Oxidative Stress Markers and Histological Analysis in Diverse Organs from Rats Treated with a Hepatotoxic Dose of Cr(VI): Effect of ... View Full Text


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Article Info

DATE

2015-03-14

AUTHORS

Wylly Ramsés García-Niño, Zyanya Lucía Zatarain-Barrón, Rogelio Hernández-Pando, Claudia Cecilia Vega-García, Edilia Tapia, José Pedraza-Chaverri

ABSTRACT

Hexavalent chromium [Cr(VI)] compounds are extremely toxic and carcinogenic. Despite the vast quantity of reports about Cr(VI) toxicity, the information regarding its effects when it is intraperitoneally (i.p.) administered is still limited. In contrast, it has been shown that curcumin prevents hepatotoxicity induced by a single intraperitoneal injection of 15 mg/kg body weight (b.w.) of potassium dichromate (K2Cr2O7). This study aims to evaluate oxidative stress markers, the activity of antioxidant enzymes, and the potential histological injury in brain, heart, lung, kidney, spleen, pancreas, stomach, and intestine from rats treated with a hepatotoxic dose of K2Cr2O7 (15 mg/kg b.w.), and the effect of curcumin pretreatment. Rats were divided into four groups: control, curcumin, K2Cr2O7, and curcumin+K2Cr2O7. At the end of the treatment, plasma and ascites fluid were collected and target organs were dissected out for biochemical and histological analysis. K2Cr2O7 induced hepatotoxicity but failed to induce in all the other studied organs either oxidative or histological injury, since levels of malondialdehyde (MDA), glutathione (GSH), and the activity of superoxide dismutase (SOD), catalase (CAT), and related GSH enzymes were unchanged. As expected, curcumin was safe. Lack of K2Cr2O7-induced toxicity in those target organs could be due to the following: (1) route of administration, (2) absorption through the portal circulation, (3) lower dose than needed, (4) short time of exposure, or (5) repeated doses are required to produce damage. Thus, the intraperitoneal injection of 15 mg/kg of K2Cr2O7, that is able to induce hepatotoxicity, was unable to induce histological and oxidative damage in other target organs. More... »

PAGES

130-145

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12011-015-0283-x

DOI

http://dx.doi.org/10.1007/s12011-015-0283-x

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25774041


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44 schema:description Hexavalent chromium [Cr(VI)] compounds are extremely toxic and carcinogenic. Despite the vast quantity of reports about Cr(VI) toxicity, the information regarding its effects when it is intraperitoneally (i.p.) administered is still limited. In contrast, it has been shown that curcumin prevents hepatotoxicity induced by a single intraperitoneal injection of 15 mg/kg body weight (b.w.) of potassium dichromate (K2Cr2O7). This study aims to evaluate oxidative stress markers, the activity of antioxidant enzymes, and the potential histological injury in brain, heart, lung, kidney, spleen, pancreas, stomach, and intestine from rats treated with a hepatotoxic dose of K2Cr2O7 (15 mg/kg b.w.), and the effect of curcumin pretreatment. Rats were divided into four groups: control, curcumin, K2Cr2O7, and curcumin+K2Cr2O7. At the end of the treatment, plasma and ascites fluid were collected and target organs were dissected out for biochemical and histological analysis. K2Cr2O7 induced hepatotoxicity but failed to induce in all the other studied organs either oxidative or histological injury, since levels of malondialdehyde (MDA), glutathione (GSH), and the activity of superoxide dismutase (SOD), catalase (CAT), and related GSH enzymes were unchanged. As expected, curcumin was safe. Lack of K2Cr2O7-induced toxicity in those target organs could be due to the following: (1) route of administration, (2) absorption through the portal circulation, (3) lower dose than needed, (4) short time of exposure, or (5) repeated doses are required to produce damage. Thus, the intraperitoneal injection of 15 mg/kg of K2Cr2O7, that is able to induce hepatotoxicity, was unable to induce histological and oxidative damage in other target organs.
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53 K2Cr2O7-induced toxicity
54 absorption
55 activity
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59 antioxidant enzymes
60 ascites fluid
61 body weight
62 brain
63 catalase
64 chromium compounds
65 circulation
66 compounds
67 contrast
68 control
69 curcumin
70 curcumin pretreatment
71 curcumin prevents hepatotoxicity
72 damage
73 dichromate
74 dismutase
75 diverse organs
76 dose
77 doses
78 effect
79 effect of curcumin
80 end
81 enzyme
82 exposure
83 fluid
84 glutathione
85 group
86 heart
87 hepatotoxic dose
88 hepatotoxicity
89 hexavalent chromium compounds
90 histological analysis
91 histological injury
92 information
93 injection
94 injury
95 intestine
96 intraperitoneal injection
97 kidney
98 lack
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103 malondialdehyde
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108 pancreas
109 plasma
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111 potassium dichromate
112 potential histological injury
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