Involvement of Zn Depletion in Cd-Induced Toxicity on Prenatal Bone Formation in Rat View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-11

AUTHORS

Sana Boughammoura, Marouane Chemek, Safa Ben Mimouna, Mohamed Banni, Imed Messaoudi

ABSTRACT

This study explored the potential toxicity of Cd on the Zn bone depletion in prenatal bone formation. Female rats received either tap water, Cd, Zn, or Cd + Zn in their drinking water during gestation, and some markers of bone formation were studied in their fetuses removed at the 20th day of pregnancy (GD20). Cd exposure induced maternal hypozincemia and Zn depletion in the femur of the fetuses. A striking inhibition of bone formation in fetuses, expressed by decreases in femur length, width, and area, by the shortening of diaphysis, and by a decrease in length and area of distal and proximal proliferative zones, was observed in fetuses from Cd-exposed mothers. At the molecular level, Cd caused upregulation of MT-1 and ZIP2 genes and significantly depressed the expression of the ZnT5, colα1, osteocalcin, and ALP genes in the femur. Interestingly, Zn treatment ameliorated the Cd-induced maternal hypozincemia and femoral changes and partially restored the normal histomorphometry of the femur. These results suggest that the observed toxic effects of Cd are, at least in part, mediated by the disruption of maternal Zn metabolism during pregnancy leading to Zn depletion and thus to perturbation of prenatal bone formation. More... »

PAGES

70-80

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12011-017-0981-7

DOI

http://dx.doi.org/10.1007/s12011-017-0981-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084033671

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28261762


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Paediatrics and Reproductive Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Weight", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone and Bones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cadmium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Femur", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Developmental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Maternal Nutritional Physiological Phenomena", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metallothionein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osteogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Placenta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pregnancy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Wistar", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zinc", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Monastir", 
          "id": "https://www.grid.ac/institutes/grid.411838.7", 
          "name": [
            "LR11ES41: G\u00e9n\u00e9tique, Biodiversit\u00e9 et Valorisation des Bioressources, Institut de Biotechnologie, Universit\u00e9 de Monastir, 5000, Monastir, Tunisia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boughammoura", 
        "givenName": "Sana", 
        "id": "sg:person.01125603254.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125603254.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Monastir", 
          "id": "https://www.grid.ac/institutes/grid.411838.7", 
          "name": [
            "LR11ES41: G\u00e9n\u00e9tique, Biodiversit\u00e9 et Valorisation des Bioressources, Institut de Biotechnologie, Universit\u00e9 de Monastir, 5000, Monastir, Tunisia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chemek", 
        "givenName": "Marouane", 
        "id": "sg:person.01045614462.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045614462.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Monastir", 
          "id": "https://www.grid.ac/institutes/grid.411838.7", 
          "name": [
            "LR11ES41: G\u00e9n\u00e9tique, Biodiversit\u00e9 et Valorisation des Bioressources, Institut de Biotechnologie, Universit\u00e9 de Monastir, 5000, Monastir, Tunisia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mimouna", 
        "givenName": "Safa Ben", 
        "id": "sg:person.01130571125.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130571125.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratoire de Biochimie et Toxicologie Environnementale, ISA Chott-Mariem, 4042, Sousse, Tunisia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Banni", 
        "givenName": "Mohamed", 
        "id": "sg:person.0765560256.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765560256.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Monastir", 
          "id": "https://www.grid.ac/institutes/grid.411838.7", 
          "name": [
            "LR11ES41: G\u00e9n\u00e9tique, Biodiversit\u00e9 et Valorisation des Bioressources, Institut de Biotechnologie, Universit\u00e9 de Monastir, 5000, Monastir, Tunisia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Messaoudi", 
        "givenName": "Imed", 
        "id": "sg:person.01045600265.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045600265.67"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.jnutbio.2010.01.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000476429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12011-015-0255-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004814458", 
          "https://doi.org/10.1007/s12011-015-0255-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/alcalc/37.3.213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005822070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0946-672x(99)80019-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006044480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0300-483x(01)00402-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008019681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bone.2009.02.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008905044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.85.22.8761", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010678402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1939-4640.2000.tb02133.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012064975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01973625", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013208089", 
          "https://doi.org/10.1007/bf01973625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bone.2011.08.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013752209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bone.2009.11.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014203114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/382448a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014453235", 
          "https://doi.org/10.1038/382448a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00297116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016142641", 
          "https://doi.org/10.1007/bf00297116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.etp.2010.03.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017273278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.reprotox.2010.01.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017607200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bone.2012.03.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017723890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jor.1100100304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018825934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/9.2.141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019397049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/9.2.141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019397049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.toxlet.2004.12.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022060433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jat.3055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022307050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00244-010-9494-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032523731", 
          "https://doi.org/10.1007/s00244-010-9494-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00244-010-9494-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032523731", 
          "https://doi.org/10.1007/s00244-010-9494-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2007.11.067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033454902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cbi.2011.06.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035100937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/003655299750025895", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035551356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.reprotox.2016.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037212531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s8756-3282(01)00616-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037945405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m411247200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038351983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/15376516.2012.702796", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038680253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00278646", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040991969", 
          "https://doi.org/10.1007/bf00278646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00278646", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040991969", 
          "https://doi.org/10.1007/bf00278646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/b:biom.0000045727.76054.f3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044250171", 
          "https://doi.org/10.1023/b:biom.0000045727.76054.f3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.20958", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044414087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11010-011-0852-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045088002", 
          "https://doi.org/10.1007/s11010-011-0852-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0278-6915(01)00048-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048436211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/30.9.e36", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049412343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0018904", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052695955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0406085102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052855256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.abb.2014.05.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052933481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002239900597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053336643", 
          "https://doi.org/10.1007/s002239900597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/edrv.21.4.0403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064238505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo-114-5-1860", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064257997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1289/ehp.7928131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064742788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jn/132.4.665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075023815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076588761", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082907454", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-11", 
    "datePublishedReg": "2017-11-01", 
    "description": "This study explored the potential toxicity of Cd on the Zn bone depletion in prenatal bone formation. Female rats received either tap water, Cd, Zn, or Cd + Zn in their drinking water during gestation, and some markers of bone formation were studied in their fetuses removed at the 20th day of pregnancy (GD20). Cd exposure induced maternal hypozincemia and Zn depletion in the femur of the fetuses. A striking inhibition of bone formation in fetuses, expressed by decreases in femur length, width, and area, by the shortening of diaphysis, and by a decrease in length and area of distal and proximal proliferative zones, was observed in fetuses from Cd-exposed mothers. At the molecular level, Cd caused upregulation of MT-1 and ZIP2 genes and significantly depressed the expression of the ZnT5, col\u03b11, osteocalcin, and ALP genes in the femur. Interestingly, Zn treatment ameliorated the Cd-induced maternal hypozincemia and femoral changes and partially restored the normal histomorphometry of the femur. These results suggest that the observed toxic effects of Cd are, at least in part, mediated by the disruption of maternal Zn metabolism during pregnancy leading to Zn depletion and thus to perturbation of prenatal bone formation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12011-017-0981-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1090652", 
        "issn": [
          "0163-4984", 
          "1559-0720"
        ], 
        "name": "Biological Trace Element Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "180"
      }
    ], 
    "name": "Involvement of Zn Depletion in Cd-Induced Toxicity on Prenatal Bone Formation in Rat", 
    "pagination": "70-80", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7e72fc40db354f1ec82b936d9cd9131b1f1286ec8af29ecd92547dcc31c309ac"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28261762"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7911509"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12011-017-0981-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1084033671"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12011-017-0981-7", 
      "https://app.dimensions.ai/details/publication/pub.1084033671"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:54", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89798_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs12011-017-0981-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12011-017-0981-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12011-017-0981-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12011-017-0981-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12011-017-0981-7'


 

This table displays all metadata directly associated to this object as RDF triples.

310 TRIPLES      21 PREDICATES      91 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12011-017-0981-7 schema:about N06b0fb4ea3a6492fa77d0b65b24921e4
2 N0c3b59e54324474dbaffacca8f9de6f4
3 N1074835aa79c4e6a86977bf97de1a45a
4 N12a6f4b41109416b81df3e363b8da297
5 N2917d814bcb34fca9a542f9c9d60cfe1
6 N2e1741513483481080417a7cfee8a7a4
7 N392126ee57024c9e8b734ae01d4acb29
8 N45dc853862c340499114b34dbe9df475
9 N57daed5e1ce64a1eb95243b8dc5af645
10 N62b78d4610a64205b30ea00efb4e2524
11 N67e47e1615d542329fad64cb11c61d6f
12 N71b68b9faade4bb697f8733b114b068b
13 N75eb70be525f4a8682a75b301ea8f5d7
14 N83f45ac7229f4046af709ea17e001471
15 Ne45e2ef71af9410b9883b3cbfcf04cf0
16 Ne4e7502b4800495a86d16188a562b9c8
17 Ne7d0cfab729c4324b7aca3bea7cbb4e6
18 Nf690e5168b6345adb5fa8128a8a2d3de
19 anzsrc-for:11
20 anzsrc-for:1114
21 schema:author N4afb00a3da34406db70db608851e1d6c
22 schema:citation sg:pub.10.1007/bf00278646
23 sg:pub.10.1007/bf00297116
24 sg:pub.10.1007/bf01973625
25 sg:pub.10.1007/s002239900597
26 sg:pub.10.1007/s00244-010-9494-5
27 sg:pub.10.1007/s11010-011-0852-z
28 sg:pub.10.1007/s12011-015-0255-1
29 sg:pub.10.1023/b:biom.0000045727.76054.f3
30 sg:pub.10.1038/382448a0
31 https://app.dimensions.ai/details/publication/pub.1076588761
32 https://app.dimensions.ai/details/publication/pub.1082907454
33 https://doi.org/10.1002/j.1939-4640.2000.tb02133.x
34 https://doi.org/10.1002/jat.3055
35 https://doi.org/10.1002/jcb.20958
36 https://doi.org/10.1002/jor.1100100304
37 https://doi.org/10.1016/j.abb.2014.05.015
38 https://doi.org/10.1016/j.bbrc.2007.11.067
39 https://doi.org/10.1016/j.bone.2009.02.011
40 https://doi.org/10.1016/j.bone.2009.11.003
41 https://doi.org/10.1016/j.bone.2011.08.019
42 https://doi.org/10.1016/j.bone.2012.03.018
43 https://doi.org/10.1016/j.cbi.2011.06.010
44 https://doi.org/10.1016/j.etp.2010.03.010
45 https://doi.org/10.1016/j.jnutbio.2010.01.003
46 https://doi.org/10.1016/j.reprotox.2010.01.004
47 https://doi.org/10.1016/j.reprotox.2016.06.005
48 https://doi.org/10.1016/j.toxlet.2004.12.009
49 https://doi.org/10.1016/s0278-6915(01)00048-5
50 https://doi.org/10.1016/s0300-483x(01)00402-4
51 https://doi.org/10.1016/s0946-672x(99)80019-4
52 https://doi.org/10.1016/s8756-3282(01)00616-0
53 https://doi.org/10.1073/pnas.0406085102
54 https://doi.org/10.1073/pnas.85.22.8761
55 https://doi.org/10.1074/jbc.m411247200
56 https://doi.org/10.1080/003655299750025895
57 https://doi.org/10.1093/alcalc/37.3.213
58 https://doi.org/10.1093/jn/132.4.665
59 https://doi.org/10.1093/nar/30.9.e36
60 https://doi.org/10.1177/9.2.141
61 https://doi.org/10.1210/edrv.21.4.0403
62 https://doi.org/10.1210/endo-114-5-1860
63 https://doi.org/10.1289/ehp.7928131
64 https://doi.org/10.1371/journal.pone.0018904
65 https://doi.org/10.3109/15376516.2012.702796
66 schema:datePublished 2017-11
67 schema:datePublishedReg 2017-11-01
68 schema:description This study explored the potential toxicity of Cd on the Zn bone depletion in prenatal bone formation. Female rats received either tap water, Cd, Zn, or Cd + Zn in their drinking water during gestation, and some markers of bone formation were studied in their fetuses removed at the 20th day of pregnancy (GD20). Cd exposure induced maternal hypozincemia and Zn depletion in the femur of the fetuses. A striking inhibition of bone formation in fetuses, expressed by decreases in femur length, width, and area, by the shortening of diaphysis, and by a decrease in length and area of distal and proximal proliferative zones, was observed in fetuses from Cd-exposed mothers. At the molecular level, Cd caused upregulation of MT-1 and ZIP2 genes and significantly depressed the expression of the ZnT5, colα1, osteocalcin, and ALP genes in the femur. Interestingly, Zn treatment ameliorated the Cd-induced maternal hypozincemia and femoral changes and partially restored the normal histomorphometry of the femur. These results suggest that the observed toxic effects of Cd are, at least in part, mediated by the disruption of maternal Zn metabolism during pregnancy leading to Zn depletion and thus to perturbation of prenatal bone formation.
69 schema:genre research_article
70 schema:inLanguage en
71 schema:isAccessibleForFree false
72 schema:isPartOf N6e0c7d8eed8144c0b956a12cd02dfa69
73 Nf42650df2adf49abb393cb7f5d9def0e
74 sg:journal.1090652
75 schema:name Involvement of Zn Depletion in Cd-Induced Toxicity on Prenatal Bone Formation in Rat
76 schema:pagination 70-80
77 schema:productId N45208eebb0e7420f9a5633a125c1b188
78 N9c5800f8091944dcb42bf5a4762cfd3e
79 N9d307c4f94be45c09e2302d1a6699ab9
80 Na1ef17b2bcba4d22bb10dd79f2c5023a
81 Nb123a17ee02d4cc79815051844f8a5e6
82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084033671
83 https://doi.org/10.1007/s12011-017-0981-7
84 schema:sdDatePublished 2019-04-11T09:54
85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
86 schema:sdPublisher Nba5d0731bb1b4ec8bd4d12262f57d11e
87 schema:url https://link.springer.com/10.1007%2Fs12011-017-0981-7
88 sgo:license sg:explorer/license/
89 sgo:sdDataset articles
90 rdf:type schema:ScholarlyArticle
91 N06b0fb4ea3a6492fa77d0b65b24921e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Osteogenesis
93 rdf:type schema:DefinedTerm
94 N0c3b59e54324474dbaffacca8f9de6f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Animals
96 rdf:type schema:DefinedTerm
97 N1074835aa79c4e6a86977bf97de1a45a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Pregnancy
99 rdf:type schema:DefinedTerm
100 N12a6f4b41109416b81df3e363b8da297 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Maternal Nutritional Physiological Phenomena
102 rdf:type schema:DefinedTerm
103 N2917d814bcb34fca9a542f9c9d60cfe1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Liver
105 rdf:type schema:DefinedTerm
106 N2e1741513483481080417a7cfee8a7a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Metallothionein
108 rdf:type schema:DefinedTerm
109 N392126ee57024c9e8b734ae01d4acb29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Female
111 rdf:type schema:DefinedTerm
112 N45208eebb0e7420f9a5633a125c1b188 schema:name nlm_unique_id
113 schema:value 7911509
114 rdf:type schema:PropertyValue
115 N45dc853862c340499114b34dbe9df475 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Cadmium
117 rdf:type schema:DefinedTerm
118 N4afb00a3da34406db70db608851e1d6c rdf:first sg:person.01125603254.57
119 rdf:rest Nde509c352b714bc1b96843e8ecd32091
120 N57daed5e1ce64a1eb95243b8dc5af645 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Femur
122 rdf:type schema:DefinedTerm
123 N62b78d4610a64205b30ea00efb4e2524 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Zinc
125 rdf:type schema:DefinedTerm
126 N67e47e1615d542329fad64cb11c61d6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Body Weight
128 rdf:type schema:DefinedTerm
129 N6e0c7d8eed8144c0b956a12cd02dfa69 schema:volumeNumber 180
130 rdf:type schema:PublicationVolume
131 N71b68b9faade4bb697f8733b114b068b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Bone and Bones
133 rdf:type schema:DefinedTerm
134 N75eb70be525f4a8682a75b301ea8f5d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Calcium
136 rdf:type schema:DefinedTerm
137 N83f45ac7229f4046af709ea17e001471 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Gene Expression Regulation, Developmental
139 rdf:type schema:DefinedTerm
140 N9c5800f8091944dcb42bf5a4762cfd3e schema:name dimensions_id
141 schema:value pub.1084033671
142 rdf:type schema:PropertyValue
143 N9d307c4f94be45c09e2302d1a6699ab9 schema:name doi
144 schema:value 10.1007/s12011-017-0981-7
145 rdf:type schema:PropertyValue
146 Na1ef17b2bcba4d22bb10dd79f2c5023a schema:name readcube_id
147 schema:value 7e72fc40db354f1ec82b936d9cd9131b1f1286ec8af29ecd92547dcc31c309ac
148 rdf:type schema:PropertyValue
149 Nb123a17ee02d4cc79815051844f8a5e6 schema:name pubmed_id
150 schema:value 28261762
151 rdf:type schema:PropertyValue
152 Nba5d0731bb1b4ec8bd4d12262f57d11e schema:name Springer Nature - SN SciGraph project
153 rdf:type schema:Organization
154 Ncb838ebb7725413699721d5d86cef1cb rdf:first sg:person.01045600265.67
155 rdf:rest rdf:nil
156 Ndd0c668e51964835a7329185d467c355 schema:name Laboratoire de Biochimie et Toxicologie Environnementale, ISA Chott-Mariem, 4042, Sousse, Tunisia
157 rdf:type schema:Organization
158 Nde509c352b714bc1b96843e8ecd32091 rdf:first sg:person.01045614462.47
159 rdf:rest Nf6d7aaddf045451dabbc8bdae79d6216
160 Ne45e2ef71af9410b9883b3cbfcf04cf0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Rats, Wistar
162 rdf:type schema:DefinedTerm
163 Ne4e7502b4800495a86d16188a562b9c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Male
165 rdf:type schema:DefinedTerm
166 Ne7d0cfab729c4324b7aca3bea7cbb4e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Biomarkers
168 rdf:type schema:DefinedTerm
169 Nf42650df2adf49abb393cb7f5d9def0e schema:issueNumber 1
170 rdf:type schema:PublicationIssue
171 Nf473afdd98e645a5baf54d715210f7f3 rdf:first sg:person.0765560256.35
172 rdf:rest Ncb838ebb7725413699721d5d86cef1cb
173 Nf690e5168b6345adb5fa8128a8a2d3de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Placenta
175 rdf:type schema:DefinedTerm
176 Nf6d7aaddf045451dabbc8bdae79d6216 rdf:first sg:person.01130571125.06
177 rdf:rest Nf473afdd98e645a5baf54d715210f7f3
178 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
179 schema:name Medical and Health Sciences
180 rdf:type schema:DefinedTerm
181 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
182 schema:name Paediatrics and Reproductive Medicine
183 rdf:type schema:DefinedTerm
184 sg:journal.1090652 schema:issn 0163-4984
185 1559-0720
186 schema:name Biological Trace Element Research
187 rdf:type schema:Periodical
188 sg:person.01045600265.67 schema:affiliation https://www.grid.ac/institutes/grid.411838.7
189 schema:familyName Messaoudi
190 schema:givenName Imed
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045600265.67
192 rdf:type schema:Person
193 sg:person.01045614462.47 schema:affiliation https://www.grid.ac/institutes/grid.411838.7
194 schema:familyName Chemek
195 schema:givenName Marouane
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045614462.47
197 rdf:type schema:Person
198 sg:person.01125603254.57 schema:affiliation https://www.grid.ac/institutes/grid.411838.7
199 schema:familyName Boughammoura
200 schema:givenName Sana
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125603254.57
202 rdf:type schema:Person
203 sg:person.01130571125.06 schema:affiliation https://www.grid.ac/institutes/grid.411838.7
204 schema:familyName Mimouna
205 schema:givenName Safa Ben
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130571125.06
207 rdf:type schema:Person
208 sg:person.0765560256.35 schema:affiliation Ndd0c668e51964835a7329185d467c355
209 schema:familyName Banni
210 schema:givenName Mohamed
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765560256.35
212 rdf:type schema:Person
213 sg:pub.10.1007/bf00278646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040991969
214 https://doi.org/10.1007/bf00278646
215 rdf:type schema:CreativeWork
216 sg:pub.10.1007/bf00297116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016142641
217 https://doi.org/10.1007/bf00297116
218 rdf:type schema:CreativeWork
219 sg:pub.10.1007/bf01973625 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013208089
220 https://doi.org/10.1007/bf01973625
221 rdf:type schema:CreativeWork
222 sg:pub.10.1007/s002239900597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053336643
223 https://doi.org/10.1007/s002239900597
224 rdf:type schema:CreativeWork
225 sg:pub.10.1007/s00244-010-9494-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032523731
226 https://doi.org/10.1007/s00244-010-9494-5
227 rdf:type schema:CreativeWork
228 sg:pub.10.1007/s11010-011-0852-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1045088002
229 https://doi.org/10.1007/s11010-011-0852-z
230 rdf:type schema:CreativeWork
231 sg:pub.10.1007/s12011-015-0255-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004814458
232 https://doi.org/10.1007/s12011-015-0255-1
233 rdf:type schema:CreativeWork
234 sg:pub.10.1023/b:biom.0000045727.76054.f3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044250171
235 https://doi.org/10.1023/b:biom.0000045727.76054.f3
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/382448a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014453235
238 https://doi.org/10.1038/382448a0
239 rdf:type schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1076588761 schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1082907454 schema:CreativeWork
242 https://doi.org/10.1002/j.1939-4640.2000.tb02133.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012064975
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1002/jat.3055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022307050
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1002/jcb.20958 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044414087
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1002/jor.1100100304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018825934
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.abb.2014.05.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052933481
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.bbrc.2007.11.067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033454902
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.bone.2009.02.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008905044
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.bone.2009.11.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014203114
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.bone.2011.08.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013752209
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.bone.2012.03.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017723890
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/j.cbi.2011.06.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035100937
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.etp.2010.03.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017273278
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.jnutbio.2010.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000476429
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.reprotox.2010.01.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017607200
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/j.reprotox.2016.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037212531
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/j.toxlet.2004.12.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022060433
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/s0278-6915(01)00048-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048436211
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/s0300-483x(01)00402-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008019681
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/s0946-672x(99)80019-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006044480
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/s8756-3282(01)00616-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037945405
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1073/pnas.0406085102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052855256
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1073/pnas.85.22.8761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010678402
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1074/jbc.m411247200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038351983
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1080/003655299750025895 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035551356
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1093/alcalc/37.3.213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005822070
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1093/jn/132.4.665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075023815
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1093/nar/30.9.e36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049412343
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1177/9.2.141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019397049
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1210/edrv.21.4.0403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064238505
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1210/endo-114-5-1860 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064257997
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1289/ehp.7928131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064742788
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1371/journal.pone.0018904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052695955
305 rdf:type schema:CreativeWork
306 https://doi.org/10.3109/15376516.2012.702796 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038680253
307 rdf:type schema:CreativeWork
308 https://www.grid.ac/institutes/grid.411838.7 schema:alternateName University of Monastir
309 schema:name LR11ES41: Génétique, Biodiversité et Valorisation des Bioressources, Institut de Biotechnologie, Université de Monastir, 5000, Monastir, Tunisia
310 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...