Preoperative serum thyroid stimulating hormone levels in well-differentiated thyroid carcinoma is a predictive factor for lateral lymph node metastasis as ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-12-14

AUTHORS

Sang Soo Kim, Byung Joo Lee, Jin Choon Lee, Sang Heon Song, Bo Hyun Kim, Seok Man Son, In Ju Kim, Yong Ki Kim, Yang Ho Kang

ABSTRACT

It has been known that thyroid stimulating hormone (TSH) stimulates the growth or development of thyroid malignancy and higher serum TSH has association with both thyroid cancer incidence and advanced tumor stage. However, the role of TSH in high-risk features of well-differentiated thyroid cancer was not fully evaluated especially in Asian population. The purpose of our study is to evaluate the association of preoperative serum TSH levels with the advance of differentiated thyroid cancer and its high-risk clinicopathological features in Korean patients. We evaluated 554 patients retrospectively who underwent thyroidectomy and diagnosed as differentiated thyroid cancer during a 3-year period at Pusan National University Hospital. The preoperative TSH levels were significantly higher in the patients with extrathyroidal extension (P = 0.002) and those with lateral lymph node metastasis (P = 0.007). As the increase of the serum TSH concentration, there were significant rising trends in the prevalence of extrathyroidal extension (P = 0.009). In the patients with TSH ≥ 2.5 mIU/L, the prevalences of extrathyroidal extension (P = 0.006) and lateral lymph node metastasis (P = 0.024) were also significantly higher. Using multiple logistic regression, preoperative TSH level was a predictive factor for the presence of extrathyroidal extension (P = 0.008) and lateral lymph node metastasis (P = 0.025). Hashimoto’s thyroiditis itself was not associated with the status of extrathyroidal extension and lateral lymph node metastasis. In conclusion, preoperative TSH levels were associated with lateral lymph node matastasis, a novel finding, and extrathyroidal extension in well differentiated thyroid cancer and might be useful as a preoperative supplementary marker for determining the optimal extent of differentiated thyroid cancer surgery in Korean patients. More... »

PAGES

259-265

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12020-010-9430-5

DOI

http://dx.doi.org/10.1007/s12020-010-9430-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018944302

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21161440


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Korea", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphatic Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Preoperative Period", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thyroid Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thyroidectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thyrotropin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Medical Research Institute, Pusan National University, 602-739, Busan, Korea", 
          "id": "http://www.grid.ac/institutes/grid.262229.f", 
          "name": [
            "Department of Internal Medicine, Pusan National University Hospital, 602-739, Busan, Korea", 
            "Medical Research Institute, Pusan National University, 602-739, Busan, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Sang Soo", 
        "id": "sg:person.01122642102.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122642102.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Otolaryngology, Pusan National University Hospital, 602-739, Busan, Korea", 
          "id": "http://www.grid.ac/institutes/grid.412588.2", 
          "name": [
            "Department of Otolaryngology, Pusan National University Hospital, 602-739, Busan, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Byung Joo", 
        "id": "sg:person.010332072074.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010332072074.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Otolaryngology, Pusan National University Hospital, 602-739, Busan, Korea", 
          "id": "http://www.grid.ac/institutes/grid.412588.2", 
          "name": [
            "Department of Otolaryngology, Pusan National University Hospital, 602-739, Busan, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Jin Choon", 
        "id": "sg:person.015655263124.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015655263124.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Pusan National University Hospital, 602-739, Busan, Korea", 
          "id": "http://www.grid.ac/institutes/grid.412588.2", 
          "name": [
            "Department of Internal Medicine, Pusan National University Hospital, 602-739, Busan, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Song", 
        "givenName": "Sang Heon", 
        "id": "sg:person.01032567265.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032567265.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Pusan National University Hospital, 602-739, Busan, Korea", 
          "id": "http://www.grid.ac/institutes/grid.412588.2", 
          "name": [
            "Department of Internal Medicine, Pusan National University Hospital, 602-739, Busan, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Bo Hyun", 
        "id": "sg:person.010657730644.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010657730644.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Diabetes Center and Endocrine Clinic, Pusan National University Yangsan Hospital, 626-770, Yangsan, Korea", 
          "id": "http://www.grid.ac/institutes/grid.412591.a", 
          "name": [
            "Diabetes Center and Endocrine Clinic, Pusan National University Yangsan Hospital, 626-770, Yangsan, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Son", 
        "givenName": "Seok Man", 
        "id": "sg:person.01027510627.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027510627.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Pusan National University Hospital, 602-739, Busan, Korea", 
          "id": "http://www.grid.ac/institutes/grid.412588.2", 
          "name": [
            "Department of Internal Medicine, Pusan National University Hospital, 602-739, Busan, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "In Ju", 
        "id": "sg:person.0636056263.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636056263.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Pusan National University Hospital, 602-739, Busan, Korea", 
          "id": "http://www.grid.ac/institutes/grid.412588.2", 
          "name": [
            "Department of Internal Medicine, Pusan National University Hospital, 602-739, Busan, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Yong Ki", 
        "id": "sg:person.01342545452.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342545452.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical Research Institute, Pusan National University, 602-739, Busan, Korea", 
          "id": "http://www.grid.ac/institutes/grid.262229.f", 
          "name": [
            "Diabetes Center and Endocrine Clinic, Pusan National University Yangsan Hospital, 626-770, Yangsan, Korea", 
            "Medical Research Institute, Pusan National University, 602-739, Busan, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kang", 
        "givenName": "Yang Ho", 
        "id": "sg:person.01231760661.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231760661.50"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00268-004-7192-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051920619", 
          "https://doi.org/10.1007/s00268-004-7192-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-008-0373-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019427921", 
          "https://doi.org/10.1007/s00432-008-0373-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-004-7644-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050534564", 
          "https://doi.org/10.1007/s00268-004-7644-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncpendmet0020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020356795", 
          "https://doi.org/10.1038/ncpendmet0020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02848773", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011199656", 
          "https://doi.org/10.1007/bf02848773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/aso.2004.03.066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034006245", 
          "https://doi.org/10.1245/aso.2004.03.066"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-12-14", 
    "datePublishedReg": "2010-12-14", 
    "description": "It has been known that thyroid stimulating hormone (TSH) stimulates the growth or development of thyroid malignancy and higher serum TSH has association with both thyroid cancer incidence and advanced tumor stage. However, the role of TSH in high-risk features of well-differentiated thyroid cancer was not fully evaluated especially in Asian population. The purpose of our study is to evaluate the association of preoperative serum TSH levels with the advance of differentiated thyroid cancer and its high-risk clinicopathological features in Korean patients. We evaluated 554 patients retrospectively who underwent thyroidectomy and diagnosed as differentiated thyroid cancer during a 3-year period at Pusan National University Hospital. The preoperative TSH levels were significantly higher in the patients with extrathyroidal extension (P\u00a0=\u00a00.002) and those with lateral lymph node metastasis (P\u00a0=\u00a00.007). As the increase of the serum TSH concentration, there were significant rising trends in the prevalence of extrathyroidal extension (P\u00a0=\u00a00.009). In the patients with TSH\u00a0\u2265\u00a02.5 mIU/L, the prevalences of extrathyroidal extension (P\u00a0=\u00a00.006) and lateral lymph node metastasis (P\u00a0=\u00a00.024) were also significantly higher. Using multiple logistic regression, preoperative TSH level was a predictive factor for the presence of extrathyroidal extension (P\u00a0=\u00a00.008) and lateral lymph node metastasis (P\u00a0=\u00a00.025). Hashimoto\u2019s thyroiditis itself was not associated with the status of extrathyroidal extension and lateral lymph node metastasis. In conclusion, preoperative TSH levels were associated with lateral lymph node matastasis, a novel finding, and extrathyroidal extension in well differentiated thyroid cancer and might be useful as a preoperative supplementary marker for determining the optimal extent of differentiated thyroid cancer surgery in Korean patients.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s12020-010-9430-5", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1112251", 
        "issn": [
          "1355-008X", 
          "1559-0100"
        ], 
        "name": "Endocrine", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "39"
      }
    ], 
    "keywords": [
      "lateral lymph node metastasis", 
      "lymph node metastasis", 
      "preoperative TSH levels", 
      "differentiated thyroid cancer", 
      "node metastasis", 
      "TSH levels", 
      "thyroid cancer", 
      "Korean patients", 
      "predictive factors", 
      "high-risk clinicopathological features", 
      "Pusan National University Hospital", 
      "thyroid cancer surgery", 
      "single-center experience", 
      "high-risk features", 
      "serum TSH levels", 
      "serum TSH concentrations", 
      "higher serum TSH", 
      "National University Hospital", 
      "mIU/L", 
      "advanced tumor stage", 
      "thyroid cancer incidence", 
      "multiple logistic regression", 
      "role of TSH", 
      "serum thyroid", 
      "serum TSH", 
      "clinicopathological features", 
      "cancer surgery", 
      "tumor stage", 
      "University Hospital", 
      "Hashimoto's thyroiditis", 
      "TSH concentrations", 
      "cancer incidence", 
      "hormone levels", 
      "thyroid malignancy", 
      "thyroid carcinoma", 
      "patients", 
      "metastasis", 
      "logistic regression", 
      "cancer", 
      "optimal extent", 
      "TSH", 
      "Asian populations", 
      "thyroiditis", 
      "supplementary marker", 
      "novel findings", 
      "thyroid", 
      "prevalence", 
      "association", 
      "thyroidectomy", 
      "levels", 
      "surgery", 
      "malignancy", 
      "carcinoma", 
      "hospital", 
      "matastasis", 
      "incidence", 
      "hormone", 
      "factors", 
      "markers", 
      "status", 
      "conclusion", 
      "regression", 
      "population", 
      "findings", 
      "period", 
      "study", 
      "role", 
      "increase", 
      "features", 
      "presence", 
      "experience", 
      "concentration", 
      "stage", 
      "advances", 
      "purpose", 
      "extent", 
      "development", 
      "trends", 
      "growth", 
      "extension", 
      "preoperative serum TSH levels", 
      "lateral lymph node matastasis", 
      "lymph node matastasis", 
      "node matastasis", 
      "preoperative supplementary marker", 
      "differentiated thyroid cancer surgery", 
      "Preoperative serum thyroid"
    ], 
    "name": "Preoperative serum thyroid stimulating hormone levels in well-differentiated thyroid carcinoma is a predictive factor for lateral lymph node metastasis as well as extrathyroidal extension in Korean patients: a single-center experience", 
    "pagination": "259-265", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1018944302"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12020-010-9430-5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21161440"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12020-010-9430-5", 
      "https://app.dimensions.ai/details/publication/pub.1018944302"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:21", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_515.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s12020-010-9430-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12020-010-9430-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12020-010-9430-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12020-010-9430-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12020-010-9430-5'


 

This table displays all metadata directly associated to this object as RDF triples.

295 TRIPLES      22 PREDICATES      133 URIs      119 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12020-010-9430-5 schema:about N001bd79f0dd44f72970bf0a3b5d933ec
2 N02c10c97d4c04a008ef3751a1e59caab
3 N0d6d5c288c9d47d5996cd282a77d52a8
4 N1820a5bf5ebc43cfad7f5602924d2bbd
5 N46e2c7f071ee4c87b443b200a322a62d
6 N53c258898f1045dc85dca91a3202e664
7 N588bdb6fba15471b8a5ccb9a395f795c
8 N5e14a8a0a138465389565c90ed1653fb
9 N733d6ccaacf54bb9be26ad791228a264
10 N95db8d8cae93419dbcda6c97f283d1b3
11 Na65bffab9e3d4ef4ac0696aac955df81
12 Nab386bb1bcf64680a2c3b238d50abcd0
13 Nbba29075d3cd40db8e440a5f2e7e1180
14 Nf3729c69afa7412ab2332fd8c225eb46
15 anzsrc-for:11
16 anzsrc-for:1112
17 schema:author Na2cf885de9f14101b5bc66939e81c802
18 schema:citation sg:pub.10.1007/bf02848773
19 sg:pub.10.1007/s00268-004-7192-z
20 sg:pub.10.1007/s00268-004-7644-5
21 sg:pub.10.1007/s00432-008-0373-7
22 sg:pub.10.1038/ncpendmet0020
23 sg:pub.10.1245/aso.2004.03.066
24 schema:datePublished 2010-12-14
25 schema:datePublishedReg 2010-12-14
26 schema:description It has been known that thyroid stimulating hormone (TSH) stimulates the growth or development of thyroid malignancy and higher serum TSH has association with both thyroid cancer incidence and advanced tumor stage. However, the role of TSH in high-risk features of well-differentiated thyroid cancer was not fully evaluated especially in Asian population. The purpose of our study is to evaluate the association of preoperative serum TSH levels with the advance of differentiated thyroid cancer and its high-risk clinicopathological features in Korean patients. We evaluated 554 patients retrospectively who underwent thyroidectomy and diagnosed as differentiated thyroid cancer during a 3-year period at Pusan National University Hospital. The preoperative TSH levels were significantly higher in the patients with extrathyroidal extension (P = 0.002) and those with lateral lymph node metastasis (P = 0.007). As the increase of the serum TSH concentration, there were significant rising trends in the prevalence of extrathyroidal extension (P = 0.009). In the patients with TSH ≥ 2.5 mIU/L, the prevalences of extrathyroidal extension (P = 0.006) and lateral lymph node metastasis (P = 0.024) were also significantly higher. Using multiple logistic regression, preoperative TSH level was a predictive factor for the presence of extrathyroidal extension (P = 0.008) and lateral lymph node metastasis (P = 0.025). Hashimoto’s thyroiditis itself was not associated with the status of extrathyroidal extension and lateral lymph node metastasis. In conclusion, preoperative TSH levels were associated with lateral lymph node matastasis, a novel finding, and extrathyroidal extension in well differentiated thyroid cancer and might be useful as a preoperative supplementary marker for determining the optimal extent of differentiated thyroid cancer surgery in Korean patients.
27 schema:genre article
28 schema:inLanguage en
29 schema:isAccessibleForFree false
30 schema:isPartOf N3b94ee65107c4ae0a050c9016c7e25fb
31 N6ec1ffda9da940aa86f814ee18984f9e
32 sg:journal.1112251
33 schema:keywords Asian populations
34 Hashimoto's thyroiditis
35 Korean patients
36 National University Hospital
37 Preoperative serum thyroid
38 Pusan National University Hospital
39 TSH
40 TSH concentrations
41 TSH levels
42 University Hospital
43 advanced tumor stage
44 advances
45 association
46 cancer
47 cancer incidence
48 cancer surgery
49 carcinoma
50 clinicopathological features
51 concentration
52 conclusion
53 development
54 differentiated thyroid cancer
55 differentiated thyroid cancer surgery
56 experience
57 extension
58 extent
59 factors
60 features
61 findings
62 growth
63 high-risk clinicopathological features
64 high-risk features
65 higher serum TSH
66 hormone
67 hormone levels
68 hospital
69 incidence
70 increase
71 lateral lymph node matastasis
72 lateral lymph node metastasis
73 levels
74 logistic regression
75 lymph node matastasis
76 lymph node metastasis
77 mIU/L
78 malignancy
79 markers
80 matastasis
81 metastasis
82 multiple logistic regression
83 node matastasis
84 node metastasis
85 novel findings
86 optimal extent
87 patients
88 period
89 population
90 predictive factors
91 preoperative TSH levels
92 preoperative serum TSH levels
93 preoperative supplementary marker
94 presence
95 prevalence
96 purpose
97 regression
98 role
99 role of TSH
100 serum TSH
101 serum TSH concentrations
102 serum TSH levels
103 serum thyroid
104 single-center experience
105 stage
106 status
107 study
108 supplementary marker
109 surgery
110 thyroid
111 thyroid cancer
112 thyroid cancer incidence
113 thyroid cancer surgery
114 thyroid carcinoma
115 thyroid malignancy
116 thyroidectomy
117 thyroiditis
118 trends
119 tumor stage
120 schema:name Preoperative serum thyroid stimulating hormone levels in well-differentiated thyroid carcinoma is a predictive factor for lateral lymph node metastasis as well as extrathyroidal extension in Korean patients: a single-center experience
121 schema:pagination 259-265
122 schema:productId N08df6145389e45a5a9617e611d6c55c1
123 Nbe1fdc72b3a244738b3ee7bc7be67662
124 Nfbef3a9263444f85a148a729b0fe0614
125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018944302
126 https://doi.org/10.1007/s12020-010-9430-5
127 schema:sdDatePublished 2022-01-01T18:21
128 schema:sdLicense https://scigraph.springernature.com/explorer/license/
129 schema:sdPublisher Nc7be1cdd354a47b2a9ee26412232b3a3
130 schema:url https://doi.org/10.1007/s12020-010-9430-5
131 sgo:license sg:explorer/license/
132 sgo:sdDataset articles
133 rdf:type schema:ScholarlyArticle
134 N001bd79f0dd44f72970bf0a3b5d933ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Thyroidectomy
136 rdf:type schema:DefinedTerm
137 N02c10c97d4c04a008ef3751a1e59caab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Lymphatic Metastasis
139 rdf:type schema:DefinedTerm
140 N08df6145389e45a5a9617e611d6c55c1 schema:name pubmed_id
141 schema:value 21161440
142 rdf:type schema:PropertyValue
143 N0d6d5c288c9d47d5996cd282a77d52a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Korea
145 rdf:type schema:DefinedTerm
146 N1820a5bf5ebc43cfad7f5602924d2bbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Neoplasm Staging
148 rdf:type schema:DefinedTerm
149 N18ace9bbdf2c4e669a7966beb34b95af rdf:first sg:person.015655263124.97
150 rdf:rest Nd62afa9dd3df422481b093b14d8bd73d
151 N25d3131e0cf743bf9144c62163fb39d4 rdf:first sg:person.010657730644.17
152 rdf:rest N3c548d2725784aa9bb58802475254126
153 N3b94ee65107c4ae0a050c9016c7e25fb schema:issueNumber 3
154 rdf:type schema:PublicationIssue
155 N3c548d2725784aa9bb58802475254126 rdf:first sg:person.01027510627.33
156 rdf:rest N6af0ee26cba6475983d46f2af301479d
157 N46e2c7f071ee4c87b443b200a322a62d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Female
159 rdf:type schema:DefinedTerm
160 N50914316c49644f4a176842cd096c447 rdf:first sg:person.010332072074.47
161 rdf:rest N18ace9bbdf2c4e669a7966beb34b95af
162 N53c258898f1045dc85dca91a3202e664 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Risk Factors
164 rdf:type schema:DefinedTerm
165 N588bdb6fba15471b8a5ccb9a395f795c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Retrospective Studies
167 rdf:type schema:DefinedTerm
168 N5e14a8a0a138465389565c90ed1653fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Thyroid Neoplasms
170 rdf:type schema:DefinedTerm
171 N6af0ee26cba6475983d46f2af301479d rdf:first sg:person.0636056263.51
172 rdf:rest N77916f961df04c50ba9b98e20d9f97c5
173 N6ec1ffda9da940aa86f814ee18984f9e schema:volumeNumber 39
174 rdf:type schema:PublicationVolume
175 N733d6ccaacf54bb9be26ad791228a264 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Thyrotropin
177 rdf:type schema:DefinedTerm
178 N77916f961df04c50ba9b98e20d9f97c5 rdf:first sg:person.01342545452.40
179 rdf:rest Ne28a23750c3249fa897aa2d0aa5e8c4c
180 N95db8d8cae93419dbcda6c97f283d1b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Middle Aged
182 rdf:type schema:DefinedTerm
183 Na2cf885de9f14101b5bc66939e81c802 rdf:first sg:person.01122642102.04
184 rdf:rest N50914316c49644f4a176842cd096c447
185 Na65bffab9e3d4ef4ac0696aac955df81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Male
187 rdf:type schema:DefinedTerm
188 Nab386bb1bcf64680a2c3b238d50abcd0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Adult
190 rdf:type schema:DefinedTerm
191 Nbba29075d3cd40db8e440a5f2e7e1180 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Preoperative Period
193 rdf:type schema:DefinedTerm
194 Nbe1fdc72b3a244738b3ee7bc7be67662 schema:name dimensions_id
195 schema:value pub.1018944302
196 rdf:type schema:PropertyValue
197 Nc7be1cdd354a47b2a9ee26412232b3a3 schema:name Springer Nature - SN SciGraph project
198 rdf:type schema:Organization
199 Nd62afa9dd3df422481b093b14d8bd73d rdf:first sg:person.01032567265.78
200 rdf:rest N25d3131e0cf743bf9144c62163fb39d4
201 Ne28a23750c3249fa897aa2d0aa5e8c4c rdf:first sg:person.01231760661.50
202 rdf:rest rdf:nil
203 Nf3729c69afa7412ab2332fd8c225eb46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Humans
205 rdf:type schema:DefinedTerm
206 Nfbef3a9263444f85a148a729b0fe0614 schema:name doi
207 schema:value 10.1007/s12020-010-9430-5
208 rdf:type schema:PropertyValue
209 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
210 schema:name Medical and Health Sciences
211 rdf:type schema:DefinedTerm
212 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
213 schema:name Oncology and Carcinogenesis
214 rdf:type schema:DefinedTerm
215 sg:journal.1112251 schema:issn 1355-008X
216 1559-0100
217 schema:name Endocrine
218 schema:publisher Springer Nature
219 rdf:type schema:Periodical
220 sg:person.01027510627.33 schema:affiliation grid-institutes:grid.412591.a
221 schema:familyName Son
222 schema:givenName Seok Man
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027510627.33
224 rdf:type schema:Person
225 sg:person.01032567265.78 schema:affiliation grid-institutes:grid.412588.2
226 schema:familyName Song
227 schema:givenName Sang Heon
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032567265.78
229 rdf:type schema:Person
230 sg:person.010332072074.47 schema:affiliation grid-institutes:grid.412588.2
231 schema:familyName Lee
232 schema:givenName Byung Joo
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010332072074.47
234 rdf:type schema:Person
235 sg:person.010657730644.17 schema:affiliation grid-institutes:grid.412588.2
236 schema:familyName Kim
237 schema:givenName Bo Hyun
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010657730644.17
239 rdf:type schema:Person
240 sg:person.01122642102.04 schema:affiliation grid-institutes:grid.262229.f
241 schema:familyName Kim
242 schema:givenName Sang Soo
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122642102.04
244 rdf:type schema:Person
245 sg:person.01231760661.50 schema:affiliation grid-institutes:grid.262229.f
246 schema:familyName Kang
247 schema:givenName Yang Ho
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231760661.50
249 rdf:type schema:Person
250 sg:person.01342545452.40 schema:affiliation grid-institutes:grid.412588.2
251 schema:familyName Kim
252 schema:givenName Yong Ki
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342545452.40
254 rdf:type schema:Person
255 sg:person.015655263124.97 schema:affiliation grid-institutes:grid.412588.2
256 schema:familyName Lee
257 schema:givenName Jin Choon
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015655263124.97
259 rdf:type schema:Person
260 sg:person.0636056263.51 schema:affiliation grid-institutes:grid.412588.2
261 schema:familyName Kim
262 schema:givenName In Ju
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636056263.51
264 rdf:type schema:Person
265 sg:pub.10.1007/bf02848773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011199656
266 https://doi.org/10.1007/bf02848773
267 rdf:type schema:CreativeWork
268 sg:pub.10.1007/s00268-004-7192-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1051920619
269 https://doi.org/10.1007/s00268-004-7192-z
270 rdf:type schema:CreativeWork
271 sg:pub.10.1007/s00268-004-7644-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050534564
272 https://doi.org/10.1007/s00268-004-7644-5
273 rdf:type schema:CreativeWork
274 sg:pub.10.1007/s00432-008-0373-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019427921
275 https://doi.org/10.1007/s00432-008-0373-7
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/ncpendmet0020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020356795
278 https://doi.org/10.1038/ncpendmet0020
279 rdf:type schema:CreativeWork
280 sg:pub.10.1245/aso.2004.03.066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034006245
281 https://doi.org/10.1245/aso.2004.03.066
282 rdf:type schema:CreativeWork
283 grid-institutes:grid.262229.f schema:alternateName Medical Research Institute, Pusan National University, 602-739, Busan, Korea
284 schema:name Department of Internal Medicine, Pusan National University Hospital, 602-739, Busan, Korea
285 Diabetes Center and Endocrine Clinic, Pusan National University Yangsan Hospital, 626-770, Yangsan, Korea
286 Medical Research Institute, Pusan National University, 602-739, Busan, Korea
287 rdf:type schema:Organization
288 grid-institutes:grid.412588.2 schema:alternateName Department of Internal Medicine, Pusan National University Hospital, 602-739, Busan, Korea
289 Department of Otolaryngology, Pusan National University Hospital, 602-739, Busan, Korea
290 schema:name Department of Internal Medicine, Pusan National University Hospital, 602-739, Busan, Korea
291 Department of Otolaryngology, Pusan National University Hospital, 602-739, Busan, Korea
292 rdf:type schema:Organization
293 grid-institutes:grid.412591.a schema:alternateName Diabetes Center and Endocrine Clinic, Pusan National University Yangsan Hospital, 626-770, Yangsan, Korea
294 schema:name Diabetes Center and Endocrine Clinic, Pusan National University Yangsan Hospital, 626-770, Yangsan, Korea
295 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...