Fatty liver as a risk factor for progression from metabolically healthy to metabolically abnormal in non-overweight individuals View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-05-16

AUTHORS

Yoshitaka Hashimoto, Masahide Hamaguchi, Takuya Fukuda, Akihiro Ohbora, Takao Kojima, Michiaki Fukui

ABSTRACT

PurposeRecent studies identified that metabolically abnormal non-obese phenotype is a risk factor for cardiovascular diseases. However, little is known about risk factor for progression from metabolically healthy non-overweight to metabolically abnormal phenotype. We hypothesized that fatty liver had a clinical impact on progression from metabolically healthy non-overweight to metabolically abnormal phenotype.MethodsIn this retrospective cohort study, 14,093 Japanese (7557 men and 6736 women), who received the health-checkup program from 2004 to 2012, were enrolled. Overweight and obesity were defined as body mass index 23.0–25.0 and ≥25.0 kg/m2. Four metabolic factors (impaired fasting glucose, hypertension, hypertriglyceridemia and low high density lipoprotein-cholesterol concentration) were used for definition of metabolically healthy (less than two factors) or metabolically abnormal (two or more). We divided the participants into three groups: metabolically healthy non-overweight (9755 individuals, men/women = 4290/5465), metabolically healthy overweight (2547 individuals, 1800/747) and metabolically healthy obesity (1791 individuals, 1267/524). Fatty liver was diagnosed by ultrasonography.ResultsOver the median follow-up period of 5.3 years, 873 metabolically healthy non-overweight, 512 metabolically healthy overweight and 536 metabolically healthy obesity individuals progressed to metabolically abnormal. The adjusted hazard risks of fatty liver on progression were 1.49 (95% confidence interval 1.20–1.83, p = 0.005) in metabolically healthy non-overweight, 1.37 (1.12–1.66, p = 0.002) in metabolically healthy overweight and 1.38 (1.15–1.66, p < 0.001) in metabolically healthy obesity, after adjusting for age, sex, alcohol, smoking, exercise, impaired fasting glucose, hypertension, hypertriglyceridemia, low high density lipoprotein-cholesterol concentration, and abdominal obesity.ConclusionsFatty liver is an independent risk factor for progression from metabolically healthy status to metabolically abnormal phenotype, even in non-overweight individuals. More... »

PAGES

89-97

References to SciGraph publications

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  • 2007-05-17. Light to Moderate Alcohol Consumption Is Associated With Lower Frequency of Hypertransaminasemia in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
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  • 2007-09-25. The Severity of Ultrasonographic Findings in Nonalcoholic Fatty Liver Disease Reflects the Metabolic Syndrome and Visceral Fat Accumulation in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2015-04-29. Visceral abdominal fat accumulation predicts the conversion of metabolically healthy obese subjects to an unhealthy phenotype in INTERNATIONAL JOURNAL OF OBESITY
  • 2014-10-02. Association of physical activity with lower type 2 diabetes incidence is weaker among individuals at high genetic risk in DIABETOLOGIA
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    http://scigraph.springernature.com/pub.10.1007/s12020-017-1313-6

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    http://dx.doi.org/10.1007/s12020-017-1313-6

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    https://www.ncbi.nlm.nih.gov/pubmed/28508194


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