Protective Effects of Salidroside on Lead Acetate-induced Oxidative Stress and Hepatotoxicity in Sprague-Dawley Rats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-01-21

AUTHORS

Chen Chen, Beibei Lin, Shanshan Qi, Jia He, Hongxing Zheng

ABSTRACT

Lead has heavy metal toxicity which endangers human and animal health. Salidroside (SDS) is a natural antioxidant that has extensive pharmacological usage. However, its protective effects on lead-induced oxidative stress and hepatotoxicity has not been reported. In this study, we established an animal model to evaluate the protective effects of SDS on chronic lead exposure induced oxidative stress and hepatotoxicity. Forty healthy Sprague-Dawley (SD) rats were assigned to control group (control, animals were provided with distilled water, n = 10); lead acetate-exposed group (PbAc, animals received lead acetate solution of 500 ppm for 60 days, n = 10); low dosage of SDS-treated group (PbAc-SDS-L, lead acetate exposed animals were given intragastric SDS 150 mg/kg body weight for 60 days, n = 10); and high dosage of SDS-treated group (PbAc-SDS-H, lead acetate exposed animals were given intragastric SDS 300 mg/kg body weight for 60 days, n = 10). The results showed that lead exposure caused a significant increase in serum ALP, AST, ALT, and TB (P < 0.01), and these were reversed after treatment with salidroside for 60 days. Compared to the control, the liver GSH, SOD, and GSH-Px were decreased significantly after lead acetate exposure (P < 0.01). However, after treatment with SDS for 60 days, those were dose-dependently reversed. Similarly, MDA was significantly increased in the PbAc group (P < 0.01), and it was significantly decreased in SDS treatment group. Moreover, SDS ameliorated lead-induced congestion and necrosis of hepatocytes. In addition, the RT-PCR and immunohistochemistry results revealed that the PbAc group showed a significant increase in the protein and mRNA of cytochrome P450 2E1 (CYP2E1) and NADPH oxidase 2 (NOX2) in rat liver. Treatment with SDS significantly reversed CYP2E1 and NOX2 expressions in the liver of lead-exposed rats. The results above indicated that SDS has obvious antioxidant activity; it can cure liver injury caused by lead acetate by inhibiting oxidative stress and increasing the antioxidant stress activity, thus improving the liver tissue structure. More... »

PAGES

1-9

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12011-019-1635-8

DOI

http://dx.doi.org/10.1007/s12011-019-1635-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111577323

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30666592


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Shaanxi University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.412500.2", 
          "name": [
            "Chinese-German Joint Laboratory for Natural Product Research, College of Biological Science and Engineering, Shaanxi University of Technology, Chaoyang Road, Hantai District, 723000, Hanzhong, Shaanxi, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Chen", 
        "id": "sg:person.0747671506.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747671506.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shaanxi University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.412500.2", 
          "name": [
            "Chinese-German Joint Laboratory for Natural Product Research, College of Biological Science and Engineering, Shaanxi University of Technology, Chaoyang Road, Hantai District, 723000, Hanzhong, Shaanxi, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Beibei", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shaanxi University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.412500.2", 
          "name": [
            "Vitamin D research institute, Shaanxi University of Technology, Chaoyang Road, Hantai District, 723000, Hanzhong, Shaanxi, China", 
            "Qinling-Bashan Mountains Bioresources Comprehensive Development, Collaborative Innovation Center, 723000, Hanzhong, Shaanxi, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Qi", 
        "givenName": "Shanshan", 
        "id": "sg:person.016175000477.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016175000477.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shaanxi University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.412500.2", 
          "name": [
            "Vitamin D research institute, Shaanxi University of Technology, Chaoyang Road, Hantai District, 723000, Hanzhong, Shaanxi, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "He", 
        "givenName": "Jia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shaanxi University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.412500.2", 
          "name": [
            "Chinese-German Joint Laboratory for Natural Product Research, College of Biological Science and Engineering, Shaanxi University of Technology, Chaoyang Road, Hantai District, 723000, Hanzhong, Shaanxi, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zheng", 
        "givenName": "Hongxing", 
        "id": "sg:person.016647105536.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016647105536.80"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0300-483x(02)00380-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002122545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-230x-14-81", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003775418", 
          "https://doi.org/10.1186/1471-230x-14-81"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/tox.20530", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005663184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00044-012-0247-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008137684", 
          "https://doi.org/10.1007/s00044-012-0247-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12011-009-8553-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011830897", 
          "https://doi.org/10.1007/s12011-009-8553-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12011-009-8553-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011830897", 
          "https://doi.org/10.1007/s12011-009-8553-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40360-016-0059-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015088634", 
          "https://doi.org/10.1186/s40360-016-0059-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12011-011-9022-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020942037", 
          "https://doi.org/10.1007/s12011-011-9022-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuint.2010.06.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022429390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fct.2009.01.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023438859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12011-010-8882-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024507611", 
          "https://doi.org/10.1007/s12011-010-8882-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fct.2011.09.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027042505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/oem.58.2.95", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028284380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/oem.58.2.95", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028284380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.toxlet.2016.07.574", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031138862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0955-2863(02)00208-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031289848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0955-2863(02)00208-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031289848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5897/ajpp2013.3465", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032932133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/atvbaha.109.191437", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035792957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/atvbaha.109.191437", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035792957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11746-998-0032-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037699997", 
          "https://doi.org/10.1007/s11746-998-0032-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/13510002.2016.1140406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038078337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/01480540903373654", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038544095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejps.2012.09.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038574065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules16129912", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041466259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules16129912", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041466259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-8741(01)00237-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044951320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2014/435857", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045161242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/cpb.58.1627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046911014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/cpb.58.1627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046911014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0960327116665674", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048940934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0960327116665674", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048940934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1289/ehp.93100177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064744870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1568026013394831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069192755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3402/ljm.v5i0.4621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071274408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcma.2016.10.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084086169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcma.2016.10.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084086169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fct.2017.08.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091086334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jnutbio.2017.09.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092194913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ol.2017.7594", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099798140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.intimp.2018.01.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100812573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.intimp.2018.01.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100812573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.toxrep.2018.02.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101349500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2131/jts.43.275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103164567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/ijerph15040759", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103386013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12011-018-1362-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103878604", 
          "https://doi.org/10.1007/s12011-018-1362-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12011-018-1358-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104008861", 
          "https://doi.org/10.1007/s12011-018-1358-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/dddt.s160776", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104155635"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-01-21", 
    "datePublishedReg": "2019-01-21", 
    "description": "Lead has heavy metal toxicity which endangers human and animal health. Salidroside (SDS) is a natural antioxidant that has extensive pharmacological usage. However, its protective effects on lead-induced oxidative stress and hepatotoxicity has not been reported. In this study, we established an animal model to evaluate the protective effects of SDS on chronic lead exposure induced oxidative stress and hepatotoxicity. Forty healthy Sprague-Dawley (SD) rats were assigned to control group (control, animals were provided with distilled water, n\u2009=\u200910); lead acetate-exposed group (PbAc, animals received lead acetate solution of 500\u00a0ppm for 60\u00a0days, n\u2009=\u200910); low dosage of SDS-treated group (PbAc-SDS-L, lead acetate exposed animals were given intragastric SDS 150\u00a0mg/kg body weight for 60\u00a0days, n\u2009=\u200910); and high dosage of SDS-treated group (PbAc-SDS-H, lead acetate exposed animals were given intragastric SDS 300\u00a0mg/kg body weight for 60\u00a0days, n\u2009=\u200910). The results showed that lead exposure caused a significant increase in serum ALP, AST, ALT, and TB (P\u2009<\u20090.01), and these were reversed after treatment with salidroside for 60\u00a0days. Compared to the control, the liver GSH, SOD, and GSH-Px were decreased significantly after lead acetate exposure (P\u2009<\u20090.01). However, after treatment with SDS for 60\u00a0days, those were dose-dependently reversed. Similarly, MDA was significantly increased in the PbAc group (P\u2009<\u20090.01), and it was significantly decreased in SDS treatment group. Moreover, SDS ameliorated lead-induced congestion and necrosis of hepatocytes. In addition, the RT-PCR and immunohistochemistry results revealed that the PbAc group showed a significant increase in the protein and mRNA of cytochrome P450 2E1 (CYP2E1) and NADPH oxidase 2 (NOX2) in rat liver. Treatment with SDS significantly reversed CYP2E1 and NOX2 expressions in the liver of lead-exposed rats. The results above indicated that SDS has obvious antioxidant activity; it can cure liver injury caused by lead acetate by inhibiting oxidative stress and increasing the antioxidant stress activity, thus improving the liver tissue structure.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12011-019-1635-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1090652", 
        "issn": [
          "0163-4984", 
          "1559-0720"
        ], 
        "name": "Biological Trace Element Research", 
        "type": "Periodical"
      }
    ], 
    "name": "Protective Effects of Salidroside on Lead Acetate-induced Oxidative Stress and Hepatotoxicity in Sprague-Dawley Rats", 
    "pagination": "1-9", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1e5e3f7acc7372e8f8c3d822cc41d4d1dd57f08341ccc2d2ea5b1de921c39e7c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30666592"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7911509"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12011-019-1635-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111577323"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12011-019-1635-8", 
      "https://app.dimensions.ai/details/publication/pub.1111577323"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T08:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000325_0000000325/records_100788_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs12011-019-1635-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12011-019-1635-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12011-019-1635-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12011-019-1635-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12011-019-1635-8'


 

This table displays all metadata directly associated to this object as RDF triples.

217 TRIPLES      21 PREDICATES      65 URIs      18 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12011-019-1635-8 schema:about anzsrc-for:11
2 anzsrc-for:1115
3 schema:author Ndac431325d064b8abe8d8493aa995bed
4 schema:citation sg:pub.10.1007/s00044-012-0247-z
5 sg:pub.10.1007/s11746-998-0032-9
6 sg:pub.10.1007/s12011-009-8553-0
7 sg:pub.10.1007/s12011-010-8882-z
8 sg:pub.10.1007/s12011-011-9022-0
9 sg:pub.10.1007/s12011-018-1358-2
10 sg:pub.10.1007/s12011-018-1362-6
11 sg:pub.10.1186/1471-230x-14-81
12 sg:pub.10.1186/s40360-016-0059-8
13 https://doi.org/10.1002/tox.20530
14 https://doi.org/10.1016/j.ejps.2012.09.018
15 https://doi.org/10.1016/j.fct.2009.01.012
16 https://doi.org/10.1016/j.fct.2011.09.007
17 https://doi.org/10.1016/j.fct.2017.08.007
18 https://doi.org/10.1016/j.intimp.2018.01.014
19 https://doi.org/10.1016/j.jcma.2016.10.014
20 https://doi.org/10.1016/j.jnutbio.2017.09.025
21 https://doi.org/10.1016/j.neuint.2010.06.021
22 https://doi.org/10.1016/j.toxlet.2016.07.574
23 https://doi.org/10.1016/j.toxrep.2018.02.009
24 https://doi.org/10.1016/s0300-483x(02)00380-3
25 https://doi.org/10.1016/s0378-8741(01)00237-9
26 https://doi.org/10.1016/s0955-2863(02)00208-5
27 https://doi.org/10.1080/13510002.2016.1140406
28 https://doi.org/10.1136/oem.58.2.95
29 https://doi.org/10.1155/2014/435857
30 https://doi.org/10.1161/atvbaha.109.191437
31 https://doi.org/10.1177/0960327116665674
32 https://doi.org/10.1248/cpb.58.1627
33 https://doi.org/10.1289/ehp.93100177
34 https://doi.org/10.2131/jts.43.275
35 https://doi.org/10.2147/dddt.s160776
36 https://doi.org/10.2174/1568026013394831
37 https://doi.org/10.3109/01480540903373654
38 https://doi.org/10.3390/ijerph15040759
39 https://doi.org/10.3390/molecules16129912
40 https://doi.org/10.3402/ljm.v5i0.4621
41 https://doi.org/10.3892/ol.2017.7594
42 https://doi.org/10.5897/ajpp2013.3465
43 schema:datePublished 2019-01-21
44 schema:datePublishedReg 2019-01-21
45 schema:description Lead has heavy metal toxicity which endangers human and animal health. Salidroside (SDS) is a natural antioxidant that has extensive pharmacological usage. However, its protective effects on lead-induced oxidative stress and hepatotoxicity has not been reported. In this study, we established an animal model to evaluate the protective effects of SDS on chronic lead exposure induced oxidative stress and hepatotoxicity. Forty healthy Sprague-Dawley (SD) rats were assigned to control group (control, animals were provided with distilled water, n = 10); lead acetate-exposed group (PbAc, animals received lead acetate solution of 500 ppm for 60 days, n = 10); low dosage of SDS-treated group (PbAc-SDS-L, lead acetate exposed animals were given intragastric SDS 150 mg/kg body weight for 60 days, n = 10); and high dosage of SDS-treated group (PbAc-SDS-H, lead acetate exposed animals were given intragastric SDS 300 mg/kg body weight for 60 days, n = 10). The results showed that lead exposure caused a significant increase in serum ALP, AST, ALT, and TB (P < 0.01), and these were reversed after treatment with salidroside for 60 days. Compared to the control, the liver GSH, SOD, and GSH-Px were decreased significantly after lead acetate exposure (P < 0.01). However, after treatment with SDS for 60 days, those were dose-dependently reversed. Similarly, MDA was significantly increased in the PbAc group (P < 0.01), and it was significantly decreased in SDS treatment group. Moreover, SDS ameliorated lead-induced congestion and necrosis of hepatocytes. In addition, the RT-PCR and immunohistochemistry results revealed that the PbAc group showed a significant increase in the protein and mRNA of cytochrome P450 2E1 (CYP2E1) and NADPH oxidase 2 (NOX2) in rat liver. Treatment with SDS significantly reversed CYP2E1 and NOX2 expressions in the liver of lead-exposed rats. The results above indicated that SDS has obvious antioxidant activity; it can cure liver injury caused by lead acetate by inhibiting oxidative stress and increasing the antioxidant stress activity, thus improving the liver tissue structure.
46 schema:genre research_article
47 schema:inLanguage en
48 schema:isAccessibleForFree false
49 schema:isPartOf sg:journal.1090652
50 schema:name Protective Effects of Salidroside on Lead Acetate-induced Oxidative Stress and Hepatotoxicity in Sprague-Dawley Rats
51 schema:pagination 1-9
52 schema:productId N7826ce8822ac47258a2e0d2321691ccb
53 N9d9fe6433acd4bbbb2e64605137e5f1b
54 Nd230398581164fd0aee1d4f70eaa3507
55 Ned7ce47085b3469ca8d68efd51d9f7f5
56 Nf7a88e9146c54161a5015bd53bcc8580
57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111577323
58 https://doi.org/10.1007/s12011-019-1635-8
59 schema:sdDatePublished 2019-04-11T08:56
60 schema:sdLicense https://scigraph.springernature.com/explorer/license/
61 schema:sdPublisher N6bc22311a0df4eb4b9098a6085696606
62 schema:url https://link.springer.com/10.1007%2Fs12011-019-1635-8
63 sgo:license sg:explorer/license/
64 sgo:sdDataset articles
65 rdf:type schema:ScholarlyArticle
66 N3e64059d49464a148f3059a2dd187df8 rdf:first sg:person.016647105536.80
67 rdf:rest rdf:nil
68 N6bc22311a0df4eb4b9098a6085696606 schema:name Springer Nature - SN SciGraph project
69 rdf:type schema:Organization
70 N7826ce8822ac47258a2e0d2321691ccb schema:name readcube_id
71 schema:value 1e5e3f7acc7372e8f8c3d822cc41d4d1dd57f08341ccc2d2ea5b1de921c39e7c
72 rdf:type schema:PropertyValue
73 N9d9fe6433acd4bbbb2e64605137e5f1b schema:name pubmed_id
74 schema:value 30666592
75 rdf:type schema:PropertyValue
76 Na82e95c4ea5145c4a382c51607490ac9 rdf:first Nce7db097d87c45c28f1de96000d858e7
77 rdf:rest N3e64059d49464a148f3059a2dd187df8
78 Na898f3565de440659b1172c0a9c97f4d schema:affiliation https://www.grid.ac/institutes/grid.412500.2
79 schema:familyName Lin
80 schema:givenName Beibei
81 rdf:type schema:Person
82 Ncde0d0a6bf2e4f0fbabf2062590bbebd rdf:first sg:person.016175000477.83
83 rdf:rest Na82e95c4ea5145c4a382c51607490ac9
84 Nce7db097d87c45c28f1de96000d858e7 schema:affiliation https://www.grid.ac/institutes/grid.412500.2
85 schema:familyName He
86 schema:givenName Jia
87 rdf:type schema:Person
88 Nd230398581164fd0aee1d4f70eaa3507 schema:name dimensions_id
89 schema:value pub.1111577323
90 rdf:type schema:PropertyValue
91 Ndac431325d064b8abe8d8493aa995bed rdf:first sg:person.0747671506.29
92 rdf:rest Nfccf4d73bab0461e9696d8294ce882ef
93 Ned7ce47085b3469ca8d68efd51d9f7f5 schema:name nlm_unique_id
94 schema:value 7911509
95 rdf:type schema:PropertyValue
96 Nf7a88e9146c54161a5015bd53bcc8580 schema:name doi
97 schema:value 10.1007/s12011-019-1635-8
98 rdf:type schema:PropertyValue
99 Nfccf4d73bab0461e9696d8294ce882ef rdf:first Na898f3565de440659b1172c0a9c97f4d
100 rdf:rest Ncde0d0a6bf2e4f0fbabf2062590bbebd
101 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
102 schema:name Medical and Health Sciences
103 rdf:type schema:DefinedTerm
104 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
105 schema:name Pharmacology and Pharmaceutical Sciences
106 rdf:type schema:DefinedTerm
107 sg:journal.1090652 schema:issn 0163-4984
108 1559-0720
109 schema:name Biological Trace Element Research
110 rdf:type schema:Periodical
111 sg:person.016175000477.83 schema:affiliation https://www.grid.ac/institutes/grid.412500.2
112 schema:familyName Qi
113 schema:givenName Shanshan
114 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016175000477.83
115 rdf:type schema:Person
116 sg:person.016647105536.80 schema:affiliation https://www.grid.ac/institutes/grid.412500.2
117 schema:familyName Zheng
118 schema:givenName Hongxing
119 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016647105536.80
120 rdf:type schema:Person
121 sg:person.0747671506.29 schema:affiliation https://www.grid.ac/institutes/grid.412500.2
122 schema:familyName Chen
123 schema:givenName Chen
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747671506.29
125 rdf:type schema:Person
126 sg:pub.10.1007/s00044-012-0247-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1008137684
127 https://doi.org/10.1007/s00044-012-0247-z
128 rdf:type schema:CreativeWork
129 sg:pub.10.1007/s11746-998-0032-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037699997
130 https://doi.org/10.1007/s11746-998-0032-9
131 rdf:type schema:CreativeWork
132 sg:pub.10.1007/s12011-009-8553-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011830897
133 https://doi.org/10.1007/s12011-009-8553-0
134 rdf:type schema:CreativeWork
135 sg:pub.10.1007/s12011-010-8882-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1024507611
136 https://doi.org/10.1007/s12011-010-8882-z
137 rdf:type schema:CreativeWork
138 sg:pub.10.1007/s12011-011-9022-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020942037
139 https://doi.org/10.1007/s12011-011-9022-0
140 rdf:type schema:CreativeWork
141 sg:pub.10.1007/s12011-018-1358-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104008861
142 https://doi.org/10.1007/s12011-018-1358-2
143 rdf:type schema:CreativeWork
144 sg:pub.10.1007/s12011-018-1362-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103878604
145 https://doi.org/10.1007/s12011-018-1362-6
146 rdf:type schema:CreativeWork
147 sg:pub.10.1186/1471-230x-14-81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003775418
148 https://doi.org/10.1186/1471-230x-14-81
149 rdf:type schema:CreativeWork
150 sg:pub.10.1186/s40360-016-0059-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015088634
151 https://doi.org/10.1186/s40360-016-0059-8
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1002/tox.20530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005663184
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1016/j.ejps.2012.09.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038574065
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1016/j.fct.2009.01.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023438859
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1016/j.fct.2011.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027042505
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1016/j.fct.2017.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091086334
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1016/j.intimp.2018.01.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100812573
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1016/j.jcma.2016.10.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084086169
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1016/j.jnutbio.2017.09.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092194913
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1016/j.neuint.2010.06.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022429390
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1016/j.toxlet.2016.07.574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031138862
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1016/j.toxrep.2018.02.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101349500
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1016/s0300-483x(02)00380-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002122545
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1016/s0378-8741(01)00237-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044951320
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/s0955-2863(02)00208-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031289848
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1080/13510002.2016.1140406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038078337
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1136/oem.58.2.95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028284380
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1155/2014/435857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045161242
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1161/atvbaha.109.191437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035792957
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1177/0960327116665674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048940934
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1248/cpb.58.1627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046911014
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1289/ehp.93100177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064744870
194 rdf:type schema:CreativeWork
195 https://doi.org/10.2131/jts.43.275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103164567
196 rdf:type schema:CreativeWork
197 https://doi.org/10.2147/dddt.s160776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104155635
198 rdf:type schema:CreativeWork
199 https://doi.org/10.2174/1568026013394831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069192755
200 rdf:type schema:CreativeWork
201 https://doi.org/10.3109/01480540903373654 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038544095
202 rdf:type schema:CreativeWork
203 https://doi.org/10.3390/ijerph15040759 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103386013
204 rdf:type schema:CreativeWork
205 https://doi.org/10.3390/molecules16129912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041466259
206 rdf:type schema:CreativeWork
207 https://doi.org/10.3402/ljm.v5i0.4621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071274408
208 rdf:type schema:CreativeWork
209 https://doi.org/10.3892/ol.2017.7594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099798140
210 rdf:type schema:CreativeWork
211 https://doi.org/10.5897/ajpp2013.3465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032932133
212 rdf:type schema:CreativeWork
213 https://www.grid.ac/institutes/grid.412500.2 schema:alternateName Shaanxi University of Technology
214 schema:name Chinese-German Joint Laboratory for Natural Product Research, College of Biological Science and Engineering, Shaanxi University of Technology, Chaoyang Road, Hantai District, 723000, Hanzhong, Shaanxi, China
215 Qinling-Bashan Mountains Bioresources Comprehensive Development, Collaborative Innovation Center, 723000, Hanzhong, Shaanxi, China
216 Vitamin D research institute, Shaanxi University of Technology, Chaoyang Road, Hantai District, 723000, Hanzhong, Shaanxi, China
217 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...