Marrow Fat and Bone: New Insights from Mice and Humans View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-05-23

AUTHORS

Masanobu Kawai, Clifford J. Rosen

ABSTRACT

Adipocytes are an essential component of the bone marrow micro-environment. Developmentally, fatty infiltration of the marrow in the appendicular skeleton occurs at the time of peak bone acquisition. Conversely, vertebral marrow fat is most predominant with advancing age. Recent studies suggest that the amount of marrow fat is inversely associated with bone mineral density. It may also be a predictor of subsequent fracture. The molecular cellular and genetic aspects of marrow fat in mouse models and humans are discussed. More studies are needed to understand the relationship of marrow fat to mineral metabolism, energy balance, and skeletal fragility. More... »

PAGES

216-223

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12018-009-9050-x

    DOI

    http://dx.doi.org/10.1007/s12018-009-9050-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022946324


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