The Iron State in Spleen and Liver Tissues from Patients with Hematological Malignancies Studied Using Magnetization Measurements and Mössbauer Spectroscopy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03

AUTHORS

I. V. Alenkina, A. V. Vinogradov, I. Felner, T. S. Konstantinova, E. Kuzmann, V. A. Semionkin, M. I. Oshtrakh

ABSTRACT

In this overview, we present the results of the study of spleen and liver tissues taken from healthy donors in comparison with those from patients with (i) non-Hodgkin B-cell lymphomas, namely, mantle cell lymphoma and marginal zone B-cell lymphoma, (ii) acute myeloid leukemia, and (iii) primary myelofibrosis. The study was carried out using Mössbauer spectroscopy and magnetization measurements for the analysis of ferritin-like iron in spleen and liver tissues. Magnetization measurements demonstrated small differences in the saturation magnetic moments and revealed additional paramagnetic components. Two liver samples demonstrated unusual behavior of the magnetic moment when the zero-field-cooled curve was over the field-cooled curve in the temperature range between ~40 and ~70 K. Relative iron content variations in the tissue cells as well as small variations in the 57Fe hyperfine parameters were demonstrated for healthy and patients' spleen and liver tissues on the base of measured Mössbauer spectra. The results obtained permit us to suggest small differences in the ferritin iron core structure in spleen and liver tissues from healthy donors and patients with hematological malignancies. More... »

PAGES

33-46

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12013-018-0855-4

DOI

http://dx.doi.org/10.1007/s12013-018-0855-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106834334

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30191452


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