Gliomatosis Cerebri: A Review View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-02

AUTHORS

Roberta Rudà, Luca Bertero, Marc Sanson

ABSTRACT

OPINION STATEMENT: Gliomatosis cerebri (GC) is an intriguing disease for several reasons. First, it is difficult to draw the border between GC and diffuse gliomas. In this regard, GC could represent the most invasive form of diffuse gliomas. Second, both in terms of histologic grading and clinical course, GC is a heterogeneous disease, ranging from rapidly evolving to slowly and somewhat indolent forms. Because of the extensive spread of the disease, surgery-outside a biopsy for diagnosis-is rarely indicated in gliomatosis cerebri. Therapeutic options include radiotherapy, generally involving the whole brain, and chemotherapy with temozolomide or nitrosoureas. Because of the rarity of the disease, no trial comparing these two modalities has been undertaken so far. Decision is, therefore, based on small retrospective noncomparative studies and expert opinions. On one hand, there is a rationale to postpone the whole brain radiotherapy because of late neurotoxicity, but on the other hand, there is also the risk that an aggressive disease evolves to intracranial hypertension making the radiotherapy hazardous or even impossible. As a consequence, the patient would lose the opportunity to receive a potentially effective treatment. In this decision, the evaluation of histologic data together with clinical and radiologic features, performance status, and molecular profile may be of help. Because radiotherapy usually involves large volumes of the brain, chemotherapy is generally preferred up front in patients with a slowly evolving disease. Conversely, in patients with rapidly (ie, over few weeks) evolving disease with neurologic deficits or when histologic features of glioblastoma are evident, whole brain radiotherapy (45 Gy with 1.8 Gy fractions), alone or associated with concomitant temozolomide, is often preferred. The value of advanced of magnetic resonance imaging and positron emission tomography techniques to predict outcome and monitoring the treatment still remains to be defined. More... »

PAGES

273

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11940-013-0273-2

DOI

http://dx.doi.org/10.1007/s11940-013-0273-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027681061

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24390814


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Division of Neuro-Oncology, Department of Neuroscience, University and AO Citt\u00e0 della Salute e della Scienza di Torino, Via Cherasco 15, 10126, Turin, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rud\u00e0", 
        "givenName": "Roberta", 
        "id": "sg:person.0723227673.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723227673.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Neuro-Oncology, Department of Neuroscience, University and AO Citt\u00e0 della Salute e della Scienza di Torino, Via Cherasco 15, 10126, Turin, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bertero", 
        "givenName": "Luca", 
        "id": "sg:person.01141770554.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141770554.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Service de Neurologie 2, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, Universit\u00e9 Pierre et Marie Curie, 47-83 Bd de l\u2019H\u00f4pital, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sanson", 
        "givenName": "Marc", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/01.rct.0000148453.29579.51", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000083228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.rct.0000148453.29579.51", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000083228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.rct.0000148453.29579.51", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000083228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-10-424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000697011", 
          "https://doi.org/10.1186/1471-2407-10-424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00381-012-2016-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001123384", 
          "https://doi.org/10.1007/s00381-012-2016-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002340050345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001684800", 
          "https://doi.org/10.1007/s002340050345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.10665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002676277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.10297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005962469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19961015)78:8<1789::aid-cncr20>3.0.co;2-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008598777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-005-5263-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009559987", 
          "https://doi.org/10.1007/s11060-005-5263-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-005-5263-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009559987", 
          "https://doi.org/10.1007/s11060-005-5263-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clineuro.2012.01.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010277223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000163057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011690783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/02688690120082396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013734489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/02688690410001732823", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017312508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002340000343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019168919", 
          "https://doi.org/10.1007/s002340000343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-12-0084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023787699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1019934901750", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025543372", 
          "https://doi.org/10.1023/a:1019934901750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/neuonc/noq055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026194040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/neuonc/noq055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026194040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-013-1058-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026318147", 
          "https://doi.org/10.1007/s11060-013-1058-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s007010050176", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026430068", 
          "https://doi.org/10.1007/s007010050176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejrad.2006.03.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027802157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.22478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028914419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004728-200401000-00018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031201611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004728-200401000-00018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031201611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(03)00293-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032150611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(03)00293-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032150611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0090-3019(91)90156-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033260268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1227/01.neu.0000073527.20655.e6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040534657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002340050551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040854028", 
          "https://doi.org/10.1007/s002340050551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-011-0587-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040924422", 
          "https://doi.org/10.1007/s11060-011-0587-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.10909", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042055030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.2005.072223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042823555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00234-003-1057-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044690040", 
          "https://doi.org/10.1007/s00234-003-1057-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa043330", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052112015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2004-818519", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057430930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/088307389501000111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063856220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/088307389501000111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063856220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000129985.39973.e4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000129985.39973.e4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000129985.39973.e4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000130249.41341.58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000130249.41341.58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000130249.41341.58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000299896.65604.ae", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064349977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000299896.65604.ae", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064349977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000299896.65604.ae", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064349977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3181b163e2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064354529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3181b163e2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064354529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3181b163e2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064354529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.60.1.151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064381427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.60.1.151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064381427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.60.1.151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064381427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2214/ajr.06.0055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069298030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2214/ajr.161.4.8372774", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069318181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2003.98.2.0269", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071100645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2003.98.2.0269", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071100645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2003.98.2.0269", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071100645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2005.102.1.0072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071101388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2005.102.1.0072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071101388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2005.102.1.0072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071101388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2005.102.1.0072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071101388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/ped.2005.102.1.0072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071102510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ol.2011.445", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071525374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074597725", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075016509", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075286467", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077286103", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077451035", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080102911", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082552651", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiology.198.3.8628879", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082885177"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-02", 
    "datePublishedReg": "2014-02-01", 
    "description": "OPINION STATEMENT: Gliomatosis cerebri (GC) is an intriguing disease for several reasons. First, it is difficult to draw the border between GC and diffuse gliomas. In this regard, GC could represent the most invasive form of diffuse gliomas. Second, both in terms of histologic grading and clinical course, GC is a heterogeneous disease, ranging from rapidly evolving to slowly and somewhat indolent forms. Because of the extensive spread of the disease, surgery-outside a biopsy for diagnosis-is rarely indicated in gliomatosis cerebri. Therapeutic options include radiotherapy, generally involving the whole brain, and chemotherapy with temozolomide or nitrosoureas. Because of the rarity of the disease, no trial comparing these two modalities has been undertaken so far. Decision is, therefore, based on small retrospective noncomparative studies and expert opinions. On one hand, there is a rationale to postpone the whole brain radiotherapy because of late neurotoxicity, but on the other hand, there is also the risk that an aggressive disease evolves to intracranial hypertension making the radiotherapy hazardous or even impossible. As a consequence, the patient would lose the opportunity to receive a potentially effective treatment. In this decision, the evaluation of histologic data together with clinical and radiologic features, performance status, and molecular profile may be of help. Because radiotherapy usually involves large volumes of the brain, chemotherapy is generally preferred up front in patients with a slowly evolving disease. Conversely, in patients with rapidly (ie, over few weeks) evolving disease with neurologic deficits or when histologic features of glioblastoma are evident, whole brain radiotherapy (45\u00a0Gy with 1.8\u00a0Gy fractions), alone or associated with concomitant temozolomide, is often preferred. The value of advanced of magnetic resonance imaging and positron emission tomography techniques to predict outcome and monitoring the treatment still remains to be defined.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11940-013-0273-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1119514", 
        "issn": [
          "1092-8480", 
          "1534-3138"
        ], 
        "name": "Current Treatment Options in Neurology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "16"
      }
    ], 
    "name": "Gliomatosis Cerebri: A Review", 
    "pagination": "273", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "83de18a6068343f0ace6ffd5509789fc33e0ef77c8cfa9e2506941d7ff688040"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24390814"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9815940"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11940-013-0273-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1027681061"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11940-013-0273-2", 
      "https://app.dimensions.ai/details/publication/pub.1027681061"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:12", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000522.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11940-013-0273-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11940-013-0273-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11940-013-0273-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11940-013-0273-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11940-013-0273-2'


 

This table displays all metadata directly associated to this object as RDF triples.

242 TRIPLES      21 PREDICATES      80 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11940-013-0273-2 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N5d276d3e0c114509819e772d45db2248
4 schema:citation sg:pub.10.1007/s00234-003-1057-2
5 sg:pub.10.1007/s002340000343
6 sg:pub.10.1007/s002340050345
7 sg:pub.10.1007/s002340050551
8 sg:pub.10.1007/s00381-012-2016-1
9 sg:pub.10.1007/s007010050176
10 sg:pub.10.1007/s11060-005-5263-0
11 sg:pub.10.1007/s11060-011-0587-4
12 sg:pub.10.1007/s11060-013-1058-x
13 sg:pub.10.1023/a:1019934901750
14 sg:pub.10.1186/1471-2407-10-424
15 https://app.dimensions.ai/details/publication/pub.1074597725
16 https://app.dimensions.ai/details/publication/pub.1075016509
17 https://app.dimensions.ai/details/publication/pub.1075286467
18 https://app.dimensions.ai/details/publication/pub.1077286103
19 https://app.dimensions.ai/details/publication/pub.1077451035
20 https://app.dimensions.ai/details/publication/pub.1080102911
21 https://app.dimensions.ai/details/publication/pub.1082552651
22 https://doi.org/10.1002/(sici)1097-0142(19961015)78:8<1789::aid-cncr20>3.0.co;2-t
23 https://doi.org/10.1002/ana.10297
24 https://doi.org/10.1002/ana.22478
25 https://doi.org/10.1002/cncr.10909
26 https://doi.org/10.1002/mds.10665
27 https://doi.org/10.1016/0090-3019(91)90156-4
28 https://doi.org/10.1016/j.clineuro.2012.01.030
29 https://doi.org/10.1016/j.ejrad.2006.03.001
30 https://doi.org/10.1016/s0360-3016(03)00293-1
31 https://doi.org/10.1055/s-2004-818519
32 https://doi.org/10.1056/nejmoa043330
33 https://doi.org/10.1080/02688690120082396
34 https://doi.org/10.1080/02688690410001732823
35 https://doi.org/10.1093/neuonc/noq055
36 https://doi.org/10.1097/00004728-200401000-00018
37 https://doi.org/10.1097/01.rct.0000148453.29579.51
38 https://doi.org/10.1136/jnnp.2005.072223
39 https://doi.org/10.1148/radiology.198.3.8628879
40 https://doi.org/10.1158/1078-0432.ccr-12-0084
41 https://doi.org/10.1159/000163057
42 https://doi.org/10.1177/088307389501000111
43 https://doi.org/10.1212/01.wnl.0000129985.39973.e4
44 https://doi.org/10.1212/01.wnl.0000130249.41341.58
45 https://doi.org/10.1212/01.wnl.0000299896.65604.ae
46 https://doi.org/10.1212/wnl.0b013e3181b163e2
47 https://doi.org/10.1212/wnl.60.1.151
48 https://doi.org/10.1227/01.neu.0000073527.20655.e6
49 https://doi.org/10.2214/ajr.06.0055
50 https://doi.org/10.2214/ajr.161.4.8372774
51 https://doi.org/10.3171/jns.2003.98.2.0269
52 https://doi.org/10.3171/jns.2005.102.1.0072
53 https://doi.org/10.3171/ped.2005.102.1.0072
54 https://doi.org/10.3892/ol.2011.445
55 schema:datePublished 2014-02
56 schema:datePublishedReg 2014-02-01
57 schema:description OPINION STATEMENT: Gliomatosis cerebri (GC) is an intriguing disease for several reasons. First, it is difficult to draw the border between GC and diffuse gliomas. In this regard, GC could represent the most invasive form of diffuse gliomas. Second, both in terms of histologic grading and clinical course, GC is a heterogeneous disease, ranging from rapidly evolving to slowly and somewhat indolent forms. Because of the extensive spread of the disease, surgery-outside a biopsy for diagnosis-is rarely indicated in gliomatosis cerebri. Therapeutic options include radiotherapy, generally involving the whole brain, and chemotherapy with temozolomide or nitrosoureas. Because of the rarity of the disease, no trial comparing these two modalities has been undertaken so far. Decision is, therefore, based on small retrospective noncomparative studies and expert opinions. On one hand, there is a rationale to postpone the whole brain radiotherapy because of late neurotoxicity, but on the other hand, there is also the risk that an aggressive disease evolves to intracranial hypertension making the radiotherapy hazardous or even impossible. As a consequence, the patient would lose the opportunity to receive a potentially effective treatment. In this decision, the evaluation of histologic data together with clinical and radiologic features, performance status, and molecular profile may be of help. Because radiotherapy usually involves large volumes of the brain, chemotherapy is generally preferred up front in patients with a slowly evolving disease. Conversely, in patients with rapidly (ie, over few weeks) evolving disease with neurologic deficits or when histologic features of glioblastoma are evident, whole brain radiotherapy (45 Gy with 1.8 Gy fractions), alone or associated with concomitant temozolomide, is often preferred. The value of advanced of magnetic resonance imaging and positron emission tomography techniques to predict outcome and monitoring the treatment still remains to be defined.
58 schema:genre research_article
59 schema:inLanguage en
60 schema:isAccessibleForFree false
61 schema:isPartOf N4385582aa70c4935a35bca73d56b865e
62 N82fba92325f04d47867ba63911af7c0b
63 sg:journal.1119514
64 schema:name Gliomatosis Cerebri: A Review
65 schema:pagination 273
66 schema:productId N1cc2bc8b135443b7badb85ba0c8ff330
67 N47156cfd0f2d4167a12d8442d6c1e4cf
68 N5eefd6508cbe4eceb8c4c0d03ee572b2
69 N91cd790aa558435988621a5e5bd8697e
70 Nc1a0ffb40c354343bf0dc6b07943dcd4
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027681061
72 https://doi.org/10.1007/s11940-013-0273-2
73 schema:sdDatePublished 2019-04-10T14:12
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher N390135cbb94d45ad9581f349b33b15af
76 schema:url http://link.springer.com/10.1007%2Fs11940-013-0273-2
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N0227d8a8272c4e01acbc4acf10f559f7 rdf:first sg:person.01141770554.98
81 rdf:rest N97f11f1e06da4c69854d80741f71e479
82 N1a5024cc89f74ff8a85cc46321b217d6 schema:name Division of Neuro-Oncology, Department of Neuroscience, University and AO Città della Salute e della Scienza di Torino, Via Cherasco 15, 10126, Turin, Italy
83 rdf:type schema:Organization
84 N1cc2bc8b135443b7badb85ba0c8ff330 schema:name nlm_unique_id
85 schema:value 9815940
86 rdf:type schema:PropertyValue
87 N390135cbb94d45ad9581f349b33b15af schema:name Springer Nature - SN SciGraph project
88 rdf:type schema:Organization
89 N4385582aa70c4935a35bca73d56b865e schema:volumeNumber 16
90 rdf:type schema:PublicationVolume
91 N47156cfd0f2d4167a12d8442d6c1e4cf schema:name dimensions_id
92 schema:value pub.1027681061
93 rdf:type schema:PropertyValue
94 N5d0bb9eec1b442d7b288eb578a81f837 schema:affiliation N620f0bb231c54020825e7b544e633831
95 schema:familyName Sanson
96 schema:givenName Marc
97 rdf:type schema:Person
98 N5d276d3e0c114509819e772d45db2248 rdf:first sg:person.0723227673.64
99 rdf:rest N0227d8a8272c4e01acbc4acf10f559f7
100 N5eefd6508cbe4eceb8c4c0d03ee572b2 schema:name doi
101 schema:value 10.1007/s11940-013-0273-2
102 rdf:type schema:PropertyValue
103 N620f0bb231c54020825e7b544e633831 schema:name Service de Neurologie 2, Groupe Hospitalier Pitié-Salpêtrière, Université Pierre et Marie Curie, 47-83 Bd de l’Hôpital, Paris, France
104 rdf:type schema:Organization
105 N82fba92325f04d47867ba63911af7c0b schema:issueNumber 2
106 rdf:type schema:PublicationIssue
107 N91cd790aa558435988621a5e5bd8697e schema:name pubmed_id
108 schema:value 24390814
109 rdf:type schema:PropertyValue
110 N97f11f1e06da4c69854d80741f71e479 rdf:first N5d0bb9eec1b442d7b288eb578a81f837
111 rdf:rest rdf:nil
112 Nbfec44f05bc846f6ad6a751e7a279233 schema:name Division of Neuro-Oncology, Department of Neuroscience, University and AO Città della Salute e della Scienza di Torino, Via Cherasco 15, 10126, Turin, Italy
113 rdf:type schema:Organization
114 Nc1a0ffb40c354343bf0dc6b07943dcd4 schema:name readcube_id
115 schema:value 83de18a6068343f0ace6ffd5509789fc33e0ef77c8cfa9e2506941d7ff688040
116 rdf:type schema:PropertyValue
117 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
118 schema:name Medical and Health Sciences
119 rdf:type schema:DefinedTerm
120 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
121 schema:name Oncology and Carcinogenesis
122 rdf:type schema:DefinedTerm
123 sg:journal.1119514 schema:issn 1092-8480
124 1534-3138
125 schema:name Current Treatment Options in Neurology
126 rdf:type schema:Periodical
127 sg:person.01141770554.98 schema:affiliation Nbfec44f05bc846f6ad6a751e7a279233
128 schema:familyName Bertero
129 schema:givenName Luca
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141770554.98
131 rdf:type schema:Person
132 sg:person.0723227673.64 schema:affiliation N1a5024cc89f74ff8a85cc46321b217d6
133 schema:familyName Rudà
134 schema:givenName Roberta
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723227673.64
136 rdf:type schema:Person
137 sg:pub.10.1007/s00234-003-1057-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044690040
138 https://doi.org/10.1007/s00234-003-1057-2
139 rdf:type schema:CreativeWork
140 sg:pub.10.1007/s002340000343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019168919
141 https://doi.org/10.1007/s002340000343
142 rdf:type schema:CreativeWork
143 sg:pub.10.1007/s002340050345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001684800
144 https://doi.org/10.1007/s002340050345
145 rdf:type schema:CreativeWork
146 sg:pub.10.1007/s002340050551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040854028
147 https://doi.org/10.1007/s002340050551
148 rdf:type schema:CreativeWork
149 sg:pub.10.1007/s00381-012-2016-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001123384
150 https://doi.org/10.1007/s00381-012-2016-1
151 rdf:type schema:CreativeWork
152 sg:pub.10.1007/s007010050176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026430068
153 https://doi.org/10.1007/s007010050176
154 rdf:type schema:CreativeWork
155 sg:pub.10.1007/s11060-005-5263-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009559987
156 https://doi.org/10.1007/s11060-005-5263-0
157 rdf:type schema:CreativeWork
158 sg:pub.10.1007/s11060-011-0587-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040924422
159 https://doi.org/10.1007/s11060-011-0587-4
160 rdf:type schema:CreativeWork
161 sg:pub.10.1007/s11060-013-1058-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026318147
162 https://doi.org/10.1007/s11060-013-1058-x
163 rdf:type schema:CreativeWork
164 sg:pub.10.1023/a:1019934901750 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025543372
165 https://doi.org/10.1023/a:1019934901750
166 rdf:type schema:CreativeWork
167 sg:pub.10.1186/1471-2407-10-424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000697011
168 https://doi.org/10.1186/1471-2407-10-424
169 rdf:type schema:CreativeWork
170 https://app.dimensions.ai/details/publication/pub.1074597725 schema:CreativeWork
171 https://app.dimensions.ai/details/publication/pub.1075016509 schema:CreativeWork
172 https://app.dimensions.ai/details/publication/pub.1075286467 schema:CreativeWork
173 https://app.dimensions.ai/details/publication/pub.1077286103 schema:CreativeWork
174 https://app.dimensions.ai/details/publication/pub.1077451035 schema:CreativeWork
175 https://app.dimensions.ai/details/publication/pub.1080102911 schema:CreativeWork
176 https://app.dimensions.ai/details/publication/pub.1082552651 schema:CreativeWork
177 https://doi.org/10.1002/(sici)1097-0142(19961015)78:8<1789::aid-cncr20>3.0.co;2-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1008598777
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1002/ana.10297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005962469
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1002/ana.22478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028914419
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1002/cncr.10909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042055030
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1002/mds.10665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002676277
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/0090-3019(91)90156-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033260268
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/j.clineuro.2012.01.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010277223
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/j.ejrad.2006.03.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027802157
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/s0360-3016(03)00293-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032150611
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1055/s-2004-818519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057430930
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1056/nejmoa043330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052112015
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1080/02688690120082396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013734489
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1080/02688690410001732823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017312508
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1093/neuonc/noq055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026194040
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1097/00004728-200401000-00018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031201611
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1097/01.rct.0000148453.29579.51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000083228
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1136/jnnp.2005.072223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042823555
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1148/radiology.198.3.8628879 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082885177
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1158/1078-0432.ccr-12-0084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023787699
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1159/000163057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011690783
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1177/088307389501000111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063856220
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1212/01.wnl.0000129985.39973.e4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064346089
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1212/01.wnl.0000130249.41341.58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064346112
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1212/01.wnl.0000299896.65604.ae schema:sameAs https://app.dimensions.ai/details/publication/pub.1064349977
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1212/wnl.0b013e3181b163e2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064354529
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1212/wnl.60.1.151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064381427
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1227/01.neu.0000073527.20655.e6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040534657
230 rdf:type schema:CreativeWork
231 https://doi.org/10.2214/ajr.06.0055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069298030
232 rdf:type schema:CreativeWork
233 https://doi.org/10.2214/ajr.161.4.8372774 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069318181
234 rdf:type schema:CreativeWork
235 https://doi.org/10.3171/jns.2003.98.2.0269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071100645
236 rdf:type schema:CreativeWork
237 https://doi.org/10.3171/jns.2005.102.1.0072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071101388
238 rdf:type schema:CreativeWork
239 https://doi.org/10.3171/ped.2005.102.1.0072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071102510
240 rdf:type schema:CreativeWork
241 https://doi.org/10.3892/ol.2011.445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071525374
242 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...