Photoprotective Properties of Vitamin D and Lumisterol Hydroxyderivatives View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-05-22

AUTHORS

Andrzej T. Slominski, Anyamanee Chaiprasongsuk, Zorica Janjetovic, Tae-Kang Kim, Joanna Stefan, Radomir M. Slominski, Vidya Sagar Hanumanthu, Chander Raman, Shariq Qayyum, Yuwei Song, Yuhua Song, Uraiwan Panich, David K. Crossman, Mohammad Athar, Michael F. Holick, Anton M. Jetten, Michal A. Zmijewski, Jaroslaw Zmijewski, Robert C. Tuckey

ABSTRACT

We have previously described new pathways of vitamin D3 activation by CYP11A1 to produce a variety of metabolites including 20(OH)D3 and 20,23(OH)2D3. These can be further hydroxylated by CYP27B1 to produce their C1α-hydroxyderivatives. CYP11A1 similarly initiates the metabolism of lumisterol (L3) through sequential hydroxylation of the side chain to produce 20(OH)L3, 22(OH)L3, 20,22(OH)2L3 and 24(OH)L3. CYP11A1 also acts on 7-dehydrocholesterol (7DHC) producing 22(OH)7DHC, 20,22(OH)27DHC and 7-dehydropregnenolone (7DHP) which can be converted to the D3 and L3 configurations following exposure to UVB. These CYP11A1-derived compounds are produced in vivo and are biologically active displaying anti-proliferative, anti-inflammatory, anti-cancer and pro-differentiation properties. Since the protective role of the classical form of vitamin D3 (1,25(OH)2D3) against UVB-induced damage is recognized, we recently tested whether novel CYP11A1-derived D3- and L3-hydroxyderivatives protect against UVB-induced damage in epidermal human keratinocytes and melanocytes. We found that along with 1,25(OH)2D3, CYP11A1-derived D3-hydroxyderivatives and L3 and its hydroxyderivatives exert photoprotective effects. These included induction of intracellular free radical scavenging and attenuation and repair of DNA damage. The protection of human keratinocytes against DNA damage included the activation of the NRF2-regulated antioxidant response, p53-phosphorylation and its translocation to the nucleus, and DNA repair induction. These data indicate that novel derivatives of vitamin D3 and lumisterol are promising photoprotective agents. However, detailed mechanisms of action, and the involvement of specific nuclear receptors, other vitamin D binding proteins or mitochondria, remain to be established. More... »

PAGES

165-180

References to SciGraph publications

  • 2015-10-08. Detection of novel CYP11A1-derived secosteroids in the human epidermis and serum and pig adrenal gland in SCIENTIFIC REPORTS
  • 2011-11-17. High basal NF-κB activity in nonpigmented melanoma cells is associated with an enhanced sensitivity to vitamin D3 derivatives in BRITISH JOURNAL OF CANCER
  • 2018-01-24. Investigation of 20S-hydroxyvitamin D3 analogs and their 1α-OH derivatives as potent vitamin D receptor agonists with anti-inflammatory activities in SCIENTIFIC REPORTS
  • 2012-12-01. Differential photoprotective effects of 1,25-dihydroxyvitamin D3 and a low calcaemic deltanoid in PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
  • 2017-09-12. Characterization of a new pathway that activates lumisterol in vivo to biologically active hydroxylumisterols in SCIENTIFIC REPORTS
  • 2010-12-01. Vitamin D, disease and therapeutic opportunities in NATURE REVIEWS DRUG DISCOVERY
  • 2010-01-27. Vitamin D and the skin in JOURNAL OF BONE AND MINERAL METABOLISM
  • 2012-01. UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer in PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
  • 2017-08-31. 1α,20S-Dihydroxyvitamin D3 Interacts with Vitamin D Receptor: Crystal Structure and Route of Chemical Synthesis in SCIENTIFIC REPORTS
  • 2005-10-19. Differential biologic effects of CPD and 6-4PP UV-induced DNA damage on the induction of apoptosis and cell-cycle arrest in BMC CANCER
  • 2006-02. Endogenous UVA-photosensitizers: mediators of skin photodamage and novel targets for skin photoprotection in PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
  • 2012-07-26. Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice in SCIENTIFIC REPORTS
  • 2014. Protection from Ultraviolet Damage and Photocarcinogenesis by Vitamin D Compounds in SUNLIGHT, VITAMIN D AND SKIN CANCER
  • 2017-08-12. Melatonin, mitochondria, and the skin in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2019-11-27. Disassociation of Vitamin D’s Calcemic Activity and Non-calcemic Genomic Activity and Individual Responsiveness: A Randomized Controlled Double-Blind Clinical Trial in SCIENTIFIC REPORTS
  • 2008-09-04. Synthesis and photo-conversion of androsta- and pregna-5,7-dienes to vitamin D3-like derivatives in PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
  • 2017-02-20. Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management in LABORATORY INVESTIGATION
  • 2013-06-21. DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control in BMC BIOLOGY
  • 2020-09-12. The Role of Classical and Novel Forms of Vitamin D in the Pathogenesis and Progression of Nonmelanoma Skin Cancers in SUNLIGHT, VITAMIN D AND SKIN CANCER
  • 2017-04-28. Melatonin and its metabolites protect human melanocytes against UVB-induced damage: Involvement of NRF2-mediated pathways in SCIENTIFIC REPORTS
  • 2012-01-08. Oxysterols are allosteric activators of the oncoprotein Smoothened in NATURE CHEMICAL BIOLOGY
  • Journal

    TITLE

    Cell Biochemistry and Biophysics

    ISSUE

    2

    VOLUME

    78

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12013-020-00913-6

    DOI

    http://dx.doi.org/10.1007/s12013-020-00913-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1127837999

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/32441029


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