A Critical Insight into the Clinical Translation of PD-1/PD-L1 Blockade Therapy in Clear Cell Renal Cell Carcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-01

AUTHORS

Caroline E. Nunes-Xavier, Javier C. Angulo, Rafael Pulido, José I. López

ABSTRACT

PURPOSE OF REVIEW: Targeting PD-1/PD-L1 immune checkpoints is a new therapeutic tool in patients with locally advanced and metastatic clear cell renal cell carcinoma (CCRCC). The purpose of this review is to offer clinicians an updated translational insight into the current status of a therapeutic alternative that may impact significantly patient's life. RECENT FINDINGS: Immune checkpoint inhibition has recently demonstrated promising results in selected CCRCC patients with respect to tumor progression and survival. The decision to treat these patients with immune checkpoint inhibitors (ICI) relies on the immunohistochemical detection of PD-1/PD-L1 positivity in inflammatory cells in the tumor, which makes the role of the pathologist crucial, but clinical concern upon the reliability to use immunohistochemistry (IHC) to predict therapeutic response is increasing. We review the state of the art of the immune checkpoint inhibition in CCRCC, from the basic science and its fundamentals to the daily application in clinical routine. More... »

PAGES

1

References to SciGraph publications

  • 2001-03. PD-L2 is a second ligand for PD-1 and inhibits T cell activation in NATURE IMMUNOLOGY
  • 1999-12. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion in NATURE MEDICINE
  • 2005-04. Identification of a novel splice variant of human PD-L1 mRNA encoding an isoform-lacking Igv-like domain in ACTA PHARMACOLOGICA SINICA
  • 2017-10. PD-L1 immunohistochemistry in clinical diagnostics of lung cancer: inter-pathologist variability is higher than assay variability in MODERN PATHOLOGY
  • 2015-08. PD-L1 induces epithelial-to-mesenchymal transition via activating SREBP-1c in renal cell carcinoma in MEDICAL ONCOLOGY
  • 2017-03-09. Renal cell carcinoma in NATURE REVIEWS DISEASE PRIMERS
  • 2017-02. Systemic therapy in metastatic renal cell carcinoma in WORLD JOURNAL OF UROLOGY
  • 2018-05. Prognostic and clinicopathological significance of PD-L1 in patients with renal cell carcinoma: a meta-analysis based on 1863 individuals in CLINICAL AND EXPERIMENTAL MEDICINE
  • 2016-02. Clinicopathologic Analysis of PD-L1 and PD-L2 Expression in Renal Cell Carcinoma: Association with Oncogenic Proteins Status in ANNALS OF SURGICAL ONCOLOGY
  • 2017-03. Next generation predictive biomarkers for immune checkpoint inhibition in CANCER AND METASTASIS REVIEWS
  • 2016-04. Prognostic Role of PD-L1 Expression in Renal Cell Carcinoma. A Systematic Review and Meta-Analysis in TARGETED ONCOLOGY
  • 2018-12. The Correlation Between the Immune and Epithelial-Mesenchymal Transition Signatures Suggests Potential Therapeutic Targets and Prognosis Prediction Approaches in Kidney Cancer in SCIENTIFIC REPORTS
  • 2015-01. Large (>3.8 cm) clear cell renal cell carcinomas are morphologically and immunohistochemically heterogeneous in VIRCHOWS ARCHIV
  • 2016-12. Tumor cell-intrinsic PD-L1 promotes tumor-initiating cell generation and functions in melanoma and ovarian cancer in SIGNAL TRANSDUCTION AND TARGETED THERAPY
  • 2018-12. Prognostic significance of the programmed death ligand 1 expression in clear cell renal cell carcinoma and correlation with the tumor microenvironment and hypoxia-inducible factor expression in DIAGNOSTIC PATHOLOGY
  • 2016-07. Intratumoral expression of programmed death ligand 1 (PD-L1) in patients with clear cell renal cell carcinoma (ccRCC) in MEDICAL ONCOLOGY
  • 2018-12. The intracellular signalosome of PD-L1 in cancer cells in SIGNAL TRANSDUCTION AND TARGETED THERAPY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11934-019-0866-8

    DOI

    http://dx.doi.org/10.1007/s11934-019-0866-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111429842

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30645700


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Agents, Immunological", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "B7-H1 Antigen", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinoma, Renal Cell", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Kidney Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Targeted Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Programmed Cell Death 1 Receptor", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Oslo University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.55325.34", 
              "name": [
                "Biomarkers in Cancer Unit, Biocruces-Bizkaia Health Research Institute, Barakaldo, Bizkaia, Spain", 
                "Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nunes-Xavier", 
            "givenName": "Caroline E.", 
            "id": "sg:person.0645101465.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645101465.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "European University of Madrid", 
              "id": "https://www.grid.ac/institutes/grid.119375.8", 
              "name": [
                "Department of Urology, University Hospital of Getafe, Getafe, Madrid, Spain", 
                "Clinical Department, European University of Madrid, Laureate Universities, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Angulo", 
            "givenName": "Javier C.", 
            "id": "sg:person.0773436503.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773436503.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ikerbasque", 
              "id": "https://www.grid.ac/institutes/grid.424810.b", 
              "name": [
                "Biomarkers in Cancer Unit, Biocruces-Bizkaia Health Research Institute, Barakaldo, Bizkaia, Spain", 
                "IKERBASQUE, The Basque Foundation for Science, Bilbao, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pulido", 
            "givenName": "Rafael", 
            "id": "sg:person.0735250361.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735250361.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of the Basque Country", 
              "id": "https://www.grid.ac/institutes/grid.11480.3c", 
              "name": [
                "Biomarkers in Cancer Unit, Biocruces-Bizkaia Health Research Institute, Barakaldo, Bizkaia, Spain", 
                "Department of Pathology, Cruces University Hospital, Plaza de Cruces s/n, 48903, Barakaldo, Bizkaia, Spain", 
                "Department of Medical-Surgical Specialties, University of the Basque Country (UPV/EHU), Leioa, Bizkaia, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "L\u00f3pez", 
            "givenName": "Jos\u00e9 I.", 
            "id": "sg:person.013251056272.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013251056272.76"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1146/annurev.immunol.23.021704.115611", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000712023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1745-7254.2005.00086.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001394709", 
              "https://doi.org/10.1111/j.1745-7254.2005.00086.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-10-0250", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001945922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.30077", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002199726"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cellimm.2005.07.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002515810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sigtrans.2016.30", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004803463", 
              "https://doi.org/10.1038/sigtrans.2016.30"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/70932", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005008226", 
              "https://doi.org/10.1038/70932"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.26.021607.090331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005008646"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2004.07.083", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005055472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jso.10302", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006018615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(16)30406-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006797272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20131916", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007547643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12032-015-0655-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007960730", 
              "https://doi.org/10.1007/s12032-015-0655-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2326-6066.cir-13-0133", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009133817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-06-2599", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009135816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/abbs/36.4.284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009443143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/abbs/36.4.284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009443143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2014.59.0703", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009621823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00428-014-1673-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011389805", 
              "https://doi.org/10.1007/s00428-014-1673-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00428-014-1673-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011389805", 
              "https://doi.org/10.1007/s00428-014-1673-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.30429", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011779317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11523-015-0392-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012361695", 
              "https://doi.org/10.1007/s11523-015-0392-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdv615", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013858384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(16)00561-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017311610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.231486598", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017347730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(16)30408-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017906099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7150/jca.8167", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018758803"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1510665", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019970557"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/14728214.2016.1226798", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022203694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.173.2.945", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025128086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000089686", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025517040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000089686", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025517040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00345-016-1868-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026627857", 
              "https://doi.org/10.1007/s00345-016-1868-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00345-016-1868-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026627857", 
              "https://doi.org/10.1007/s00345-016-1868-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jamaoncol.2016.0775", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027950456"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-05-4303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028547319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/85330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028604363", 
              "https://doi.org/10.1038/85330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/85330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028604363", 
              "https://doi.org/10.1038/85330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.10303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031240207"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.clim.2005.01.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031240807"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1517/13543784.2013.822066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032357303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.vetimm.2009.10.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033168523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.13895", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033899414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scisignal.2002796", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036931577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pai.0b013e3181dddb20", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038994287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pai.0b013e3181dddb20", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038994287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pai.0b013e3181dddb20", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038994287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.semcdb.2016.08.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040891102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/00313020701570012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041913935"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/00313020701570012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041913935"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/emmm.201100128", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042193134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-15-0283", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042848118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/1744666x.2016.1214575", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042872761"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.prp.2013.01.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043190205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12032-016-0794-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044635757", 
              "https://doi.org/10.1007/s12032-016-0794-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12032-016-0794-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044635757", 
              "https://doi.org/10.1007/s12032-016-0794-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.00319-13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045091664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0378-1119(97)00260-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045756029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2326-6066.cir-16-0072", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046824335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.eururo.2015.11.029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049158062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.smim.2013.02.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050144499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.192.7.1027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050568666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10555-016-9652-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052190417", 
              "https://doi.org/10.1007/s10555-016-9652-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10555-016-9652-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052190417", 
              "https://doi.org/10.1007/s10555-016-9652-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-015-4903-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052780297", 
              "https://doi.org/10.1245/s10434-015-4903-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1063/1.2834500", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1057877409"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-16-0258", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063216144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra1601333", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074211544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.169.7.3581", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075128315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077310707", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2017.02.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083858868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.humpath.2017.02.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083870272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neo.2017.02.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084098106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neo.2017.02.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084098106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrdp.2017.9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084129661", 
              "https://doi.org/10.1038/nrdp.2017.9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/theoncologist.2016-0419", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084355313"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.critrevonc.2017.06.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085968123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2017.59", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090294601", 
              "https://doi.org/10.1038/modpathol.2017.59"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fimmu.2017.00961", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091144369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.euf.2017.10.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092293462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.euf.2017.10.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092293462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/cs20160894", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092420786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/cs20160894", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092420786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.clgc.2017.10.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092579772"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mou.0000000000000466", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092605977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mou.0000000000000466", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092605977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jtho.2017.11.112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092998959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jtho.2017.11.112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092998959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jtho.2017.11.112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092998959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jtho.2017.11.112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092998959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jtho.2017.11.112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092998959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3322/caac.21442", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100164642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.anndiagpath.2018.01.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100273953"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdy014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100407368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10238-018-0488-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100588041", 
              "https://doi.org/10.1007/s10238-018-0488-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2017.77.6385", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101034912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.k793", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101530919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1712126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101673751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.anndiagpath.2018.03.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101745060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2018.03.043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103228551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-018-25002-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103565914", 
              "https://doi.org/10.1038/s41598-018-25002-w"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jtho.2018.04.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103639702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jtho.2018.04.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103639702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jtho.2018.05.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104138195"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.prp.2018.06.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104532624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0000000000001105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104569985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0000000000001105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104569985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0000000000001105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104569985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1758835918777427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104577319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1758835918777427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104577319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1758835918777427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104577319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ctrv.2018.07.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105735588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fimmu.2018.01774", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105900690"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.humpath.2018.07.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105928116"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13000-018-0742-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106340463", 
              "https://doi.org/10.1186/s13000-018-0742-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.k3529", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106905187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.k3529", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106905187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.k3529", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106905187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20181617", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106947696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20181617", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106947696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20181617", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106947696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fonc.2018.00386", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107082744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41392-018-0022-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107189116", 
              "https://doi.org/10.1038/s41392-018-0022-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fonc.2018.00385", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107203660"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-01", 
        "datePublishedReg": "2019-01-01", 
        "description": "PURPOSE OF REVIEW: Targeting PD-1/PD-L1 immune checkpoints is a new therapeutic tool in patients with locally advanced and metastatic clear cell renal cell carcinoma (CCRCC). The purpose of this review is to offer clinicians an updated translational insight into the current status of a therapeutic alternative that may impact significantly patient's life.\nRECENT FINDINGS: Immune checkpoint inhibition has recently demonstrated promising results in selected CCRCC patients with respect to tumor progression and survival. The decision to treat these patients with immune checkpoint inhibitors (ICI) relies on the immunohistochemical detection of PD-1/PD-L1 positivity in inflammatory cells in the tumor, which makes the role of the pathologist crucial, but clinical concern upon the reliability to use immunohistochemistry (IHC) to predict therapeutic response is increasing. We review the state of the art of the immune checkpoint inhibition in CCRCC, from the basic science and its fundamentals to the daily application in clinical routine.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s11934-019-0866-8", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1022078", 
            "issn": [
              "1527-2737", 
              "1534-6285"
            ], 
            "name": "Current Urology Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "20"
          }
        ], 
        "name": "A Critical Insight into the Clinical Translation of PD-1/PD-L1 Blockade Therapy in Clear Cell Renal Cell Carcinoma", 
        "pagination": "1", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "0b48e9dab77f2cb83bab27898a53517412b64dec47200050b2820c0da4cc0ea0"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30645700"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100900943"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s11934-019-0866-8"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1111429842"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s11934-019-0866-8", 
          "https://app.dimensions.ai/details/publication/pub.1111429842"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T11:38", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000358_0000000358/records_127432_00000011.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs11934-019-0866-8"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11934-019-0866-8'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11934-019-0866-8'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11934-019-0866-8'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11934-019-0866-8'


     

    This table displays all metadata directly associated to this object as RDF triples.

    439 TRIPLES      21 PREDICATES      133 URIs      28 LITERALS      16 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s11934-019-0866-8 schema:about N1a7908e862ac4e9ba4582c8074e522a3
    2 N1ed6115c40e249408b61aee8b8b3f863
    3 N5a7dd0d346f54ee0a2836e0f2b5111db
    4 N80789b4d8e9c4257b5ffcb2414da7980
    5 N8b8d5e64d1264229917b6bfe88ad62e8
    6 Ndb0304cd0fde4407a6155c8a03453634
    7 Ne728c6b9f93141608fb7eda0c29fe225
    8 anzsrc-for:11
    9 anzsrc-for:1107
    10 schema:author N450a7fb216a54ccb9197961fd6cc65b5
    11 schema:citation sg:pub.10.1007/s00345-016-1868-5
    12 sg:pub.10.1007/s00428-014-1673-8
    13 sg:pub.10.1007/s10238-018-0488-3
    14 sg:pub.10.1007/s10555-016-9652-y
    15 sg:pub.10.1007/s11523-015-0392-7
    16 sg:pub.10.1007/s12032-015-0655-2
    17 sg:pub.10.1007/s12032-016-0794-0
    18 sg:pub.10.1038/70932
    19 sg:pub.10.1038/85330
    20 sg:pub.10.1038/modpathol.2017.59
    21 sg:pub.10.1038/nrdp.2017.9
    22 sg:pub.10.1038/s41392-018-0022-9
    23 sg:pub.10.1038/s41598-018-25002-w
    24 sg:pub.10.1038/sigtrans.2016.30
    25 sg:pub.10.1111/j.1745-7254.2005.00086.x
    26 sg:pub.10.1186/s13000-018-0742-8
    27 sg:pub.10.1245/s10434-015-4903-7
    28 https://app.dimensions.ai/details/publication/pub.1077310707
    29 https://doi.org/10.1001/jamaoncol.2016.0775
    30 https://doi.org/10.1002/emmm.201100128
    31 https://doi.org/10.1002/ijc.10303
    32 https://doi.org/10.1002/ijc.30077
    33 https://doi.org/10.1002/ijc.30429
    34 https://doi.org/10.1002/jso.10302
    35 https://doi.org/10.1016/j.anndiagpath.2018.01.001
    36 https://doi.org/10.1016/j.anndiagpath.2018.03.007
    37 https://doi.org/10.1016/j.cell.2018.03.043
    38 https://doi.org/10.1016/j.cellimm.2005.07.007
    39 https://doi.org/10.1016/j.clgc.2017.10.017
    40 https://doi.org/10.1016/j.clim.2005.01.005
    41 https://doi.org/10.1016/j.critrevonc.2017.06.001
    42 https://doi.org/10.1016/j.ctrv.2018.07.009
    43 https://doi.org/10.1016/j.euf.2017.10.001
    44 https://doi.org/10.1016/j.eururo.2015.11.029
    45 https://doi.org/10.1016/j.febslet.2004.07.083
    46 https://doi.org/10.1016/j.humpath.2017.02.010
    47 https://doi.org/10.1016/j.humpath.2018.07.024
    48 https://doi.org/10.1016/j.immuni.2017.02.001
    49 https://doi.org/10.1016/j.jtho.2017.11.112
    50 https://doi.org/10.1016/j.jtho.2018.04.017
    51 https://doi.org/10.1016/j.jtho.2018.05.013
    52 https://doi.org/10.1016/j.neo.2017.02.006
    53 https://doi.org/10.1016/j.prp.2013.01.007
    54 https://doi.org/10.1016/j.prp.2018.06.003
    55 https://doi.org/10.1016/j.semcdb.2016.08.025
    56 https://doi.org/10.1016/j.smim.2013.02.002
    57 https://doi.org/10.1016/j.vetimm.2009.10.006
    58 https://doi.org/10.1016/s0140-6736(16)00561-4
    59 https://doi.org/10.1016/s0378-1119(97)00260-6
    60 https://doi.org/10.1016/s1470-2045(16)30406-5
    61 https://doi.org/10.1016/s1470-2045(16)30408-9
    62 https://doi.org/10.1042/cs20160894
    63 https://doi.org/10.1056/nejmoa1510665
    64 https://doi.org/10.1056/nejmoa1712126
    65 https://doi.org/10.1056/nejmra1601333
    66 https://doi.org/10.1063/1.2834500
    67 https://doi.org/10.1073/pnas.231486598
    68 https://doi.org/10.1080/00313020701570012
    69 https://doi.org/10.1080/14728214.2016.1226798
    70 https://doi.org/10.1080/1744666x.2016.1214575
    71 https://doi.org/10.1084/jem.192.7.1027
    72 https://doi.org/10.1084/jem.20131916
    73 https://doi.org/10.1084/jem.20181617
    74 https://doi.org/10.1093/abbs/36.4.284
    75 https://doi.org/10.1093/annonc/mdv615
    76 https://doi.org/10.1093/annonc/mdy014
    77 https://doi.org/10.1097/mou.0000000000000466
    78 https://doi.org/10.1097/pai.0b013e3181dddb20
    79 https://doi.org/10.1097/pas.0000000000001105
    80 https://doi.org/10.1126/scisignal.2002796
    81 https://doi.org/10.1128/mcb.00319-13
    82 https://doi.org/10.1136/bmj.k3529
    83 https://doi.org/10.1136/bmj.k793
    84 https://doi.org/10.1146/annurev.immunol.23.021704.115611
    85 https://doi.org/10.1146/annurev.immunol.26.021607.090331
    86 https://doi.org/10.1158/0008-5472.can-05-4303
    87 https://doi.org/10.1158/0008-5472.can-16-0258
    88 https://doi.org/10.1158/1078-0432.ccr-06-2599
    89 https://doi.org/10.1158/1078-0432.ccr-10-0250
    90 https://doi.org/10.1158/2159-8290.cd-15-0283
    91 https://doi.org/10.1158/2326-6066.cir-13-0133
    92 https://doi.org/10.1158/2326-6066.cir-16-0072
    93 https://doi.org/10.1159/000089686
    94 https://doi.org/10.1177/1758835918777427
    95 https://doi.org/10.1200/jco.2014.59.0703
    96 https://doi.org/10.1200/jco.2017.77.6385
    97 https://doi.org/10.1517/13543784.2013.822066
    98 https://doi.org/10.1634/theoncologist.2016-0419
    99 https://doi.org/10.18632/oncotarget.13895
    100 https://doi.org/10.3322/caac.21442
    101 https://doi.org/10.3389/fimmu.2017.00961
    102 https://doi.org/10.3389/fimmu.2018.01774
    103 https://doi.org/10.3389/fonc.2018.00385
    104 https://doi.org/10.3389/fonc.2018.00386
    105 https://doi.org/10.4049/jimmunol.169.7.3581
    106 https://doi.org/10.4049/jimmunol.173.2.945
    107 https://doi.org/10.7150/jca.8167
    108 schema:datePublished 2019-01
    109 schema:datePublishedReg 2019-01-01
    110 schema:description PURPOSE OF REVIEW: Targeting PD-1/PD-L1 immune checkpoints is a new therapeutic tool in patients with locally advanced and metastatic clear cell renal cell carcinoma (CCRCC). The purpose of this review is to offer clinicians an updated translational insight into the current status of a therapeutic alternative that may impact significantly patient's life. RECENT FINDINGS: Immune checkpoint inhibition has recently demonstrated promising results in selected CCRCC patients with respect to tumor progression and survival. The decision to treat these patients with immune checkpoint inhibitors (ICI) relies on the immunohistochemical detection of PD-1/PD-L1 positivity in inflammatory cells in the tumor, which makes the role of the pathologist crucial, but clinical concern upon the reliability to use immunohistochemistry (IHC) to predict therapeutic response is increasing. We review the state of the art of the immune checkpoint inhibition in CCRCC, from the basic science and its fundamentals to the daily application in clinical routine.
    111 schema:genre research_article
    112 schema:inLanguage en
    113 schema:isAccessibleForFree false
    114 schema:isPartOf N3ee5f730c9974216ae05e8910b563332
    115 N694584592d6f4eb2b5208a413ca8d5dd
    116 sg:journal.1022078
    117 schema:name A Critical Insight into the Clinical Translation of PD-1/PD-L1 Blockade Therapy in Clear Cell Renal Cell Carcinoma
    118 schema:pagination 1
    119 schema:productId N0a5d241ed7bd40abb426b2cfc163e183
    120 N15d151973d8545e49b26a8a2b76cca9a
    121 N979c4dbc50764a868441af6ad56aa4da
    122 Nbe2bb2b39ea44b37a27f8ec032e0a3a3
    123 Nfb992894da2b46c5b8bef14c8091ecf6
    124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111429842
    125 https://doi.org/10.1007/s11934-019-0866-8
    126 schema:sdDatePublished 2019-04-11T11:38
    127 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    128 schema:sdPublisher Nfc60bacb4758448184eea940ee7108ca
    129 schema:url https://link.springer.com/10.1007%2Fs11934-019-0866-8
    130 sgo:license sg:explorer/license/
    131 sgo:sdDataset articles
    132 rdf:type schema:ScholarlyArticle
    133 N0a5d241ed7bd40abb426b2cfc163e183 schema:name dimensions_id
    134 schema:value pub.1111429842
    135 rdf:type schema:PropertyValue
    136 N15d151973d8545e49b26a8a2b76cca9a schema:name pubmed_id
    137 schema:value 30645700
    138 rdf:type schema:PropertyValue
    139 N1a7908e862ac4e9ba4582c8074e522a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Kidney Neoplasms
    141 rdf:type schema:DefinedTerm
    142 N1ed6115c40e249408b61aee8b8b3f863 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Molecular Targeted Therapy
    144 rdf:type schema:DefinedTerm
    145 N3ee5f730c9974216ae05e8910b563332 schema:issueNumber 1
    146 rdf:type schema:PublicationIssue
    147 N450a7fb216a54ccb9197961fd6cc65b5 rdf:first sg:person.0645101465.43
    148 rdf:rest Nfd14c0a5fd3f45c6a61c9c7489305be4
    149 N5a7dd0d346f54ee0a2836e0f2b5111db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Programmed Cell Death 1 Receptor
    151 rdf:type schema:DefinedTerm
    152 N694584592d6f4eb2b5208a413ca8d5dd schema:volumeNumber 20
    153 rdf:type schema:PublicationVolume
    154 N80789b4d8e9c4257b5ffcb2414da7980 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Antineoplastic Agents, Immunological
    156 rdf:type schema:DefinedTerm
    157 N8b8d5e64d1264229917b6bfe88ad62e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name B7-H1 Antigen
    159 rdf:type schema:DefinedTerm
    160 N92320424c8de40dbadb19e511b116def rdf:first sg:person.013251056272.76
    161 rdf:rest rdf:nil
    162 N979c4dbc50764a868441af6ad56aa4da schema:name readcube_id
    163 schema:value 0b48e9dab77f2cb83bab27898a53517412b64dec47200050b2820c0da4cc0ea0
    164 rdf:type schema:PropertyValue
    165 Nbe2bb2b39ea44b37a27f8ec032e0a3a3 schema:name doi
    166 schema:value 10.1007/s11934-019-0866-8
    167 rdf:type schema:PropertyValue
    168 Nc817b1d36f8a441090ae77afc37d8757 rdf:first sg:person.0735250361.27
    169 rdf:rest N92320424c8de40dbadb19e511b116def
    170 Ndb0304cd0fde4407a6155c8a03453634 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Humans
    172 rdf:type schema:DefinedTerm
    173 Ne728c6b9f93141608fb7eda0c29fe225 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Carcinoma, Renal Cell
    175 rdf:type schema:DefinedTerm
    176 Nfb992894da2b46c5b8bef14c8091ecf6 schema:name nlm_unique_id
    177 schema:value 100900943
    178 rdf:type schema:PropertyValue
    179 Nfc60bacb4758448184eea940ee7108ca schema:name Springer Nature - SN SciGraph project
    180 rdf:type schema:Organization
    181 Nfd14c0a5fd3f45c6a61c9c7489305be4 rdf:first sg:person.0773436503.58
    182 rdf:rest Nc817b1d36f8a441090ae77afc37d8757
    183 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    184 schema:name Medical and Health Sciences
    185 rdf:type schema:DefinedTerm
    186 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    187 schema:name Immunology
    188 rdf:type schema:DefinedTerm
    189 sg:journal.1022078 schema:issn 1527-2737
    190 1534-6285
    191 schema:name Current Urology Reports
    192 rdf:type schema:Periodical
    193 sg:person.013251056272.76 schema:affiliation https://www.grid.ac/institutes/grid.11480.3c
    194 schema:familyName López
    195 schema:givenName José I.
    196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013251056272.76
    197 rdf:type schema:Person
    198 sg:person.0645101465.43 schema:affiliation https://www.grid.ac/institutes/grid.55325.34
    199 schema:familyName Nunes-Xavier
    200 schema:givenName Caroline E.
    201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645101465.43
    202 rdf:type schema:Person
    203 sg:person.0735250361.27 schema:affiliation https://www.grid.ac/institutes/grid.424810.b
    204 schema:familyName Pulido
    205 schema:givenName Rafael
    206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735250361.27
    207 rdf:type schema:Person
    208 sg:person.0773436503.58 schema:affiliation https://www.grid.ac/institutes/grid.119375.8
    209 schema:familyName Angulo
    210 schema:givenName Javier C.
    211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773436503.58
    212 rdf:type schema:Person
    213 sg:pub.10.1007/s00345-016-1868-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026627857
    214 https://doi.org/10.1007/s00345-016-1868-5
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1007/s00428-014-1673-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011389805
    217 https://doi.org/10.1007/s00428-014-1673-8
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1007/s10238-018-0488-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100588041
    220 https://doi.org/10.1007/s10238-018-0488-3
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1007/s10555-016-9652-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1052190417
    223 https://doi.org/10.1007/s10555-016-9652-y
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1007/s11523-015-0392-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012361695
    226 https://doi.org/10.1007/s11523-015-0392-7
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1007/s12032-015-0655-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007960730
    229 https://doi.org/10.1007/s12032-015-0655-2
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1007/s12032-016-0794-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044635757
    232 https://doi.org/10.1007/s12032-016-0794-0
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1038/70932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005008226
    235 https://doi.org/10.1038/70932
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1038/85330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028604363
    238 https://doi.org/10.1038/85330
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1038/modpathol.2017.59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090294601
    241 https://doi.org/10.1038/modpathol.2017.59
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1038/nrdp.2017.9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129661
    244 https://doi.org/10.1038/nrdp.2017.9
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1038/s41392-018-0022-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107189116
    247 https://doi.org/10.1038/s41392-018-0022-9
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1038/s41598-018-25002-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1103565914
    250 https://doi.org/10.1038/s41598-018-25002-w
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1038/sigtrans.2016.30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004803463
    253 https://doi.org/10.1038/sigtrans.2016.30
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1111/j.1745-7254.2005.00086.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001394709
    256 https://doi.org/10.1111/j.1745-7254.2005.00086.x
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1186/s13000-018-0742-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106340463
    259 https://doi.org/10.1186/s13000-018-0742-8
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1245/s10434-015-4903-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052780297
    262 https://doi.org/10.1245/s10434-015-4903-7
    263 rdf:type schema:CreativeWork
    264 https://app.dimensions.ai/details/publication/pub.1077310707 schema:CreativeWork
    265 https://doi.org/10.1001/jamaoncol.2016.0775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027950456
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1002/emmm.201100128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042193134
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1002/ijc.10303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031240207
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1002/ijc.30077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002199726
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1002/ijc.30429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011779317
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1002/jso.10302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006018615
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/j.anndiagpath.2018.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100273953
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/j.anndiagpath.2018.03.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101745060
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/j.cell.2018.03.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103228551
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/j.cellimm.2005.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002515810
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/j.clgc.2017.10.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092579772
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/j.clim.2005.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031240807
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/j.critrevonc.2017.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085968123
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1016/j.ctrv.2018.07.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105735588
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1016/j.euf.2017.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092293462
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1016/j.eururo.2015.11.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049158062
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1016/j.febslet.2004.07.083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005055472
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/j.humpath.2017.02.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083870272
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1016/j.humpath.2018.07.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105928116
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1016/j.immuni.2017.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083858868
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1016/j.jtho.2017.11.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092998959
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1016/j.jtho.2018.04.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103639702
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1016/j.jtho.2018.05.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104138195
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1016/j.neo.2017.02.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084098106
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/j.prp.2013.01.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043190205
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1016/j.prp.2018.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104532624
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/j.semcdb.2016.08.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040891102
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1016/j.smim.2013.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050144499
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1016/j.vetimm.2009.10.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033168523
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1016/s0140-6736(16)00561-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017311610
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1016/s0378-1119(97)00260-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045756029
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1016/s1470-2045(16)30406-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006797272
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1016/s1470-2045(16)30408-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017906099
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1042/cs20160894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092420786
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1056/nejmoa1510665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019970557
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1056/nejmoa1712126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101673751
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1056/nejmra1601333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074211544
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1063/1.2834500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057877409
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1073/pnas.231486598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017347730
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1080/00313020701570012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041913935
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1080/14728214.2016.1226798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022203694
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1080/1744666x.2016.1214575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042872761
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1084/jem.192.7.1027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050568666
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1084/jem.20131916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007547643
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1084/jem.20181617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106947696
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1093/abbs/36.4.284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009443143
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1093/annonc/mdv615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013858384
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1093/annonc/mdy014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100407368
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1097/mou.0000000000000466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092605977
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1097/pai.0b013e3181dddb20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038994287
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1097/pas.0000000000001105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104569985
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1126/scisignal.2002796 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036931577
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1128/mcb.00319-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045091664
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1136/bmj.k3529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106905187
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1136/bmj.k793 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101530919
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1146/annurev.immunol.23.021704.115611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000712023
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1146/annurev.immunol.26.021607.090331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005008646
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1158/0008-5472.can-05-4303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028547319
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1158/0008-5472.can-16-0258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063216144
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1158/1078-0432.ccr-06-2599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009135816
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1158/1078-0432.ccr-10-0250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001945922
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1158/2159-8290.cd-15-0283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042848118
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1158/2326-6066.cir-13-0133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009133817
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1158/2326-6066.cir-16-0072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046824335
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1159/000089686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025517040
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1177/1758835918777427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104577319
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1200/jco.2014.59.0703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009621823
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1200/jco.2017.77.6385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101034912
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1517/13543784.2013.822066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032357303
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1634/theoncologist.2016-0419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084355313
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.18632/oncotarget.13895 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033899414
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.3322/caac.21442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100164642
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.3389/fimmu.2017.00961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091144369
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.3389/fimmu.2018.01774 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105900690
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.3389/fonc.2018.00385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107203660
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.3389/fonc.2018.00386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107082744
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.4049/jimmunol.169.7.3581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075128315
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.4049/jimmunol.173.2.945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025128086
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.7150/jca.8167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018758803
    422 rdf:type schema:CreativeWork
    423 https://www.grid.ac/institutes/grid.11480.3c schema:alternateName University of the Basque Country
    424 schema:name Biomarkers in Cancer Unit, Biocruces-Bizkaia Health Research Institute, Barakaldo, Bizkaia, Spain
    425 Department of Medical-Surgical Specialties, University of the Basque Country (UPV/EHU), Leioa, Bizkaia, Spain
    426 Department of Pathology, Cruces University Hospital, Plaza de Cruces s/n, 48903, Barakaldo, Bizkaia, Spain
    427 rdf:type schema:Organization
    428 https://www.grid.ac/institutes/grid.119375.8 schema:alternateName European University of Madrid
    429 schema:name Clinical Department, European University of Madrid, Laureate Universities, Madrid, Spain
    430 Department of Urology, University Hospital of Getafe, Getafe, Madrid, Spain
    431 rdf:type schema:Organization
    432 https://www.grid.ac/institutes/grid.424810.b schema:alternateName Ikerbasque
    433 schema:name Biomarkers in Cancer Unit, Biocruces-Bizkaia Health Research Institute, Barakaldo, Bizkaia, Spain
    434 IKERBASQUE, The Basque Foundation for Science, Bilbao, Spain
    435 rdf:type schema:Organization
    436 https://www.grid.ac/institutes/grid.55325.34 schema:alternateName Oslo University Hospital
    437 schema:name Biomarkers in Cancer Unit, Biocruces-Bizkaia Health Research Institute, Barakaldo, Bizkaia, Spain
    438 Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway
    439 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...