Periprosthetic Infection Due to Resistant Staphylococci: Serious Problems on the Horizon View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-07

AUTHORS

Javad Parvizi, Khalid Azzam, Elie Ghanem, Matthew S. Austin, Richard H. Rothman

ABSTRACT

Prosthetic joint infections (PJI) caused by methicillin-resistant staphylococci represent a major therapeutic challenge. We examined the effectiveness of surgical treatment in treating infection of total hip or knee arthroplasty caused by methicillin-resistant staphylococcal strains and the variables influencing treatment success. One hundred and twenty-seven patients were treated at our institution between 1999 and 2006. There were 58 men and 69 women, with an average age of 66 years. Patients were followed for a minimum of 2 years or until recurrence of infection. Débridement and retention of the prosthesis was performed in 35 patients and resection arthroplasty in 92. Débridement controlled the infection in only 37% of cases whereas two-stage exchange arthroplasty controlled the infection in 75% of hips and 60% of knees. Preexisting cardiac disease was associated with a higher likelihood of failure to control infection in all treatment groups. Antibiotic-resistant Staphylococci continue to compromise treatment outcome of prosthetic joint infections, especially in patients with medical comorbidities. New preventive and therapeutic strategies are needed. LEVEL OF EVIDENCE: Level IV, therapeutic study. More... »

PAGES

1732-1739

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11999-009-0857-z

DOI

http://dx.doi.org/10.1007/s11999-009-0857-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028390048

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19408061


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