Clinical Assessment and Management of Cytopenias in Lupus Patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-04-19

AUTHORS

Alana B. Levine, Doruk Erkan

ABSTRACT

Anemia, leukopenia, and/or thrombocytopenia can occur as a result of non-immune- and immune-mediated mechanisms in patients with systemic lupus erythematosus. Although the differential diagnosis of these cytopenias is broad and warrants a thorough evaluation, lupus disease activity and medications are common etiologic factors. Corticosteroids are the mainstay of initial treatment for immune-mediated hemolytic anemia and severe thrombocytopenia; immunosuppressive agents such as mycophenolate mofetil or azathioprine are often added for their steroid-sparing effects. Rituximab and intravenous immunoglobulin can be considered for refractory cytopenias based on a large body of anecdotal evidence and case series. Newer biologic agents such as belimumab or epratuzumab have yet to be studied specifically in systemic lupus erythematosus–mediated hematologic disorders. More... »

PAGES

291-299

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11926-011-0179-5

DOI

http://dx.doi.org/10.1007/s11926-011-0179-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051350294

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21503695


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