Absence of Mitochondrial Toxicity in Hearts of Transgenic Mice Treated with Abacavir View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-06

AUTHORS

James J. Kohler, Seyed H. Hosseini, Elgin Green, Earl Fields, Allison Abuin, Tomika Ludaway, Rodney Russ, William Lewis

ABSTRACT

Abacavir (ABC) is a guanosine nucleoside reverse transcriptase inhibitor (NRTI) with potent antiretroviral activity. Since NRTIs exhibit tissue-specific inhibition of mitochondrial DNA (mtDNA) synthesis, the ability of ABC to inhibit mtDNA synthesis in vivo was evaluated. Inbred wild-type (WT) and transgenic mice (TG) treated with ABC (3.125 mg/d p. o., 35 days) were used to define mitochondrial oxidative stress and cardiac function. Chosen TGs exhibited overexpression of HIV-1 viral proteins (NL4-3Deltagag/pol, non-replication competent), hemizygous depletion or overexpression of mitochondrial superoxide dismutase (SOD2(+/-) knock-out (KO) or MnSOD OX, respectively), overexpression of mitochondrially targeted catalase (MCAT), or double "knockout" deletion of aldehyde dehydrogenase activity (ALDH2 KO). Impact on mtDNA synthesis was assessed by comparing changes in mtDNA abundance between ABC-treated and vehicle-treated WTs and TGs. No changes in mtDNA abundance occurred from ABC treatment in any mice, suggesting no inhibition of mtDNA synthesis. Left ventricle (LV) mass and LV end-diastolic dimension (LVEDD) were defined echocardiographically and remained unchanged as well. These results indicate that treatment with ABC has no visible cardiotoxicity in these adult mice exposed for 5 weeks compared to findings with other antiretroviral NRTI studies and support some claims for its relative safety. More... »

PAGES

146-151

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12012-010-9070-2

DOI

http://dx.doi.org/10.1007/s12012-010-9070-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027385679

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20379802


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-HIV Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Mitochondrial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dideoxynucleosides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Echocardiography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart Ventricles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred Strains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondria, Heart", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxidative Stress", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Superoxide Dismutase", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Department of Pathology, Emory University School of Medicine, 7126 Woodruff Memorial Building, 101 Woodruff Circle, 30322, Atlanta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kohler", 
        "givenName": "James J.", 
        "id": "sg:person.01327275104.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327275104.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Department of Pathology, Emory University School of Medicine, 7126 Woodruff Memorial Building, 101 Woodruff Circle, 30322, Atlanta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hosseini", 
        "givenName": "Seyed H.", 
        "id": "sg:person.0603671004.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603671004.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Department of Pathology, Emory University School of Medicine, 7126 Woodruff Memorial Building, 101 Woodruff Circle, 30322, Atlanta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Green", 
        "givenName": "Elgin", 
        "id": "sg:person.01177525165.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177525165.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Department of Pathology, Emory University School of Medicine, 7126 Woodruff Memorial Building, 101 Woodruff Circle, 30322, Atlanta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fields", 
        "givenName": "Earl", 
        "id": "sg:person.01247436210.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247436210.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Department of Pathology, Emory University School of Medicine, 7126 Woodruff Memorial Building, 101 Woodruff Circle, 30322, Atlanta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abuin", 
        "givenName": "Allison", 
        "id": "sg:person.01313753565.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313753565.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Department of Pathology, Emory University School of Medicine, 7126 Woodruff Memorial Building, 101 Woodruff Circle, 30322, Atlanta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ludaway", 
        "givenName": "Tomika", 
        "id": "sg:person.01240176541.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240176541.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Department of Pathology, Emory University School of Medicine, 7126 Woodruff Memorial Building, 101 Woodruff Circle, 30322, Atlanta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Russ", 
        "givenName": "Rodney", 
        "id": "sg:person.01135664377.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135664377.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Department of Pathology, Emory University School of Medicine, 7126 Woodruff Memorial Building, 101 Woodruff Circle, 30322, Atlanta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lewis", 
        "givenName": "William", 
        "id": "sg:person.01312066120.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312066120.49"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0003-9861(03)00316-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001345182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0003-9861(03)00316-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001345182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199004193221602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001371255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd1201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002739069", 
          "https://doi.org/10.1038/nrd1201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd1201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002739069", 
          "https://doi.org/10.1038/nrd1201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.2008.121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003771516", 
          "https://doi.org/10.1038/labinvest.2008.121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2001.tb03902.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004142288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2001.tb03902.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004142288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1468-1293.2009.00733.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004299865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3780366", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005451823", 
          "https://doi.org/10.1038/labinvest.3780366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3780366", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005451823", 
          "https://doi.org/10.1038/labinvest.3780366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0009-2797(02)00059-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008664512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0595-417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008779394", 
          "https://doi.org/10.1038/nm0595-417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/pcad.2000.9031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013465785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2353/ajpath.2007.060655", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017090372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/21.5.1059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020052337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3700523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022971840", 
          "https://doi.org/10.1038/labinvest.3700523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3700523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022971840", 
          "https://doi.org/10.1038/labinvest.3700523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3700523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022971840", 
          "https://doi.org/10.1038/labinvest.3700523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1592/phco.21.1.11.34439", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024312704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/em.20223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024708281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0149-2918(01)80132-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024888788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/coh.0b013e3281df3410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028031231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/coh.0b013e3281df3410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028031231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/coh.0b013e3281df3410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028031231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.aids.0000216367.23325.58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030567152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.aids.0000216367.23325.58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030567152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.aids.0000216367.23325.58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030567152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0307067101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030915212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpba.2004.03.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036001309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpba.2004.03.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036001309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.2009.14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037052004", 
          "https://doi.org/10.1038/labinvest.2009.14"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.2009.14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037052004", 
          "https://doi.org/10.1038/labinvest.2009.14"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lfs.2004.06.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037070558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0042-6822(91)90759-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037159008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.8.3592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037249602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/593022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037281639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/605440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037493628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(00)01710-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040972408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-3542(97)01033-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041637163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003088-200847060-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044215920", 
          "https://doi.org/10.2165/00003088-200847060-00001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/375353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046630083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.2009.39", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047490418", 
          "https://doi.org/10.1038/labinvest.2009.39"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1106653", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050321208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0891-5849(98)00199-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050383573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0298-159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051107507", 
          "https://doi.org/10.1038/ng0298-159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.107.189622", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051894931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0149-2918(00)90004-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052231962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.genet.39.110304.095751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053197411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.genet.39.110304.095751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053197411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12012-008-9015-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053572743", 
          "https://doi.org/10.1007/s12012-008-9015-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/367849", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058662782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/367849", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058662782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1289/ehp.98106s51219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064747181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2307/3433989", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070323504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077519579", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077629111", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083037746", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.41.5.1099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083087388"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-06", 
    "datePublishedReg": "2010-06-01", 
    "description": "Abacavir (ABC) is a guanosine nucleoside reverse transcriptase inhibitor (NRTI) with potent antiretroviral activity. Since NRTIs exhibit tissue-specific inhibition of mitochondrial DNA (mtDNA) synthesis, the ability of ABC to inhibit mtDNA synthesis in vivo was evaluated. Inbred wild-type (WT) and transgenic mice (TG) treated with ABC (3.125 mg/d p. o., 35 days) were used to define mitochondrial oxidative stress and cardiac function. Chosen TGs exhibited overexpression of HIV-1 viral proteins (NL4-3Deltagag/pol, non-replication competent), hemizygous depletion or overexpression of mitochondrial superoxide dismutase (SOD2(+/-) knock-out (KO) or MnSOD OX, respectively), overexpression of mitochondrially targeted catalase (MCAT), or double \"knockout\" deletion of aldehyde dehydrogenase activity (ALDH2 KO). Impact on mtDNA synthesis was assessed by comparing changes in mtDNA abundance between ABC-treated and vehicle-treated WTs and TGs. No changes in mtDNA abundance occurred from ABC treatment in any mice, suggesting no inhibition of mtDNA synthesis. Left ventricle (LV) mass and LV end-diastolic dimension (LVEDD) were defined echocardiographically and remained unchanged as well. These results indicate that treatment with ABC has no visible cardiotoxicity in these adult mice exposed for 5 weeks compared to findings with other antiretroviral NRTI studies and support some claims for its relative safety.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12012-010-9070-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2536224", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2404160", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2540350", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1030406", 
        "issn": [
          "1530-7905", 
          "1559-0259"
        ], 
        "name": "Cardiovascular Toxicology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "Absence of Mitochondrial Toxicity in Hearts of Transgenic Mice Treated with Abacavir", 
    "pagination": "146-151", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "8274b860907de3d04e2926ab4d558f265b014b73ba33f032b71b783fae66d414"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20379802"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101135818"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12012-010-9070-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1027385679"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12012-010-9070-2", 
      "https://app.dimensions.ai/details/publication/pub.1027385679"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54334_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs12012-010-9070-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12012-010-9070-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12012-010-9070-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12012-010-9070-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12012-010-9070-2'


 

This table displays all metadata directly associated to this object as RDF triples.

326 TRIPLES      21 PREDICATES      89 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12012-010-9070-2 schema:about N1067d28a3bed4c7a9b8dcab4a7a5a88e
2 N3886071e19064640b3b2f3d15b49d40d
3 N44eb823bb3104fcea1d6bfabc7a8cf14
4 N493df7abc5e2458c8d17da52b91927f4
5 N502a65915758491188bb4a49f590aa5b
6 N5be9c1a6302c4a8a97b8ebd326052813
7 N7576929efe09440c96d18dcb603c0398
8 Na657ab03fab4487bb6da76f7a81cbe11
9 Nb06e9aafa3c64792bf9cdd5e64b506d2
10 Ncee16ce8562842918eca5c1f62b535f6
11 Ne1a7d7f57d5f438f81798f18a31195db
12 Nf510420229a7486bb1540441f634e177
13 Nfc54eb3f63844ed6821f49b5cc0115d8
14 Nfedf11b1458b479ab6d833e7fdd53202
15 Nfff7c2b2194b472d9f7f3b45f4fda278
16 anzsrc-for:11
17 anzsrc-for:1103
18 schema:author N649d1b27d7254b31a9def149dbc5e916
19 schema:citation sg:pub.10.1007/s12012-008-9015-1
20 sg:pub.10.1038/labinvest.2008.121
21 sg:pub.10.1038/labinvest.2009.14
22 sg:pub.10.1038/labinvest.2009.39
23 sg:pub.10.1038/labinvest.3700523
24 sg:pub.10.1038/labinvest.3780366
25 sg:pub.10.1038/ng0298-159
26 sg:pub.10.1038/nm0595-417
27 sg:pub.10.1038/nrd1201
28 sg:pub.10.2165/00003088-200847060-00001
29 https://app.dimensions.ai/details/publication/pub.1077519579
30 https://app.dimensions.ai/details/publication/pub.1077629111
31 https://app.dimensions.ai/details/publication/pub.1083037746
32 https://doi.org/10.1002/em.20223
33 https://doi.org/10.1016/0042-6822(91)90759-5
34 https://doi.org/10.1016/j.jpba.2004.03.007
35 https://doi.org/10.1016/j.lfs.2004.06.020
36 https://doi.org/10.1016/s0003-9861(03)00316-3
37 https://doi.org/10.1016/s0009-2797(02)00059-5
38 https://doi.org/10.1016/s0014-5793(00)01710-5
39 https://doi.org/10.1016/s0149-2918(00)90004-3
40 https://doi.org/10.1016/s0149-2918(01)80132-6
41 https://doi.org/10.1016/s0166-3542(97)01033-4
42 https://doi.org/10.1016/s0891-5849(98)00199-3
43 https://doi.org/10.1053/pcad.2000.9031
44 https://doi.org/10.1056/nejm199004193221602
45 https://doi.org/10.1073/pnas.0307067101
46 https://doi.org/10.1073/pnas.93.8.3592
47 https://doi.org/10.1086/367849
48 https://doi.org/10.1086/375353
49 https://doi.org/10.1086/593022
50 https://doi.org/10.1086/605440
51 https://doi.org/10.1093/carcin/21.5.1059
52 https://doi.org/10.1097/01.aids.0000216367.23325.58
53 https://doi.org/10.1097/coh.0b013e3281df3410
54 https://doi.org/10.1111/j.1468-1293.2009.00733.x
55 https://doi.org/10.1111/j.1749-6632.2001.tb03902.x
56 https://doi.org/10.1126/science.1106653
57 https://doi.org/10.1128/aac.41.5.1099
58 https://doi.org/10.1146/annurev.genet.39.110304.095751
59 https://doi.org/10.1161/circulationaha.107.189622
60 https://doi.org/10.1289/ehp.98106s51219
61 https://doi.org/10.1592/phco.21.1.11.34439
62 https://doi.org/10.2307/3433989
63 https://doi.org/10.2353/ajpath.2007.060655
64 schema:datePublished 2010-06
65 schema:datePublishedReg 2010-06-01
66 schema:description Abacavir (ABC) is a guanosine nucleoside reverse transcriptase inhibitor (NRTI) with potent antiretroviral activity. Since NRTIs exhibit tissue-specific inhibition of mitochondrial DNA (mtDNA) synthesis, the ability of ABC to inhibit mtDNA synthesis in vivo was evaluated. Inbred wild-type (WT) and transgenic mice (TG) treated with ABC (3.125 mg/d p. o., 35 days) were used to define mitochondrial oxidative stress and cardiac function. Chosen TGs exhibited overexpression of HIV-1 viral proteins (NL4-3Deltagag/pol, non-replication competent), hemizygous depletion or overexpression of mitochondrial superoxide dismutase (SOD2(+/-) knock-out (KO) or MnSOD OX, respectively), overexpression of mitochondrially targeted catalase (MCAT), or double "knockout" deletion of aldehyde dehydrogenase activity (ALDH2 KO). Impact on mtDNA synthesis was assessed by comparing changes in mtDNA abundance between ABC-treated and vehicle-treated WTs and TGs. No changes in mtDNA abundance occurred from ABC treatment in any mice, suggesting no inhibition of mtDNA synthesis. Left ventricle (LV) mass and LV end-diastolic dimension (LVEDD) were defined echocardiographically and remained unchanged as well. These results indicate that treatment with ABC has no visible cardiotoxicity in these adult mice exposed for 5 weeks compared to findings with other antiretroviral NRTI studies and support some claims for its relative safety.
67 schema:genre research_article
68 schema:inLanguage en
69 schema:isAccessibleForFree false
70 schema:isPartOf Nc9d3a21b36f8480fa138822f6570ca58
71 Nc9e01eaa322e45339f78242d45f87b9e
72 sg:journal.1030406
73 schema:name Absence of Mitochondrial Toxicity in Hearts of Transgenic Mice Treated with Abacavir
74 schema:pagination 146-151
75 schema:productId N50bf18ff80ff4e23b57d51f58a6282f5
76 N56084d0c3e744b4ba7f63278a408555f
77 N950b9e8f2bbf4748b20b01793157576a
78 N96c38aa1bdc547e7b7057c95e146fb02
79 Na5d69f0c3a344b188b9d1e1c4d75e8ab
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027385679
81 https://doi.org/10.1007/s12012-010-9070-2
82 schema:sdDatePublished 2019-04-11T10:20
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher Nb7f72d33cbca45b5bae0189be13f049b
85 schema:url http://link.springer.com/10.1007%2Fs12012-010-9070-2
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N1067d28a3bed4c7a9b8dcab4a7a5a88e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Heart
91 rdf:type schema:DefinedTerm
92 N3886071e19064640b3b2f3d15b49d40d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Oxidative Stress
94 rdf:type schema:DefinedTerm
95 N44eb823bb3104fcea1d6bfabc7a8cf14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Mice, Inbred C57BL
97 rdf:type schema:DefinedTerm
98 N493df7abc5e2458c8d17da52b91927f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Echocardiography
100 rdf:type schema:DefinedTerm
101 N502a65915758491188bb4a49f590aa5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Mice, Inbred Strains
103 rdf:type schema:DefinedTerm
104 N50bf18ff80ff4e23b57d51f58a6282f5 schema:name doi
105 schema:value 10.1007/s12012-010-9070-2
106 rdf:type schema:PropertyValue
107 N56084d0c3e744b4ba7f63278a408555f schema:name nlm_unique_id
108 schema:value 101135818
109 rdf:type schema:PropertyValue
110 N5be9c1a6302c4a8a97b8ebd326052813 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Mice, Knockout
112 rdf:type schema:DefinedTerm
113 N649d1b27d7254b31a9def149dbc5e916 rdf:first sg:person.01327275104.21
114 rdf:rest Nf71311a544e644a09762689acd73063e
115 N6e5f122c6379415f8e19481d649ad0fe rdf:first sg:person.01177525165.85
116 rdf:rest Ne314e88abb37418b93f1abdd07131bd1
117 N7576929efe09440c96d18dcb603c0398 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Mice
119 rdf:type schema:DefinedTerm
120 N950b9e8f2bbf4748b20b01793157576a schema:name dimensions_id
121 schema:value pub.1027385679
122 rdf:type schema:PropertyValue
123 N96c38aa1bdc547e7b7057c95e146fb02 schema:name readcube_id
124 schema:value 8274b860907de3d04e2926ab4d558f265b014b73ba33f032b71b783fae66d414
125 rdf:type schema:PropertyValue
126 N97ea8effc5514b60bcdcf45bc1a6982d rdf:first sg:person.01135664377.40
127 rdf:rest Nc36aecc0a2f94b0f970b5291af806b56
128 Na5d69f0c3a344b188b9d1e1c4d75e8ab schema:name pubmed_id
129 schema:value 20379802
130 rdf:type schema:PropertyValue
131 Na657ab03fab4487bb6da76f7a81cbe11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Heart Diseases
133 rdf:type schema:DefinedTerm
134 Nb06e9aafa3c64792bf9cdd5e64b506d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Animals
136 rdf:type schema:DefinedTerm
137 Nb7f72d33cbca45b5bae0189be13f049b schema:name Springer Nature - SN SciGraph project
138 rdf:type schema:Organization
139 Nc36aecc0a2f94b0f970b5291af806b56 rdf:first sg:person.01312066120.49
140 rdf:rest rdf:nil
141 Nc9d3a21b36f8480fa138822f6570ca58 schema:issueNumber 2
142 rdf:type schema:PublicationIssue
143 Nc9e01eaa322e45339f78242d45f87b9e schema:volumeNumber 10
144 rdf:type schema:PublicationVolume
145 Ncee16ce8562842918eca5c1f62b535f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Anti-HIV Agents
147 rdf:type schema:DefinedTerm
148 Nd1f3106497eb4805bf1cc17542a449d4 rdf:first sg:person.01313753565.35
149 rdf:rest Ne01c6dc25280414185cc3f7774962dc5
150 Ne01c6dc25280414185cc3f7774962dc5 rdf:first sg:person.01240176541.08
151 rdf:rest N97ea8effc5514b60bcdcf45bc1a6982d
152 Ne1a7d7f57d5f438f81798f18a31195db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Heart Ventricles
154 rdf:type schema:DefinedTerm
155 Ne314e88abb37418b93f1abdd07131bd1 rdf:first sg:person.01247436210.07
156 rdf:rest Nd1f3106497eb4805bf1cc17542a449d4
157 Nf510420229a7486bb1540441f634e177 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name DNA, Mitochondrial
159 rdf:type schema:DefinedTerm
160 Nf71311a544e644a09762689acd73063e rdf:first sg:person.0603671004.53
161 rdf:rest N6e5f122c6379415f8e19481d649ad0fe
162 Nfc54eb3f63844ed6821f49b5cc0115d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Mitochondria, Heart
164 rdf:type schema:DefinedTerm
165 Nfedf11b1458b479ab6d833e7fdd53202 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Dideoxynucleosides
167 rdf:type schema:DefinedTerm
168 Nfff7c2b2194b472d9f7f3b45f4fda278 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Superoxide Dismutase
170 rdf:type schema:DefinedTerm
171 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
172 schema:name Medical and Health Sciences
173 rdf:type schema:DefinedTerm
174 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
175 schema:name Clinical Sciences
176 rdf:type schema:DefinedTerm
177 sg:grant.2404160 http://pending.schema.org/fundedItem sg:pub.10.1007/s12012-010-9070-2
178 rdf:type schema:MonetaryGrant
179 sg:grant.2536224 http://pending.schema.org/fundedItem sg:pub.10.1007/s12012-010-9070-2
180 rdf:type schema:MonetaryGrant
181 sg:grant.2540350 http://pending.schema.org/fundedItem sg:pub.10.1007/s12012-010-9070-2
182 rdf:type schema:MonetaryGrant
183 sg:journal.1030406 schema:issn 1530-7905
184 1559-0259
185 schema:name Cardiovascular Toxicology
186 rdf:type schema:Periodical
187 sg:person.01135664377.40 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
188 schema:familyName Russ
189 schema:givenName Rodney
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135664377.40
191 rdf:type schema:Person
192 sg:person.01177525165.85 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
193 schema:familyName Green
194 schema:givenName Elgin
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177525165.85
196 rdf:type schema:Person
197 sg:person.01240176541.08 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
198 schema:familyName Ludaway
199 schema:givenName Tomika
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240176541.08
201 rdf:type schema:Person
202 sg:person.01247436210.07 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
203 schema:familyName Fields
204 schema:givenName Earl
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247436210.07
206 rdf:type schema:Person
207 sg:person.01312066120.49 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
208 schema:familyName Lewis
209 schema:givenName William
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312066120.49
211 rdf:type schema:Person
212 sg:person.01313753565.35 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
213 schema:familyName Abuin
214 schema:givenName Allison
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313753565.35
216 rdf:type schema:Person
217 sg:person.01327275104.21 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
218 schema:familyName Kohler
219 schema:givenName James J.
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327275104.21
221 rdf:type schema:Person
222 sg:person.0603671004.53 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
223 schema:familyName Hosseini
224 schema:givenName Seyed H.
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603671004.53
226 rdf:type schema:Person
227 sg:pub.10.1007/s12012-008-9015-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053572743
228 https://doi.org/10.1007/s12012-008-9015-1
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/labinvest.2008.121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003771516
231 https://doi.org/10.1038/labinvest.2008.121
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/labinvest.2009.14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037052004
234 https://doi.org/10.1038/labinvest.2009.14
235 rdf:type schema:CreativeWork
236 sg:pub.10.1038/labinvest.2009.39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047490418
237 https://doi.org/10.1038/labinvest.2009.39
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/labinvest.3700523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022971840
240 https://doi.org/10.1038/labinvest.3700523
241 rdf:type schema:CreativeWork
242 sg:pub.10.1038/labinvest.3780366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005451823
243 https://doi.org/10.1038/labinvest.3780366
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/ng0298-159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051107507
246 https://doi.org/10.1038/ng0298-159
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/nm0595-417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008779394
249 https://doi.org/10.1038/nm0595-417
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/nrd1201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002739069
252 https://doi.org/10.1038/nrd1201
253 rdf:type schema:CreativeWork
254 sg:pub.10.2165/00003088-200847060-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044215920
255 https://doi.org/10.2165/00003088-200847060-00001
256 rdf:type schema:CreativeWork
257 https://app.dimensions.ai/details/publication/pub.1077519579 schema:CreativeWork
258 https://app.dimensions.ai/details/publication/pub.1077629111 schema:CreativeWork
259 https://app.dimensions.ai/details/publication/pub.1083037746 schema:CreativeWork
260 https://doi.org/10.1002/em.20223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024708281
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/0042-6822(91)90759-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037159008
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.jpba.2004.03.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036001309
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.lfs.2004.06.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037070558
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/s0003-9861(03)00316-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001345182
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/s0009-2797(02)00059-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008664512
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/s0014-5793(00)01710-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040972408
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/s0149-2918(00)90004-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052231962
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/s0149-2918(01)80132-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024888788
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/s0166-3542(97)01033-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041637163
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/s0891-5849(98)00199-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050383573
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1053/pcad.2000.9031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013465785
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1056/nejm199004193221602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001371255
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1073/pnas.0307067101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030915212
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1073/pnas.93.8.3592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037249602
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1086/367849 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058662782
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1086/375353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046630083
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1086/593022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037281639
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1086/605440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037493628
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1093/carcin/21.5.1059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020052337
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1097/01.aids.0000216367.23325.58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030567152
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1097/coh.0b013e3281df3410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028031231
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1111/j.1468-1293.2009.00733.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004299865
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1111/j.1749-6632.2001.tb03902.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004142288
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1126/science.1106653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050321208
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1128/aac.41.5.1099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083087388
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1146/annurev.genet.39.110304.095751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053197411
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1161/circulationaha.107.189622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051894931
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1289/ehp.98106s51219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064747181
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1592/phco.21.1.11.34439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024312704
319 rdf:type schema:CreativeWork
320 https://doi.org/10.2307/3433989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070323504
321 rdf:type schema:CreativeWork
322 https://doi.org/10.2353/ajpath.2007.060655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017090372
323 rdf:type schema:CreativeWork
324 https://www.grid.ac/institutes/grid.189967.8 schema:alternateName Emory University
325 schema:name Department of Pathology, Emory University School of Medicine, 7126 Woodruff Memorial Building, 101 Woodruff Circle, 30322, Atlanta, GA, USA
326 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...