Blood Levels of Carbonic Anhydrase 9 Correlate with Clear Cell Renal Cell Carcinoma Activity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-07-12

AUTHORS

Peter Hulick, Michael Zimmer, Vitaly Margulis, Steven Skates, Maureen Hamel, Douglas M. Dahl, Dror M. Michaelson, Towia Liebermann, Sabina Signoretti, Walter Carney, Christopher Wood, Othon Iliopoulos

ABSTRACT

IntroductionBiomarkers for early detection of renal cell carcinoma (RCC) may help diagnose minimal residual disease in patients at risk for RCC, can guide anti-angiogenic therapy, or may help identify candidates for adjuvant treatment. In this study, we investigated whether blood levels of carbonic anhydrase 9 (CA9) correlate with RCC tumor burden and therefore disease activity.MethodsCA9 is a von Hippel–Lindau–hypoxia inducible factor target upregulated in clear cell RCC. We used an anti-CA9 antibody (M75)-based enzyme-linked immunosorbent assay test to measure CA9 levels in blood obtained before and after nephrectomy for clinically localized disease in patients with: (1) clear cell RCC, (2) papillary and chromophobe RCC or oncocytoma, or (3) benign kidney lesions, and we compared these samples to blood drawn from normal control individuals.ResultsWe observed a significant (p < 0.006) decrease in the blood levels of CA9, after nephrectomy for localized disease, in the majority of patients with clear cell RCC (57%). In contrast, patients with nonclear cell RCC, benign disease, or those having undergone debulking nephrectomy for metastatic disease did not have a decrease in CA9 blood levels after nephrectomy. Preliminary longitudinal follow up measurements of CA9 levels in a small group of patients indicated that rising CA9 levels may correlate with disease progression.ConclusionsPlasma CA9 levels correlate with disease activity in a subset of clear cell RCC patients and should be considered in future multiplex RCC biomarker development algorithms. More... »

PAGES

37-45

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12014-008-9012-1

DOI

http://dx.doi.org/10.1007/s12014-008-9012-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029778748


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