Pheochromocytoma crisis after a dexamethasone suppression test for adrenal incidentaloma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-01-05

AUTHORS

Dong Won Yi, Sun Young Kim, Dong Hoon Shin, Yang Ho Kang, Seok Man Son

ABSTRACT

A 61-year-old woman was referred to our department for evaluation of an incidental adrenal mass. An abdominal CT scan revealed a 4.1 cm right adrenal mass. The patient had been diagnosed with hypertension 7 years earlier and had taken antihypertensive medications intermittently. Her physical examination demonstrated a round face, central obesity, and mild hypertension. Serum catecholamines, renin, aldosterone, ACTH and 24-h urine-free cortisol, vanillylmandelic acid levels were within normal limits. However, serum cortisol level was markedly elevated and the circadian rhythm was disturbed. Successive low-dose and high-dose dexamethasone suppression tests were ordered for evaluation of a functioning adrenal incidentaloma. About 2 h after taking the second dose of 2 mg dexamethasone, she suddenly developed nausea and vomiting, palpitations, and anxiety with severe hypertension. On the same day, we measured serum catecholamines, which were markedly elevated. An elective laparoscopic right adrenalectomy was performed and pathologic examination confirmed the diagnosis of pheochromocytoma. One week after surgery, serum and urine catecholamine levels returned to normal. The patient has remained normotensive without any medications and clinically well. Patients with adrenal incidentalomas may have a functional mass that does not always manifest as a full symptomatic disease. During the investigation of adrenal incidentalomas, pheochromocytoma should ideally be ruled out before administering corticosteroids. More... »

PAGES

213-219

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12020-009-9303-y

DOI

http://dx.doi.org/10.1007/s12020-009-9303-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040226263

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20963573


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214 Diabetes Center and Endocrine Clinic, Pusan National University Yangsan Hospital, 626-770, Yangsan, Korea
215 rdf:type schema:Organization
216 grid-institutes:grid.412591.a schema:alternateName Department of Pathology, Pusan National University Yangsan Hospital, 626-770, Yangsan, Korea
217 schema:name Department of Pathology, Pusan National University Yangsan Hospital, 626-770, Yangsan, Korea
218 rdf:type schema:Organization
 




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