Serum IGF-binding protein 2 (IGFBP-2) concentrations change early after gastric bypass bariatric surgery revealing a possible marker of leptin sensitivity ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-03

AUTHORS

Giovanni Ceccarini, Caterina Pelosini, Federica Ferrari, Silvia Magno, Jacopo Vitti, Guido Salvetti, Carlo Moretto, Antonio Marioni, Piero Buccianti, Paolo Piaggi, Margherita Maffei, Ferruccio Santini

ABSTRACT

PURPOSE: Expression of IGFBP-2 in mice is regulated by leptin. Over-expression of IGFBP-2 is associated with reduced caloric intake and resistance to weight gain. Hormonal variations contributing to weight loss occur very early after bariatric surgery but have not been fully elucidated. We evaluated IGFBP-2 serum changes after bariatric surgery and their relationship with leptin variations to test the hypothesis that an increase of leptin sensitivity may explain some of the effects of gastric bypass. METHODS: This is a historical prospective study. Fifty-one obese patients (41 women e 10 men), 9 non-obese surgical controls and 41 lean matched controls were studied. Serum IGFBP-2 and leptin were measured after bariatric bypass surgery at various time points up to 18 months, after non-bariatric laparoscopic surgery in a control group, and in lean matched controls. RESULTS: Compared to lean controls, serum IGFBP-2 levels were lower in obese patients. After gastric bypass, IGFBP-2 significantly increased at 3 days and became normal before the occurrence of relevant changes in body weight, remaining stable up to 18 months after surgery. IGFBP-2/leptin ratio increased early after surgery and became normal after one year. CONCLUSIONS: After gastric bypass, serum IGFBP-2 increases in a window of time when variations of hormones mediating the effects of bariatric surgery occur. Our results suggest that IGFBP-2, a leptin-regulated protein, may be an in-vivo marker of leptin action. If this is the case, an early improvement of leptin sensitivity might contribute to the anorectic effect of gastric bypass. More... »

References to SciGraph publications

  • 2015-06. Early postoperative weight loss predicts maximal weight loss after sleeve gastrectomy and Roux-en-Y gastric bypass in SURGICAL ENDOSCOPY
  • 2015-05. IGFBP-2 inhibits adipogenesis and lipogenesis in human visceral, but not subcutaneous, adipocytes in INTERNATIONAL JOURNAL OF OBESITY
  • 2016-02. IGF-binding protein 2 is a candidate target of therapeutic potential in cancer in TUMOR BIOLOGY
  • 2011-02. Changes in neurohormonal gut peptides following bariatric surgery in INTERNATIONAL JOURNAL OF OBESITY
  • 2015-02. Fuel homeostasis and locomotor behavior: role of leptin and melanocortin pathways in JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • 2016-12. Does gastric bypass surgery change body weight set point? in INTERNATIONAL JOURNAL OF OBESITY SUPPLEMENTS
  • 2015-05. Leptin deficient ob/ob mice and diet-induced obese mice responded differently to Roux-en-Y bypass surgery in INTERNATIONAL JOURNAL OF OBESITY
  • 2017-02-24. The cellular and molecular bases of leptin and ghrelin resistance in obesity in NATURE REVIEWS ENDOCRINOLOGY
  • 2014-01. IGFBP-2 nuclear translocation is mediated by a functional NLS sequence and is essential for its pro-tumorigenic actions in cancer cells in ONCOGENE
  • 2010-03. Insulin-like growth factor binding protein: a possible marker for the metabolic syndrome? in ACTA DIABETOLOGICA
  • 2008-12. Bariatric surgery and reduction in morbidity and mortality: experiences from the SOS study in INTERNATIONAL JOURNAL OF OBESITY
  • 2011-08. Surgical approaches to the treatment of obesity in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12020-019-01915-y

    DOI

    http://dx.doi.org/10.1007/s12020-019-01915-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113182481

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30945111


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
              "id": "https://www.grid.ac/institutes/grid.144189.1", 
              "name": [
                "Obesity Center, Endocrinology Unit, University Hospital of Pisa, Pisa, Italy. giovanni.ceccarini@unipi.it."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ceccarini", 
            "givenName": "Giovanni", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
              "id": "https://www.grid.ac/institutes/grid.144189.1", 
              "name": [
                "Obesity Center, Endocrinology Unit, University Hospital of Pisa, Pisa, Italy."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pelosini", 
            "givenName": "Caterina", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
              "id": "https://www.grid.ac/institutes/grid.144189.1", 
              "name": [
                "Obesity Center, Endocrinology Unit, University Hospital of Pisa, Pisa, Italy."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ferrari", 
            "givenName": "Federica", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
              "id": "https://www.grid.ac/institutes/grid.144189.1", 
              "name": [
                "Obesity Center, Endocrinology Unit, University Hospital of Pisa, Pisa, Italy."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Magno", 
            "givenName": "Silvia", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
              "id": "https://www.grid.ac/institutes/grid.144189.1", 
              "name": [
                "Obesity Center, Endocrinology Unit, University Hospital of Pisa, Pisa, Italy."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vitti", 
            "givenName": "Jacopo", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
              "id": "https://www.grid.ac/institutes/grid.144189.1", 
              "name": [
                "Obesity Center, Endocrinology Unit, University Hospital of Pisa, Pisa, Italy."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Salvetti", 
            "givenName": "Guido", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
              "id": "https://www.grid.ac/institutes/grid.144189.1", 
              "name": [
                "Unit of Bariatric Surgery, University Hospital of Pisa, Pisa, Italy."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Moretto", 
            "givenName": "Carlo", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
              "id": "https://www.grid.ac/institutes/grid.144189.1", 
              "name": [
                "Unit of Surgery, University Hospital of Pisa, Pisa, Italy."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Marioni", 
            "givenName": "Antonio", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
              "id": "https://www.grid.ac/institutes/grid.144189.1", 
              "name": [
                "Unit of Surgery, University Hospital of Pisa, Pisa, Italy."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Buccianti", 
            "givenName": "Piero", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Diabetes and Digestive and Kidney Diseases", 
              "id": "https://www.grid.ac/institutes/grid.419635.c", 
              "name": [
                "Obesity Center, Endocrinology Unit, University Hospital of Pisa, Pisa, Italy.", 
                "National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, United States."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Piaggi", 
            "givenName": "Paolo", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Istituto di Fisiologia Clinica", 
              "id": "https://www.grid.ac/institutes/grid.418529.3", 
              "name": [
                "Obesity Center, Endocrinology Unit, University Hospital of Pisa, Pisa, Italy.", 
                "Institute of Clinical Physiology, Italian National Research Council, Pisa, Italy."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Maffei", 
            "givenName": "Margherita", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
              "id": "https://www.grid.ac/institutes/grid.144189.1", 
              "name": [
                "Obesity Center, Endocrinology Unit, University Hospital of Pisa, Pisa, Italy."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Santini", 
            "givenName": "Ferruccio", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s13277-015-4561-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002031398", 
              "https://doi.org/10.1007/s13277-015-4561-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ijo.2008.244", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005274660", 
              "https://doi.org/10.1038/ijo.2008.244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.atherosclerosis.2014.09.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006971036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40618-014-0225-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015150812", 
              "https://doi.org/10.1007/s40618-014-0225-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2009.11.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015576745"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1520-7560(199909/10)15:5<314::aid-dmrr56>3.0.co;2-e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020678080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1520-7560(199909/10)15:5<314::aid-dmrr56>3.0.co;2-e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020678080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/193229681100500536", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020994341"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/193229681100500536", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020994341"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0706473105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021655042"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.beem.2015.07.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023164446"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ijosup.2016.9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025953710", 
              "https://doi.org/10.1038/ijosup.2016.9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.soard.2016.01.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026092109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tem.2009.01.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027892322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrgastro.2011.112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028779330", 
              "https://doi.org/10.1038/nrgastro.2011.112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1677/jme.1.01955", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028791477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/oby.2012.90", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031231273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2302/kjm.60.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031420580"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ijo.2014.192", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037078176", 
              "https://doi.org/10.1038/ijo.2014.192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00464-014-3829-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042011243", 
              "https://doi.org/10.1007/s00464-014-3829-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00464-014-3829-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042011243", 
              "https://doi.org/10.1007/s00464-014-3829-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ijo.2010.132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043193435", 
              "https://doi.org/10.1038/ijo.2010.132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.physbeh.2008.04.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044270768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.physbeh.2008.04.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044270768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00592-009-0142-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044775493", 
              "https://doi.org/10.1007/s00592-009-0142-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00592-009-0142-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044775493", 
              "https://doi.org/10.1007/s00592-009-0142-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00592-009-0142-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044775493", 
              "https://doi.org/10.1007/s00592-009-0142-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/oby.20433", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045038670"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2012.630", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046393118", 
              "https://doi.org/10.1038/onc.2012.630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2012.630", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046393118", 
              "https://doi.org/10.1038/onc.2012.630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ijo.2014.189", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047409115", 
              "https://doi.org/10.1038/ijo.2014.189"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/db06-0436", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049056737"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2014.16968", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049238419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circgenetics.113.000490", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049539329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circgenetics.113.000490", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049539329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2013.07.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049735979"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0139960", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051872933"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1055/s-0030-1262854", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1057227016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci19511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063416497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/en.2008-0770", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064249539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/en.2013-1236", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064251933"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/en.2013-1622", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064252053"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/en.2013-2099", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064252241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/endo.135.5.7525256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064279526"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2004-0433", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064287777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2006-0745", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064289262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/me.2008-0168", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064328180"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrendo.2016.222", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083862276", 
              "https://doi.org/10.1038/nrendo.2016.222"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-04-03", 
        "datePublishedReg": "2019-04-03", 
        "description": "PURPOSE: Expression of IGFBP-2 in mice is regulated by leptin. Over-expression of IGFBP-2 is associated with reduced caloric intake and resistance to weight gain. Hormonal variations contributing to weight loss occur very early after bariatric surgery but have not been fully elucidated. We evaluated IGFBP-2 serum changes after bariatric surgery and their relationship with leptin variations to test the hypothesis that an increase of leptin sensitivity may explain some of the effects of gastric bypass.\nMETHODS: This is a historical prospective study. Fifty-one obese patients (41 women e 10 men), 9 non-obese surgical controls and 41 lean matched controls were studied. Serum IGFBP-2 and leptin were measured after bariatric bypass surgery at various time points up to 18 months, after non-bariatric laparoscopic surgery in a control group, and in lean matched controls.\nRESULTS: Compared to lean controls, serum IGFBP-2 levels were lower in obese patients. After gastric bypass, IGFBP-2 significantly increased at 3 days and became normal before the occurrence of relevant changes in body weight, remaining stable up to 18 months after surgery. IGFBP-2/leptin ratio increased early after surgery and became normal after one year.\nCONCLUSIONS: After gastric bypass, serum IGFBP-2 increases in a window of time when variations of hormones mediating the effects of bariatric surgery occur. Our results suggest that IGFBP-2, a leptin-regulated protein, may be an in-vivo marker of leptin action. If this is the case, an early improvement of leptin sensitivity might contribute to the anorectic effect of gastric bypass.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s12020-019-01915-y", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1112251", 
            "issn": [
              "1355-008X", 
              "1559-0100"
            ], 
            "name": "Endocrine", 
            "type": "Periodical"
          }
        ], 
        "name": "Serum IGF-binding protein 2 (IGFBP-2) concentrations change early after gastric bypass bariatric surgery revealing a possible marker of leptin sensitivity in obese subjects.", 
        "productId": [
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30945111"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9434444"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s12020-019-01915-y"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1113182481"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s12020-019-01915-y", 
          "https://app.dimensions.ai/details/publication/pub.1113182481"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:53", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130805_00000006.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007/s12020-019-01915-y"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12020-019-01915-y'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12020-019-01915-y'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12020-019-01915-y'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12020-019-01915-y'


     

    This table displays all metadata directly associated to this object as RDF triples.

    266 TRIPLES      20 PREDICATES      64 URIs      16 LITERALS      6 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s12020-019-01915-y schema:about anzsrc-for:11
    2 anzsrc-for:1103
    3 schema:author N900fd14fa2df40519d7fd77380cfdc37
    4 schema:citation sg:pub.10.1007/s00464-014-3829-7
    5 sg:pub.10.1007/s00592-009-0142-3
    6 sg:pub.10.1007/s13277-015-4561-1
    7 sg:pub.10.1007/s40618-014-0225-z
    8 sg:pub.10.1038/ijo.2008.244
    9 sg:pub.10.1038/ijo.2010.132
    10 sg:pub.10.1038/ijo.2014.189
    11 sg:pub.10.1038/ijo.2014.192
    12 sg:pub.10.1038/ijosup.2016.9
    13 sg:pub.10.1038/nrendo.2016.222
    14 sg:pub.10.1038/nrgastro.2011.112
    15 sg:pub.10.1038/onc.2012.630
    16 https://doi.org/10.1001/jama.2014.16968
    17 https://doi.org/10.1002/(sici)1520-7560(199909/10)15:5<314::aid-dmrr56>3.0.co;2-e
    18 https://doi.org/10.1002/oby.20433
    19 https://doi.org/10.1016/j.atherosclerosis.2014.09.022
    20 https://doi.org/10.1016/j.beem.2015.07.002
    21 https://doi.org/10.1016/j.cmet.2009.11.007
    22 https://doi.org/10.1016/j.cmet.2013.07.004
    23 https://doi.org/10.1016/j.physbeh.2008.04.009
    24 https://doi.org/10.1016/j.soard.2016.01.035
    25 https://doi.org/10.1016/j.tem.2009.01.002
    26 https://doi.org/10.1038/oby.2012.90
    27 https://doi.org/10.1055/s-0030-1262854
    28 https://doi.org/10.1073/pnas.0706473105
    29 https://doi.org/10.1161/circgenetics.113.000490
    30 https://doi.org/10.1172/jci19511
    31 https://doi.org/10.1177/193229681100500536
    32 https://doi.org/10.1210/en.2008-0770
    33 https://doi.org/10.1210/en.2013-1236
    34 https://doi.org/10.1210/en.2013-1622
    35 https://doi.org/10.1210/en.2013-2099
    36 https://doi.org/10.1210/endo.135.5.7525256
    37 https://doi.org/10.1210/jc.2004-0433
    38 https://doi.org/10.1210/jc.2006-0745
    39 https://doi.org/10.1210/me.2008-0168
    40 https://doi.org/10.1371/journal.pone.0139960
    41 https://doi.org/10.1677/jme.1.01955
    42 https://doi.org/10.2302/kjm.60.1
    43 https://doi.org/10.2337/db06-0436
    44 schema:datePublished 2019-04-03
    45 schema:datePublishedReg 2019-04-03
    46 schema:description PURPOSE: Expression of IGFBP-2 in mice is regulated by leptin. Over-expression of IGFBP-2 is associated with reduced caloric intake and resistance to weight gain. Hormonal variations contributing to weight loss occur very early after bariatric surgery but have not been fully elucidated. We evaluated IGFBP-2 serum changes after bariatric surgery and their relationship with leptin variations to test the hypothesis that an increase of leptin sensitivity may explain some of the effects of gastric bypass. METHODS: This is a historical prospective study. Fifty-one obese patients (41 women e 10 men), 9 non-obese surgical controls and 41 lean matched controls were studied. Serum IGFBP-2 and leptin were measured after bariatric bypass surgery at various time points up to 18 months, after non-bariatric laparoscopic surgery in a control group, and in lean matched controls. RESULTS: Compared to lean controls, serum IGFBP-2 levels were lower in obese patients. After gastric bypass, IGFBP-2 significantly increased at 3 days and became normal before the occurrence of relevant changes in body weight, remaining stable up to 18 months after surgery. IGFBP-2/leptin ratio increased early after surgery and became normal after one year. CONCLUSIONS: After gastric bypass, serum IGFBP-2 increases in a window of time when variations of hormones mediating the effects of bariatric surgery occur. Our results suggest that IGFBP-2, a leptin-regulated protein, may be an in-vivo marker of leptin action. If this is the case, an early improvement of leptin sensitivity might contribute to the anorectic effect of gastric bypass.
    47 schema:genre research_article
    48 schema:inLanguage en
    49 schema:isAccessibleForFree false
    50 schema:isPartOf sg:journal.1112251
    51 schema:name Serum IGF-binding protein 2 (IGFBP-2) concentrations change early after gastric bypass bariatric surgery revealing a possible marker of leptin sensitivity in obese subjects.
    52 schema:productId N731d774188eb4a588485d3d87ca12748
    53 N88f122acfdaf48858822394fe070f23b
    54 Na2f1a0b3f53c4110a52ee6e6a32f3fd6
    55 Necbc6ec7bd1143509595fcc1d92d3d2a
    56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113182481
    57 https://doi.org/10.1007/s12020-019-01915-y
    58 schema:sdDatePublished 2019-04-11T13:53
    59 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    60 schema:sdPublisher N69caad87e38b452e96a3a0a0c50921e3
    61 schema:url http://link.springer.com/10.1007/s12020-019-01915-y
    62 sgo:license sg:explorer/license/
    63 sgo:sdDataset articles
    64 rdf:type schema:ScholarlyArticle
    65 N0ce2649312e74f58906a264e3e445c19 rdf:first Ncce9a431cf5c4e0dba31fddc4dfbdee0
    66 rdf:rest Nc02edf43686f4d098da5568e15879e9d
    67 N2bbbed93ed6a4af0b1d52b5a072fbd8b schema:affiliation https://www.grid.ac/institutes/grid.144189.1
    68 schema:familyName Moretto
    69 schema:givenName Carlo
    70 rdf:type schema:Person
    71 N2e18f4fce29349719d45524e9eaed527 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
    72 schema:familyName Marioni
    73 schema:givenName Antonio
    74 rdf:type schema:Person
    75 N4828bd6271a2474ab4f022f3d8b18c51 rdf:first N2e18f4fce29349719d45524e9eaed527
    76 rdf:rest Ndd6fea583573474f9fb8f03e687b7392
    77 N50f8aaf727c44b7487d0df991485befc rdf:first Ncede5b9a1a634cab9716c460ec795be0
    78 rdf:rest Nfe64bd916a434772b12ad7d0d56f2b6f
    79 N600d52c40ebe44e4ac2e75db8e726c43 schema:affiliation https://www.grid.ac/institutes/grid.418529.3
    80 schema:familyName Maffei
    81 schema:givenName Margherita
    82 rdf:type schema:Person
    83 N662dfd98566c4e2f8b5a4be804764df8 rdf:first N74127fd66aae47b68e69e9bf1d5f031c
    84 rdf:rest N87617ed878cb49ceb08cb113385c6173
    85 N6846c3f35cf441e7a6db2b0885eab9ae rdf:first N68e0c792f2cf409f8a3a473c9113195d
    86 rdf:rest rdf:nil
    87 N68e0c792f2cf409f8a3a473c9113195d schema:affiliation https://www.grid.ac/institutes/grid.144189.1
    88 schema:familyName Santini
    89 schema:givenName Ferruccio
    90 rdf:type schema:Person
    91 N69caad87e38b452e96a3a0a0c50921e3 schema:name Springer Nature - SN SciGraph project
    92 rdf:type schema:Organization
    93 N731d774188eb4a588485d3d87ca12748 schema:name pubmed_id
    94 schema:value 30945111
    95 rdf:type schema:PropertyValue
    96 N74127fd66aae47b68e69e9bf1d5f031c schema:affiliation https://www.grid.ac/institutes/grid.419635.c
    97 schema:familyName Piaggi
    98 schema:givenName Paolo
    99 rdf:type schema:Person
    100 N7a02aae947554da785bdaf54a2d608f2 rdf:first N861605f8211a4c52a6a9cd274ba99339
    101 rdf:rest N90f9ea7ee9e84f44ae4d10b218a73fb5
    102 N7aeccf872b6545afbc78bad6e8a49368 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
    103 schema:familyName Ferrari
    104 schema:givenName Federica
    105 rdf:type schema:Person
    106 N7c2d64dc503c44fa9129475d91bf8ed6 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
    107 schema:familyName Buccianti
    108 schema:givenName Piero
    109 rdf:type schema:Person
    110 N861605f8211a4c52a6a9cd274ba99339 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
    111 schema:familyName Pelosini
    112 schema:givenName Caterina
    113 rdf:type schema:Person
    114 N87617ed878cb49ceb08cb113385c6173 rdf:first N600d52c40ebe44e4ac2e75db8e726c43
    115 rdf:rest N6846c3f35cf441e7a6db2b0885eab9ae
    116 N88f122acfdaf48858822394fe070f23b schema:name dimensions_id
    117 schema:value pub.1113182481
    118 rdf:type schema:PropertyValue
    119 N900fd14fa2df40519d7fd77380cfdc37 rdf:first Ncc3251bd9db44fb29be2b5a73b0f2273
    120 rdf:rest N7a02aae947554da785bdaf54a2d608f2
    121 N90f9ea7ee9e84f44ae4d10b218a73fb5 rdf:first N7aeccf872b6545afbc78bad6e8a49368
    122 rdf:rest N50f8aaf727c44b7487d0df991485befc
    123 N9b000b6ab3bd4337922cf253acae7041 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
    124 schema:familyName Vitti
    125 schema:givenName Jacopo
    126 rdf:type schema:Person
    127 Na2f1a0b3f53c4110a52ee6e6a32f3fd6 schema:name nlm_unique_id
    128 schema:value 9434444
    129 rdf:type schema:PropertyValue
    130 Nc02edf43686f4d098da5568e15879e9d rdf:first N2bbbed93ed6a4af0b1d52b5a072fbd8b
    131 rdf:rest N4828bd6271a2474ab4f022f3d8b18c51
    132 Ncc3251bd9db44fb29be2b5a73b0f2273 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
    133 schema:familyName Ceccarini
    134 schema:givenName Giovanni
    135 rdf:type schema:Person
    136 Ncce9a431cf5c4e0dba31fddc4dfbdee0 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
    137 schema:familyName Salvetti
    138 schema:givenName Guido
    139 rdf:type schema:Person
    140 Ncede5b9a1a634cab9716c460ec795be0 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
    141 schema:familyName Magno
    142 schema:givenName Silvia
    143 rdf:type schema:Person
    144 Ndd6fea583573474f9fb8f03e687b7392 rdf:first N7c2d64dc503c44fa9129475d91bf8ed6
    145 rdf:rest N662dfd98566c4e2f8b5a4be804764df8
    146 Necbc6ec7bd1143509595fcc1d92d3d2a schema:name doi
    147 schema:value 10.1007/s12020-019-01915-y
    148 rdf:type schema:PropertyValue
    149 Nfe64bd916a434772b12ad7d0d56f2b6f rdf:first N9b000b6ab3bd4337922cf253acae7041
    150 rdf:rest N0ce2649312e74f58906a264e3e445c19
    151 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    152 schema:name Medical and Health Sciences
    153 rdf:type schema:DefinedTerm
    154 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    155 schema:name Clinical Sciences
    156 rdf:type schema:DefinedTerm
    157 sg:journal.1112251 schema:issn 1355-008X
    158 1559-0100
    159 schema:name Endocrine
    160 rdf:type schema:Periodical
    161 sg:pub.10.1007/s00464-014-3829-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042011243
    162 https://doi.org/10.1007/s00464-014-3829-7
    163 rdf:type schema:CreativeWork
    164 sg:pub.10.1007/s00592-009-0142-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044775493
    165 https://doi.org/10.1007/s00592-009-0142-3
    166 rdf:type schema:CreativeWork
    167 sg:pub.10.1007/s13277-015-4561-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002031398
    168 https://doi.org/10.1007/s13277-015-4561-1
    169 rdf:type schema:CreativeWork
    170 sg:pub.10.1007/s40618-014-0225-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1015150812
    171 https://doi.org/10.1007/s40618-014-0225-z
    172 rdf:type schema:CreativeWork
    173 sg:pub.10.1038/ijo.2008.244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005274660
    174 https://doi.org/10.1038/ijo.2008.244
    175 rdf:type schema:CreativeWork
    176 sg:pub.10.1038/ijo.2010.132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043193435
    177 https://doi.org/10.1038/ijo.2010.132
    178 rdf:type schema:CreativeWork
    179 sg:pub.10.1038/ijo.2014.189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047409115
    180 https://doi.org/10.1038/ijo.2014.189
    181 rdf:type schema:CreativeWork
    182 sg:pub.10.1038/ijo.2014.192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037078176
    183 https://doi.org/10.1038/ijo.2014.192
    184 rdf:type schema:CreativeWork
    185 sg:pub.10.1038/ijosup.2016.9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025953710
    186 https://doi.org/10.1038/ijosup.2016.9
    187 rdf:type schema:CreativeWork
    188 sg:pub.10.1038/nrendo.2016.222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083862276
    189 https://doi.org/10.1038/nrendo.2016.222
    190 rdf:type schema:CreativeWork
    191 sg:pub.10.1038/nrgastro.2011.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028779330
    192 https://doi.org/10.1038/nrgastro.2011.112
    193 rdf:type schema:CreativeWork
    194 sg:pub.10.1038/onc.2012.630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046393118
    195 https://doi.org/10.1038/onc.2012.630
    196 rdf:type schema:CreativeWork
    197 https://doi.org/10.1001/jama.2014.16968 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049238419
    198 rdf:type schema:CreativeWork
    199 https://doi.org/10.1002/(sici)1520-7560(199909/10)15:5<314::aid-dmrr56>3.0.co;2-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1020678080
    200 rdf:type schema:CreativeWork
    201 https://doi.org/10.1002/oby.20433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045038670
    202 rdf:type schema:CreativeWork
    203 https://doi.org/10.1016/j.atherosclerosis.2014.09.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006971036
    204 rdf:type schema:CreativeWork
    205 https://doi.org/10.1016/j.beem.2015.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023164446
    206 rdf:type schema:CreativeWork
    207 https://doi.org/10.1016/j.cmet.2009.11.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015576745
    208 rdf:type schema:CreativeWork
    209 https://doi.org/10.1016/j.cmet.2013.07.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049735979
    210 rdf:type schema:CreativeWork
    211 https://doi.org/10.1016/j.physbeh.2008.04.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044270768
    212 rdf:type schema:CreativeWork
    213 https://doi.org/10.1016/j.soard.2016.01.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026092109
    214 rdf:type schema:CreativeWork
    215 https://doi.org/10.1016/j.tem.2009.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027892322
    216 rdf:type schema:CreativeWork
    217 https://doi.org/10.1038/oby.2012.90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031231273
    218 rdf:type schema:CreativeWork
    219 https://doi.org/10.1055/s-0030-1262854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057227016
    220 rdf:type schema:CreativeWork
    221 https://doi.org/10.1073/pnas.0706473105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021655042
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.1161/circgenetics.113.000490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049539329
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1172/jci19511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416497
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1177/193229681100500536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020994341
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1210/en.2008-0770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064249539
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1210/en.2013-1236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064251933
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1210/en.2013-1622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064252053
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1210/en.2013-2099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064252241
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1210/endo.135.5.7525256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064279526
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1210/jc.2004-0433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064287777
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1210/jc.2006-0745 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064289262
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1210/me.2008-0168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064328180
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1371/journal.pone.0139960 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051872933
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1677/jme.1.01955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028791477
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.2302/kjm.60.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031420580
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.2337/db06-0436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049056737
    252 rdf:type schema:CreativeWork
    253 https://www.grid.ac/institutes/grid.144189.1 schema:alternateName Azienda Ospedaliera Universitaria Pisana
    254 schema:name Obesity Center, Endocrinology Unit, University Hospital of Pisa, Pisa, Italy.
    255 Obesity Center, Endocrinology Unit, University Hospital of Pisa, Pisa, Italy. giovanni.ceccarini@unipi.it.
    256 Unit of Bariatric Surgery, University Hospital of Pisa, Pisa, Italy.
    257 Unit of Surgery, University Hospital of Pisa, Pisa, Italy.
    258 rdf:type schema:Organization
    259 https://www.grid.ac/institutes/grid.418529.3 schema:alternateName Istituto di Fisiologia Clinica
    260 schema:name Institute of Clinical Physiology, Italian National Research Council, Pisa, Italy.
    261 Obesity Center, Endocrinology Unit, University Hospital of Pisa, Pisa, Italy.
    262 rdf:type schema:Organization
    263 https://www.grid.ac/institutes/grid.419635.c schema:alternateName National Institute of Diabetes and Digestive and Kidney Diseases
    264 schema:name National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, United States.
    265 Obesity Center, Endocrinology Unit, University Hospital of Pisa, Pisa, Italy.
    266 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...