Imaging of diabetic bone View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-03-14

AUTHORS

Federico Ponti, Sara Guerri, Claudia Sassi, Giuseppe Battista, Giuseppe Guglielmi, Alberto Bazzocchi

ABSTRACT

Diabetes is an important concern in terms of medical and socioeconomic costs; a high risk for low-trauma fractures has been reported in patients with both type 1 and type 2 diabetes. The mechanism involved in the increased fracture risk from diabetes is highly complex and still not entirely understood; obesity could play an important role: recent evidence suggests that the influence of fat on bone is mainly dependent on the pattern of regional fat deposition and that an increased amount of visceral adipose tissue negatively affects skeletal health.Correct and timely individuation of people with high fracture risk is critical for both prevention and treatment: Dual-energy X-ray Absorptiometry (currently the “gold standard” for diagnosis of osteoporosis) underestimates fracture risk in diabetic patients and therefore is not sufficient by itself to investigate bone status. This paper is focused on imaging, covering different modalities involved in the evaluation of skeletal deterioration in diabetes, discussing the limitations of conventional methods and exploring the potential of new tools and recent high-resolution techniques, with the intent to provide interesting insight into pathophysiology and fracture risk. More... »

PAGES

426-441

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12020-017-1278-5

    DOI

    http://dx.doi.org/10.1007/s12020-017-1278-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1084033724

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28293856


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