ER-alpha and ER-beta expression in differentiated thyroid cancer: relation with tumor phenotype across the TNM staging and peri-tumor inflammation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-06

AUTHORS

Flavia Magri, Valentina Capelli, Margherita Gaiti, Laura Villani, Francesca Zerbini, Luigi La Manna, Mario Rotondi, Luca Chiovato

ABSTRACT

Thyroid cancer may express estrogen receptors (ERs) and various grades of peri-tumor inflammation. The aim of the study was to evaluate the expression of ERs in relation to the TNM stage and peri-tumor inflammatory infiltrate in differentiated thyroid cancers. 127 patients (109 females, 18 males) with differentiated thyroid cancer (T1 = 91, T2 = 18, T3 = 11, T4 = 7) were evaluated. In tumors and in the correspondent extra-tumor parenchyma, ERs expression was evaluated by immunohistochemistry. In 114 tumors and correspondent peri-tumor tissues, the presence of inflammatory infiltration was also recorded. ER-alpha expression was higher in clinical than in incidental tumors of the T1 subgroup (p = 0.037), and was associated with capsular invasion in T2 tumors (p < 0.0001). ER-beta expression was negatively associated with vascular invasion in T1 (p = 0.005) and T2 tumors (p = 0.015). No significant relationship between ERs expression and tumor phenotype emerged in T3 and T4 subgroups. Tumors without inflammatory cell infiltrate showed a higher expression of both ER-alpha (p = 0.035) and ER-beta (p = 0.026) than the ones with inflammatory infiltrate. The relationship between tumor phenotype and ERs expression did not vary in the presence or absence of peri-tumor inflammatory infiltration. ER-alpha positivity and ER-beta negativity are associated with a more aggressive phenotype in both T1 and T2 thyroid cancers, suggesting that tumor biology may be more relevant than tumor size for cancer risk assessment. Inflammatory status is also associated with ERs expression, but not with tumor growth or phenotype. More... »

PAGES

429-435

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12020-014-0457-x

DOI

http://dx.doi.org/10.1007/s12020-014-0457-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018611078

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25338203


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Estrogen Receptor alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Estrogen Receptor beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thyroid Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Pavia", 
          "id": "https://www.grid.ac/institutes/grid.8982.b", 
          "name": [
            "Unit of Internal Medicine and Endocrinology, Fondazione S. Maugeri, IRCCS, University of Pavia, Pavia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Magri", 
        "givenName": "Flavia", 
        "id": "sg:person.01060511476.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060511476.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pavia", 
          "id": "https://www.grid.ac/institutes/grid.8982.b", 
          "name": [
            "Unit of Internal Medicine and Endocrinology, Fondazione S. Maugeri, IRCCS, University of Pavia, Pavia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Capelli", 
        "givenName": "Valentina", 
        "id": "sg:person.01316472003.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316472003.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pavia", 
          "id": "https://www.grid.ac/institutes/grid.8982.b", 
          "name": [
            "Unit of Internal Medicine and Endocrinology, Fondazione S. Maugeri, IRCCS, University of Pavia, Pavia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gaiti", 
        "givenName": "Margherita", 
        "id": "sg:person.01007334171.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007334171.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Unit of Pathology and Cytology, Fondazione S. Maugeri, Pavia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Villani", 
        "givenName": "Laura", 
        "id": "sg:person.01122336053.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122336053.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pavia", 
          "id": "https://www.grid.ac/institutes/grid.8982.b", 
          "name": [
            "Unit of Internal Medicine and Endocrinology, Fondazione S. Maugeri, IRCCS, University of Pavia, Pavia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zerbini", 
        "givenName": "Francesca", 
        "id": "sg:person.01351222767.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351222767.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of General and Mininvasive Surgery, Fondazione S. Maugeri, Pavia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "La Manna", 
        "givenName": "Luigi", 
        "id": "sg:person.0707314303.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707314303.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pavia", 
          "id": "https://www.grid.ac/institutes/grid.8982.b", 
          "name": [
            "Unit of Internal Medicine and Endocrinology, Fondazione S. Maugeri, IRCCS, University of Pavia, Pavia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rotondi", 
        "givenName": "Mario", 
        "id": "sg:person.01026365414.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026365414.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pavia", 
          "id": "https://www.grid.ac/institutes/grid.8982.b", 
          "name": [
            "Unit of Internal Medicine and Endocrinology, Fondazione S. Maugeri, IRCCS, University of Pavia, Pavia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chiovato", 
        "givenName": "Luca", 
        "id": "sg:person.01342727464.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342727464.20"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf03349859", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000631209", 
          "https://doi.org/10.1007/bf03349859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.26282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009074681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00130404-200503000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009846664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00130404-200503000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009846664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/bcr2255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009977688", 
          "https://doi.org/10.1186/bcr2255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.2297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013204349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/erc-11-0389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018504996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm200101253440407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020296383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-14-383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020785301", 
          "https://doi.org/10.1186/1471-2407-14-383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-14-383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020785301", 
          "https://doi.org/10.1186/1471-2407-14-383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopha.2013.10.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021475196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.02.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023540354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/erc-13-0431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023932298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/thy.2011.0059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024443164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/thy.2011.0059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024443164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12029-011-9332-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025935623", 
          "https://doi.org/10.1007/s12029-011-9332-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12029-011-9332-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025935623", 
          "https://doi.org/10.1007/s12029-011-9332-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopha.2012.08.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029205830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopha.2012.08.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029205830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.28383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030324850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2184.2007.00471.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038320080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/erc.1.00800", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039564943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/erc.1.00800", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039564943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mce.2009.10.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050555244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1998.8324", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051557451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/joe-13-0029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052319744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.05869-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052969801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/thy.2009.0296", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059320636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/thy.2012.0363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059321504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.86.3.1072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064301770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/me.2004-0021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064327190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/156800908785133150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069190893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078574776", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-06", 
    "datePublishedReg": "2015-06-01", 
    "description": "Thyroid cancer may express estrogen receptors (ERs) and various grades of peri-tumor inflammation. The aim of the study was to evaluate the expression of ERs in relation to the TNM stage and peri-tumor inflammatory infiltrate in differentiated thyroid cancers. 127 patients (109 females, 18 males) with differentiated thyroid cancer (T1 = 91, T2 = 18, T3 = 11, T4 = 7) were evaluated. In tumors and in the correspondent extra-tumor parenchyma, ERs expression was evaluated by immunohistochemistry. In 114 tumors and correspondent peri-tumor tissues, the presence of inflammatory infiltration was also recorded. ER-alpha expression was higher in clinical than in incidental tumors of the T1 subgroup (p = 0.037), and was associated with capsular invasion in T2 tumors (p < 0.0001). ER-beta expression was negatively associated with vascular invasion in T1 (p = 0.005) and T2 tumors (p = 0.015). No significant relationship between ERs expression and tumor phenotype emerged in T3 and T4 subgroups. Tumors without inflammatory cell infiltrate showed a higher expression of both ER-alpha (p = 0.035) and ER-beta (p = 0.026) than the ones with inflammatory infiltrate. The relationship between tumor phenotype and ERs expression did not vary in the presence or absence of peri-tumor inflammatory infiltration. ER-alpha positivity and ER-beta negativity are associated with a more aggressive phenotype in both T1 and T2 thyroid cancers, suggesting that tumor biology may be more relevant than tumor size for cancer risk assessment. Inflammatory status is also associated with ERs expression, but not with tumor growth or phenotype.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12020-014-0457-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1112251", 
        "issn": [
          "1355-008X", 
          "1559-0100"
        ], 
        "name": "Endocrine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "49"
      }
    ], 
    "name": "ER-alpha and ER-beta expression in differentiated thyroid cancer: relation with tumor phenotype across the TNM staging and peri-tumor inflammation", 
    "pagination": "429-435", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "58ac98ee1111b012aaa359adf2dac23553a852c11af98c3bafe9446c901ee667"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25338203"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9434444"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12020-014-0457-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1018611078"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12020-014-0457-x", 
      "https://app.dimensions.ai/details/publication/pub.1018611078"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:44", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000521.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs12020-014-0457-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12020-014-0457-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12020-014-0457-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12020-014-0457-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12020-014-0457-x'


 

This table displays all metadata directly associated to this object as RDF triples.

266 TRIPLES      21 PREDICATES      71 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12020-014-0457-x schema:about N20eb9a26e44d42cc9604e141d38515b9
2 N2b65069a9f1f4806a8e90aadebbccdbf
3 N2fb047e1973d4443be8ba4a8206e6cd9
4 N5f1de914c7d243ae8c0fed8dc27ecf6a
5 N61004275614a4a4da36ab420f8557554
6 N73c264a0cc2e429e9178a8d338ce78c5
7 N74a3daf54a344b48b8cea89a44cc8fbf
8 N7f37a0d51c8b4c77882b7a2c5cd42a86
9 N7f5c193a61b842baaeab3249f577bffa
10 N94318a2e84e3499788ed4eead517a3af
11 Nabbf2cb88d8044aaa48b0796ce46e74d
12 Nb4b9627b5562447faeaca9a497430f28
13 Nc75a8195659d4db4ad98cc65ce1918ab
14 Nd6ecb5c9ddd2479db5b882c255c51bc7
15 Nebd46d3e611d4c889a10ab14e0bce03a
16 anzsrc-for:11
17 anzsrc-for:1112
18 schema:author N392b37b210924c11b56db0c5a2f5f544
19 schema:citation sg:pub.10.1007/bf03349859
20 sg:pub.10.1007/s12029-011-9332-7
21 sg:pub.10.1186/1471-2407-14-383
22 sg:pub.10.1186/bcr2255
23 https://app.dimensions.ai/details/publication/pub.1078574776
24 https://doi.org/10.1002/cncr.26282
25 https://doi.org/10.1002/cncr.28383
26 https://doi.org/10.1002/path.2297
27 https://doi.org/10.1006/bbrc.1998.8324
28 https://doi.org/10.1016/j.biopha.2012.08.003
29 https://doi.org/10.1016/j.biopha.2013.10.013
30 https://doi.org/10.1016/j.cell.2011.02.013
31 https://doi.org/10.1016/j.mce.2009.10.010
32 https://doi.org/10.1056/nejm200101253440407
33 https://doi.org/10.1089/thy.2009.0296
34 https://doi.org/10.1089/thy.2011.0059
35 https://doi.org/10.1089/thy.2012.0363
36 https://doi.org/10.1097/00130404-200503000-00006
37 https://doi.org/10.1111/j.1365-2184.2007.00471.x
38 https://doi.org/10.1128/mcb.05869-11
39 https://doi.org/10.1210/jc.86.3.1072
40 https://doi.org/10.1210/me.2004-0021
41 https://doi.org/10.1530/erc-11-0389
42 https://doi.org/10.1530/erc-13-0431
43 https://doi.org/10.1530/joe-13-0029
44 https://doi.org/10.1677/erc.1.00800
45 https://doi.org/10.2174/156800908785133150
46 schema:datePublished 2015-06
47 schema:datePublishedReg 2015-06-01
48 schema:description Thyroid cancer may express estrogen receptors (ERs) and various grades of peri-tumor inflammation. The aim of the study was to evaluate the expression of ERs in relation to the TNM stage and peri-tumor inflammatory infiltrate in differentiated thyroid cancers. 127 patients (109 females, 18 males) with differentiated thyroid cancer (T1 = 91, T2 = 18, T3 = 11, T4 = 7) were evaluated. In tumors and in the correspondent extra-tumor parenchyma, ERs expression was evaluated by immunohistochemistry. In 114 tumors and correspondent peri-tumor tissues, the presence of inflammatory infiltration was also recorded. ER-alpha expression was higher in clinical than in incidental tumors of the T1 subgroup (p = 0.037), and was associated with capsular invasion in T2 tumors (p < 0.0001). ER-beta expression was negatively associated with vascular invasion in T1 (p = 0.005) and T2 tumors (p = 0.015). No significant relationship between ERs expression and tumor phenotype emerged in T3 and T4 subgroups. Tumors without inflammatory cell infiltrate showed a higher expression of both ER-alpha (p = 0.035) and ER-beta (p = 0.026) than the ones with inflammatory infiltrate. The relationship between tumor phenotype and ERs expression did not vary in the presence or absence of peri-tumor inflammatory infiltration. ER-alpha positivity and ER-beta negativity are associated with a more aggressive phenotype in both T1 and T2 thyroid cancers, suggesting that tumor biology may be more relevant than tumor size for cancer risk assessment. Inflammatory status is also associated with ERs expression, but not with tumor growth or phenotype.
49 schema:genre research_article
50 schema:inLanguage en
51 schema:isAccessibleForFree false
52 schema:isPartOf N6236d2ef023f4d46973dc3e74cff9fe4
53 N6815ca5a252a4dcba0164e344a3f680b
54 sg:journal.1112251
55 schema:name ER-alpha and ER-beta expression in differentiated thyroid cancer: relation with tumor phenotype across the TNM staging and peri-tumor inflammation
56 schema:pagination 429-435
57 schema:productId N067103cb48424fd5a70f3572566bfb89
58 N51a6d0cf114e4e7381c52beeda1ca8e5
59 N960556a442884adc8863d5286274c673
60 Nf2bcbbfd8fbb47178cffe220e537f9f4
61 Nfc9c2deabf3348f38d562b3120913a51
62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018611078
63 https://doi.org/10.1007/s12020-014-0457-x
64 schema:sdDatePublished 2019-04-10T16:44
65 schema:sdLicense https://scigraph.springernature.com/explorer/license/
66 schema:sdPublisher Nfd174d82b5ec4b7ab649fd64a5ba62a9
67 schema:url http://link.springer.com/10.1007%2Fs12020-014-0457-x
68 sgo:license sg:explorer/license/
69 sgo:sdDataset articles
70 rdf:type schema:ScholarlyArticle
71 N058e1a7661d74c3a9b3812e8bb440a9a rdf:first sg:person.01342727464.20
72 rdf:rest rdf:nil
73 N067103cb48424fd5a70f3572566bfb89 schema:name pubmed_id
74 schema:value 25338203
75 rdf:type schema:PropertyValue
76 N20eb9a26e44d42cc9604e141d38515b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Female
78 rdf:type schema:DefinedTerm
79 N27b8f31d877742e2955a51051be24db3 rdf:first sg:person.0707314303.00
80 rdf:rest Ne067c1fe35db42938d46d3ce9809726e
81 N281b24ffa531460abbfc3ba34e6771ff rdf:first sg:person.01351222767.73
82 rdf:rest N27b8f31d877742e2955a51051be24db3
83 N2b65069a9f1f4806a8e90aadebbccdbf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Estrogen Receptor beta
85 rdf:type schema:DefinedTerm
86 N2fb047e1973d4443be8ba4a8206e6cd9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Aged, 80 and over
88 rdf:type schema:DefinedTerm
89 N392b37b210924c11b56db0c5a2f5f544 rdf:first sg:person.01060511476.96
90 rdf:rest N802b38a744d14df49ca3f42afa99d024
91 N51a6d0cf114e4e7381c52beeda1ca8e5 schema:name dimensions_id
92 schema:value pub.1018611078
93 rdf:type schema:PropertyValue
94 N5f1de914c7d243ae8c0fed8dc27ecf6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Gene Expression Regulation, Neoplastic
96 rdf:type schema:DefinedTerm
97 N61004275614a4a4da36ab420f8557554 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Adult
99 rdf:type schema:DefinedTerm
100 N6236d2ef023f4d46973dc3e74cff9fe4 schema:issueNumber 2
101 rdf:type schema:PublicationIssue
102 N6815ca5a252a4dcba0164e344a3f680b schema:volumeNumber 49
103 rdf:type schema:PublicationVolume
104 N6b38737156f542208a6d74087d9cd4d3 rdf:first sg:person.01122336053.92
105 rdf:rest N281b24ffa531460abbfc3ba34e6771ff
106 N6ca3b3c004c34be8867f058aefdb5e41 rdf:first sg:person.01007334171.52
107 rdf:rest N6b38737156f542208a6d74087d9cd4d3
108 N73c264a0cc2e429e9178a8d338ce78c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Young Adult
110 rdf:type schema:DefinedTerm
111 N74a3daf54a344b48b8cea89a44cc8fbf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Thyroid Neoplasms
113 rdf:type schema:DefinedTerm
114 N7f37a0d51c8b4c77882b7a2c5cd42a86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Inflammation
116 rdf:type schema:DefinedTerm
117 N7f5c193a61b842baaeab3249f577bffa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Aged
119 rdf:type schema:DefinedTerm
120 N802b38a744d14df49ca3f42afa99d024 rdf:first sg:person.01316472003.97
121 rdf:rest N6ca3b3c004c34be8867f058aefdb5e41
122 N94318a2e84e3499788ed4eead517a3af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Male
124 rdf:type schema:DefinedTerm
125 N960556a442884adc8863d5286274c673 schema:name readcube_id
126 schema:value 58ac98ee1111b012aaa359adf2dac23553a852c11af98c3bafe9446c901ee667
127 rdf:type schema:PropertyValue
128 Nabbf2cb88d8044aaa48b0796ce46e74d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Middle Aged
130 rdf:type schema:DefinedTerm
131 Nb4b9627b5562447faeaca9a497430f28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Phenotype
133 rdf:type schema:DefinedTerm
134 Nba5d0fed492a4334ba4eeb772a12a814 schema:name Department of General and Mininvasive Surgery, Fondazione S. Maugeri, Pavia, Italy
135 rdf:type schema:Organization
136 Nc75a8195659d4db4ad98cc65ce1918ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Neoplasm Staging
138 rdf:type schema:DefinedTerm
139 Nd6ecb5c9ddd2479db5b882c255c51bc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Humans
141 rdf:type schema:DefinedTerm
142 Ne067c1fe35db42938d46d3ce9809726e rdf:first sg:person.01026365414.58
143 rdf:rest N058e1a7661d74c3a9b3812e8bb440a9a
144 Nebd46d3e611d4c889a10ab14e0bce03a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Estrogen Receptor alpha
146 rdf:type schema:DefinedTerm
147 Nec39ba70a4184af1968f9e57af110c08 schema:name Unit of Pathology and Cytology, Fondazione S. Maugeri, Pavia, Italy
148 rdf:type schema:Organization
149 Nf2bcbbfd8fbb47178cffe220e537f9f4 schema:name nlm_unique_id
150 schema:value 9434444
151 rdf:type schema:PropertyValue
152 Nfc9c2deabf3348f38d562b3120913a51 schema:name doi
153 schema:value 10.1007/s12020-014-0457-x
154 rdf:type schema:PropertyValue
155 Nfd174d82b5ec4b7ab649fd64a5ba62a9 schema:name Springer Nature - SN SciGraph project
156 rdf:type schema:Organization
157 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
158 schema:name Medical and Health Sciences
159 rdf:type schema:DefinedTerm
160 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
161 schema:name Oncology and Carcinogenesis
162 rdf:type schema:DefinedTerm
163 sg:journal.1112251 schema:issn 1355-008X
164 1559-0100
165 schema:name Endocrine
166 rdf:type schema:Periodical
167 sg:person.01007334171.52 schema:affiliation https://www.grid.ac/institutes/grid.8982.b
168 schema:familyName Gaiti
169 schema:givenName Margherita
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007334171.52
171 rdf:type schema:Person
172 sg:person.01026365414.58 schema:affiliation https://www.grid.ac/institutes/grid.8982.b
173 schema:familyName Rotondi
174 schema:givenName Mario
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026365414.58
176 rdf:type schema:Person
177 sg:person.01060511476.96 schema:affiliation https://www.grid.ac/institutes/grid.8982.b
178 schema:familyName Magri
179 schema:givenName Flavia
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060511476.96
181 rdf:type schema:Person
182 sg:person.01122336053.92 schema:affiliation Nec39ba70a4184af1968f9e57af110c08
183 schema:familyName Villani
184 schema:givenName Laura
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122336053.92
186 rdf:type schema:Person
187 sg:person.01316472003.97 schema:affiliation https://www.grid.ac/institutes/grid.8982.b
188 schema:familyName Capelli
189 schema:givenName Valentina
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316472003.97
191 rdf:type schema:Person
192 sg:person.01342727464.20 schema:affiliation https://www.grid.ac/institutes/grid.8982.b
193 schema:familyName Chiovato
194 schema:givenName Luca
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342727464.20
196 rdf:type schema:Person
197 sg:person.01351222767.73 schema:affiliation https://www.grid.ac/institutes/grid.8982.b
198 schema:familyName Zerbini
199 schema:givenName Francesca
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351222767.73
201 rdf:type schema:Person
202 sg:person.0707314303.00 schema:affiliation Nba5d0fed492a4334ba4eeb772a12a814
203 schema:familyName La Manna
204 schema:givenName Luigi
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707314303.00
206 rdf:type schema:Person
207 sg:pub.10.1007/bf03349859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000631209
208 https://doi.org/10.1007/bf03349859
209 rdf:type schema:CreativeWork
210 sg:pub.10.1007/s12029-011-9332-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025935623
211 https://doi.org/10.1007/s12029-011-9332-7
212 rdf:type schema:CreativeWork
213 sg:pub.10.1186/1471-2407-14-383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020785301
214 https://doi.org/10.1186/1471-2407-14-383
215 rdf:type schema:CreativeWork
216 sg:pub.10.1186/bcr2255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009977688
217 https://doi.org/10.1186/bcr2255
218 rdf:type schema:CreativeWork
219 https://app.dimensions.ai/details/publication/pub.1078574776 schema:CreativeWork
220 https://doi.org/10.1002/cncr.26282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009074681
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1002/cncr.28383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030324850
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1002/path.2297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013204349
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1006/bbrc.1998.8324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051557451
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.biopha.2012.08.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029205830
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.biopha.2013.10.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021475196
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/j.cell.2011.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023540354
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/j.mce.2009.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050555244
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1056/nejm200101253440407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020296383
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1089/thy.2009.0296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059320636
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1089/thy.2011.0059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024443164
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1089/thy.2012.0363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059321504
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1097/00130404-200503000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009846664
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1111/j.1365-2184.2007.00471.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038320080
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1128/mcb.05869-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052969801
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1210/jc.86.3.1072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064301770
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1210/me.2004-0021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064327190
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1530/erc-11-0389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018504996
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1530/erc-13-0431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023932298
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1530/joe-13-0029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052319744
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1677/erc.1.00800 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039564943
261 rdf:type schema:CreativeWork
262 https://doi.org/10.2174/156800908785133150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069190893
263 rdf:type schema:CreativeWork
264 https://www.grid.ac/institutes/grid.8982.b schema:alternateName University of Pavia
265 schema:name Unit of Internal Medicine and Endocrinology, Fondazione S. Maugeri, IRCCS, University of Pavia, Pavia, Italy
266 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...