What is the Need for Prostatic Biomarkers in Prostate Cancer Management? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-10

AUTHORS

Martin Spahn, Silvan Boxler, Steven Joniau, Marco Moschini, Bertrand Tombal, R. Jeffrey Karnes

ABSTRACT

Discriminating patients with a low risk of progression from those with lethal prostate cancer is one of the main challenges in prostate cancer management. Indeed, such discrimination is essential if we aim to avoid overtreatment in men with indolent disease and to improve survival in those men with lethal disease. We are reporting on the current literature on such prognostic tools that are now available, their clinical role and their limitations in individualizing care. There is an urgent need to incorporate such genomic tools into new platform-based clinical trial structures to further develop and validate prognostic and predictive biomarkers and provide prostate cancer patients with an effective and cost-efficient access to new drugs in the setting of personalized treatment. More... »

PAGES

70

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11934-015-0545-3

DOI

http://dx.doi.org/10.1007/s11934-015-0545-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008997264

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26267226


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