Is serum TSH a biomarker of thyroid carcinoma in patients residing in a mildly iodine-deficient area? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-08

AUTHORS

Kristine Zøylner Swan, Viveque Egsgaard Nielsen, Christian Godballe, Jens Faunø Thrane, Marie Riis Mortensen, Sten Schytte, Henrik Baymler Pedersen, Peer Christiansen, Steen Joop Bonnema

ABSTRACT

PURPOSE: To investigate the association between the pre-operative serum TSH (s-TSH) level and differentiated thyroid carcinoma (DTC) in a mildly iodine-deficient area. METHODS: Patients undergoing surgery for thyroid nodular disease (TND) were included from three tertiary surgical departments. Data were collected from a national thyroid surgery database (THYKIR) and from patient charts. Individuals with overtly coexisting thyroid disorders were excluded for subgroup analyses. Patients were compared with the Danish background population, employing previous data from DanThyr, a study initiated to monitor the iodine fortification program in Denmark. RESULTS: Nine-hundred ninety-eight patients [cases/controls: 265/733; female/male: 794/204; age (mean ± SD): 51 ± 15 years] were included. S-TSH was significantly higher in the DTC group [median (IQR): 1.3 (0.9-1.9 mIU/L)] compared with the benign TND group [0.9 (0.6-1.5 mIU/L)] (p < 0.0001). The median s-TSH in the background population was similar to that found among DTC patients (p = 1.00), but markedly higher than the s-TSH level in the benign TND group (p < 0.0001). There was no association between s-TSH and DTC disease stage (p = 0.08-0.87). CONCLUSIONS: s-TSH was significantly higher in patients with DTC than in those with benign TND. However, this difference can be explained by abnormally lower s-TSH level in the latter group, probably caused by subtle nodular functional autonomy. Due to the huge overlap and the small difference in median s-TSH between patients with benign and malignant TND, s-TSH is not suitable as a biomarker of DTC in a clinical setting. More... »

PAGES

308-316

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12020-018-1637-x

DOI

http://dx.doi.org/10.1007/s12020-018-1637-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104331774

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29855783


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Aarhus University", 
          "id": "https://www.grid.ac/institutes/grid.7048.b", 
          "name": [
            "Department of Oto-rhino-laryngology (ORL) Head & Neck Surgery, Aarhus University Hospital, N\u00f8rrebrogade 44, 8000, Aarhus C, Denmark", 
            "Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 82, 8200, Aarhus N, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Swan", 
        "givenName": "Kristine Z\u00f8ylner", 
        "id": "sg:person.012145242205.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012145242205.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aarhus University", 
          "id": "https://www.grid.ac/institutes/grid.7048.b", 
          "name": [
            "Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 82, 8200, Aarhus N, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nielsen", 
        "givenName": "Viveque Egsgaard", 
        "id": "sg:person.0632755103.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632755103.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Odense University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.7143.1", 
          "name": [
            "Department of ORL Head & Neck Surgery, Odense University Hospital, J.B. Winsl\u00f8ws Vej 4, 5000, Odense C, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Godballe", 
        "givenName": "Christian", 
        "id": "sg:person.01176557152.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176557152.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aalborg Hospital", 
          "id": "https://www.grid.ac/institutes/grid.27530.33", 
          "name": [
            "Department of Oto-rhino-laryngology (ORL) Head & Neck Surgery, Aarhus University Hospital, N\u00f8rrebrogade 44, 8000, Aarhus C, Denmark", 
            "Department of ORL Head & Neck Surgery, Aalborg University Hospital, Hobrovej 18-22, 9000, Aalborg, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thrane", 
        "givenName": "Jens Faun\u00f8", 
        "id": "sg:person.016226616472.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016226616472.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Odense University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.7143.1", 
          "name": [
            "Department of Endocrinology, Odense University Hospital, Kl\u00f8verv\u00e6nget 6, 5000, Odense C, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mortensen", 
        "givenName": "Marie Riis", 
        "id": "sg:person.0603350474.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603350474.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aarhus University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.154185.c", 
          "name": [
            "Department of Oto-rhino-laryngology (ORL) Head & Neck Surgery, Aarhus University Hospital, N\u00f8rrebrogade 44, 8000, Aarhus C, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schytte", 
        "givenName": "Sten", 
        "id": "sg:person.01314665701.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314665701.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aalborg Hospital", 
          "id": "https://www.grid.ac/institutes/grid.27530.33", 
          "name": [
            "Department of ORL Head & Neck Surgery, Aalborg University Hospital, Hobrovej 18-22, 9000, Aalborg, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pedersen", 
        "givenName": "Henrik Baymler", 
        "id": "sg:person.012115444322.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012115444322.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aarhus University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.154185.c", 
          "name": [
            "Department of Plastic and Breast surgery, Aarhus University Hospital, N\u00f8rrebrogade 44, 8000, Aarhus C, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Christiansen", 
        "givenName": "Peer", 
        "id": "sg:person.0620270652.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620270652.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Odense University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.7143.1", 
          "name": [
            "Department of Endocrinology, Odense University Hospital, Kl\u00f8verv\u00e6nget 6, 5000, Odense C, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bonnema", 
        "givenName": "Steen Joop", 
        "id": "sg:person.01243162517.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243162517.49"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1056/nejmcp031436", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005004234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/thy.2015.0020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007626247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ecl.2014.02.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008205579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.amjoto.2012.12.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009273417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.amjoto.2012.12.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009273417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0007114514003225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012514407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hed.23252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012655418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.endonu.2014.06.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014385193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ando.2011.07.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018330672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2265.2000.01121.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024040165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3402/fnr.v60.31969", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028082397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/dju097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028653030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00405-009-0949-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032677715", 
          "https://doi.org/10.1007/s00405-009-0949-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00405-009-0949-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032677715", 
          "https://doi.org/10.1007/s00405-009-0949-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00405-009-0949-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032677715", 
          "https://doi.org/10.1007/s00405-009-0949-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12262-014-1084-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034437569", 
          "https://doi.org/10.1007/s12262-014-1084-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.9201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036292604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/erc-09-0036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039694554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/er.2002-0016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040557635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(08)61005-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043851063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2265.2008.03241.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048170590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(03)12488-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049412081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2265.1993.tb02365.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049650914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/105072502320908295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059204266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/edrv.22.5.0444", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064238545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2003-031641", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064287350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2006-0527", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064289193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2007-2215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064290318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2012-1083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064293404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2012-2508", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064293742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2014-2438", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064295292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem.87.2.8182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064324901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-159-5-201309030-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073713841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1055-9965.epi-16-0845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084513118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1055-9965.epi-16-0845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084513118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/1450-1147.207277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085721137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000478927", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091099821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0188123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092735934"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-08", 
    "datePublishedReg": "2018-08-01", 
    "description": "PURPOSE: To investigate the association between the pre-operative serum TSH (s-TSH) level and differentiated thyroid carcinoma (DTC) in a mildly iodine-deficient area.\nMETHODS: Patients undergoing surgery for thyroid nodular disease (TND) were included from three tertiary surgical departments. Data were collected from a national thyroid surgery database (THYKIR) and from patient charts. Individuals with overtly coexisting thyroid disorders were excluded for subgroup analyses. Patients were compared with the Danish background population, employing previous data from DanThyr, a study initiated to monitor the iodine fortification program in Denmark.\nRESULTS: Nine-hundred ninety-eight patients [cases/controls: 265/733; female/male: 794/204; age (mean\u2009\u00b1\u2009SD): 51\u2009\u00b1\u200915 years] were included. S-TSH was significantly higher in the DTC group [median (IQR): 1.3 (0.9-1.9\u2009mIU/L)] compared with the benign TND group [0.9 (0.6-1.5 mIU/L)] (p\u2009<\u20090.0001). The median s-TSH in the background population was similar to that found among DTC patients (p\u2009=\u20091.00), but markedly higher than the s-TSH level in the benign TND group (p\u2009<\u20090.0001). There was no association between s-TSH and DTC disease stage (p\u2009=\u20090.08-0.87).\nCONCLUSIONS: s-TSH was significantly higher in patients with DTC than in those with benign TND. However, this difference can be explained by abnormally lower s-TSH level in the latter group, probably caused by subtle nodular functional autonomy. Due to the huge overlap and the small difference in median s-TSH between patients with benign and malignant TND, s-TSH is not suitable as a biomarker of DTC in a clinical setting.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12020-018-1637-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1112251", 
        "issn": [
          "1355-008X", 
          "1559-0100"
        ], 
        "name": "Endocrine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "61"
      }
    ], 
    "name": "Is serum TSH a biomarker of thyroid carcinoma in patients residing in a mildly iodine-deficient area?", 
    "pagination": "308-316", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9bfb009cfd1310624a4a7b605d03a8082c2fc2fd39b40eff9e6db0748e7ab110"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29855783"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9434444"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12020-018-1637-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1104331774"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12020-018-1637-x", 
      "https://app.dimensions.ai/details/publication/pub.1104331774"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000564.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs12020-018-1637-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12020-018-1637-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12020-018-1637-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12020-018-1637-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12020-018-1637-x'


 

This table displays all metadata directly associated to this object as RDF triples.

242 TRIPLES      21 PREDICATES      63 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12020-018-1637-x schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author Nad4f4ef121cd498baeb50eb7d1aaafaf
4 schema:citation sg:pub.10.1007/s00405-009-0949-0
5 sg:pub.10.1007/s12262-014-1084-8
6 https://doi.org/10.1002/hed.23252
7 https://doi.org/10.1016/j.amjoto.2012.12.013
8 https://doi.org/10.1016/j.ando.2011.07.032
9 https://doi.org/10.1016/j.ecl.2014.02.012
10 https://doi.org/10.1016/j.endonu.2014.06.002
11 https://doi.org/10.1016/s0140-6736(03)12488-9
12 https://doi.org/10.1016/s0140-6736(08)61005-3
13 https://doi.org/10.1017/s0007114514003225
14 https://doi.org/10.1046/j.1365-2265.2000.01121.x
15 https://doi.org/10.1056/nejmcp031436
16 https://doi.org/10.1089/105072502320908295
17 https://doi.org/10.1089/thy.2015.0020
18 https://doi.org/10.1093/jnci/dju097
19 https://doi.org/10.1111/j.1365-2265.1993.tb02365.x
20 https://doi.org/10.1111/j.1365-2265.2008.03241.x
21 https://doi.org/10.1158/1055-9965.epi-16-0845
22 https://doi.org/10.1159/000478927
23 https://doi.org/10.1210/edrv.22.5.0444
24 https://doi.org/10.1210/er.2002-0016
25 https://doi.org/10.1210/jc.2003-031641
26 https://doi.org/10.1210/jc.2006-0527
27 https://doi.org/10.1210/jc.2007-2215
28 https://doi.org/10.1210/jc.2012-1083
29 https://doi.org/10.1210/jc.2012-2508
30 https://doi.org/10.1210/jc.2014-2438
31 https://doi.org/10.1210/jcem.87.2.8182
32 https://doi.org/10.1371/journal.pone.0188123
33 https://doi.org/10.1677/erc-09-0036
34 https://doi.org/10.18632/oncotarget.9201
35 https://doi.org/10.3402/fnr.v60.31969
36 https://doi.org/10.4103/1450-1147.207277
37 https://doi.org/10.7326/0003-4819-159-5-201309030-00006
38 schema:datePublished 2018-08
39 schema:datePublishedReg 2018-08-01
40 schema:description PURPOSE: To investigate the association between the pre-operative serum TSH (s-TSH) level and differentiated thyroid carcinoma (DTC) in a mildly iodine-deficient area. METHODS: Patients undergoing surgery for thyroid nodular disease (TND) were included from three tertiary surgical departments. Data were collected from a national thyroid surgery database (THYKIR) and from patient charts. Individuals with overtly coexisting thyroid disorders were excluded for subgroup analyses. Patients were compared with the Danish background population, employing previous data from DanThyr, a study initiated to monitor the iodine fortification program in Denmark. RESULTS: Nine-hundred ninety-eight patients [cases/controls: 265/733; female/male: 794/204; age (mean ± SD): 51 ± 15 years] were included. S-TSH was significantly higher in the DTC group [median (IQR): 1.3 (0.9-1.9 mIU/L)] compared with the benign TND group [0.9 (0.6-1.5 mIU/L)] (p < 0.0001). The median s-TSH in the background population was similar to that found among DTC patients (p = 1.00), but markedly higher than the s-TSH level in the benign TND group (p < 0.0001). There was no association between s-TSH and DTC disease stage (p = 0.08-0.87). CONCLUSIONS: s-TSH was significantly higher in patients with DTC than in those with benign TND. However, this difference can be explained by abnormally lower s-TSH level in the latter group, probably caused by subtle nodular functional autonomy. Due to the huge overlap and the small difference in median s-TSH between patients with benign and malignant TND, s-TSH is not suitable as a biomarker of DTC in a clinical setting.
41 schema:genre research_article
42 schema:inLanguage en
43 schema:isAccessibleForFree false
44 schema:isPartOf N00ec76a009e04f5da58546e0664a8a35
45 N52e541c87a424e3abe9b3e50eb626f7e
46 sg:journal.1112251
47 schema:name Is serum TSH a biomarker of thyroid carcinoma in patients residing in a mildly iodine-deficient area?
48 schema:pagination 308-316
49 schema:productId N14a6d0bdab2642afa4e00ac84581671e
50 N62f6cf94300d4688b94533f00d044f52
51 N805ace14909847a9889cab8566776d2c
52 Necaf66b2bcbc4ed9b999bfb180afee31
53 Nf8afe9e7e914474383cc23353dcd6621
54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104331774
55 https://doi.org/10.1007/s12020-018-1637-x
56 schema:sdDatePublished 2019-04-10T13:27
57 schema:sdLicense https://scigraph.springernature.com/explorer/license/
58 schema:sdPublisher N9ca0b0fe5f3d4a0496cc03f3312e61d9
59 schema:url https://link.springer.com/10.1007%2Fs12020-018-1637-x
60 sgo:license sg:explorer/license/
61 sgo:sdDataset articles
62 rdf:type schema:ScholarlyArticle
63 N00ec76a009e04f5da58546e0664a8a35 schema:issueNumber 2
64 rdf:type schema:PublicationIssue
65 N0618fb9378034ef09025b880a59047b6 rdf:first sg:person.012115444322.23
66 rdf:rest Nec60859b155b456194cc54b5322d21c7
67 N14a6d0bdab2642afa4e00ac84581671e schema:name readcube_id
68 schema:value 9bfb009cfd1310624a4a7b605d03a8082c2fc2fd39b40eff9e6db0748e7ab110
69 rdf:type schema:PropertyValue
70 N3891dae7e2934575b734606244dc8426 rdf:first sg:person.0632755103.00
71 rdf:rest Nc4db4bf92b9544ecb01dfdc33d503b4a
72 N522e753a9d3c49629eb6e61fbbb67061 rdf:first sg:person.0603350474.04
73 rdf:rest N6b1df73ed6584886b44446c2914eeecd
74 N52e541c87a424e3abe9b3e50eb626f7e schema:volumeNumber 61
75 rdf:type schema:PublicationVolume
76 N55046fa190a24589afadb43a7dbd5b05 rdf:first sg:person.016226616472.90
77 rdf:rest N522e753a9d3c49629eb6e61fbbb67061
78 N62f6cf94300d4688b94533f00d044f52 schema:name pubmed_id
79 schema:value 29855783
80 rdf:type schema:PropertyValue
81 N6b1df73ed6584886b44446c2914eeecd rdf:first sg:person.01314665701.01
82 rdf:rest N0618fb9378034ef09025b880a59047b6
83 N776af94c7679490e8c04e73ebff88aa6 rdf:first sg:person.01243162517.49
84 rdf:rest rdf:nil
85 N805ace14909847a9889cab8566776d2c schema:name nlm_unique_id
86 schema:value 9434444
87 rdf:type schema:PropertyValue
88 N9ca0b0fe5f3d4a0496cc03f3312e61d9 schema:name Springer Nature - SN SciGraph project
89 rdf:type schema:Organization
90 Nad4f4ef121cd498baeb50eb7d1aaafaf rdf:first sg:person.012145242205.28
91 rdf:rest N3891dae7e2934575b734606244dc8426
92 Nc4db4bf92b9544ecb01dfdc33d503b4a rdf:first sg:person.01176557152.13
93 rdf:rest N55046fa190a24589afadb43a7dbd5b05
94 Nec60859b155b456194cc54b5322d21c7 rdf:first sg:person.0620270652.90
95 rdf:rest N776af94c7679490e8c04e73ebff88aa6
96 Necaf66b2bcbc4ed9b999bfb180afee31 schema:name dimensions_id
97 schema:value pub.1104331774
98 rdf:type schema:PropertyValue
99 Nf8afe9e7e914474383cc23353dcd6621 schema:name doi
100 schema:value 10.1007/s12020-018-1637-x
101 rdf:type schema:PropertyValue
102 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
103 schema:name Medical and Health Sciences
104 rdf:type schema:DefinedTerm
105 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
106 schema:name Clinical Sciences
107 rdf:type schema:DefinedTerm
108 sg:journal.1112251 schema:issn 1355-008X
109 1559-0100
110 schema:name Endocrine
111 rdf:type schema:Periodical
112 sg:person.01176557152.13 schema:affiliation https://www.grid.ac/institutes/grid.7143.1
113 schema:familyName Godballe
114 schema:givenName Christian
115 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176557152.13
116 rdf:type schema:Person
117 sg:person.012115444322.23 schema:affiliation https://www.grid.ac/institutes/grid.27530.33
118 schema:familyName Pedersen
119 schema:givenName Henrik Baymler
120 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012115444322.23
121 rdf:type schema:Person
122 sg:person.012145242205.28 schema:affiliation https://www.grid.ac/institutes/grid.7048.b
123 schema:familyName Swan
124 schema:givenName Kristine Zøylner
125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012145242205.28
126 rdf:type schema:Person
127 sg:person.01243162517.49 schema:affiliation https://www.grid.ac/institutes/grid.7143.1
128 schema:familyName Bonnema
129 schema:givenName Steen Joop
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243162517.49
131 rdf:type schema:Person
132 sg:person.01314665701.01 schema:affiliation https://www.grid.ac/institutes/grid.154185.c
133 schema:familyName Schytte
134 schema:givenName Sten
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314665701.01
136 rdf:type schema:Person
137 sg:person.016226616472.90 schema:affiliation https://www.grid.ac/institutes/grid.27530.33
138 schema:familyName Thrane
139 schema:givenName Jens Faunø
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016226616472.90
141 rdf:type schema:Person
142 sg:person.0603350474.04 schema:affiliation https://www.grid.ac/institutes/grid.7143.1
143 schema:familyName Mortensen
144 schema:givenName Marie Riis
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603350474.04
146 rdf:type schema:Person
147 sg:person.0620270652.90 schema:affiliation https://www.grid.ac/institutes/grid.154185.c
148 schema:familyName Christiansen
149 schema:givenName Peer
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620270652.90
151 rdf:type schema:Person
152 sg:person.0632755103.00 schema:affiliation https://www.grid.ac/institutes/grid.7048.b
153 schema:familyName Nielsen
154 schema:givenName Viveque Egsgaard
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632755103.00
156 rdf:type schema:Person
157 sg:pub.10.1007/s00405-009-0949-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032677715
158 https://doi.org/10.1007/s00405-009-0949-0
159 rdf:type schema:CreativeWork
160 sg:pub.10.1007/s12262-014-1084-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034437569
161 https://doi.org/10.1007/s12262-014-1084-8
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1002/hed.23252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012655418
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1016/j.amjoto.2012.12.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009273417
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1016/j.ando.2011.07.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018330672
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1016/j.ecl.2014.02.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008205579
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1016/j.endonu.2014.06.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014385193
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1016/s0140-6736(03)12488-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049412081
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1016/s0140-6736(08)61005-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043851063
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1017/s0007114514003225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012514407
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1046/j.1365-2265.2000.01121.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024040165
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1056/nejmcp031436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005004234
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1089/105072502320908295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059204266
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1089/thy.2015.0020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007626247
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1093/jnci/dju097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028653030
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1111/j.1365-2265.1993.tb02365.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049650914
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1111/j.1365-2265.2008.03241.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048170590
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1158/1055-9965.epi-16-0845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084513118
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1159/000478927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091099821
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1210/edrv.22.5.0444 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064238545
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1210/er.2002-0016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040557635
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1210/jc.2003-031641 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064287350
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1210/jc.2006-0527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064289193
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1210/jc.2007-2215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064290318
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1210/jc.2012-1083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064293404
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1210/jc.2012-2508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064293742
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1210/jc.2014-2438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064295292
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1210/jcem.87.2.8182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064324901
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1371/journal.pone.0188123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092735934
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1677/erc-09-0036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039694554
218 rdf:type schema:CreativeWork
219 https://doi.org/10.18632/oncotarget.9201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036292604
220 rdf:type schema:CreativeWork
221 https://doi.org/10.3402/fnr.v60.31969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028082397
222 rdf:type schema:CreativeWork
223 https://doi.org/10.4103/1450-1147.207277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085721137
224 rdf:type schema:CreativeWork
225 https://doi.org/10.7326/0003-4819-159-5-201309030-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073713841
226 rdf:type schema:CreativeWork
227 https://www.grid.ac/institutes/grid.154185.c schema:alternateName Aarhus University Hospital
228 schema:name Department of Oto-rhino-laryngology (ORL) Head & Neck Surgery, Aarhus University Hospital, Nørrebrogade 44, 8000, Aarhus C, Denmark
229 Department of Plastic and Breast surgery, Aarhus University Hospital, Nørrebrogade 44, 8000, Aarhus C, Denmark
230 rdf:type schema:Organization
231 https://www.grid.ac/institutes/grid.27530.33 schema:alternateName Aalborg Hospital
232 schema:name Department of ORL Head & Neck Surgery, Aalborg University Hospital, Hobrovej 18-22, 9000, Aalborg, Denmark
233 Department of Oto-rhino-laryngology (ORL) Head & Neck Surgery, Aarhus University Hospital, Nørrebrogade 44, 8000, Aarhus C, Denmark
234 rdf:type schema:Organization
235 https://www.grid.ac/institutes/grid.7048.b schema:alternateName Aarhus University
236 schema:name Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 82, 8200, Aarhus N, Denmark
237 Department of Oto-rhino-laryngology (ORL) Head & Neck Surgery, Aarhus University Hospital, Nørrebrogade 44, 8000, Aarhus C, Denmark
238 rdf:type schema:Organization
239 https://www.grid.ac/institutes/grid.7143.1 schema:alternateName Odense University Hospital
240 schema:name Department of Endocrinology, Odense University Hospital, Kløvervænget 6, 5000, Odense C, Denmark
241 Department of ORL Head & Neck Surgery, Odense University Hospital, J.B. Winsløws Vej 4, 5000, Odense C, Denmark
242 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...