Ontology type: schema:ScholarlyArticle Open Access: True
2018-11-19
AUTHORSAndreas Selberherr, Oskar Koperek, Philipp Riss, Christian Scheuba, Reto Kaderli, Aurel Perren, Bruno Niederle
ABSTRACTThe diagnosis of neuroendocrine neoplasia (NEN) is often made at an advanced stage of disease, including hepatic metastasis. At this point, the primary may still be unknown and sometimes cannot even be detected by functional imaging, especially in very small tumors of the pancreas (pan) and small intestinal (si) entities. The site of the primary may be based on biopsy specimens of the liver applying a specific set of markers. Specimens of liver metastases from 87 patients with NENs were studied. In retrospect, 50 patients had si and 37 pan NENs. Tissue samples were evaluated by immunohistochemistry. The markers applied were insulin gene enhancer protein Islet-1 (ISL-1), homeobox protein CDX-2 (CDX2), thyroid transcription factor 1 (TTF-1), and serotonin. Positive stains for CDX2 were documented in 43 (86%) and for serotonin in 45 (90%) of 50 siNENs. Three panNENs were positive for CDX2 and one for serotonin, respectively. ISL-1 was negative throughout in siNENs and also negative in 8 of 50 panNENs (21.6%). TTF-1 was negative in more than 90% of the specimens of either entity. Immunohistochemical markers in liver metastasis can lead the way to the site of the primary NEN. They should always be used in combined clusters. More... »
PAGES31-34
http://scigraph.springernature.com/pub.10.1007/s12022-018-9558-z
DOIhttp://dx.doi.org/10.1007/s12022-018-9558-z
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1110028242
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30456697
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged, 80 and over",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biomarkers, Tumor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "CDX2 Transcription Factor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunohistochemistry",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "LIM-Homeodomain Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Liver Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neuroendocrine Tumors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Serotonin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Thyroid Nuclear Factor 1",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Transcription Factors",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Section \u201cEndocrine Surgery\u201d, Division of General Surgery, Department of Surgery, Medical University Vienna, W\u00e4hringer G\u00fcrtel 18-20, 1090, Vienna, Austria",
"id": "http://www.grid.ac/institutes/grid.22937.3d",
"name": [
"Section \u201cEndocrine Surgery\u201d, Division of General Surgery, Department of Surgery, Medical University Vienna, W\u00e4hringer G\u00fcrtel 18-20, 1090, Vienna, Austria"
],
"type": "Organization"
},
"familyName": "Selberherr",
"givenName": "Andreas",
"id": "sg:person.01365255052.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365255052.76"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, Medical University, W\u00e4hringer G\u00fcrtel 18-20, 1090, Vienna, Austria",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Pathology, Medical University, W\u00e4hringer G\u00fcrtel 18-20, 1090, Vienna, Austria"
],
"type": "Organization"
},
"familyName": "Koperek",
"givenName": "Oskar",
"id": "sg:person.0637444237.30",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637444237.30"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Section \u201cEndocrine Surgery\u201d, Division of General Surgery, Department of Surgery, Medical University Vienna, W\u00e4hringer G\u00fcrtel 18-20, 1090, Vienna, Austria",
"id": "http://www.grid.ac/institutes/grid.22937.3d",
"name": [
"Section \u201cEndocrine Surgery\u201d, Division of General Surgery, Department of Surgery, Medical University Vienna, W\u00e4hringer G\u00fcrtel 18-20, 1090, Vienna, Austria"
],
"type": "Organization"
},
"familyName": "Riss",
"givenName": "Philipp",
"id": "sg:person.01107211310.34",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107211310.34"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Section \u201cEndocrine Surgery\u201d, Division of General Surgery, Department of Surgery, Medical University Vienna, W\u00e4hringer G\u00fcrtel 18-20, 1090, Vienna, Austria",
"id": "http://www.grid.ac/institutes/grid.22937.3d",
"name": [
"Section \u201cEndocrine Surgery\u201d, Division of General Surgery, Department of Surgery, Medical University Vienna, W\u00e4hringer G\u00fcrtel 18-20, 1090, Vienna, Austria"
],
"type": "Organization"
},
"familyName": "Scheuba",
"givenName": "Christian",
"id": "sg:person.0617351314.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617351314.15"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Section \u201cEndocrine Surgery\u201d, Division of General Surgery, Department of Surgery, Medical University Vienna, W\u00e4hringer G\u00fcrtel 18-20, 1090, Vienna, Austria",
"id": "http://www.grid.ac/institutes/grid.22937.3d",
"name": [
"Section \u201cEndocrine Surgery\u201d, Division of General Surgery, Department of Surgery, Medical University Vienna, W\u00e4hringer G\u00fcrtel 18-20, 1090, Vienna, Austria"
],
"type": "Organization"
},
"familyName": "Kaderli",
"givenName": "Reto",
"id": "sg:person.01327210221.79",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327210221.79"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute of Pathology, University of Bern, Murtenstrasse 31, 3012, Bern, Switzerland",
"id": "http://www.grid.ac/institutes/grid.5734.5",
"name": [
"Institute of Pathology, University of Bern, Murtenstrasse 31, 3012, Bern, Switzerland"
],
"type": "Organization"
},
"familyName": "Perren",
"givenName": "Aurel",
"id": "sg:person.0660235001.55",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660235001.55"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Section \u201cEndocrine Surgery\u201d, Division of General Surgery, Department of Surgery, Medical University Vienna, W\u00e4hringer G\u00fcrtel 18-20, 1090, Vienna, Austria",
"id": "http://www.grid.ac/institutes/grid.22937.3d",
"name": [
"Section \u201cEndocrine Surgery\u201d, Division of General Surgery, Department of Surgery, Medical University Vienna, W\u00e4hringer G\u00fcrtel 18-20, 1090, Vienna, Austria"
],
"type": "Organization"
},
"familyName": "Niederle",
"givenName": "Bruno",
"id": "sg:person.0671724636.94",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671724636.94"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/s12022-013-9264-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051456436",
"https://doi.org/10.1007/s12022-013-9264-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/modpathol.2013.40",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029669666",
"https://doi.org/10.1038/modpathol.2013.40"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s40364-018-0129-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103471898",
"https://doi.org/10.1186/s40364-018-0129-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00428-006-0250-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017988295",
"https://doi.org/10.1007/s00428-006-0250-1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00428-007-0461-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007268859",
"https://doi.org/10.1007/s00428-007-0461-0"
],
"type": "CreativeWork"
}
],
"datePublished": "2018-11-19",
"datePublishedReg": "2018-11-19",
"description": "The diagnosis of neuroendocrine neoplasia (NEN) is often made at an advanced stage of disease, including hepatic metastasis. At this point, the primary may still be unknown and sometimes cannot even be detected by functional imaging, especially in very small tumors of the pancreas (pan) and small intestinal (si) entities. The site of the primary may be based on biopsy specimens of the liver applying a specific set of markers. Specimens of liver metastases from 87 patients with NENs were studied. In retrospect, 50 patients had si and 37 pan NENs. Tissue samples were evaluated by immunohistochemistry. The markers applied were insulin gene enhancer protein Islet-1 (ISL-1), homeobox protein CDX-2 (CDX2), thyroid transcription factor 1 (TTF-1), and serotonin. Positive stains for CDX2 were documented in 43 (86%) and for serotonin in 45 (90%) of 50 siNENs. Three panNENs were positive for CDX2 and one for serotonin, respectively. ISL-1 was negative throughout in siNENs and also negative in 8 of 50 panNENs (21.6%). TTF-1 was negative in more than 90% of the specimens of either entity. Immunohistochemical markers in liver metastasis can lead the way to the site of the primary NEN. They should always be used in combined clusters.",
"genre": "article",
"id": "sg:pub.10.1007/s12022-018-9558-z",
"inLanguage": "en",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1100468",
"issn": [
"1046-3976",
"1559-0097"
],
"name": "Endocrine Pathology",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "30"
}
],
"keywords": [
"neuroendocrine neoplasia",
"liver metastases",
"CDX-2",
"neuroendocrine liver metastases",
"thyroid transcription factor-1",
"primary tumor site",
"hepatic metastases",
"transcription factor 1",
"biopsy specimens",
"small tumors",
"immunohistochemical markers",
"advanced stage",
"TTF-1",
"tumor site",
"metastasis",
"positive stain",
"functional imaging",
"serotonin",
"Islet-1",
"tissue samples",
"factor 1",
"negative throughout",
"patients",
"markers",
"PanNENs",
"primary",
"neoplasia",
"immunohistochemistry",
"tumors",
"pancreas",
"disease",
"liver",
"diagnosis",
"specimens",
"entities",
"stain",
"imaging",
"sites",
"specific set",
"throughout",
"stage",
"retrospect",
"samples",
"combined clusters",
"point",
"clusters",
"way",
"set"
],
"name": "Neuroendocrine Liver Metastasis\u2014a Specific Set of Markers to Detect Primary Tumor Sites",
"pagination": "31-34",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1110028242"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s12022-018-9558-z"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30456697"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s12022-018-9558-z",
"https://app.dimensions.ai/details/publication/pub.1110028242"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-10T10:19",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_791.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s12022-018-9558-z"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12022-018-9558-z'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12022-018-9558-z'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12022-018-9558-z'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12022-018-9558-z'
This table displays all metadata directly associated to this object as RDF triples.
242 TRIPLES
22 PREDICATES
95 URIs
82 LITERALS
23 BLANK NODES