The Role of ARGR Repressor Regulation on L-arginine Production in Corynebacterium crenatum View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-06

AUTHORS

Meijuan Xu, Zhiming Rao, Wenfang Dou, Zhenghong Xu

ABSTRACT

Corynebacterium crenatum SYA is an aerobic, Gram-positive, non-sporulating coryneform bacterium, and the mutant C. crenatum strain SYPA 5-5 can produce 30 g/l L-arginine under optimal culture conditions. In this study, the evolution of the cluster argCJBDFRGH (argC~H) involved in arginine biosynthesis in C. crenatum SYA, and SYPA 5-5 was investigated. Compared to the argR of its wild type C. crenatum SYA, a nucleotide substitution (C→T) within the argR gene of the mutant C. crenatum strain SYPA 5-5 was found. The inactivation of ARGR resulted in increased enzyme activities involved in L-arginine biosynthesis and increased L-arginine production in C. crenatum. In contrast, constructing an overexpressing argR C. crenatum/pTR, a complete and functional ARGR decreased the expression of enzymes, depressed transcriptional level of the argC~H cluster, and reduced the production of L-arginine in C. crenatum. It was thus evident that the inactivation of an ARGR suppressor could relieve a bottleneck in downstream steps of the L-arginine biosynthetic pathway, providing a good strategy for improving L-arginine production. More... »

PAGES

587-597

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12010-013-0212-4

DOI

http://dx.doi.org/10.1007/s12010-013-0212-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042849697

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23564434


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