Postprandial hyperglycemia was ameliorated by taking metformin 30 min before a meal than taking metformin with a meal; a randomized, ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-10-30

AUTHORS

Yoshitaka Hashimoto, Muhei Tanaka, Hiroshi Okada, Kazuteru Mistuhashi, Toshihiro Kimura, Noriyuki Kitagawa, Takuya Fukuda, Saori Majima, Yukiko Fukuda, Yoshimitsu Tanaka, Shunji Yamada, Takafumi Senmaru, Masahide Hamaguchi, Mai Asano, Masahiro Yamazaki, Yohei Oda, Goji Hasegawa, Naoto Nakamura, Michiaki Fukui

ABSTRACT

Taking metformin with a meal has been shown to decrease bioavailability of metformin. We hypothesized that taking metformin 30 min before a meal improves glucose metabolism. As an animal model, 18 Zucker-rats were divided into three groups as follows: no medication (Control), metformin (600 mg/kg) with meal (Met), and metformin 10 min before meal (pre-Met). In addition, five diabetic patients were recruited and randomized to take metformin (1000 mg) either 30 min before a meal (pre-Met protocol) or with a meal (Met protocol). In the animal model, the peak glucose level of pre-Met (7.8 ± 1.5 mmol/L) was lower than that of Control (12.6 ± 2.5 mmol/L, P = 0.010) or Met (14.1 ± 2.9 mmol/L, P = 0.020). Although there was no statistical difference among the three groups, total GLP-1 level at t = 0 min of pre-Met (7.4 ± 2.7 pmol/L) tended to be higher than that of Control (3.7 ± 2.0 pmol/L, P = 0.030) or Met (3.9 ± 1.2 pmol/L, P = 0.020). In diabetic patients, the peak glucose level of pre-Met protocol (7.0 ± 0.4 mmol/L) was lower than that of Met protocol (8.5 ± 0.9 mmol/L, P = 0.021). Total GLP-1 level at t = 30 min of pre-Met protocol (11.0 ± 6.1 pmol/L) was higher than that of Met protocol (6.7 ± 3.9 pmol/L, P = 0.033). Taking metformin 30 min before a meal ameliorated postprandial hyperglycemia. This promises to be a novel approach for postprandial hyperglycemia. More... »

PAGES

271-276

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12020-015-0786-4

DOI

http://dx.doi.org/10.1007/s12020-015-0786-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025367139

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26518190


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    "description": "Abstract\nTaking metformin with a meal has been shown to decrease bioavailability of metformin. We hypothesized that taking metformin 30\u00a0min before a meal improves glucose metabolism. As an animal model, 18 Zucker-rats were divided into three groups as follows: no medication (Control), metformin (600\u00a0mg/kg) with meal (Met), and metformin 10\u00a0min before meal (pre-Met). In addition, five diabetic patients were recruited and randomized to take metformin (1000\u00a0mg) either 30\u00a0min before a meal (pre-Met protocol) or with a meal (Met protocol). In the animal model, the peak glucose level of pre-Met (7.8\u00a0\u00b1\u00a01.5\u00a0mmol/L) was lower than that of Control (12.6\u00a0\u00b1\u00a02.5\u00a0mmol/L, P\u00a0=\u00a00.010) or Met (14.1\u00a0\u00b1\u00a02.9\u00a0mmol/L, P\u00a0=\u00a00.020). Although there was no statistical difference among the three groups, total GLP-1 level at t\u00a0=\u00a00\u00a0min of pre-Met (7.4\u00a0\u00b1\u00a02.7\u00a0pmol/L) tended to be higher than that of Control (3.7\u00a0\u00b1\u00a02.0\u00a0pmol/L, P\u00a0=\u00a00.030) or Met (3.9\u00a0\u00b1\u00a01.2\u00a0pmol/L, P\u00a0=\u00a00.020). In diabetic patients, the peak glucose level of pre-Met protocol (7.0\u00a0\u00b1\u00a00.4\u00a0mmol/L) was lower than that of Met protocol (8.5\u00a0\u00b1\u00a00.9\u00a0mmol/L, P\u00a0=\u00a00.021). Total GLP-1 level at t\u00a0=\u00a030\u00a0min of pre-Met protocol (11.0\u00a0\u00b1\u00a06.1\u00a0pmol/L) was higher than that of Met protocol (6.7\u00a0\u00b1\u00a03.9\u00a0pmol/L, P\u00a0=\u00a00.033). Taking metformin 30\u00a0min before a meal ameliorated postprandial hyperglycemia. This promises to be a novel approach for postprandial hyperglycemia.", 
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