Impaired pulmonary immunity post-bone marrow transplant View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-05

AUTHORS

Stephanie M. Coomes, Leah L. N. Hubbard, Bethany B. Moore

ABSTRACT

Infectious complications are a serious cause of morbidity and mortality following hematopoietic stem cell transplantation (HSCT), and the lung is a particular target organ post-transplant. Our laboratory has used a murine bone marrow transplant model to study alterations in immunity that occur as a result of transplantation. Our studies focus on immune responses that occur following immune cell reconstitution in the absence of immunosuppressive drug therapy or graft-versus-host disease. We have found that impaired clearance of both bacterial and viral pulmonary infections is related to specific alterations in immune cell function and cytokine production. Our data offer insight into mechanisms that contribute to opportunistic infections in HSCT recipients. More... »

PAGES

78-86

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12026-010-8200-z

    DOI

    http://dx.doi.org/10.1007/s12026-010-8200-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049694057

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21170739


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