Enhanced Production of l-Arginine by Expression of Vitreoscilla Hemoglobin Using a Novel Expression System in Corynebacterium crenatum View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-03

AUTHORS

Meijuan Xu, Zhiming Rao, Hong Xu, Chunyan Lan, Wenfang Dou, Xiaomei Zhang, Hongyu Xu, Jian Jin, Zhenghong Xu

ABSTRACT

Corynebacterium crenatum SYPA 5-5 is an aerobic and industrial L: -arginine producer. It was proved that the Corynebacterium glutamicum/Escherichia coli shuttle vector pJC1 could be extended in C. crenatum efficiently when using the chloramphenicol acetyltransferase gene (cat) as a reporter under the control of promoter tac. The expression system was applied to over-express the gene vgb coding Vitreoscilla hemoglobin (VHb) to further increase the dissolved oxygen in C. crenatum. As a result, the recombinant C. crenatum containing the pJC-tac-vgb plasmid expressed VHb at a level of 3.4 nmol g(-1), and the oxygen uptake rates reached 0.25 mg A(562)(-1) h(-1) which enhanced 38.8% compared to the wild-type strain. Thus, the final L: -arginine concentration of the batch fermentation reached a high level of 35.9 g L(-1), and the biomass was largely increased to 6.45 g L(-1), which were 17.3% and 10.5% higher than those obtained by the wild-type strain, respectively. To our knowledge, this is the first report that the efficient expression system was constructed to introduce vgb gene increasing the oxygen and energy supply for L: -arginine production in C. crenatum, which supplies a good strategy for the improvement of amino acid products. More... »

PAGES

707-719

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12010-010-9076-z

DOI

http://dx.doi.org/10.1007/s12010-010-9076-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039256156

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20835781


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