Cancerous leptomeningitis and familial congenital hypopituitarism View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-05

AUTHORS

S. Vujovic, S. Vujosevic, S. Kavaric, J. Sopta, M. Ivovic, A. Saveanu, T. Brue, M. Korbonits, V. Popovic

ABSTRACT

People are at higher risk of cancer as they get older or have a strong family history of cancer. The potential influence of environmental and behavioral factors remains poorly understood. Earlier population and case control studies reported that upper quartile of circulating IGF-I is associated with a higher risk of developing cancer suggesting possible involvement of the growth hormone (GH)/IGF system in initiation or progression of cancer. Since GH therapy increases IGF-1 levels, there have been concerns that GH therapy in hypopituitarism might increase the risk of cancer. We report a 42-year-old female patient who presented with subacute onset of symptoms of meningitis and with the absence of fever which resulted in death 70 days after the onset of symptoms. The patient together with her younger brother was diagnosed at the age of 5 years with familial congenital hypopituitarism, due to homozygous mutation c.150delA in PROP1 gene. Due to evolving hypopituitarism, she was replaced with thyroxine (from age 5), hydrocortisone (from age 13), GH (from age 13 until 17), and sex steroids in adolescence and adulthood. Her consanguineous family has a prominent history of malignant diseases. Six close relatives had malignant disease including her late maternal aunt with breast cancer. BRCA 1 and BRCA 2 mutational analysis in the patient's mother was negative. Histology after autopsy disclosed advanced ovarian cancer with multiple metastases to the brain, leptomeninges, lungs, heart, and adrenals. Low circulating IGF-1 did not seem to protect this patient from cancer initiation and progression in the context of strong family history of malignancies. More... »

PAGES

231-235

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12020-016-0868-y

DOI

http://dx.doi.org/10.1007/s12020-016-0868-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045160595

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26886902


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fatal Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Growth Hormone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homeodomain Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hormone Replacement Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypopituitarism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Meningeal Carcinomatosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ovarian Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ovary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pedigree", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Clinic of Endocrinology, Clinical Center Serbia and Medical Faculty, University of Belgrade, Dr Subotic Str 13, 11000, Belgrade, Serbia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vujovic", 
        "givenName": "S.", 
        "id": "sg:person.01071135502.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071135502.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Clinical Center of Montenegro and Faculty of Medicine, University of Montenegro, Podgorica, Montenegro"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vujosevic", 
        "givenName": "S.", 
        "id": "sg:person.0736002022.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736002022.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Clinical Center of Montenegro and Faculty of Medicine, University of Montenegro, Podgorica, Montenegro"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kavaric", 
        "givenName": "S.", 
        "id": "sg:person.01034772672.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034772672.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Belgrade", 
          "id": "https://www.grid.ac/institutes/grid.7149.b", 
          "name": [
            "Institute of Pathology, Medical Faculty, University of Belgrade, Belgrade, Serbia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sopta", 
        "givenName": "J.", 
        "id": "sg:person.01164522233.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164522233.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Clinic of Endocrinology, Clinical Center Serbia and Medical Faculty, University of Belgrade, Dr Subotic Str 13, 11000, Belgrade, Serbia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ivovic", 
        "givenName": "M.", 
        "id": "sg:person.01242436411.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242436411.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital de la Conception", 
          "id": "https://www.grid.ac/institutes/grid.411535.7", 
          "name": [
            "Aix-Marseille Universit\u00e9, CNRS, CRN2M UMR 7286, 13344, Marseille Cedex 15, France", 
            "APHM, H\u00f4pital Conception, Service d\u2019Endocrinologie, Diab\u00e8te et Maladies M\u00e9taboliques, Centre de R\u00e9f\u00e9rence des Maladies Rares d\u2019Origine Hypophysaire DEFHY, and Laboratoire de Biologie Moleculaire, GeOneE (Genetique Oncologique et Endocrinienne), 13385, Marseille Cedex 15, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saveanu", 
        "givenName": "A.", 
        "id": "sg:person.01123110416.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123110416.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital de la Conception", 
          "id": "https://www.grid.ac/institutes/grid.411535.7", 
          "name": [
            "Aix-Marseille Universit\u00e9, CNRS, CRN2M UMR 7286, 13344, Marseille Cedex 15, France", 
            "APHM, H\u00f4pital Conception, Service d\u2019Endocrinologie, Diab\u00e8te et Maladies M\u00e9taboliques, Centre de R\u00e9f\u00e9rence des Maladies Rares d\u2019Origine Hypophysaire DEFHY, and Laboratoire de Biologie Moleculaire, GeOneE (Genetique Oncologique et Endocrinienne), 13385, Marseille Cedex 15, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brue", 
        "givenName": "T.", 
        "id": "sg:person.0770445741.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770445741.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Queen Mary University of London", 
          "id": "https://www.grid.ac/institutes/grid.4868.2", 
          "name": [
            "Department of Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, Charterhouse Square, EC1M 6BQ, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Korbonits", 
        "givenName": "M.", 
        "id": "sg:person.01120510730.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120510730.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Clinic of Endocrinology, Clinical Center Serbia and Medical Faculty, University of Belgrade, Dr Subotic Str 13, 11000, Belgrade, Serbia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Popovic", 
        "givenName": "V.", 
        "id": "sg:person.01266470231.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266470231.25"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/bjc.2014.566", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006243155", 
          "https://doi.org/10.1038/bjc.2014.566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2014.566", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006243155", 
          "https://doi.org/10.1038/bjc.2014.566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje-13-0389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010603394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12032-011-0076-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014331652", 
          "https://doi.org/10.1007/s12032-011-0076-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12032-011-0076-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014331652", 
          "https://doi.org/10.1007/s12032-011-0076-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015516287", 
          "https://doi.org/10.1038/nrc1387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015516287", 
          "https://doi.org/10.1038/nrc1387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(04)16044-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015678229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.29210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018963471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje-10-0859", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023068868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/beem.2002.0218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024127634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/beem.2002.0218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024127634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/384327a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024836305", 
          "https://doi.org/10.1038/384327a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027289274", 
          "https://doi.org/10.1038/modpathol.3800306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3800306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027289274", 
          "https://doi.org/10.1038/modpathol.3800306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3001845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027898360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.critrevonc.2013.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028073866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0298-147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030737601", 
          "https://doi.org/10.1038/ng0298-147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep12891", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046819137", 
          "https://doi.org/10.1038/srep12891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddr087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053346363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddr087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053346363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1399-0004.2000.570503.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053406966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2005-0058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064247311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2009-1879", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064291678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2011-2294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064293104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.84.1.50", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064300467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/mco.2015.516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071519287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077181444", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-05", 
    "datePublishedReg": "2016-05-01", 
    "description": "People are at higher risk of cancer as they get older or have a strong family history of cancer. The potential influence of environmental and behavioral factors remains poorly understood. Earlier population and case control studies reported that upper quartile of circulating IGF-I is associated with a higher risk of developing cancer suggesting possible involvement of the growth hormone (GH)/IGF system in initiation or progression of cancer. Since GH therapy increases IGF-1 levels, there have been concerns that GH therapy in hypopituitarism might increase the risk of cancer. We report a 42-year-old female patient who presented with subacute onset of symptoms of meningitis and with the absence of fever which resulted in death 70 days after the onset of symptoms. The patient together with her younger brother was diagnosed at the age of 5 years with familial congenital hypopituitarism, due to homozygous mutation c.150delA in PROP1 gene. Due to evolving hypopituitarism, she was replaced with thyroxine (from age 5), hydrocortisone (from age 13), GH (from age 13 until 17), and sex steroids in adolescence and adulthood. Her consanguineous family has a prominent history of malignant diseases. Six close relatives had malignant disease including her late maternal aunt with breast cancer. BRCA 1 and BRCA 2 mutational analysis in the patient's mother was negative. Histology after autopsy disclosed advanced ovarian cancer with multiple metastases to the brain, leptomeninges, lungs, heart, and adrenals. Low circulating IGF-1 did not seem to protect this patient from cancer initiation and progression in the context of strong family history of malignancies.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12020-016-0868-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1112251", 
        "issn": [
          "1355-008X", 
          "1559-0100"
        ], 
        "name": "Endocrine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "52"
      }
    ], 
    "name": "Cancerous leptomeningitis and familial congenital hypopituitarism", 
    "pagination": "231-235", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d71d75fa85300628a241edaa36f0b59d2e7de8fca5023c474a2c35bf33283807"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26886902"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9434444"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12020-016-0868-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1045160595"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12020-016-0868-y", 
      "https://app.dimensions.ai/details/publication/pub.1045160595"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:49", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000524.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs12020-016-0868-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12020-016-0868-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12020-016-0868-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12020-016-0868-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12020-016-0868-y'


 

This table displays all metadata directly associated to this object as RDF triples.

266 TRIPLES      21 PREDICATES      64 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12020-016-0868-y schema:about N02cd155e6ca440b79a73fb63b196ae69
2 N032371d3659d47c9a6d59dee6e8d16ce
3 N16726fa50c3045eabae9a9600af63719
4 N254ffacb29cd4a9995e9e5d4ac8f4058
5 N2f0103687d3c4855b29b69a3c8007b1a
6 N4ac160094b13484e85b82dbe3dd01c07
7 N87b7ef96b1274093b73c93b9b48b58c2
8 Nb89e98b84d964c8ca6b409d448f61dad
9 Nd715d0133e0f463b819e439f199dc4f3
10 Ndfc81cd7f23a4af0bd09e94e8a45e3aa
11 Ne63b9e778a474bc4a4dff8ad1e24827f
12 Ne77fd43ef84446d6af2777333d677380
13 Neb291ace0d73404a85825900c99f2881
14 anzsrc-for:11
15 anzsrc-for:1103
16 schema:author N73f8ffc9fe4b45958bdd4206153c7084
17 schema:citation sg:pub.10.1007/s12032-011-0076-9
18 sg:pub.10.1038/384327a0
19 sg:pub.10.1038/bjc.2014.566
20 sg:pub.10.1038/modpathol.3800306
21 sg:pub.10.1038/ng0298-147
22 sg:pub.10.1038/nrc1387
23 sg:pub.10.1038/srep12891
24 https://app.dimensions.ai/details/publication/pub.1077181444
25 https://doi.org/10.1002/ijc.29210
26 https://doi.org/10.1016/j.critrevonc.2013.01.005
27 https://doi.org/10.1016/s0140-6736(04)16044-3
28 https://doi.org/10.1034/j.1399-0004.2000.570503.x
29 https://doi.org/10.1053/beem.2002.0218
30 https://doi.org/10.1093/hmg/ddr087
31 https://doi.org/10.1126/scitranslmed.3001845
32 https://doi.org/10.1210/en.2005-0058
33 https://doi.org/10.1210/jc.2009-1879
34 https://doi.org/10.1210/jc.2011-2294
35 https://doi.org/10.1210/jc.84.1.50
36 https://doi.org/10.1530/eje-10-0859
37 https://doi.org/10.1530/eje-13-0389
38 https://doi.org/10.3892/mco.2015.516
39 schema:datePublished 2016-05
40 schema:datePublishedReg 2016-05-01
41 schema:description People are at higher risk of cancer as they get older or have a strong family history of cancer. The potential influence of environmental and behavioral factors remains poorly understood. Earlier population and case control studies reported that upper quartile of circulating IGF-I is associated with a higher risk of developing cancer suggesting possible involvement of the growth hormone (GH)/IGF system in initiation or progression of cancer. Since GH therapy increases IGF-1 levels, there have been concerns that GH therapy in hypopituitarism might increase the risk of cancer. We report a 42-year-old female patient who presented with subacute onset of symptoms of meningitis and with the absence of fever which resulted in death 70 days after the onset of symptoms. The patient together with her younger brother was diagnosed at the age of 5 years with familial congenital hypopituitarism, due to homozygous mutation c.150delA in PROP1 gene. Due to evolving hypopituitarism, she was replaced with thyroxine (from age 5), hydrocortisone (from age 13), GH (from age 13 until 17), and sex steroids in adolescence and adulthood. Her consanguineous family has a prominent history of malignant diseases. Six close relatives had malignant disease including her late maternal aunt with breast cancer. BRCA 1 and BRCA 2 mutational analysis in the patient's mother was negative. Histology after autopsy disclosed advanced ovarian cancer with multiple metastases to the brain, leptomeninges, lungs, heart, and adrenals. Low circulating IGF-1 did not seem to protect this patient from cancer initiation and progression in the context of strong family history of malignancies.
42 schema:genre research_article
43 schema:inLanguage en
44 schema:isAccessibleForFree false
45 schema:isPartOf N760586e41f9344f6ab103f83af038dad
46 Nc2497c8f656a44019924d6670440825e
47 sg:journal.1112251
48 schema:name Cancerous leptomeningitis and familial congenital hypopituitarism
49 schema:pagination 231-235
50 schema:productId N183a9ab404b44b7a95f2c1a7988ca7c1
51 N3b8294cf030140d1a1b190f39730d56c
52 N537ba0677b7748a6a0ec654594c30b1f
53 N7b80328e5c0f407aaff73e81800a70ba
54 N9f932639d86e4cae8d71cdc428ea4a27
55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045160595
56 https://doi.org/10.1007/s12020-016-0868-y
57 schema:sdDatePublished 2019-04-10T20:49
58 schema:sdLicense https://scigraph.springernature.com/explorer/license/
59 schema:sdPublisher Na2ff3339dccf45039e57ccc788fc1b21
60 schema:url http://link.springer.com/10.1007%2Fs12020-016-0868-y
61 sgo:license sg:explorer/license/
62 sgo:sdDataset articles
63 rdf:type schema:ScholarlyArticle
64 N02cd155e6ca440b79a73fb63b196ae69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
65 schema:name Homeodomain Proteins
66 rdf:type schema:DefinedTerm
67 N032371d3659d47c9a6d59dee6e8d16ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Meningeal Carcinomatosis
69 rdf:type schema:DefinedTerm
70 N08ac667d248c46b8af06db037cd8880a rdf:first sg:person.01034772672.69
71 rdf:rest N864d07af4a7446a5b4931464345e11a6
72 N0f54011a0c3249989a349273fc707ec9 schema:name Clinic of Endocrinology, Clinical Center Serbia and Medical Faculty, University of Belgrade, Dr Subotic Str 13, 11000, Belgrade, Serbia
73 rdf:type schema:Organization
74 N16726fa50c3045eabae9a9600af63719 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Ovarian Neoplasms
76 rdf:type schema:DefinedTerm
77 N183a9ab404b44b7a95f2c1a7988ca7c1 schema:name readcube_id
78 schema:value d71d75fa85300628a241edaa36f0b59d2e7de8fca5023c474a2c35bf33283807
79 rdf:type schema:PropertyValue
80 N254ffacb29cd4a9995e9e5d4ac8f4058 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Ovary
82 rdf:type schema:DefinedTerm
83 N2f0103687d3c4855b29b69a3c8007b1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Humans
85 rdf:type schema:DefinedTerm
86 N3b8294cf030140d1a1b190f39730d56c schema:name doi
87 schema:value 10.1007/s12020-016-0868-y
88 rdf:type schema:PropertyValue
89 N4ac160094b13484e85b82dbe3dd01c07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Growth Hormone
91 rdf:type schema:DefinedTerm
92 N537ba0677b7748a6a0ec654594c30b1f schema:name nlm_unique_id
93 schema:value 9434444
94 rdf:type schema:PropertyValue
95 N5d3aaa2ee02f46d599f101780a5d2158 schema:name Clinical Center of Montenegro and Faculty of Medicine, University of Montenegro, Podgorica, Montenegro
96 rdf:type schema:Organization
97 N5d5f580791254e68bcc16d0520335a5d rdf:first sg:person.01266470231.25
98 rdf:rest rdf:nil
99 N6948d4ffb7cb4d2986ccef23a3e3e11e rdf:first sg:person.01242436411.54
100 rdf:rest N7ce6c6c32797433bac68b1c1b5404e0e
101 N73f8ffc9fe4b45958bdd4206153c7084 rdf:first sg:person.01071135502.28
102 rdf:rest Nb1986a639d1b4dd9a1b6ef50105f7ef3
103 N760586e41f9344f6ab103f83af038dad schema:issueNumber 2
104 rdf:type schema:PublicationIssue
105 N7829603be728489d878a0a8791f3b418 rdf:first sg:person.01120510730.55
106 rdf:rest N5d5f580791254e68bcc16d0520335a5d
107 N7b80328e5c0f407aaff73e81800a70ba schema:name pubmed_id
108 schema:value 26886902
109 rdf:type schema:PropertyValue
110 N7ce6c6c32797433bac68b1c1b5404e0e rdf:first sg:person.01123110416.22
111 rdf:rest N8c063c88d6704309a027c87e958906ca
112 N864d07af4a7446a5b4931464345e11a6 rdf:first sg:person.01164522233.86
113 rdf:rest N6948d4ffb7cb4d2986ccef23a3e3e11e
114 N87b7ef96b1274093b73c93b9b48b58c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Hypopituitarism
116 rdf:type schema:DefinedTerm
117 N8c063c88d6704309a027c87e958906ca rdf:first sg:person.0770445741.31
118 rdf:rest N7829603be728489d878a0a8791f3b418
119 N9f932639d86e4cae8d71cdc428ea4a27 schema:name dimensions_id
120 schema:value pub.1045160595
121 rdf:type schema:PropertyValue
122 Na2ff3339dccf45039e57ccc788fc1b21 schema:name Springer Nature - SN SciGraph project
123 rdf:type schema:Organization
124 Na32e64f526a548ccb2b03f4796fda410 schema:name Clinical Center of Montenegro and Faculty of Medicine, University of Montenegro, Podgorica, Montenegro
125 rdf:type schema:Organization
126 Nb1986a639d1b4dd9a1b6ef50105f7ef3 rdf:first sg:person.0736002022.07
127 rdf:rest N08ac667d248c46b8af06db037cd8880a
128 Nb89e98b84d964c8ca6b409d448f61dad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Female
130 rdf:type schema:DefinedTerm
131 Nbc3b2174faed4a8ebdd0cc3d8e0f2cf8 schema:name Clinic of Endocrinology, Clinical Center Serbia and Medical Faculty, University of Belgrade, Dr Subotic Str 13, 11000, Belgrade, Serbia
132 rdf:type schema:Organization
133 Nbd2a07caa67c4878bff4a7cef5517847 schema:name Clinic of Endocrinology, Clinical Center Serbia and Medical Faculty, University of Belgrade, Dr Subotic Str 13, 11000, Belgrade, Serbia
134 rdf:type schema:Organization
135 Nc2497c8f656a44019924d6670440825e schema:volumeNumber 52
136 rdf:type schema:PublicationVolume
137 Nd715d0133e0f463b819e439f199dc4f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Pedigree
139 rdf:type schema:DefinedTerm
140 Ndfc81cd7f23a4af0bd09e94e8a45e3aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Hormone Replacement Therapy
142 rdf:type schema:DefinedTerm
143 Ne63b9e778a474bc4a4dff8ad1e24827f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Fatal Outcome
145 rdf:type schema:DefinedTerm
146 Ne77fd43ef84446d6af2777333d677380 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Carcinoma
148 rdf:type schema:DefinedTerm
149 Neb291ace0d73404a85825900c99f2881 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Adult
151 rdf:type schema:DefinedTerm
152 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
153 schema:name Medical and Health Sciences
154 rdf:type schema:DefinedTerm
155 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
156 schema:name Clinical Sciences
157 rdf:type schema:DefinedTerm
158 sg:journal.1112251 schema:issn 1355-008X
159 1559-0100
160 schema:name Endocrine
161 rdf:type schema:Periodical
162 sg:person.01034772672.69 schema:affiliation Na32e64f526a548ccb2b03f4796fda410
163 schema:familyName Kavaric
164 schema:givenName S.
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034772672.69
166 rdf:type schema:Person
167 sg:person.01071135502.28 schema:affiliation Nbd2a07caa67c4878bff4a7cef5517847
168 schema:familyName Vujovic
169 schema:givenName S.
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071135502.28
171 rdf:type schema:Person
172 sg:person.01120510730.55 schema:affiliation https://www.grid.ac/institutes/grid.4868.2
173 schema:familyName Korbonits
174 schema:givenName M.
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120510730.55
176 rdf:type schema:Person
177 sg:person.01123110416.22 schema:affiliation https://www.grid.ac/institutes/grid.411535.7
178 schema:familyName Saveanu
179 schema:givenName A.
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123110416.22
181 rdf:type schema:Person
182 sg:person.01164522233.86 schema:affiliation https://www.grid.ac/institutes/grid.7149.b
183 schema:familyName Sopta
184 schema:givenName J.
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164522233.86
186 rdf:type schema:Person
187 sg:person.01242436411.54 schema:affiliation Nbc3b2174faed4a8ebdd0cc3d8e0f2cf8
188 schema:familyName Ivovic
189 schema:givenName M.
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242436411.54
191 rdf:type schema:Person
192 sg:person.01266470231.25 schema:affiliation N0f54011a0c3249989a349273fc707ec9
193 schema:familyName Popovic
194 schema:givenName V.
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266470231.25
196 rdf:type schema:Person
197 sg:person.0736002022.07 schema:affiliation N5d3aaa2ee02f46d599f101780a5d2158
198 schema:familyName Vujosevic
199 schema:givenName S.
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736002022.07
201 rdf:type schema:Person
202 sg:person.0770445741.31 schema:affiliation https://www.grid.ac/institutes/grid.411535.7
203 schema:familyName Brue
204 schema:givenName T.
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770445741.31
206 rdf:type schema:Person
207 sg:pub.10.1007/s12032-011-0076-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014331652
208 https://doi.org/10.1007/s12032-011-0076-9
209 rdf:type schema:CreativeWork
210 sg:pub.10.1038/384327a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024836305
211 https://doi.org/10.1038/384327a0
212 rdf:type schema:CreativeWork
213 sg:pub.10.1038/bjc.2014.566 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006243155
214 https://doi.org/10.1038/bjc.2014.566
215 rdf:type schema:CreativeWork
216 sg:pub.10.1038/modpathol.3800306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027289274
217 https://doi.org/10.1038/modpathol.3800306
218 rdf:type schema:CreativeWork
219 sg:pub.10.1038/ng0298-147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030737601
220 https://doi.org/10.1038/ng0298-147
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/nrc1387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015516287
223 https://doi.org/10.1038/nrc1387
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/srep12891 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046819137
226 https://doi.org/10.1038/srep12891
227 rdf:type schema:CreativeWork
228 https://app.dimensions.ai/details/publication/pub.1077181444 schema:CreativeWork
229 https://doi.org/10.1002/ijc.29210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018963471
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/j.critrevonc.2013.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028073866
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/s0140-6736(04)16044-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015678229
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1034/j.1399-0004.2000.570503.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053406966
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1053/beem.2002.0218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024127634
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1093/hmg/ddr087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053346363
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1126/scitranslmed.3001845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027898360
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1210/en.2005-0058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064247311
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1210/jc.2009-1879 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064291678
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1210/jc.2011-2294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064293104
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1210/jc.84.1.50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064300467
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1530/eje-10-0859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023068868
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1530/eje-13-0389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010603394
254 rdf:type schema:CreativeWork
255 https://doi.org/10.3892/mco.2015.516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071519287
256 rdf:type schema:CreativeWork
257 https://www.grid.ac/institutes/grid.411535.7 schema:alternateName Hôpital de la Conception
258 schema:name APHM, Hôpital Conception, Service d’Endocrinologie, Diabète et Maladies Métaboliques, Centre de Référence des Maladies Rares d’Origine Hypophysaire DEFHY, and Laboratoire de Biologie Moleculaire, GeOneE (Genetique Oncologique et Endocrinienne), 13385, Marseille Cedex 15, France
259 Aix-Marseille Université, CNRS, CRN2M UMR 7286, 13344, Marseille Cedex 15, France
260 rdf:type schema:Organization
261 https://www.grid.ac/institutes/grid.4868.2 schema:alternateName Queen Mary University of London
262 schema:name Department of Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, Charterhouse Square, EC1M 6BQ, London, UK
263 rdf:type schema:Organization
264 https://www.grid.ac/institutes/grid.7149.b schema:alternateName University of Belgrade
265 schema:name Institute of Pathology, Medical Faculty, University of Belgrade, Belgrade, Serbia
266 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...