Management of refractory ulcerative colitis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-06

AUTHORS

Sunana Sohi, Russell D. Cohen

ABSTRACT

A physician's approach to patients with ulcerative colitis (UC) who are refractory to standard first-line therapies must be thoughtful and systematic and include the individual's physical and emotional state as the physician examines the various dietary, medical, and surgical options currently available. It is of foremost importance to confirm that the refractory patient's symptoms are not simply due to dietary indiscretion, concomitant bowel infection (especially with Clostridium difficile), an incorrect diagnosis (eg, colitis due to infection, NSAIDs, ischemia, diverticulitis, or Crohn's disease), or even a concomitant diagnosis (eg, celiac sprue, pancreatic insufficiency, functional bowel disorder, laxative or sorbitol intake). The ability to quickly assess the status of the colonic mucosa with flexible sigmoidoscopy aids in the ability to distinguish patients with refractory inflammation from those with other diagnoses. The initiation and optimization of the long-term purine analogues azathioprine (AZA) or 6-mercaptopurine (6-MP) remain the backbone of medical therapy for patients with refractory UC. For those unresponsive to corticosteroids, quicker induction of remission may necessitate infliximab, cyclosporine, or tacrolimus. Successful induction and maintenance with AZA, 6-MP, and/or infliximab should be followed by long-term therapy with these agents. Cessation of therapy often leads to relapse. Novel therapies under investigation hold the promise of offering more options for both the induction and maintenance of remission in refractory UC patients. Discussions of surgical intervention should not be put off as a last resort but rather included in the overall treatment plan offered to the patient. More... »

PAGES

234-245

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11938-006-0042-3

DOI

http://dx.doi.org/10.1007/s11938-006-0042-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010599564

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16901387


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "familyName": "Sohi", 
        "givenName": "Sunana", 
        "id": "sg:person.0606065602.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606065602.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Chicago Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412578.d", 
          "name": [
            "Department of Medicine, Section of Gastroenterology, University of Chicago Medical Center, MC 4076, 5841 South Maryland Avenue, 60637, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cohen", 
        "givenName": "Russell D.", 
        "id": "sg:person.01032256365.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032256365.21"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s1542-3565(05)00738-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000261382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00054725-200209000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000604015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00054725-200209000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000604015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00054725-200209000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000604015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(03)00171-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001441522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(03)00171-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001441522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1526-0968.2002.00441.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002559350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(03)00938-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002740336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(03)00938-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002740336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2036.2002.01205.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003109594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2036.2003.01581.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004026367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.2000.02010.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008119904", 
          "https://doi.org/10.1111/j.1572-0241.2000.02010.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.2000.9370", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008880639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198303000-00018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009324308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198303000-00018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009324308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2036.2005.02331.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010620014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mib.0000161308.65951.db", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011835049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mib.0000161308.65951.db", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011835049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mib.0000161308.65951.db", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011835049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.2003.50145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014185986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00054725-200405000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014466668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00054725-200405000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014466668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1542-3565(05)00208-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016545698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00042737-200510000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016620738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00042737-200510000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016620738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00042737-200510000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016620738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2036.2003.01662.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019280277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa051586", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019383829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa051586", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019383829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2005.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019675172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.52.7.998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019963189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.52.12.1728", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020177832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00054725-200105000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020342571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00054725-200105000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020342571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00054725-200105000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020342571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.2000.03287.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022334688", 
          "https://doi.org/10.1111/j.1572-0241.2000.03287.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s003840100346", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028126881", 
          "https://doi.org/10.1007/s003840100346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa042982", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028366810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa042982", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028366810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2362.2003.01130.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028810209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2036.2005.02552.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029454505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004836-200309000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029831138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004836-200309000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029831138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2036.2002.01264.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030397540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00054725-200203000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032873275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00054725-200203000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032873275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004836-200208000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033473118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004836-200208000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033473118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa013136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034443746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2036.2003.01639.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035483606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejme030075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035631870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00054725-200105000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037341581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00054725-200105000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037341581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.2003.50014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037505231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.2003.50014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037505231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(03)80033-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039600820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.2003.07239.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041536291", 
          "https://doi.org/10.1111/j.1572-0241.2003.07239.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00054725-200108000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042108268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00054725-200108000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042108268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa050516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042784686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(03)82636-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044000348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/jcgh.2003.50005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044157252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/jcgh.2003.50005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044157252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2168.1998.00689.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044784841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00042737-200501000-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045033227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00042737-200501000-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045033227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa020888", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045069711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.1800810536", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045566132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0399-8320(05)80754-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045837760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.50.4.485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048508869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000082121.84763.4c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050814170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000082121.84763.4c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050814170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci10182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053189999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004836-199707000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060191324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004836-199707000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060191324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004836-199707000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060191324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v11.i44.7001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071363945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076814864", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1385/1-59259-311-9:157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1088541334", 
          "https://doi.org/10.1385/1-59259-311-9:157"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-06", 
    "datePublishedReg": "2006-06-01", 
    "description": "A physician's approach to patients with ulcerative colitis (UC) who are refractory to standard first-line therapies must be thoughtful and systematic and include the individual's physical and emotional state as the physician examines the various dietary, medical, and surgical options currently available. It is of foremost importance to confirm that the refractory patient's symptoms are not simply due to dietary indiscretion, concomitant bowel infection (especially with Clostridium difficile), an incorrect diagnosis (eg, colitis due to infection, NSAIDs, ischemia, diverticulitis, or Crohn's disease), or even a concomitant diagnosis (eg, celiac sprue, pancreatic insufficiency, functional bowel disorder, laxative or sorbitol intake). The ability to quickly assess the status of the colonic mucosa with flexible sigmoidoscopy aids in the ability to distinguish patients with refractory inflammation from those with other diagnoses. The initiation and optimization of the long-term purine analogues azathioprine (AZA) or 6-mercaptopurine (6-MP) remain the backbone of medical therapy for patients with refractory UC. For those unresponsive to corticosteroids, quicker induction of remission may necessitate infliximab, cyclosporine, or tacrolimus. Successful induction and maintenance with AZA, 6-MP, and/or infliximab should be followed by long-term therapy with these agents. Cessation of therapy often leads to relapse. Novel therapies under investigation hold the promise of offering more options for both the induction and maintenance of remission in refractory UC patients. Discussions of surgical intervention should not be put off as a last resort but rather included in the overall treatment plan offered to the patient.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11938-006-0042-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1119515", 
        "issn": [
          "1092-8472", 
          "1534-309X"
        ], 
        "name": "Current Treatment Options in Gastroenterology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Management of refractory ulcerative colitis", 
    "pagination": "234-245", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "327f29ea220158d63b72f62b3d23f47f3415ef968b8008cdfe5ee302dd8803b6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16901387"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9815941"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11938-006-0042-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1010599564"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11938-006-0042-3", 
      "https://app.dimensions.ai/details/publication/pub.1010599564"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:26", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000520.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11938-006-0042-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11938-006-0042-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11938-006-0042-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11938-006-0042-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11938-006-0042-3'


 

This table displays all metadata directly associated to this object as RDF triples.

241 TRIPLES      21 PREDICATES      83 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11938-006-0042-3 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author Nfc1739ed389741e3adf455e89080c5b6
4 schema:citation sg:pub.10.1007/s003840100346
5 sg:pub.10.1111/j.1572-0241.2000.02010.x
6 sg:pub.10.1111/j.1572-0241.2000.03287.x
7 sg:pub.10.1111/j.1572-0241.2003.07239.x
8 sg:pub.10.1385/1-59259-311-9:157
9 https://app.dimensions.ai/details/publication/pub.1076814864
10 https://doi.org/10.1002/bjs.1800810536
11 https://doi.org/10.1016/s0016-5085(03)00171-9
12 https://doi.org/10.1016/s0016-5085(03)00938-7
13 https://doi.org/10.1016/s0016-5085(03)80033-1
14 https://doi.org/10.1016/s0016-5085(03)82636-7
15 https://doi.org/10.1016/s0399-8320(05)80754-7
16 https://doi.org/10.1016/s1542-3565(05)00208-9
17 https://doi.org/10.1016/s1542-3565(05)00738-x
18 https://doi.org/10.1046/j.1365-2036.2002.01205.x
19 https://doi.org/10.1046/j.1365-2036.2002.01264.x
20 https://doi.org/10.1046/j.1365-2036.2003.01581.x
21 https://doi.org/10.1046/j.1365-2036.2003.01639.x
22 https://doi.org/10.1046/j.1365-2036.2003.01662.x
23 https://doi.org/10.1046/j.1365-2168.1998.00689.x
24 https://doi.org/10.1046/j.1365-2362.2003.01130.x
25 https://doi.org/10.1046/j.1526-0968.2002.00441.x
26 https://doi.org/10.1053/gast.2000.9370
27 https://doi.org/10.1053/gast.2003.50014
28 https://doi.org/10.1053/gast.2003.50145
29 https://doi.org/10.1053/j.gastro.2005.01.005
30 https://doi.org/10.1053/jcgh.2003.50005
31 https://doi.org/10.1056/nejme030075
32 https://doi.org/10.1056/nejmoa013136
33 https://doi.org/10.1056/nejmoa020888
34 https://doi.org/10.1056/nejmoa042982
35 https://doi.org/10.1056/nejmoa050516
36 https://doi.org/10.1056/nejmoa051586
37 https://doi.org/10.1097/00000658-198303000-00018
38 https://doi.org/10.1097/00004836-199707000-00007
39 https://doi.org/10.1097/00004836-200208000-00007
40 https://doi.org/10.1097/00004836-200309000-00006
41 https://doi.org/10.1097/00042737-200501000-00016
42 https://doi.org/10.1097/00042737-200510000-00007
43 https://doi.org/10.1097/00054725-200105000-00001
44 https://doi.org/10.1097/00054725-200105000-00002
45 https://doi.org/10.1097/00054725-200108000-00001
46 https://doi.org/10.1097/00054725-200203000-00004
47 https://doi.org/10.1097/00054725-200209000-00002
48 https://doi.org/10.1097/00054725-200405000-00012
49 https://doi.org/10.1097/01.mib.0000161308.65951.db
50 https://doi.org/10.1097/01.sla.0000082121.84763.4c
51 https://doi.org/10.1111/j.1365-2036.2005.02331.x
52 https://doi.org/10.1111/j.1365-2036.2005.02552.x
53 https://doi.org/10.1136/gut.50.4.485
54 https://doi.org/10.1136/gut.52.12.1728
55 https://doi.org/10.1136/gut.52.7.998
56 https://doi.org/10.1172/jci10182
57 https://doi.org/10.3748/wjg.v11.i44.7001
58 schema:datePublished 2006-06
59 schema:datePublishedReg 2006-06-01
60 schema:description A physician's approach to patients with ulcerative colitis (UC) who are refractory to standard first-line therapies must be thoughtful and systematic and include the individual's physical and emotional state as the physician examines the various dietary, medical, and surgical options currently available. It is of foremost importance to confirm that the refractory patient's symptoms are not simply due to dietary indiscretion, concomitant bowel infection (especially with Clostridium difficile), an incorrect diagnosis (eg, colitis due to infection, NSAIDs, ischemia, diverticulitis, or Crohn's disease), or even a concomitant diagnosis (eg, celiac sprue, pancreatic insufficiency, functional bowel disorder, laxative or sorbitol intake). The ability to quickly assess the status of the colonic mucosa with flexible sigmoidoscopy aids in the ability to distinguish patients with refractory inflammation from those with other diagnoses. The initiation and optimization of the long-term purine analogues azathioprine (AZA) or 6-mercaptopurine (6-MP) remain the backbone of medical therapy for patients with refractory UC. For those unresponsive to corticosteroids, quicker induction of remission may necessitate infliximab, cyclosporine, or tacrolimus. Successful induction and maintenance with AZA, 6-MP, and/or infliximab should be followed by long-term therapy with these agents. Cessation of therapy often leads to relapse. Novel therapies under investigation hold the promise of offering more options for both the induction and maintenance of remission in refractory UC patients. Discussions of surgical intervention should not be put off as a last resort but rather included in the overall treatment plan offered to the patient.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree false
64 schema:isPartOf N5783c63730b1421d8a298ea852283845
65 N8d107a60488d4a908c38ea9159ec9ad2
66 sg:journal.1119515
67 schema:name Management of refractory ulcerative colitis
68 schema:pagination 234-245
69 schema:productId N34beb188193f428db4defe5de293d99e
70 N5167e68108424db3b96376a5d5034e40
71 N53e37aa9a847487a98b7b5064879c017
72 N74919d0fb6914e82a3030db610abce74
73 N9841725017494e49a1109d4c55ddc1ef
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010599564
75 https://doi.org/10.1007/s11938-006-0042-3
76 schema:sdDatePublished 2019-04-10T23:26
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher N6ddd056b3c2e49afa28d3b83c6fa1993
79 schema:url http://link.springer.com/10.1007%2Fs11938-006-0042-3
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N2df505b41a43426795e32ba2941033fa rdf:first sg:person.01032256365.21
84 rdf:rest rdf:nil
85 N34beb188193f428db4defe5de293d99e schema:name nlm_unique_id
86 schema:value 9815941
87 rdf:type schema:PropertyValue
88 N5167e68108424db3b96376a5d5034e40 schema:name doi
89 schema:value 10.1007/s11938-006-0042-3
90 rdf:type schema:PropertyValue
91 N53e37aa9a847487a98b7b5064879c017 schema:name readcube_id
92 schema:value 327f29ea220158d63b72f62b3d23f47f3415ef968b8008cdfe5ee302dd8803b6
93 rdf:type schema:PropertyValue
94 N5783c63730b1421d8a298ea852283845 schema:volumeNumber 9
95 rdf:type schema:PublicationVolume
96 N6ddd056b3c2e49afa28d3b83c6fa1993 schema:name Springer Nature - SN SciGraph project
97 rdf:type schema:Organization
98 N74919d0fb6914e82a3030db610abce74 schema:name dimensions_id
99 schema:value pub.1010599564
100 rdf:type schema:PropertyValue
101 N8d107a60488d4a908c38ea9159ec9ad2 schema:issueNumber 3
102 rdf:type schema:PublicationIssue
103 N9841725017494e49a1109d4c55ddc1ef schema:name pubmed_id
104 schema:value 16901387
105 rdf:type schema:PropertyValue
106 Nfc1739ed389741e3adf455e89080c5b6 rdf:first sg:person.0606065602.35
107 rdf:rest N2df505b41a43426795e32ba2941033fa
108 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
109 schema:name Medical and Health Sciences
110 rdf:type schema:DefinedTerm
111 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
112 schema:name Clinical Sciences
113 rdf:type schema:DefinedTerm
114 sg:journal.1119515 schema:issn 1092-8472
115 1534-309X
116 schema:name Current Treatment Options in Gastroenterology
117 rdf:type schema:Periodical
118 sg:person.01032256365.21 schema:affiliation https://www.grid.ac/institutes/grid.412578.d
119 schema:familyName Cohen
120 schema:givenName Russell D.
121 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032256365.21
122 rdf:type schema:Person
123 sg:person.0606065602.35 schema:familyName Sohi
124 schema:givenName Sunana
125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606065602.35
126 rdf:type schema:Person
127 sg:pub.10.1007/s003840100346 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028126881
128 https://doi.org/10.1007/s003840100346
129 rdf:type schema:CreativeWork
130 sg:pub.10.1111/j.1572-0241.2000.02010.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008119904
131 https://doi.org/10.1111/j.1572-0241.2000.02010.x
132 rdf:type schema:CreativeWork
133 sg:pub.10.1111/j.1572-0241.2000.03287.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022334688
134 https://doi.org/10.1111/j.1572-0241.2000.03287.x
135 rdf:type schema:CreativeWork
136 sg:pub.10.1111/j.1572-0241.2003.07239.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041536291
137 https://doi.org/10.1111/j.1572-0241.2003.07239.x
138 rdf:type schema:CreativeWork
139 sg:pub.10.1385/1-59259-311-9:157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1088541334
140 https://doi.org/10.1385/1-59259-311-9:157
141 rdf:type schema:CreativeWork
142 https://app.dimensions.ai/details/publication/pub.1076814864 schema:CreativeWork
143 https://doi.org/10.1002/bjs.1800810536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045566132
144 rdf:type schema:CreativeWork
145 https://doi.org/10.1016/s0016-5085(03)00171-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001441522
146 rdf:type schema:CreativeWork
147 https://doi.org/10.1016/s0016-5085(03)00938-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002740336
148 rdf:type schema:CreativeWork
149 https://doi.org/10.1016/s0016-5085(03)80033-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039600820
150 rdf:type schema:CreativeWork
151 https://doi.org/10.1016/s0016-5085(03)82636-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044000348
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1016/s0399-8320(05)80754-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045837760
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1016/s1542-3565(05)00208-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016545698
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1016/s1542-3565(05)00738-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000261382
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1046/j.1365-2036.2002.01205.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003109594
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1046/j.1365-2036.2002.01264.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030397540
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1046/j.1365-2036.2003.01581.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004026367
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1046/j.1365-2036.2003.01639.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035483606
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1046/j.1365-2036.2003.01662.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019280277
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1046/j.1365-2168.1998.00689.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044784841
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1046/j.1365-2362.2003.01130.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028810209
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1046/j.1526-0968.2002.00441.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002559350
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1053/gast.2000.9370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008880639
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1053/gast.2003.50014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037505231
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1053/gast.2003.50145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014185986
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1053/j.gastro.2005.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019675172
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1053/jcgh.2003.50005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044157252
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1056/nejme030075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035631870
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1056/nejmoa013136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034443746
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1056/nejmoa020888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045069711
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1056/nejmoa042982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028366810
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1056/nejmoa050516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042784686
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1056/nejmoa051586 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019383829
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1097/00000658-198303000-00018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009324308
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1097/00004836-199707000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060191324
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1097/00004836-200208000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033473118
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1097/00004836-200309000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029831138
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1097/00042737-200501000-00016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045033227
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1097/00042737-200510000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016620738
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1097/00054725-200105000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037341581
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1097/00054725-200105000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020342571
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1097/00054725-200108000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042108268
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1097/00054725-200203000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032873275
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1097/00054725-200209000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000604015
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1097/00054725-200405000-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014466668
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1097/01.mib.0000161308.65951.db schema:sameAs https://app.dimensions.ai/details/publication/pub.1011835049
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1097/01.sla.0000082121.84763.4c schema:sameAs https://app.dimensions.ai/details/publication/pub.1050814170
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1111/j.1365-2036.2005.02331.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010620014
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1111/j.1365-2036.2005.02552.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029454505
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1136/gut.50.4.485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048508869
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1136/gut.52.12.1728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020177832
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1136/gut.52.7.998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019963189
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1172/jci10182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053189999
236 rdf:type schema:CreativeWork
237 https://doi.org/10.3748/wjg.v11.i44.7001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071363945
238 rdf:type schema:CreativeWork
239 https://www.grid.ac/institutes/grid.412578.d schema:alternateName University of Chicago Medical Center
240 schema:name Department of Medicine, Section of Gastroenterology, University of Chicago Medical Center, MC 4076, 5841 South Maryland Avenue, 60637, Chicago, IL, USA
241 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...