Alcoholism and the Armanni–Ebstein lesion View Full Text


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Article Info

DATE

2012-03

AUTHORS

Jacqueline L. Parai, Sarathchandra Kodikara, Christopher M. Milroy, Michael S. Pollanen

ABSTRACT

The Armanni-Ebstein lesion is a histological change in the kidney consisting of sub-nuclear vacuolation of the proximal tubules. It has been most associated with diabetic ketoacidosis. The vacuoles have been reported to contain glycogen. More recent studies show them to contain fat. Recent papers have associated the Armanni-Ebstein lesion with non-diabetic ketoacidosis. We present 11 cases of alcoholic ketoacidosis where the Armanni-Ebstein lesion was identified. None had a history of diabetes mellitus and none showed any changes of diabetic nephropathy. All 11 cases had raised acetone levels (3-67 mg/100 mL (mean 17.9 mg/100 mL and median value of 16 mg/100 mL). In addition a case of isopropanol poisoning was found to have the Armanni-Ebstein lesion. Isopropanol is converted to acetone but is not associated with acidosis. These results indicate that the Armanni-Ebstein lesion is not specific to diabetes mellitus. More... »

PAGES

19-22

References to SciGraph publications

  • 1998-04. Ketoacidosis and lactic acidosis – frequent causes of death in chronic alcoholics? in INTERNATIONAL JOURNAL OF LEGAL MEDICINE
  • 2011-06. Armanni-Ebstein lesion, ketoacidosis and starvation in a child in FORENSIC SCIENCE, MEDICINE AND PATHOLOGY
  • 2010-06. Early diagnosis of Armanni–Ebstein phenomenon at autopsy in FORENSIC SCIENCE, MEDICINE AND PATHOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12024-011-9264-3

    DOI

    http://dx.doi.org/10.1007/s12024-011-9264-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1025227586

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21805374


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