Ontology type: schema:ScholarlyArticle
2010-08
AUTHORSLalantha Leelarathna, Louise Breen, James K. Powrie, Stephen M. Thomas, Rustom Guzder, Barbara McGowan, Paul V. Carroll
ABSTRACTThere are no consensus guidelines on the optimum long-term care of patients with primary adrenal failure. Published data suggest increased morbidity and mortality in patients treated with current therapy. Investigations of bone mineral density (BMD) in adults with adrenal failure have reported conflicting results. The objectives of this study were to determine the prevalence of auto-immune and other co-morbidities, describe the treatment regimens and to assess the BMD of adults with auto-immune Addison's disease (AAD). A retrospective, cohort study of adults with primary adrenal failure was used. Electronic and paper records were used to collect demographic, biochemical, BMD data and details of other co-morbidities. 48 patients (35% male; 65% female; 50 ± 16, years, mean ± SD) with primary adrenal failure were identified. There was high prevalence of other auto-immune co-morbidities (hypothyroidism 58%, vitamin B(12) deficiency 29%, type 1 diabetes 10%). The presence of cardiovascular risk factors including dyslipidaemia (65% had total cholesterol >5 mmol/l) and excess weight (65% had a BMI >25 kg/m(2)) were high. Using WHO criteria, 17.9 and 53.5% of patients had spinal osteoporosis and osteopenia, respectively, at the spine. This did not relate to the duration or dose of glucocorticoid replacement. Our data shows a high prevalence of both auto-immune and non-autoimmune co-morbidities in patients with AAD. In addition to common auto-immune diseases, patients should be screened for other cardiovascular risk factors. Further studies are needed to assess the cause of the observed increased prevalence of reduced BMD at the lumbar spine. There is a need for internationally agreed long-term management guidelines. More... »
PAGES113-117
http://scigraph.springernature.com/pub.10.1007/s12020-010-9359-8
DOIhttp://dx.doi.org/10.1007/s12020-010-9359-8
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1043209367
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/20960111
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Addison Disease",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Autoimmune Diseases",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Bone Density",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Comorbidity",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Diabetes Mellitus, Type 1",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Dyslipidemias",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hydrocortisone",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hypothyroidism",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Incidence",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lumbar Vertebrae",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prevalence",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retrospective Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Risk Factors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Treatment Outcome",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Vitamin B 12 Deficiency",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "St Thomas' Hospital",
"id": "https://www.grid.ac/institutes/grid.425213.3",
"name": [
"Department of Endocrinology, Guy\u2019s & St Thomas\u2019 NHS Foundation Trust, DEDC 3rd Floor Lambeth Wing, St. Thomas\u2019 Hospital, SE1 7EH, London, UK"
],
"type": "Organization"
},
"familyName": "Leelarathna",
"givenName": "Lalantha",
"id": "sg:person.01235776343.55",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235776343.55"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "St Thomas' Hospital",
"id": "https://www.grid.ac/institutes/grid.425213.3",
"name": [
"Department of Endocrinology, Guy\u2019s & St Thomas\u2019 NHS Foundation Trust, DEDC 3rd Floor Lambeth Wing, St. Thomas\u2019 Hospital, SE1 7EH, London, UK"
],
"type": "Organization"
},
"familyName": "Breen",
"givenName": "Louise",
"id": "sg:person.011157213616.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011157213616.41"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "St Thomas' Hospital",
"id": "https://www.grid.ac/institutes/grid.425213.3",
"name": [
"Department of Endocrinology, Guy\u2019s & St Thomas\u2019 NHS Foundation Trust, DEDC 3rd Floor Lambeth Wing, St. Thomas\u2019 Hospital, SE1 7EH, London, UK"
],
"type": "Organization"
},
"familyName": "Powrie",
"givenName": "James K.",
"id": "sg:person.0761664376.46",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761664376.46"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "St Thomas' Hospital",
"id": "https://www.grid.ac/institutes/grid.425213.3",
"name": [
"Department of Endocrinology, Guy\u2019s & St Thomas\u2019 NHS Foundation Trust, DEDC 3rd Floor Lambeth Wing, St. Thomas\u2019 Hospital, SE1 7EH, London, UK"
],
"type": "Organization"
},
"familyName": "Thomas",
"givenName": "Stephen M.",
"id": "sg:person.01041627254.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041627254.07"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "St Thomas' Hospital",
"id": "https://www.grid.ac/institutes/grid.425213.3",
"name": [
"Department of Endocrinology, Guy\u2019s & St Thomas\u2019 NHS Foundation Trust, DEDC 3rd Floor Lambeth Wing, St. Thomas\u2019 Hospital, SE1 7EH, London, UK"
],
"type": "Organization"
},
"familyName": "Guzder",
"givenName": "Rustom",
"id": "sg:person.01265252173.22",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265252173.22"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "St Thomas' Hospital",
"id": "https://www.grid.ac/institutes/grid.425213.3",
"name": [
"Department of Endocrinology, Guy\u2019s & St Thomas\u2019 NHS Foundation Trust, DEDC 3rd Floor Lambeth Wing, St. Thomas\u2019 Hospital, SE1 7EH, London, UK"
],
"type": "Organization"
},
"familyName": "McGowan",
"givenName": "Barbara",
"id": "sg:person.01067103203.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067103203.76"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "St Thomas' Hospital",
"id": "https://www.grid.ac/institutes/grid.425213.3",
"name": [
"Department of Endocrinology, Guy\u2019s & St Thomas\u2019 NHS Foundation Trust, DEDC 3rd Floor Lambeth Wing, St. Thomas\u2019 Hospital, SE1 7EH, London, UK"
],
"type": "Organization"
},
"familyName": "Carroll",
"givenName": "Paul V.",
"id": "sg:person.01233111241.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233111241.24"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/s0140-6736(03)13492-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000863217"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(03)13492-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000863217"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/08916930410001705466",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004321988"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s001980050251",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009240786",
"https://doi.org/10.1007/s001980050251"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1046/j.1365-2265.2002.01466.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023154056"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/qjmed/hcp053",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025776226"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/qjmed/hcp053",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025776226"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2265.2008.03340.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029404998"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1046/j.1365-2265.2002.t01-1-01552.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031863580"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1530/eje-09-0170",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034865889"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jbmr.5650090802",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034966333"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jbmr.5650090802",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034966333"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1046/j.1365-2265.2003.01761.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040226238"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.2006-0076",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064289071"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.2007-0685",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064289974"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.2007-1134",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064290072"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.2008-2380",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064291081"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.2009-1368",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064291548"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7326/0003-4819-120-3-199402010-00005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1073698416"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082657644",
"type": "CreativeWork"
}
],
"datePublished": "2010-08",
"datePublishedReg": "2010-08-01",
"description": "There are no consensus guidelines on the optimum long-term care of patients with primary adrenal failure. Published data suggest increased morbidity and mortality in patients treated with current therapy. Investigations of bone mineral density (BMD) in adults with adrenal failure have reported conflicting results. The objectives of this study were to determine the prevalence of auto-immune and other co-morbidities, describe the treatment regimens and to assess the BMD of adults with auto-immune Addison's disease (AAD). A retrospective, cohort study of adults with primary adrenal failure was used. Electronic and paper records were used to collect demographic, biochemical, BMD data and details of other co-morbidities. 48 patients (35% male; 65% female; 50 \u00b1 16, years, mean \u00b1 SD) with primary adrenal failure were identified. There was high prevalence of other auto-immune co-morbidities (hypothyroidism 58%, vitamin B(12) deficiency 29%, type 1 diabetes 10%). The presence of cardiovascular risk factors including dyslipidaemia (65% had total cholesterol >5 mmol/l) and excess weight (65% had a BMI >25 kg/m(2)) were high. Using WHO criteria, 17.9 and 53.5% of patients had spinal osteoporosis and osteopenia, respectively, at the spine. This did not relate to the duration or dose of glucocorticoid replacement. Our data shows a high prevalence of both auto-immune and non-autoimmune co-morbidities in patients with AAD. In addition to common auto-immune diseases, patients should be screened for other cardiovascular risk factors. Further studies are needed to assess the cause of the observed increased prevalence of reduced BMD at the lumbar spine. There is a need for internationally agreed long-term management guidelines.",
"genre": "research_article",
"id": "sg:pub.10.1007/s12020-010-9359-8",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1112251",
"issn": [
"1355-008X",
"1559-0100"
],
"name": "Endocrine",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "38"
}
],
"name": "Co-morbidities, management and clinical outcome of auto-immune Addison\u2019s disease",
"pagination": "113-117",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"cdd21c76fc8e005b28fda5e01d73036485a54ca09024a12abd3c52514e9748bc"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"20960111"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9434444"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s12020-010-9359-8"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1043209367"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s12020-010-9359-8",
"https://app.dimensions.ai/details/publication/pub.1043209367"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T10:32",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113655_00000001.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007%2Fs12020-010-9359-8"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12020-010-9359-8'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12020-010-9359-8'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12020-010-9359-8'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12020-010-9359-8'
This table displays all metadata directly associated to this object as RDF triples.
246 TRIPLES
21 PREDICATES
67 URIs
42 LITERALS
30 BLANK NODES