810ca4eb2b3034580b12c7f3a
142 N869515acbb4a497587cba020e08c9005
143 sg:journal.1096613
144 schema:name New treatments for inflammatory rheumatic disease
145 schema:pagination 277-288
146 schema:productId N0ca8eab3ad5b445a9be60aaab254594a
147 N2b046f4a51504f479fd62c6a9d07d98d
148 N2f5ab9ab3aad42c39f932df03af0fe9b
149 N649cdc6b979f48d39c2fa8b1e8f1bb9e
150 Nea28fc8bfdd646b79cd335a724de280c
151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021458050
152 https://doi.org/10.1007/s12026-014-8565-5
153 schema:sdDatePublished 2019-04-10T19:59
154 schema:sdLicense https://scigraph.springernature.com/explorer/license/
155 schema:sdPublisher Ne50078f7a28c483288b2521b5b705bf7
156 schema:url http://link.springer.com/10.1007%2Fs12026-014-8565-5
157 sgo:license sg:explorer/license/
158 sgo:sdDataset articles
159 rdf:type schema:ScholarlyArticle
160 N0ca8eab3ad5b445a9be60aaab254594a schema:name pubmed_id
161 schema:value 25381481
162 rdf:type schema:PropertyValue
163 N162464d810ca4eb2b3034580b12c7f3a schema:volumeNumber 60
164 rdf:type schema:PublicationVolume
165 N2b046f4a51504f479fd62c6a9d07d98d schema:name readcube_id
166 schema:value 663c99e761948a68c016eb9a0d510416c7f227080e6409b57c1a058ffe42ed9f
167 rdf:type schema:PropertyValue
168 N2b58555e783d4dc4914636ccec93b96c rdf:first sg:person.0612525772.39
169 rdf:rest rdf:nil
170 N2f5ab9ab3aad42c39f932df03af0fe9b schema:name dimensions_id
171 schema:value pub.1021458050
172 rdf:type schema:PropertyValue
173 N4fbf6f10e58444e9874fc09289230e5b rdf:first sg:person.01304066345.44
174 rdf:rest Nf925396cc82940bd8e82cb4ed66c2e94
175 N5cc2e0ddae87412399bdc31c7a12ed9b schema:name Division of Rheumatology, ASL3 Genovese, Genoa, Italy
176 rdf:type schema:Organization
177 N649cdc6b979f48d39c2fa8b1e8f1bb9e schema:name doi
178 schema:value 10.1007/s12026-014-8565-5
179 rdf:type schema:PropertyValue
180 N7573bc27e5b84cdeaf884884783b7f33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Humans
182 rdf:type schema:DefinedTerm
183 N869515acbb4a497587cba020e08c9005 schema:issueNumber 2-3
184 rdf:type schema:PublicationIssue
185 Na9f71b9b38f74ab6a52e2cf2bc4ed29b rdf:first sg:person.014502337657.50
186 rdf:rest N4fbf6f10e58444e9874fc09289230e5b
187 Nb67f9fde11524c319892ef57b5a26384 rdf:first sg:person.0607571556.89
188 rdf:rest N2b58555e783d4dc4914636ccec93b96c
189 Ne50078f7a28c483288b2521b5b705bf7 schema:name Springer Nature - SN SciGraph project
190 rdf:type schema:Organization
191 Nea28fc8bfdd646b79cd335a724de280c schema:name nlm_unique_id
192 schema:value 8611087
193 rdf:type schema:PropertyValue
194 Nf58945ab60d3406cb63076f22b0450ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Rheumatic Diseases
196 rdf:type schema:DefinedTerm
197 Nf925396cc82940bd8e82cb4ed66c2e94 rdf:first sg:person.0612675344.96
198 rdf:rest Nb67f9fde11524c319892ef57b5a26384
199 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
200 schema:name Medical and Health Sciences
201 rdf:type schema:DefinedTerm
202 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
203 schema:name Immunology
204 rdf:type schema:DefinedTerm
205 sg:journal.1096613 schema:issn 0257-277X
206 1559-0755
207 schema:name Immunologic Research
208 rdf:type schema:Periodical
209 sg:person.01304066345.44 schema:affiliation https://www.grid.ac/institutes/grid.4708.b
210 schema:familyName Generali
211 schema:givenName Elena
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304066345.44
213 rdf:type schema:Person
214 sg:person.014502337657.50 schema:affiliation https://www.grid.ac/institutes/grid.4708.b
215 schema:familyName Selmi
216 schema:givenName Carlo
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014502337657.50
218 rdf:type schema:Person
219 sg:person.0607571556.89 schema:affiliation N5cc2e0ddae87412399bdc31c7a12ed9b
220 schema:familyName Bianchi
221 schema:givenName Gerolamo
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607571556.89
223 rdf:type schema:Person
224 sg:person.0612525772.39 schema:affiliation https://www.grid.ac/institutes/grid.489604.7
225 schema:familyName Sciré
226 schema:givenName Carlo A.
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612525772.39
228 rdf:type schema:Person
229 sg:person.0612675344.96 schema:affiliation https://www.grid.ac/institutes/grid.417728.f
230 schema:familyName Massarotti
231 schema:givenName Marco
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612675344.96
233 rdf:type schema:Person
234 sg:pub.10.1007/bf03325637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003094585
235 https://doi.org/10.1007/bf03325637
236 rdf:type schema:CreativeWork
237 sg:pub.10.1007/s00296-009-1041-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018077574
238 https://doi.org/10.1007/s00296-009-1041-1
239 rdf:type schema:CreativeWork
240 sg:pub.10.1007/s00296-012-2501-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025324488
241 https://doi.org/10.1007/s00296-012-2501-6
242 rdf:type schema:CreativeWork
243 sg:pub.10.1007/s00296-012-2637-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033661451
244 https://doi.org/10.1007/s00296-012-2637-4
245 rdf:type schema:CreativeWork
246 sg:pub.10.1007/s10067-013-2294-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030580318
247 https://doi.org/10.1007/s10067-013-2294-3
248 rdf:type schema:CreativeWork
249 sg:pub.10.1007/s10067-013-2329-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045868420
250 https://doi.org/10.1007/s10067-013-2329-9
251 rdf:type schema:CreativeWork
252 sg:pub.10.1007/s11926-004-0042-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1018054484
253 https://doi.org/10.1007/s11926-004-0042-z
254 rdf:type schema:CreativeWork
255 sg:pub.10.1007/s11926-012-0257-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022778995
256 https://doi.org/10.1007/s11926-012-0257-3
257 rdf:type schema:CreativeWork
258 sg:pub.10.1007/s11926-013-0368-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042415430
259 https://doi.org/10.1007/s11926-013-0368-5
260 rdf:type schema:CreativeWork
261 sg:pub.10.1007/s13555-013-0023-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009419551
262 https://doi.org/10.1007/s13555-013-0023-0
263 rdf:type schema:CreativeWork
264 sg:pub.10.1007/s40259-013-0025-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012014989
265 https://doi.org/10.1007/s40259-013-0025-6
266 rdf:type schema:CreativeWork
267 sg:pub.10.1007/s40259-013-0031-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051315979
268 https://doi.org/10.1007/s40259-013-0031-8
269 rdf:type schema:CreativeWork
270 sg:pub.10.1038/nrrheum.2013.8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051368002
271 https://doi.org/10.1038/nrrheum.2013.8
272 rdf:type schema:CreativeWork
273 sg:pub.10.1186/1471-2474-12-153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002541037
274 https://doi.org/10.1186/1471-2474-12-153
275 rdf:type schema:CreativeWork
276 sg:pub.10.1186/ar2080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048147870
277 https://doi.org/10.1186/ar2080
278 rdf:type schema:CreativeWork
279 sg:pub.10.1186/ar2143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043880305
280 https://doi.org/10.1186/ar2143
281 rdf:type schema:CreativeWork
282 sg:pub.10.1186/ar2669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023780814
283 https://doi.org/10.1186/ar2669
284 rdf:type schema:CreativeWork
285 sg:pub.10.1186/ar3179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025194873
286 https://doi.org/10.1186/ar3179
287 rdf:type schema:CreativeWork
288 sg:pub.10.1186/ar3297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007446558
289 https://doi.org/10.1186/ar3297
290 rdf:type schema:CreativeWork
291 sg:pub.10.1186/ar3909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032518030
292 https://doi.org/10.1186/ar3909
293 rdf:type schema:CreativeWork
294 sg:pub.10.1186/ar3910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010146141
295 https://doi.org/10.1186/ar3910
296 rdf:type schema:CreativeWork
297 sg:pub.10.1186/ar4312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033190074
298 https://doi.org/10.1186/ar4312
299 rdf:type schema:CreativeWork
300 sg:pub.10.1186/ar4347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009110569
301 https://doi.org/10.1186/ar4347
302 rdf:type schema:CreativeWork
303 sg:pub.10.1590/s0482-50042010000300014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049423492
304 https://doi.org/10.1590/s0482-50042010000300014
305 rdf:type schema:CreativeWork
306 sg:pub.10.2165/11599820-000000000-00000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023379629
307 https://doi.org/10.2165/11599820-000000000-00000
308 rdf:type schema:CreativeWork
309 https://app.dimensions.ai/details/publication/pub.1077489350 schema:CreativeWork
310 https://app.dimensions.ai/details/publication/pub.1078167659 schema:CreativeWork
311 https://app.dimensions.ai/details/publication/pub.1078664733 schema:CreativeWork
312 https://doi.org/10.1002/14651858.cd005121.pub3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020198505
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1002/acr.21641 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001200429
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1002/acr.21690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029685370
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1002/acr.21791 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048793863
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1002/art.21249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001248249
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1002/art.23178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020926947
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1002/art.23732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035463599
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1002/art.24453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034333568
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1002/art.24602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003703848
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1002/art.27221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045050471
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1002/art.27334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041364825
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1002/art.27395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021971478
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1002/art.27524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007881364
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1002/art.27584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018685765
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1002/art.27600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035604441
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1002/art.27601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039312588
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1002/art.30176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025115121
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1002/art.30372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041888251
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1002/art.30373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006324367
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1002/art.33317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024179068
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1002/art.33353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046530845
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1002/art.34339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016255127
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1002/art.34627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019360116
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1002/art.37820 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041061625
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1002/art.38286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017603686
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1002/art.38617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047213793
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1002/jcph.354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025089780
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1016/j.autrev.2011.04.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040614443
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1016/j.autrev.2012.10.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043650643
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1016/j.autrev.2014.01.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046682257
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1016/j.berh.2012.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011165085
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1016/j.clim.2013.04.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024674395
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1016/j.coph.2013.02.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040900742
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1016/j.jaut.2014.06.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017682911
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1016/j.semarthrit.2014.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017623800
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1016/s0140-6736(13)60594-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006274708
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1016/s0140-6736(14)60128-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026894700
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1056/nejmoa1314258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049860938
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1056/nejmoa1315231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030324726
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1056/nejmra1004965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038098608
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1093/qjmed/hcu033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013233662
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1093/rheumatology/keh201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008608898
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1093/rheumatology/kep252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019190040
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1097/bor.0b013e3283373fa0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040116769
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1097/bor.0b013e32835190ef schema:sameAs https://app.dimensions.ai/details/publication/pub.1047996206
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1111/cei.12190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036685112
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1111/imm.12142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043104979
405 rdf:type schema:CreativeWork
406 https://doi.org/10.1111/j.1365-2125.2011.03964.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047540604
407 rdf:type schema:CreativeWork
408 https://doi.org/10.1111/j.1365-2567.2008.02878.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014498878
409 rdf:type schema:CreativeWork
410 https://doi.org/10.1111/j.1529-8019.2008.01215.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046210335
411 rdf:type schema:CreativeWork
412 https://doi.org/10.1111/j.1529-8019.2011.01405.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027661685
413 rdf:type schema:CreativeWork
414 https://doi.org/10.1111/odi.12153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035698082
415 rdf:type schema:CreativeWork
416 https://doi.org/10.1136/annrheumdis-2011-200350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009950017
417 rdf:type schema:CreativeWork
418 https://doi.org/10.1136/annrheumdis-2011-200706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019506353
419 rdf:type schema:CreativeWork
420 https://doi.org/10.1136/annrheumdis-2011-200908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007670405
421 rdf:type schema:CreativeWork
422 https://doi.org/10.1136/annrheumdis-2012-201601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025272245
423 rdf:type schema:CreativeWork
424 https://doi.org/10.1136/annrheumdis-2012-201897 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038575742
425 rdf:type schema:CreativeWork
426 https://doi.org/10.1136/annrheumdis-2012-201940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050069306
427 rdf:type schema:CreativeWork
428 https://doi.org/10.1136/annrheumdis-2012-202371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019282348
429 rdf:type schema:CreativeWork
430 https://doi.org/10.1136/annrheumdis-2012-202576 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035095468
431 rdf:type schema:CreativeWork
432 https://doi.org/10.1136/annrheumdis-2012-202646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039572764
433 rdf:type schema:CreativeWork
434 https://doi.org/10.1136/annrheumdis-2012-202715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002409751
435 rdf:type schema:CreativeWork
436 https://doi.org/10.1136/annrheumdis-2012-202775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047808006
437 rdf:type schema:CreativeWork
438 https://doi.org/10.1136/annrheumdis-2012-202864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007626613
439 rdf:type schema:CreativeWork
440 https://doi.org/10.1136/annrheumdis-2013-204405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039047837
441 rdf:type schema:CreativeWork
442 https://doi.org/10.1136/annrheumdis-2013-204655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041188784
443 rdf:type schema:CreativeWork
444 https://doi.org/10.1136/annrheumdis-2013-204741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008184536
445 rdf:type schema:CreativeWork
446 https://doi.org/10.1136/annrheumdis-2013-205056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004467907
447 rdf:type schema:CreativeWork
448 https://doi.org/10.1136/annrheumdis-2013-205067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031309883
449 rdf:type schema:CreativeWork
450 https://doi.org/10.1136/annrheumdis-2013-205137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034222911
451 rdf:type schema:CreativeWork
452 https://doi.org/10.1136/ard.2008.095257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013114571
453 rdf:type schema:CreativeWork
454 https://doi.org/10.1136/ard.2009.119404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025154014
455 rdf:type schema:CreativeWork
456 https://doi.org/10.1136/ard.2010.144063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033607308
457 rdf:type schema:CreativeWork
458 https://doi.org/10.1136/ard.2011.151522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010107337
459 rdf:type schema:CreativeWork
460 https://doi.org/10.1136/ard.59.9.688 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062764305
461 rdf:type schema:CreativeWork
462 https://doi.org/10.1136/bmj.f5648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036380848
463 rdf:type schema:CreativeWork
464 https://doi.org/10.1146/annurev-med-080911-105830 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032814612
465 rdf:type schema:CreativeWork
466 https://doi.org/10.1155/2014/321359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010710419
467 rdf:type schema:CreativeWork
468 https://doi.org/10.1155/2014/419029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023211102
469 rdf:type schema:CreativeWork
470 https://doi.org/10.1155/2014/681678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027218208
471 rdf:type schema:CreativeWork
472 https://doi.org/10.1161/circulationaha.107.731877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000088584
473 rdf:type schema:CreativeWork
474 https://doi.org/10.1177/0961203309102803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005355144
475 rdf:type schema:CreativeWork
476 https://doi.org/10.1177/0961203312469453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026448097
477 rdf:type schema:CreativeWork
478 https://doi.org/10.1177/1759720x10381431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021551490
479 rdf:type schema:CreativeWork
480 https://doi.org/10.1177/1759720x10381432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064077456
481 rdf:type schema:CreativeWork
482 https://doi.org/10.12968/hmed.2012.73.1.12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064812086
483 rdf:type schema:CreativeWork
484 https://doi.org/10.1371/journal.pone.0087379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049471757
485 rdf:type schema:CreativeWork
486 https://doi.org/10.1517/14656566.2013.810208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020564739
487 rdf:type schema:CreativeWork
488 https://doi.org/10.2147/dddt.s32713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049900245
489 rdf:type schema:CreativeWork
490 https://doi.org/10.3899/jrheum.110994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053388469
491 rdf:type schema:CreativeWork
492 https://doi.org/10.3899/jrheum.120231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071542888
493 rdf:type schema:CreativeWork
494 https://doi.org/10.3899/jrheum.120234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071542891
495 rdf:type schema:CreativeWork
496 https://doi.org/10.3899/jrheum.120886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071543042
497 rdf:type schema:CreativeWork
498 https://doi.org/10.3899/jrheum.121110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071543084
499 rdf:type schema:CreativeWork
500 https://doi.org/10.3899/jrheum.121118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015662864
501 rdf:type schema:CreativeWork
502 https://doi.org/10.3899/jrheum.130637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071543264
503 rdf:type schema:CreativeWork
504 https://doi.org/10.3899/jrheum.130677 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022572521
505 rdf:type schema:CreativeWork
506 https://doi.org/10.3899/jrheum.131226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071543365
507 rdf:type schema:CreativeWork
508 https://doi.org/10.4049/jimmunol.170.2.838 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075214792
509 rdf:type schema:CreativeWork
510 https://doi.org/10.4103/0976-500x.120943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047581316
511 rdf:type schema:CreativeWork
512 https://doi.org/10.4161/mabs.28614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072305767
513 rdf:type schema:CreativeWork
514 https://www.grid.ac/institutes/grid.417728.f schema:alternateName Humanitas Research Hospital
515 schema:name Division of Rheumatology and Clinical Immunology, Humanitas Clinical and Research Center, Humanitas Research Hospital, Via A. Manzoni 56, 20089, Rozzano, Milan, Italy
516 rdf:type schema:Organization
517 https://www.grid.ac/institutes/grid.4708.b schema:alternateName University of Milan
518 schema:name BIOMETRA Department, University of Milan, Milan, Italy
519 Division of Rheumatology and Clinical Immunology, Humanitas Clinical and Research Center, Humanitas Research Hospital, Via A. Manzoni 56, 20089, Rozzano, Milan, Italy
520 rdf:type schema:Organization
521 https://www.grid.ac/institutes/grid.489604.7 schema:alternateName Società Italiana di Reumatologia
522 schema:name Epidemiology Unit, Italian Society for Rheumatology, Milan, Italy
523 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...