Diagnosing Periprosthetic Joint Infection: Has the Era of the Biomarker Arrived? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-11

AUTHORS

Carl Deirmengian, Keith Kardos, Patrick Kilmartin, Alexander Cameron, Kevin Schiller, Javad Parvizi

ABSTRACT

BACKGROUND: The diagnosis of periprosthetic joint infection (PJI) remains a serious clinical challenge. There is a pressing need for improved diagnostic testing methods; biomarkers offer one potentially promising approach. QUESTIONS/PURPOSES: We evaluated the diagnostic characteristics of 16 promising synovial fluid biomarkers for the diagnosis of PJI. METHODS: Synovial fluid was collected from 95 patients meeting the inclusion criteria of this prospective diagnostic study. All patients were being evaluated for a revision hip or knee arthroplasty, including patients with systemic inflammatory disease and those already receiving antibiotic treatment. The Musculoskeletal Infection Society (MSIS) definition was used to classify 29 PJIs and 66 aseptic joints. Synovial fluid samples were tested by immunoassay for 16 biomarkers optimized for use in synovial fluid. Sensitivity, specificity, and receiver operating characteristic curve analysis were performed to assess for diagnostic performance. RESULTS: Five biomarkers, including human α-defensin 1-3, neutrophil elastase 2, bactericidal/permeability-increasing protein, neutrophil gelatinase-associated lipocalin, and lactoferrin, correctly predicted the MSIS classification of all patients in this study, with 100% sensitivity and specificity for the diagnosis of PJI. An additional eight biomarkers demonstrated excellent diagnostic strength, with an area under the curve of greater than 0.9. CONCLUSIONS: Synovial fluid biomarkers exhibit a high accuracy in diagnosing PJI, even when including patients with systemic inflammatory disease and those receiving antibiotic treatment. Considering that these biomarkers match the results of the more complex MSIS definition of PJI, we believe that synovial fluid biomarkers can be a valuable addition to the methods utilized for the diagnosis of infection. LEVEL OF EVIDENCE: Level II, diagnostic study. See Instructions for Authors for a complete description of levels of evidence. More... »

PAGES

3254-3262

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11999-014-3543-8

DOI

http://dx.doi.org/10.1007/s11999-014-3543-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018517501

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24590839


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acute-Phase Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antimicrobial Cationic Peptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Arthritis, Infectious", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Arthroplasty, Replacement, Hip", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Arthroplasty, Replacement, Knee", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "C-Reactive Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Equipment Failure Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Granulocyte Colony-Stimulating Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hip Prosthesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-1alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Joint Instability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Knee Prosthesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lactoferrin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukocyte Elastase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipocalin-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipocalins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prosthesis-Related Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ROC Curve", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sensitivity and Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Synovial Fluid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vascular Endothelial Growth Factor A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "alpha-Defensins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Thomas Jefferson University", 
          "id": "https://www.grid.ac/institutes/grid.265008.9", 
          "name": [
            "CD Diagnostics Inc, Lankenau Institute for Medical Research, 100 Lancaster Avenue, MOB 456, 19096, Wynnewood, PA, USA", 
            "The Rothman Institute, Thomas Jefferson University, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Deirmengian", 
        "givenName": "Carl", 
        "id": "sg:person.0644330311.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644330311.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lankenau Institute for Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.280695.0", 
          "name": [
            "CD Diagnostics Inc, Lankenau Institute for Medical Research, 100 Lancaster Avenue, MOB 456, 19096, Wynnewood, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kardos", 
        "givenName": "Keith", 
        "id": "sg:person.01027735607.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027735607.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lankenau Institute for Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.280695.0", 
          "name": [
            "CD Diagnostics Inc, Lankenau Institute for Medical Research, 100 Lancaster Avenue, MOB 456, 19096, Wynnewood, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kilmartin", 
        "givenName": "Patrick", 
        "id": "sg:person.01207713444.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207713444.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lankenau Institute for Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.280695.0", 
          "name": [
            "CD Diagnostics Inc, Lankenau Institute for Medical Research, 100 Lancaster Avenue, MOB 456, 19096, Wynnewood, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cameron", 
        "givenName": "Alexander", 
        "id": "sg:person.01256026644.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256026644.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lankenau Institute for Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.280695.0", 
          "name": [
            "CD Diagnostics Inc, Lankenau Institute for Medical Research, 100 Lancaster Avenue, MOB 456, 19096, Wynnewood, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schiller", 
        "givenName": "Kevin", 
        "id": "sg:person.01324142044.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324142044.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Thomas Jefferson University", 
          "id": "https://www.grid.ac/institutes/grid.265008.9", 
          "name": [
            "The Rothman Institute, Thomas Jefferson University, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Parvizi", 
        "givenName": "Javad", 
        "id": "sg:person.01357752371.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357752371.70"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.arth.2007.09.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004225674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11420-005-0131-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006455965", 
          "https://doi.org/10.1007/s11420-005-0131-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11420-005-0131-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006455965", 
          "https://doi.org/10.1007/s11420-005-0131-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.arth.2007.04.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007647393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/17453670710014338", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011870295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11999-010-1433-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012067453", 
          "https://doi.org/10.1007/s11999-010-1433-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/s11999-010-1433-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012067453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.9416edit", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012535197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.9416edit", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012535197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0952-7915(99)00077-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012938720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/17453670902804943", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018631847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.arth.2012.03.059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020922253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.arth.2011.03.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022700012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1302/0301-620x.90b2.19436", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023208087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1369-5274(02)00294-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024657342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.arth.2007.10.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027638555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0009358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029811885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.blo.0000185756.17401.32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030318887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.blo.0000185756.17401.32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030318887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.blo.0000185756.17401.32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030318887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jmri.23523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031293083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11999-010-1338-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031409860", 
          "https://doi.org/10.1007/s11999-010-1338-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/s11999-010-1338-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031409860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijid.2011.05.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032156102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijid.2009.02.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038176973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.arth.2010.07.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040898958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.blo.0000218727.14097.d5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041765029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.blo.0000218727.14097.d5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041765029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m200755200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042954901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/s11999-009-0945-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043129423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/s11999-009-0945-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043129423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/s11999-009-0945-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043129423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.arth.2012.02.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043144126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11999-011-2102-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046889697", 
          "https://doi.org/10.1007/s11999-011-2102-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11999-011-2102-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046889697", 
          "https://doi.org/10.1007/s11999-011-2102-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/s11999-011-2102-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046889697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1574-695x.2008.00446.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047922028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0598-615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048689553", 
          "https://doi.org/10.1038/nm0598-615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0598-615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048689553", 
          "https://doi.org/10.1038/nm0598-615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11999-010-1298-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050804234", 
          "https://doi.org/10.1007/s11999-010-1298-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11999-010-1298-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050804234", 
          "https://doi.org/10.1007/s11999-010-1298-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/s11999-010-1298-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050804234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3083.2005.01597.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052951339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3083.2005.01597.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052951339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-199407000-00036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060165784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-199407000-00036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060165784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-199407000-00036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060165784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/00004623-200704000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068897784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/00004623-200707000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068897883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.d.02602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068899467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.d.02602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068899467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.d.02602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068899467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.f.00222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068900020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.f.00222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068900020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.f.00222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068900020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.g.00470", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068900534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.g.00470", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068900534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.g.00470", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068900534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.g.01255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068900714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.g.01255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068900714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.g.01255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068900714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.h.00155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068900864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.h.00155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068900864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.h.00155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068900864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.h.00853", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068901038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.h.00853", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068901038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.h.00853", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068901038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.i.01199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068901803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.i.01199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068901803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.i.01199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068901803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.i.01256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068901817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.i.01256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068901817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.i.01256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068901817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.j.00756", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068902101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.j.00756", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068902101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.j.00756", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068902101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.k.01417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068902726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.k.01417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068902726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.k.01417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068902726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.l.00205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068903057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.l.00205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068903057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/jbjs.l.00205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068903057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/138161209788682325", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069166985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078511815", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-11", 
    "datePublishedReg": "2014-11-01", 
    "description": "BACKGROUND: The diagnosis of periprosthetic joint infection (PJI) remains a serious clinical challenge. There is a pressing need for improved diagnostic testing methods; biomarkers offer one potentially promising approach.\nQUESTIONS/PURPOSES: We evaluated the diagnostic characteristics of 16 promising synovial fluid biomarkers for the diagnosis of PJI.\nMETHODS: Synovial fluid was collected from 95 patients meeting the inclusion criteria of this prospective diagnostic study. All patients were being evaluated for a revision hip or knee arthroplasty, including patients with systemic inflammatory disease and those already receiving antibiotic treatment. The Musculoskeletal Infection Society (MSIS) definition was used to classify 29 PJIs and 66 aseptic joints. Synovial fluid samples were tested by immunoassay for 16 biomarkers optimized for use in synovial fluid. Sensitivity, specificity, and receiver operating characteristic curve analysis were performed to assess for diagnostic performance.\nRESULTS: Five biomarkers, including human \u03b1-defensin 1-3, neutrophil elastase 2, bactericidal/permeability-increasing protein, neutrophil gelatinase-associated lipocalin, and lactoferrin, correctly predicted the MSIS classification of all patients in this study, with 100% sensitivity and specificity for the diagnosis of PJI. An additional eight biomarkers demonstrated excellent diagnostic strength, with an area under the curve of greater than 0.9.\nCONCLUSIONS: Synovial fluid biomarkers exhibit a high accuracy in diagnosing PJI, even when including patients with systemic inflammatory disease and those receiving antibiotic treatment. Considering that these biomarkers match the results of the more complex MSIS definition of PJI, we believe that synovial fluid biomarkers can be a valuable addition to the methods utilized for the diagnosis of infection.\nLEVEL OF EVIDENCE: Level II, diagnostic study. See Instructions for Authors for a complete description of levels of evidence.", 
    "genre": "non_research_article", 
    "id": "sg:pub.10.1007/s11999-014-3543-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1007212", 
        "issn": [
          "0009-921X", 
          "1528-1132"
        ], 
        "name": "Clinical Orthopaedics and Related Research\u00ae", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "472"
      }
    ], 
    "name": "Diagnosing Periprosthetic Joint Infection: Has the Era of the Biomarker Arrived?", 
    "pagination": "3254-3262", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "583a7aa58191975044e43fb11064f04671fa302465c0a8914d47a726b5edbd3e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24590839"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0075674"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11999-014-3543-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1018517501"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11999-014-3543-8", 
      "https://app.dimensions.ai/details/publication/pub.1018517501"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000521.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11999-014-3543-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11999-014-3543-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11999-014-3543-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11999-014-3543-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11999-014-3543-8'


 

This table displays all metadata directly associated to this object as RDF triples.

392 TRIPLES      21 PREDICATES      111 URIs      54 LITERALS      42 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11999-014-3543-8 schema:about N01a4795d6d6e43209033017b63bfd2ea
2 N0334c4cc734948b6a76286c7efa24a48
3 N0a8e983c86a9406b950c0ecfd48fbc11
4 N0d0b90489b5f43789bf5161b496372c2
5 N12f94e02951b44c992cf84f29a588acc
6 N1a0db413366c4430938bcc5b96c9b87c
7 N1a2b8c5f23464712b69d07fcd2445e98
8 N22df9a0d783d46adb12e12f675104082
9 N26d0724419614dcaaf3e0fa89ff3dd51
10 N39f2e1d55ca74a17afd5bf93533df837
11 N3ea26d260d564f69bb13858b769a56d5
12 N53508e9a86024893a771cffb2ddf8ff4
13 N5ad643c081904e68a9872ff60c3ef965
14 N5c40ede2fdc948ddac176e920eb539a0
15 N5d69b2f142c94ecfb6731be261d618cb
16 N6fa9dc65b7934b52ba47cd4896d17584
17 N70784a2a927b49dd94ef95bb4310d0ac
18 N715d0f820fe644c591ade14ae134ed85
19 N71e3c304a45b4ed18478b4452e48e7f1
20 N734ce779760e40f2ab46d40b3c72f9ad
21 N7c71cea8b44b4b739688f501130062f0
22 N8184ddd145d04a8e8615ba5143ac5eb5
23 N95b222dba61049d591757ae97675fc5e
24 N9f63c53046b94bf79c5c1ab9214d32fd
25 Na2187e323da64829ab44ca58b0f1a4cb
26 Nbad4eb73f2aa4c9397510b27cbbf3361
27 Nc85e8cfc467746b9bb04b6cfdca62e2a
28 Ncc8d397068134acca5024bf0324fe5e5
29 Nce2545f6efc74020b454942900a6f7c2
30 Ne4b68ce221e947e4876194da52952853
31 Ne71c77fde9c84fadb2baddc92cd6059e
32 Nec77c5898a3e41b29cc0ed1a2caa5fa0
33 Neeb04bf031f4457ba45acc908e3e9541
34 anzsrc-for:11
35 anzsrc-for:1103
36 schema:author N5752d2a875e84537af372edc07e2ea35
37 schema:citation sg:pub.10.1007/s11420-005-0131-1
38 sg:pub.10.1007/s11999-010-1298-4
39 sg:pub.10.1007/s11999-010-1338-0
40 sg:pub.10.1007/s11999-010-1433-2
41 sg:pub.10.1007/s11999-011-2102-9
42 sg:pub.10.1038/nm0598-615
43 https://app.dimensions.ai/details/publication/pub.1078511815
44 https://doi.org/10.1002/jmri.23523
45 https://doi.org/10.1007/s11999-009-0945-0
46 https://doi.org/10.1007/s11999-010-1298-4
47 https://doi.org/10.1007/s11999-010-1338-0
48 https://doi.org/10.1007/s11999-010-1433-2
49 https://doi.org/10.1007/s11999-011-2102-9
50 https://doi.org/10.1016/j.arth.2007.04.013
51 https://doi.org/10.1016/j.arth.2007.09.005
52 https://doi.org/10.1016/j.arth.2007.10.017
53 https://doi.org/10.1016/j.arth.2010.07.025
54 https://doi.org/10.1016/j.arth.2011.03.025
55 https://doi.org/10.1016/j.arth.2012.02.022
56 https://doi.org/10.1016/j.arth.2012.03.059
57 https://doi.org/10.1016/j.ijid.2009.02.017
58 https://doi.org/10.1016/j.ijid.2011.05.015
59 https://doi.org/10.1016/s0952-7915(99)00077-1
60 https://doi.org/10.1016/s1369-5274(02)00294-1
61 https://doi.org/10.1074/jbc.m200755200
62 https://doi.org/10.1080/17453670710014338
63 https://doi.org/10.1080/17453670902804943
64 https://doi.org/10.1097/00003086-199407000-00036
65 https://doi.org/10.1097/01.blo.0000185756.17401.32
66 https://doi.org/10.1097/01.blo.0000218727.14097.d5
67 https://doi.org/10.1111/j.1365-3083.2005.01597.x
68 https://doi.org/10.1111/j.1574-695x.2008.00446.x
69 https://doi.org/10.1302/0301-620x.90b2.19436
70 https://doi.org/10.1371/journal.pone.0009358
71 https://doi.org/10.2106/00004623-200704000-00012
72 https://doi.org/10.2106/00004623-200707000-00001
73 https://doi.org/10.2106/jbjs.9416edit
74 https://doi.org/10.2106/jbjs.d.02602
75 https://doi.org/10.2106/jbjs.f.00222
76 https://doi.org/10.2106/jbjs.g.00470
77 https://doi.org/10.2106/jbjs.g.01255
78 https://doi.org/10.2106/jbjs.h.00155
79 https://doi.org/10.2106/jbjs.h.00853
80 https://doi.org/10.2106/jbjs.i.01199
81 https://doi.org/10.2106/jbjs.i.01256
82 https://doi.org/10.2106/jbjs.j.00756
83 https://doi.org/10.2106/jbjs.k.01417
84 https://doi.org/10.2106/jbjs.l.00205
85 https://doi.org/10.2174/138161209788682325
86 schema:datePublished 2014-11
87 schema:datePublishedReg 2014-11-01
88 schema:description BACKGROUND: The diagnosis of periprosthetic joint infection (PJI) remains a serious clinical challenge. There is a pressing need for improved diagnostic testing methods; biomarkers offer one potentially promising approach. QUESTIONS/PURPOSES: We evaluated the diagnostic characteristics of 16 promising synovial fluid biomarkers for the diagnosis of PJI. METHODS: Synovial fluid was collected from 95 patients meeting the inclusion criteria of this prospective diagnostic study. All patients were being evaluated for a revision hip or knee arthroplasty, including patients with systemic inflammatory disease and those already receiving antibiotic treatment. The Musculoskeletal Infection Society (MSIS) definition was used to classify 29 PJIs and 66 aseptic joints. Synovial fluid samples were tested by immunoassay for 16 biomarkers optimized for use in synovial fluid. Sensitivity, specificity, and receiver operating characteristic curve analysis were performed to assess for diagnostic performance. RESULTS: Five biomarkers, including human α-defensin 1-3, neutrophil elastase 2, bactericidal/permeability-increasing protein, neutrophil gelatinase-associated lipocalin, and lactoferrin, correctly predicted the MSIS classification of all patients in this study, with 100% sensitivity and specificity for the diagnosis of PJI. An additional eight biomarkers demonstrated excellent diagnostic strength, with an area under the curve of greater than 0.9. CONCLUSIONS: Synovial fluid biomarkers exhibit a high accuracy in diagnosing PJI, even when including patients with systemic inflammatory disease and those receiving antibiotic treatment. Considering that these biomarkers match the results of the more complex MSIS definition of PJI, we believe that synovial fluid biomarkers can be a valuable addition to the methods utilized for the diagnosis of infection. LEVEL OF EVIDENCE: Level II, diagnostic study. See Instructions for Authors for a complete description of levels of evidence.
89 schema:genre non_research_article
90 schema:inLanguage en
91 schema:isAccessibleForFree true
92 schema:isPartOf N25710f2b8c114f7b8162b2b255521f25
93 Nb2536bc67cc44be996ad5e1087874d87
94 sg:journal.1007212
95 schema:name Diagnosing Periprosthetic Joint Infection: Has the Era of the Biomarker Arrived?
96 schema:pagination 3254-3262
97 schema:productId N531f6a6930474ef38ce98c52be6de80d
98 N570d0b220c5f421b9efc07edea9d8e73
99 N81124d632f8249e8afc859d370c53980
100 N840a2b11ad97493fb026776638409bbc
101 Ne2a3895c7bd043a3ae2a871549fdbc6f
102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018517501
103 https://doi.org/10.1007/s11999-014-3543-8
104 schema:sdDatePublished 2019-04-10T13:19
105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
106 schema:sdPublisher N85bcbee8261f4a3f92cf05a1e6522e77
107 schema:url http://link.springer.com/10.1007%2Fs11999-014-3543-8
108 sgo:license sg:explorer/license/
109 sgo:sdDataset articles
110 rdf:type schema:ScholarlyArticle
111 N01a4795d6d6e43209033017b63bfd2ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Arthroplasty, Replacement, Hip
113 rdf:type schema:DefinedTerm
114 N0334c4cc734948b6a76286c7efa24a48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Leukocyte Elastase
116 rdf:type schema:DefinedTerm
117 N03a38c9b5df9414b9ed51f02265e8093 rdf:first sg:person.01256026644.44
118 rdf:rest N0d707de2cf31439c93d7e18751effa6b
119 N0a8e983c86a9406b950c0ecfd48fbc11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Middle Aged
121 rdf:type schema:DefinedTerm
122 N0d0b90489b5f43789bf5161b496372c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Joint Instability
124 rdf:type schema:DefinedTerm
125 N0d707de2cf31439c93d7e18751effa6b rdf:first sg:person.01324142044.08
126 rdf:rest N5c6427060360428fa508176901d52dbb
127 N12f94e02951b44c992cf84f29a588acc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Equipment Failure Analysis
129 rdf:type schema:DefinedTerm
130 N1a0db413366c4430938bcc5b96c9b87c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Interleukin-1alpha
132 rdf:type schema:DefinedTerm
133 N1a2b8c5f23464712b69d07fcd2445e98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Arthroplasty, Replacement, Knee
135 rdf:type schema:DefinedTerm
136 N22df9a0d783d46adb12e12f675104082 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Granulocyte Colony-Stimulating Factor
138 rdf:type schema:DefinedTerm
139 N25710f2b8c114f7b8162b2b255521f25 schema:issueNumber 11
140 rdf:type schema:PublicationIssue
141 N26d0724419614dcaaf3e0fa89ff3dd51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name C-Reactive Protein
143 rdf:type schema:DefinedTerm
144 N26d974a206174cf48140540be0c9a161 rdf:first sg:person.01207713444.42
145 rdf:rest N03a38c9b5df9414b9ed51f02265e8093
146 N39f2e1d55ca74a17afd5bf93533df837 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Lipocalin-2
148 rdf:type schema:DefinedTerm
149 N3ea26d260d564f69bb13858b769a56d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name alpha-Defensins
151 rdf:type schema:DefinedTerm
152 N498b35bcdfae429c9d8c0874ff67b9e5 rdf:first sg:person.01027735607.52
153 rdf:rest N26d974a206174cf48140540be0c9a161
154 N531f6a6930474ef38ce98c52be6de80d schema:name pubmed_id
155 schema:value 24590839
156 rdf:type schema:PropertyValue
157 N53508e9a86024893a771cffb2ddf8ff4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Antimicrobial Cationic Peptides
159 rdf:type schema:DefinedTerm
160 N570d0b220c5f421b9efc07edea9d8e73 schema:name doi
161 schema:value 10.1007/s11999-014-3543-8
162 rdf:type schema:PropertyValue
163 N5752d2a875e84537af372edc07e2ea35 rdf:first sg:person.0644330311.12
164 rdf:rest N498b35bcdfae429c9d8c0874ff67b9e5
165 N5ad643c081904e68a9872ff60c3ef965 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Prosthesis-Related Infections
167 rdf:type schema:DefinedTerm
168 N5c40ede2fdc948ddac176e920eb539a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Male
170 rdf:type schema:DefinedTerm
171 N5c6427060360428fa508176901d52dbb rdf:first sg:person.01357752371.70
172 rdf:rest rdf:nil
173 N5d69b2f142c94ecfb6731be261d618cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name ROC Curve
175 rdf:type schema:DefinedTerm
176 N6fa9dc65b7934b52ba47cd4896d17584 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Lipocalins
178 rdf:type schema:DefinedTerm
179 N70784a2a927b49dd94ef95bb4310d0ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Biomarkers
181 rdf:type schema:DefinedTerm
182 N715d0f820fe644c591ade14ae134ed85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Aged, 80 and over
184 rdf:type schema:DefinedTerm
185 N71e3c304a45b4ed18478b4452e48e7f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Synovial Fluid
187 rdf:type schema:DefinedTerm
188 N734ce779760e40f2ab46d40b3c72f9ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Humans
190 rdf:type schema:DefinedTerm
191 N7c71cea8b44b4b739688f501130062f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Arthritis, Infectious
193 rdf:type schema:DefinedTerm
194 N81124d632f8249e8afc859d370c53980 schema:name dimensions_id
195 schema:value pub.1018517501
196 rdf:type schema:PropertyValue
197 N8184ddd145d04a8e8615ba5143ac5eb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Knee Prosthesis
199 rdf:type schema:DefinedTerm
200 N840a2b11ad97493fb026776638409bbc schema:name readcube_id
201 schema:value 583a7aa58191975044e43fb11064f04671fa302465c0a8914d47a726b5edbd3e
202 rdf:type schema:PropertyValue
203 N85bcbee8261f4a3f92cf05a1e6522e77 schema:name Springer Nature - SN SciGraph project
204 rdf:type schema:Organization
205 N95b222dba61049d591757ae97675fc5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Lactoferrin
207 rdf:type schema:DefinedTerm
208 N9f63c53046b94bf79c5c1ab9214d32fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Female
210 rdf:type schema:DefinedTerm
211 Na2187e323da64829ab44ca58b0f1a4cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Acute-Phase Proteins
213 rdf:type schema:DefinedTerm
214 Nb2536bc67cc44be996ad5e1087874d87 schema:volumeNumber 472
215 rdf:type schema:PublicationVolume
216 Nbad4eb73f2aa4c9397510b27cbbf3361 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name Prospective Studies
218 rdf:type schema:DefinedTerm
219 Nc85e8cfc467746b9bb04b6cfdca62e2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
220 schema:name Aged
221 rdf:type schema:DefinedTerm
222 Ncc8d397068134acca5024bf0324fe5e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
223 schema:name Hip Prosthesis
224 rdf:type schema:DefinedTerm
225 Nce2545f6efc74020b454942900a6f7c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
226 schema:name Sensitivity and Specificity
227 rdf:type schema:DefinedTerm
228 Ne2a3895c7bd043a3ae2a871549fdbc6f schema:name nlm_unique_id
229 schema:value 0075674
230 rdf:type schema:PropertyValue
231 Ne4b68ce221e947e4876194da52952853 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
232 schema:name Adult
233 rdf:type schema:DefinedTerm
234 Ne71c77fde9c84fadb2baddc92cd6059e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
235 schema:name Blood Proteins
236 rdf:type schema:DefinedTerm
237 Nec77c5898a3e41b29cc0ed1a2caa5fa0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
238 schema:name Vascular Endothelial Growth Factor A
239 rdf:type schema:DefinedTerm
240 Neeb04bf031f4457ba45acc908e3e9541 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
241 schema:name Proto-Oncogene Proteins
242 rdf:type schema:DefinedTerm
243 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
244 schema:name Medical and Health Sciences
245 rdf:type schema:DefinedTerm
246 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
247 schema:name Clinical Sciences
248 rdf:type schema:DefinedTerm
249 sg:journal.1007212 schema:issn 0009-921X
250 1528-1132
251 schema:name Clinical Orthopaedics and Related Research®
252 rdf:type schema:Periodical
253 sg:person.01027735607.52 schema:affiliation https://www.grid.ac/institutes/grid.280695.0
254 schema:familyName Kardos
255 schema:givenName Keith
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027735607.52
257 rdf:type schema:Person
258 sg:person.01207713444.42 schema:affiliation https://www.grid.ac/institutes/grid.280695.0
259 schema:familyName Kilmartin
260 schema:givenName Patrick
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207713444.42
262 rdf:type schema:Person
263 sg:person.01256026644.44 schema:affiliation https://www.grid.ac/institutes/grid.280695.0
264 schema:familyName Cameron
265 schema:givenName Alexander
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256026644.44
267 rdf:type schema:Person
268 sg:person.01324142044.08 schema:affiliation https://www.grid.ac/institutes/grid.280695.0
269 schema:familyName Schiller
270 schema:givenName Kevin
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324142044.08
272 rdf:type schema:Person
273 sg:person.01357752371.70 schema:affiliation https://www.grid.ac/institutes/grid.265008.9
274 schema:familyName Parvizi
275 schema:givenName Javad
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357752371.70
277 rdf:type schema:Person
278 sg:person.0644330311.12 schema:affiliation https://www.grid.ac/institutes/grid.265008.9
279 schema:familyName Deirmengian
280 schema:givenName Carl
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644330311.12
282 rdf:type schema:Person
283 sg:pub.10.1007/s11420-005-0131-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006455965
284 https://doi.org/10.1007/s11420-005-0131-1
285 rdf:type schema:CreativeWork
286 sg:pub.10.1007/s11999-010-1298-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050804234
287 https://doi.org/10.1007/s11999-010-1298-4
288 rdf:type schema:CreativeWork
289 sg:pub.10.1007/s11999-010-1338-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031409860
290 https://doi.org/10.1007/s11999-010-1338-0
291 rdf:type schema:CreativeWork
292 sg:pub.10.1007/s11999-010-1433-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012067453
293 https://doi.org/10.1007/s11999-010-1433-2
294 rdf:type schema:CreativeWork
295 sg:pub.10.1007/s11999-011-2102-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046889697
296 https://doi.org/10.1007/s11999-011-2102-9
297 rdf:type schema:CreativeWork
298 sg:pub.10.1038/nm0598-615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048689553
299 https://doi.org/10.1038/nm0598-615
300 rdf:type schema:CreativeWork
301 https://app.dimensions.ai/details/publication/pub.1078511815 schema:CreativeWork
302 https://doi.org/10.1002/jmri.23523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031293083
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1007/s11999-009-0945-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043129423
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1007/s11999-010-1298-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050804234
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1007/s11999-010-1338-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031409860
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1007/s11999-010-1433-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012067453
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1007/s11999-011-2102-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046889697
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/j.arth.2007.04.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007647393
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/j.arth.2007.09.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004225674
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/j.arth.2007.10.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027638555
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/j.arth.2010.07.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040898958
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/j.arth.2011.03.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022700012
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/j.arth.2012.02.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043144126
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1016/j.arth.2012.03.059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020922253
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1016/j.ijid.2009.02.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038176973
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1016/j.ijid.2011.05.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032156102
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1016/s0952-7915(99)00077-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012938720
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1016/s1369-5274(02)00294-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024657342
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1074/jbc.m200755200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042954901
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1080/17453670710014338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011870295
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1080/17453670902804943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018631847
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1097/00003086-199407000-00036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060165784
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1097/01.blo.0000185756.17401.32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030318887
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1097/01.blo.0000218727.14097.d5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041765029
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1111/j.1365-3083.2005.01597.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052951339
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1111/j.1574-695x.2008.00446.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047922028
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1302/0301-620x.90b2.19436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023208087
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1371/journal.pone.0009358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029811885
355 rdf:type schema:CreativeWork
356 https://doi.org/10.2106/00004623-200704000-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068897784
357 rdf:type schema:CreativeWork
358 https://doi.org/10.2106/00004623-200707000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068897883
359 rdf:type schema:CreativeWork
360 https://doi.org/10.2106/jbjs.9416edit schema:sameAs https://app.dimensions.ai/details/publication/pub.1012535197
361 rdf:type schema:CreativeWork
362 https://doi.org/10.2106/jbjs.d.02602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068899467
363 rdf:type schema:CreativeWork
364 https://doi.org/10.2106/jbjs.f.00222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068900020
365 rdf:type schema:CreativeWork
366 https://doi.org/10.2106/jbjs.g.00470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068900534
367 rdf:type schema:CreativeWork
368 https://doi.org/10.2106/jbjs.g.01255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068900714
369 rdf:type schema:CreativeWork
370 https://doi.org/10.2106/jbjs.h.00155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068900864
371 rdf:type schema:CreativeWork
372 https://doi.org/10.2106/jbjs.h.00853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068901038
373 rdf:type schema:CreativeWork
374 https://doi.org/10.2106/jbjs.i.01199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068901803
375 rdf:type schema:CreativeWork
376 https://doi.org/10.2106/jbjs.i.01256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068901817
377 rdf:type schema:CreativeWork
378 https://doi.org/10.2106/jbjs.j.00756 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068902101
379 rdf:type schema:CreativeWork
380 https://doi.org/10.2106/jbjs.k.01417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068902726
381 rdf:type schema:CreativeWork
382 https://doi.org/10.2106/jbjs.l.00205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068903057
383 rdf:type schema:CreativeWork
384 https://doi.org/10.2174/138161209788682325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069166985
385 rdf:type schema:CreativeWork
386 https://www.grid.ac/institutes/grid.265008.9 schema:alternateName Thomas Jefferson University
387 schema:name CD Diagnostics Inc, Lankenau Institute for Medical Research, 100 Lancaster Avenue, MOB 456, 19096, Wynnewood, PA, USA
388 The Rothman Institute, Thomas Jefferson University, Philadelphia, PA, USA
389 rdf:type schema:Organization
390 https://www.grid.ac/institutes/grid.280695.0 schema:alternateName Lankenau Institute for Medical Research
391 schema:name CD Diagnostics Inc, Lankenau Institute for Medical Research, 100 Lancaster Avenue, MOB 456, 19096, Wynnewood, PA, USA
392 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...