Human Vascular Tissue Models Formed from Human Induced Pluripotent Stem Cell Derived Endothelial Cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-06

AUTHORS

David G. Belair, Jordan A. Whisler, Jorge Valdez, Jeremy Velazquez, James A. Molenda, Vernella Vickerman, Rachel Lewis, Christine Daigh, Tyler D. Hansen, David A. Mann, James A. Thomson, Linda G. Griffith, Roger D. Kamm, Michael P. Schwartz, William L. Murphy

ABSTRACT

Here we describe a strategy to model blood vessel development using a well-defined induced pluripotent stem cell-derived endothelial cell type (iPSC-EC) cultured within engineered platforms that mimic the 3D microenvironment. The iPSC-ECs used here were first characterized by expression of endothelial markers and functional properties that included VEGF responsiveness, TNF-α-induced upregulation of cell adhesion molecules (MCAM/CD146; ICAM1/CD54), thrombin-dependent barrier function, shear stress-induced alignment, and 2D and 3D capillary-like network formation in Matrigel. The iPSC-ECs also formed 3D vascular networks in a variety of engineering contexts, yielded perfusable, interconnected lumen when co-cultured with primary human fibroblasts, and aligned with flow in microfluidics devices. iPSC-EC function during tubule network formation, barrier formation, and sprouting was consistent with that of primary ECs, and the results suggest a VEGF-independent mechanism for sprouting, which is relevant to therapeutic anti-angiogenesis strategies. Our combined results demonstrate the feasibility of using a well-defined, stable source of iPSC-ECs to model blood vessel formation within a variety of contexts using standard in vitro formats. More... »

PAGES

511-525

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12015-014-9549-5

DOI

http://dx.doi.org/10.1007/s12015-014-9549-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021039851

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25190668


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455 Morgridge Institute for Research, Madison, WI, USA
456 Wisconsin Institute for Medical Research, 1111 Highland Avenue Room 5405, 53705, Madison, WI, USA
457 rdf:type schema:Organization
458 https://www.grid.ac/institutes/grid.452315.4 schema:alternateName Cellular Dynamics International (United States)
459 schema:name Cellular Dynamics International, Inc., Madison, WI, USA
460 rdf:type schema:Organization
 




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