Polyclonal immune responses to antigens associated with cancer signaling pathways and new strategies to enhance cancer vaccines View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-04

AUTHORS

Timothy M. Clay, Takuya Osada, Zachary C. Hartman, Amy Hobeika, Gayathri Devi, Michael A. Morse, H. Kim Lyerly

ABSTRACT

Aberrant signaling pathways are a hallmark of cancer. A variety of strategies for inhibiting signaling pathways have been developed, but monoclonal antibodies against receptor tyrosine kinases have been among the most successful. A challenge for these therapies is therapeutic unresponsiveness and acquired resistance due to mutations in the receptors, upregulation of alternate growth and survival pathways, or inadequate function of the monoclonal antibodies. Vaccines are able to induce polyclonal responses that can have a multitude of affects against the target molecule. We began to explore therapeutic vaccine development to antigens associated with these signaling pathways. We provide an illustrative example in developing therapeutic cancer vaccines inducing polyclonal adaptive immune responses targeting the ErbB family member HER2. Further, we will discuss new strategies to augment the clinical efficacy of cancer vaccines by enhancing vaccine immunogenicity and reversing the immunosuppressive tumor microenvironment. More... »

PAGES

235-247

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12026-010-8186-6

    DOI

    http://dx.doi.org/10.1007/s12026-010-8186-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1048717939

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21136201


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